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| 1 | The Uplift of the Longmenshan Thrust Belt and Subsidence of the West Sichuan Foreland Basin显示文摘Based on fission track dating of apatite, and measurement of vitrinite reflectance of rock samples from the Longmenshan (Longmen Mountain)area and the West Sichuan foreland basin and computer modelling it is concluded that (l)the Songpan-Garze fold belt has uplifted at least by 3-4 km with an uplift rate of no less than 0.3-0.4 mm/a since 10 Ma B.P.; (2) the Longmenshan thrust nappe belt has uplifted at least by 5-6 km with an uplift rate of more than 0.5- 0.6 mm /a since 10 Ma B.P.; (3) the Longmenshan detachment belt has uplifted by 1 - 2 km at a rate of 0.016-0.032 mm/a since 60 Ma B.P.; (4) the West Sichuan foreland basin has uplifted by 1.7-3 km at a rate of 0.028-0.05 mm/a since 60 Ma B.P.; (5) the uplift rate of the area on the west side of the Beichuan-Yingxiu-Xiaoguanzi fault for the last 10 Ma is 40 times as much as that on its east side; (6) the uplifting of the the Songpan - Garze fold belt and the subsidence of the West Sichuan foreland basin 60 Ma ago exhibit a mirro-image correlation, i. | Liu Shugen, Luo Zhili, Dai Sulan, Changlu Institute of Technology, Chengdu, Sichuan, ChinaDennis Arne Dalhousie U niversity, Canadaand C.J.L. Wilson Melbourne U niversity, Australia Jiang M inxi | 1996 | Acta Geologica Sinica(English Edition)1996，70，1： | 21 |
| 2 | Non-linear Torsional Vibration Characteristics of an Internal Combustion Engine Crankshaft Assembly显示文摘Crankshaft assembly failure is one of the main factors that affects the reliability and service life of engines.The linear lumped mass method,which has been universally applied to the dynamic modeling of engine crankshaft assembly,reveals obvious simulation errors.The nonlinear dynamic characteristics of a crankshaft assembly are instructionally significant to the improvement of modeling correctness.In this paper,a general expression for the non-constant inertia of a crankshaft assembly is derived based on the instantaneous kinetic energy equivalence method.The nonlinear dynamic equations of a multi-cylinder crankshaft assembly are established using the Lagrange rule considering nonlinear factors such as the non-constant inertia of reciprocating components and the structural damping of shaft segments.The natural frequency and mode shapes of a crankshaft assembly are investigated employing the eigenvector method.The forced vibration response of a diesel engine crankshaft assembly taking into account the non-constant inertia is studied using the numerical integral method.The simulation results are compared with a lumped mass model and a detailed model using the system matrix method.Results of non-linear torsional vibration analysis indicate that the additional excitation torque created by non-constant inertia activates the 2nd order rolling vibration,and the additional damping torque resulting from the non-constant inertia is the main nonlinear factor.The increased torsional angular displacement evoked by the high order excitation torque relates to the non-constant inertia.This research project is aimed at improving nonlinear dynamics theory,and the confirmed nonlinear parameters can be used for the structure design of a crankshaft assembly. | HUANG Ying YANG Shouping ZHANG Fujun ZHAO Changlu LING Qiang WANG Haiyan | 2012 | Chinese Journal of Mechanical Engineering2012，25，4： | 7 |
| 3 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 4 | A Green Biocompatible Fabrication of Highly Porous Functional Ceramics with High Strength and Controllable Pore Structures显示文摘A green biocompatible foaming method utilizing natural coconut oil and cornstarch was developed to fabricate highly porous functional ceramics with controllable strengths and pore structures. The porosity of Al2O3 ceramics prepared via this method reached 79.6%–86.9% while these ceramics maintained high compressive strengths of 2.2–5.5 MPa. More importantly, porous Al2O3 ceramic with a pore size gradient was also readily fabricated by casting serial layers of foams that were set for different time periods.The potential applications of porous Al2O3 and HA ceramics fabricated by this green foaming method including scaffolds for oil cleaning and cell culture, respectively, were also demonstrated. | Changlu Xu Haoran Liu Huilin Yang Lei Yang | 2016 | Journal of Materials Science & Technology2016，32，8： | 4 |
