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| 1 | Test Data Generation for Stateful Network Protocol Fuzzing Using a Rule-Based State Machine显示文摘To improve the efficiency and coverage of stateful network protocol fuzzing, this paper proposes a new method, using a rule-based state machine and a stateful rule tree to guide the generation of fuzz testing data. The method first builds a rule-based state machine model as a formal description of the states of a network protocol.This removes safety paths, to cut down the scale of the state space. Then it uses a stateful rule tree to describe the relationship between states and messages, and then remove useless items from it. According to the message sequence obtained by the analysis of paths using the stateful rule tree and the protocol specification, an abstract data model of test case generation is defined. The fuzz testing data is produced by various generation algorithms through filling data in the fields of the data model. Using the rule-based state machine and the stateful rule tree,the quantity of test data can be reduced. Experimental results indicate that our method can discover the same vulnerabilities as traditional approaches, using less test data, while optimizing test data generation and improving test efficiency. | Rui Ma Daguang Wang Changzhen Hu Wendong Ji Jingfeng Xue | 2016 | Tsinghua Science and Technology2016，21，3： | 13 |
| 2 | Anatomical variation of infra-pyloric artery origination: A prospective multicenter observational study (IPA-Origin)显示文摘Objective: Infra-pyloric artery(IPA) is an important anatomical landmark in treatment of gastric cancer and is the key vessel for pylorus-preserving gastrectomy and subgroup of infra-pyloric lymph nodes. However, its anatomical variation is not thoroughly understood. Our study aimed to clarify the origination of the IPA.Methods: We did this prospective, multicenter, open-label, observational study at gastric surgery departments of34 hospitals in China. Gastric cancer patients aged 18 years or older and scheduled to undergo elective total or distal gastrectomy were assigned. During the surgery, IPA dissecting and exposing the origination point with photographs or video clips were required. The primary outcome was the origination of the IPA. Analysis of variance, χ~2 tests and Fisher's tests were used to analyze the differences between groups. The study is registered at Clinicaltrials.gov(No. NCT03071237).Results: Between May 8 and July 31, 2017, 429 patients were assigned for the study, and 419(97.7%) patients had the IPA dissected and recorded through photograph or video and were included in the primary outcome analysis. The median age was 62 years old, and 73.7% were male. Among the patients, 78.5% received laparoscopic surgery. Single IPA origination was identified in 398(95.0%) patients, including gastroduodenal artery(GDA) in154(36.8%) patients, anterior superior pancreaticoduodenal artery(ASPDA) in 130(31.0%) patients, and right gastroepiploic artery(RGEA) in 114(27.2%) patients. Fifteen(3.6%) patients were identified with multiple IPA and 6(1.4%) patients were identified as IPA absence. The differences in the distribution of surgical approach(P=0.003) and geographic area(P=0.030) were statistically significant. No difference was shown in sex, age,gastrectomy type, tumor location, and clinical T, N and M stage.Conclusions: Our study found that the IPA originates from GDA, ASPDA and RGEA in similar proportions.Laparoscopic surgery may be more helpful in dissection of the IPA than open surgery. | Rulin Miao Jianjun Qu Zhengrong Li Daguang Wang Jiang Yu Weidong Zang Yong Li Fenglin Liu Jian Zhang Wu Song Kai Ye Su Yan Wei Wang Shuangyi Ren Lu Zang Changqing Jing Li Zhang Kuan Wang Weihua Fu Lin Fan Bin Liang Gang Zhao Jun Cai Li Yang Jiaming Zhu Jun You Kun Yang Qingxing Huang Zhaojian Niu Ning Ning Xingfeng Qiu Gang Ji Feng Liang Hua Huang Chao Gao Fei Shan Shuangxi Li Yongning Jia Lianhai Zhang Xiangji Ying Yan Zhang Zhaode Bu Xiangqian Su Gang Zhao Ziyu Li Jiafu Ji | 2018 | Chinese Journal of Cancer Research2018，30，5： | 5 |
| 3 | Ancient DNA sequences of rice from the low Yangtze reveal significant genotypic divergence显示文摘Rice (Oryza sativa) was first domesticated in the lower and middle Yangtze regions of China, and rice remains have been found in many Chinese archaeological sites. Until now, only phenotypic archeobotanical evidence, such as the spikelet bases of ancient grains, has been used to speculate on the domestication process and domestication rate of rice. In this study, we sequenced 4 genomic segments from rice remains in Tianluoshan, a site of the local Hemudu Neolithic culture in the low Yangtze and two other archaeological sites (~2400 and 1200 BC, respectively). We compared our sequences with those of the current domesticated and wild rice (O. rufipogon) populations. At least two genotypes were found in the remains from each site, suggesting a heterozygotic state of the rice seeds. One ancient genotype was not found in the current domesticated population and might have been lost. The rice remains belonged to the japonica group, and most if not all were japonica-type, suggesting that the remains might be at an early stage of indica-japonica divergence or an indica-japonica mixture. We also identified sequences with significant similarity to those from species of Sapindales, Zygophyllales, and Brassicales, which is consistent with the identification of other plant remains in the Tianluoshan site and the common rice field weeds such as mustards in southern China. | FAN LongJiang GUI YiJie ZHENG YunFei WANG Yu CAI DaGuang YOU XiuLing | 2011 | Chinese Science Bulletin2011，56，28： | 2 |
| 4 | An Study of Smelting Reduction between V-Ti Slag System and Carbon Saturated Molten Iron显示文摘 | Tu Shiwei Wang Daguang Xuan Demao | 1989 | Iron Steel Vanadium Titanium1989，10，2： | 1 |
| 5 | The Physical Chemistry Action of Vanadium between Slag and Iron Photographs in the Condition of Slag contenting Vanadium Oxide Returning to Blast Furnace显示文摘 | Wang Daguang Xia Anwu | 1980 | Engineering Chemistry & Metallurgy1980，1，2： | 1 |
| 6 | Effects of brain-derived neurotrophic factor on synapsin expression in rat spinal cord anterior horn neurons cultured in vitro显示文摘Brain-derived neurotrophic factor (BDNF) promotes synaptic formation and functional maturation by upregulating synapsin expression in cortical and hippocampal neurons. However, it remains controversial whether BDNF affects synapsin expression in spinal cord anterior horn neurons. Wistar rat spinal cord anterior horn neurons were cultured in serum-supplemented medium containing BDNF, BDNF antibody, and Hank's solution for 3 days, and then synapsin I and synaptophysin protein and mRNA expression was detected. Under serum-supplemented conditions, the number of surviving neurons in the spinal cord anterior horn was similar among BDNF, anti-BDNF, and control groups (P > 0.05). Synapsin I and synaptophysin protein and mRNA expressions were increased in BDNF-treated neurons, but decreased in BDNF antibody-treated neurons (P < 0.01). These results indicated that BDNF significantly promotes synapsin I and synaptophysin expression in in vitro-cultured rat spinal cord anterior horn neurons. | Zhifei Wang Daguang Liao Changqi Li | 2010 | Neural Regeneration Research2010，5，16： | 1 |
| 7 | Cloning and characterization of novel PDE4D isoforms PDE4D6 and PDE4D7 显示文摘 | Daguang Wang Chengjun Deng Bozena Bugaj-Gaweda | 2003 | Cellular Signalling2003，15，： | 1 |