| 5 | Interventional treatments for hepatic hemangioma:A state-of-the-art review显示文摘Hepatic hemangiomas(HHs)are the most common benign tumors of the liver.These tumors are mainly asymptomatic and do not require treatment.Nevertheless,there are some special cases that require therapeutic intervention,and surgery and intervention are currently the primary treatment modalities.Despite significant advances in the development of minimally invasive techniques and their popularization,interventional treatment of HH is still the preferred choice.In the present review,we discuss the pathological properties,type of blood supply,and treatment indications for HH and assess the status and progress of the existing interventional treatments. | Kefeng Jia Zhongsong Gao Mingge Li Changlu Yu | 2022 | Journal of Interventional Medicine2022，5，1： | 4 |
| 6 | A Model of Mobile P2P Network Architecture based on Agent显示文摘A model of mobile peer to peer (P2P) network architecture based on agent for mobile value-added services is proposed in this paper. By using this model, wireless devices can build a P2P network dynamically, and then they can access and transmit information peer to peer. An ontologybased semantic information description method is also proposed for the mobile wireless devices. The merit of this method is to enhance search efficiency. Moreover, a small system, called CellChat, has been implemented based on this model in the lab environment. Experimental results are provided to show that the benefi ts of the proposed method. This method will become an effective solution for mobile value-added services in 3G network. | Fan Chunxiao Liu Jie Zhang Xiaoying Gong Changlu | 2010 | China Communications2010，7，1： | 4 |
| 7 | Ultrastructural analysis of neuronal synapses using state-of-the-art nano-imaging techniques显示文摘Neuronal synapses are functional nodes in neural circuits.Their organization and activity define an individual's level of intelligence,emotional state and mental health.Changes in the structure and efficacy of synapses are the biological basis of learning and memory.However,investigation of the molecular architecture of synapses has been impeded by the lack of efficient techniques with sufficient resolution.Recent developments in state-of-the-art nano-imaging techniques have opened up a new window for dissecting the molecular organization of neuronal synapses with unprecedented resolution.Here,we review recent technological advances in nano-imaging techniques as well as their applications to the study of synapses,emphasizing super-resolution light microscopy and 3-dimensional electron tomography. | Changlu Tao Chenglong Xia Xiaobing Chen Z. Hong Zhou Guoqiang Bi | 2012 | Neuroscience Bulletin2012，28，4： | 3 |
| 8 | Single-cell transcriptomic landscape of human blood cells显示文摘High throughput single-cell RNA-seq has been successfully implemented to dissect the cellular and molecular features underlying hematopoiesis.However,an elaborate and comprehensive transcriptome reference of the whole blood system is lacking.Here,we profiled the transcriptomes of 7551 human blood cells representing 32 immunophenotypic cell types,including hematopoietic stem cells,progenitors and mature blood cells derived from 21 healthy donors.With high sequencing depth and coverage,we constructed a single-cell transcriptional atlas of blood cells(ABC) on the basis of both protein-coding genes and long noncoding RNAs(lncRNAs),and showed a high consistence between them.Notably,putative lncRNAs and transcription factors regulating hematopoietic cell differentiation were identified.While common transcription factor regulatory networks were activated in neutrophils and monocytes,lymphoid cells dramatically changed their regulatory networks during differentiation.Furthermore,we showed a subset of nucleated erythrocytes actively expressing immune signals,suggesting the existence of erythroid precursors with immune functions.Finally,a web portal offering transcriptome browsing and blood cell type prediction has been established.Thus,our work provides a transcriptional map of human blood cells at single-cell resolution,thereby offering a comprehensive reference for the exploration of physiological and pathological hematopoiesis. | Xiaowei Xie Mengyao Liu Yawen Zhang Bingrui Wang Caiying Zhu Chenchen Wang Qing Li Yingying Huo Jiaojiao Guo Changlu Xu Linping Hu Aiming Pang Shihui Ma Una Wang Wenbin Cao Shulian Chen Qiuling Li Sudong Zhang Xueying Zhao Wen Zhou Hongbo Luo Guoguang Zheng Erlie Jiang Sizhou Feng Lixiang Chen Lihong Shi Hui Cheng Sha Hao Ping Zhu Tao Cheng | 2021 | National Science Review2021，8，3： | 3 |
| 9 | Relationship between polymorphism of class Ⅱ transactivator gene promoters and chronic hepatitis B显示文摘AIM: To investigate the relationship between the polymorphism of class Ⅱ transactivator (CⅡTA) gene promoters and chronic hepatitis B (CHB).METHODS: Genomic DNA was prepared from peripheral blood leukocytes. Promoters Ⅰ, Ⅲ and Ⅳ of gene were analyzed respectively with polymerase chain reaction single strand conformation polymorphism (PCR-SSCP) in 65 patients with CHB, 26 patients with acute hepatitis B (AHB) and 85 normal controls.RESULTS: No abnormal migration was found in PCR-SSCP analysis of the three promoters in the three groups. Also,no sequential difference was observed at the three promoters among the CHB patients, AHB patients and normal controls.CONCLUSION: No polymorphism in promoters Ⅰ, Ⅲ and Ⅳ of CⅡTA gene exists in CHB patients, ABH patients and normal controls, suggesting that the promoter of CⅡTA gene might be a conserved domain. | Ying-RenZhao LingGong Ying-LiHe FangLiu ChangLu | 2005 | World Journal of Gastroenterology2005，11，6： | 2 |
| 10 | Investigation on the combustion characteristics of a diesel engine fueled with diesel–azides blends显示文摘 | Geng Fu Changlu Zhao Bolan Liu Fujun Zhang Siping Pang Yuchuan Li | 2011 | Applied Energy2011，，1： | 2 |
| 11 | Electrospinning preparation and characterization of polyoxometalate fibers显示文摘Poly(vinyl alcohol)/K7[SiW11O39Co(H3P2- O7)] hybrid fine fiber mats (PVA/SiW11Co-P2O7) were prepared through electrospinning technique. After calcinations of PVA/SiW11Co-P2O7 at 500℃ for 8 h, pure SiW11Co-P2O7 fine fibers were obtained with the Keggin structure keeping unchanged. The fiber mats were characterized by IR, ESR, PXRD and scanning electron microscopy (SEM) methods. The average diameter of the fibers is about 250 nm. The SiW11Co- P2O7 fibers showed color change when absorbing and desorbing moisture. | YU Hongquan PENG Jun GUAN Hongyu XIN Zhifeng PAN Yan GONG Jian SHAO Changlu DONG Baoxia | 2006 | Chinese Science Bulletin2006，51，8： | 2 |
| 12 | Electro- spun nanofibers of V-doped TiO2 with high photocatalytic activity显示文摘 | Zhang Zhenyi Shao Changlu Zhang Lina | 2010 | J Colloid Interf Sci2010，351，： | 1 |
| 13 | ldentification of new red pigments produced by Monascus rubber 显示文摘 | Xijun Lian Changlu Wang Kunliang Guo | 2007 | Dyes and Pigments2007，73，： | 1 |
| 14 | Electrospun Nanofibers of p-Type Ni O/n-Type Zn O Heterojunctions with Enhanced Photocatalytic Activity显示文摘 | Zhang Zhenyi Shao Changlu Li Xinghua | 2010 | ACS Appl Mater Interfaces2010，2，10： | 1 |
| 15 | Antifungal activity of volatile organic compounds from Streptomyces alboflavus TD-1显示文摘 | WANG Changlu WANG Zhifang QIAO Xi | 2013 | FEMS Microbiology Letters2013，341，1： | 1 |
| 16 | Identification of new red pigments produced by Monaseus rubber显示文摘 | Lian Xijun Wang Changlu Guo Kunliang | 2007 | Dyes and Pigments2007，73，： | 1 |
| 17 | Strong Verifiable Secret Sharing Scheme显示文摘 | Harn L Lin Changlu | 2010 | Information Sciences2010，180，16： | 1 |
| 18 | High Photocatalytic Activity of ZnO-Carbon Nanofiber Heteroarchitectures显示文摘 | MO Jingbo SHAO Changlu GUO Zengcai | 2011 | Applied Materials and Interfaces2011，3，： | 1 |
| 19 | Fumigant activity of volatiles from Streptomyces alboflavus TD-1 against Fusarium moniliforme Sheldon显示文摘 | WANG Zhifang WANG Changlu LI Fengjuan | 2013 | Journal of Microbiology2013，51，4： | 1 |
| 20 | Prevalence of Dyslipidemia and Associated Factors Among the Hypertensive Rural Chinese Population显示文摘 | Xingang Zhang Zhaoqing Sun Liqiang Zheng Jue Li Shuangshuang Liu Changlu Xu Jiajin Li Fenfen Zhao Dayi Hu Yingxian Sun | 2007 | Archives of Medical Research2007，，4： | 1 |
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