| 8 | Novel multifunctional theranostic nanoagents based on Ho^(3+) for CT/MRI dual-modality imaging-guided photothermal therapy显示文摘Because of the intrinsic defects of traditional treatment of cancer,it is quite needed to construct novel theranostic nanoagents that can not only improve the accuracy of imaging diagnosis but also achieve highly efficient therapy of cancer.Herein,we fabricated polydopamine-functionalized ammonium holmium fluoride nanocomposites(AHF@PDA)for dual-modality bioimaging(magnetic resonance imaging(MRI)and computed tomography(CT))owing to the high X-ray attenuation feature and magnetic property of Ho^(3+).Moreover,PDA shell endows AHF@PDA with excellent photothermal conversion performances and robust biocompatibility,leading to good treatment effect in vitro and in vivo.All above positive results certify that AHF@PDA have good potential as theranostic agents for clinical application in the future. | Dongzhi Xue Yang Liu Longhai Jin Yinghui Wang Fengzhi Cui Jianhua Liu Xiaoqing Li Songtao Zhang Ying Zhao Na Yin Rui Niu Daguang Wang Hongjie Zhang | 2021 | Science China Chemistry2021，64，4： | 1 |
| 9 | Engineering CeO_(2)/CuO heterostructure anchored on upconversion nanoparticles with boosting ROS generation-primed apoptosisferroptosis for cancer dynamic therapy显示文摘Highly toxic reactive oxygen species(ROS)induced apoptosis and ferroptosis have been considered as significant cell death pathways for cancer therapy.However,insufficient amount of intracellular ROS extremely restricts the therapeutic effect.Toward this,we report a rationally designed nanocomposite(mUCC)with enhanced ROS generation ability,inducing the combination of apoptosis and ferroptosis through synergistic photodynamic therapy(PDT)and chemodynamic therapy(CDT).Under 808 nm near-infrared(NIR)light irradiation,photocatalytic reaction is triggered starting from the separation of electron-hole pairs on the surface of heterojunction(CeO_(2)/CuO),realizing improved ROS production.Simultaneously,mUCC served as Fenton-like agent exhibits considerable ability to generate highly toxic·OH under tumor microenvironment(TME).The boosted accumulation of ROS disrupts the redox balance within tumor cells and results in the integration of apoptosis and ferroptosis.In addition,mUCC shows satisfactory tumor targeting property benefiting from the cancer cell membrane functionalization under the guidance of magnetic resonance imaging(MRI)and NIR fluorescence imaging.The intelligent mUCC with good biocompatibility and excellent antitumor response achieves efficient tumor elimination under synergistic PDT and CDT.This work offers an elective approach for further development of ROS-based therapeutic nanoplatform in cancer therapy. | Xuan Gao Jing Feng Kehong Lv Yifei Zhou Ruohao Zhang Shuyan Song Hongjie Zhang Daguang Wang | 2023 | Nano Research2023，16，4： | 1 |
| 10 | Sulfate Ions Immobilization of Calcined Layered Double Hydroxides in Hardened Cement Paste and Concrete显示文摘The sulfate ions immobilization behavior of calcined layered double hydroxides(CLDHs) in the hardened cement paste was investigated. The experimental results show that the sulfate ions in cement paste are immobilized by CLDHs to reconstruct the layered structure and aggregate around CLDHs. The immobilization amount of sulfate ions by CLDHs reaches 4.74×10^-3 mol/g, while the increasing amount indicates non-linear relation with the addition of CLDHs. The incorporation of CLDHs decreases the amount of ettringite formed to limit the expansion of cement paste, which decays the sulfate reaction to enhance the sulfate resistance of concrete. | 马军涛 WANG Daguang 段平 SHI Yanke | 2019 | Journal of Wuhan University of Technology(Materials Science)2019，34，6： | 1 |
| 11 | Feasibility of manufacturing phosphoric acid by smelting reduction technology 显示文摘 | GUO Zhancheng SONG Xueping WANG Daguang | 2005 | Mineral Processing and Extrac- tive Metallurgy ( Trans Inst Min Metall C )2005，114，1： | 1 |
| 12 | Research on the Reduction Mechanism of Iron Ore Pellets Containing Graphite显示文摘 | Guo Zhancheng Wang Daguang | 1995 | Engineering Chemistry and Metallurgy1995，16，2： | 1 |
| 13 | Nevus comedonicus with unusual bilateral band distribution around the neck 显示文摘 | Daguang Wang Wenyuan Zhu | 2005 | Eur J Pediat Dermatol2005，15，： | 1 |
| 14 | Ball-milling Synthesis of Single-atom Cu Anchored on N-Doped Carbon for Mimicking Peroxidase显示文摘Nanozymes have shown great potential for life sciences owing to their distinct advantages,such as low cost and high stability,compared with natural enzymes.Despite significant progress,state-of-art nanozymes commonly suffer from relatively low specific activities.Herein,we propose a promising to address this issue by creating single-atom nanozymes.A ball-milling-assisted strategy has been developed to induce the transformation of Cu species from bulk to single atoms.The highly-simplified steps allow a large-scale synthesis,that over 4.2 g of single-atom Cu-N doped carbon nanozymes can be achieved in one pot.It exhibits a remarkably improved peroxidase-like activity and stability compared with N doped C anchored Cu nanoparticles.Further experimental firmly reveals the crucial role of the single-atom Cu site that can generate more active·OH species for boosting the catalytic process. | XU Henan ZHANG Lingling WANG Huilin ZHANG Shaopeng LI Wei WANG Xiao SONG Shuyan WANG Daguang SHI Zhan | 2023 | Chemical Research in Chinese Universities2023，39，6： | 0 |
| 15 | Correlation between the Sulphide Capacity Index and the Slag Basicity 显示文摘CorrelationbetweentheSulphideCapacityIndexandtheSlagBasicityYangXuemin;LiuTianzhong;GuoZhancheng;YuXianpu;WangDaguangAbstract... | Yang Xuemin Liu Tianzhong Guo Zhancheng Yu Xianpu Wang Daguang | 1996 | Journal of Iron and Steel Research(International)1996，3，1： | 0 |
| 16 | Ultrastructure of Amelanotic Melanocytes from Human Hair Follicles显示文摘Objective: To investigate the ultra structure of amelanotic melanocytes (AMMC). Methods: The hair follicles obtained from normal human scalp by 0.50% collagenase type V treatment were washed with 0.1 mol/L phosphate buffer salt (PBS). Hair-follicle cell suspensions were prepared by trypsin treatment and cultured in melanocyte medium. Remaining keratinocytes were removed by differential trypsinization. 100μg/ml geneticin was used to eliminate the contaminating fibroblasts. At third passage, the cells were trypsinized, and then washed in phosphate-buffered saline and processed for transmission electron microscopy. Results: Under transmission electron microscope, the cultured cells showed round or oval shape, with single large nuclear and the karyotheca were double deck. There were obvious euchromosome within the nucleus, and sparse heterochromosome. There were various organelles in the cytoplasm, including plentiful melanosomes with nearly similar size, mitochondria, rough endoplasmic reticule(RER) and ribosome. The electron density granules in most of the melanosomes disposed along concentric circularities. Golgi apparatus in the cells was inconspicuous. Conclusion: The ultra structure of AMMC from human hair follicles is different from that of epidermal melanocytes, and these characteristics determine the functional immature of AMMC. | Ruzhi Zhang Wenyuan Zhu Mingyu Xia Daguang Wang Huijun Ma | 2007 | Journal of Nanjing Medical University2007，21，1： | 0 |
| 17 | Kinetics of Reduction of Iron Oxide in CaO-SiO_2-Al_2O_3-Fe_tO Slags with Graphite Powder显示文摘The reduction rate of Fe_tO in CaO-SiO_2-Al_2O_3-Fe_tO slags with graphite powder has been determined in an alumina crucible at 1 673-1 823 K.The effects of temperature,slag basicity and Fe_tO content on the reduction rate have also been discussed.Test results show that the reduction rate increases with the increase of temperature or Fe_tO concentration in slags,and the reduction rate has a parabolic relation with slag simple basicity or optical basicity.The maximum reduction rate is observed around CaO/SiO_2 = l.5 of molten slags.The reaction order is 1.26 or 1.31,and the reduction activation energy is 126.8 or 129.7 kJ/mol respectively in regard to Fe_tO content or Fe_tO activity calculated by using regular solution model.The reduction rate of Fe_tO in CaO-SiO_2-Al_2O_3-Fe_tO slags with graphite powder is in the range of 0.15×10^(-4)- 0.86×10^(-4) mol-O/cm^2 · s. | Yang Xuemin Huang Dianbing Kong Lingtan Yang Tianjun Xie Yusheng Wang Daguang | 1998 | Journal of Iron and Steel Research(International)1998，5，1： | 0 |
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