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| 1 | 尿激酶治疗急性心肌梗塞多中心临床试验1406例总结显示文摘为观察尿激酶天普洛欣(UKTP)经静脉溶栓治疗急性心肌梗塞(AMI)的临床有效性及安全性。收集协作组148家医院1994年11月至1996年4月经静脉UKTP溶栓治疗AMI患者1406例,观察临床疗效、副作用及病死率等。其中124例行90分钟冠状动脉造影评价梗塞血管开通情况。结果:梗塞血管临床再灌注率为73.5%,90分钟冠状动脉造影血管开通率为72.6%,5周总病死率为7.8%(109/1406),轻度出血10.2%(143/1406),中重度出血0.43%(6/1406),脑出血0.50%(7/1406)。老年(>65岁)甚至高龄(>75岁)患者溶栓及距发病超过6小时者,其用药仍然安全有效,UKTP合适的用药剂量可能为150万U左右。结果提示UKTP治疗AMI安全有效。 | The collaborative study group for national multicenter clinical trial of urokinase thrombolytic therapy (Correspondence: Hu Dayi, Xu Zhimin. Beijing Red Cross Chao Yao Hospital, Beijing 100020) | 1997 | 中华心血管病杂志1997，25，3： | 139 |
| 2 | 不稳定性心绞痛、急性非Q波心肌梗死不同抗栓疗法的对比研究显示文摘目的 观察不同抗栓方案对急性冠状动脉综合征心脏事件、出血风险和预后的影响。方法 本研究为前瞻性、多中心、随机、开放试验 ,入选患者随机分为静脉滴注普通肝素组和皮下注射低分子量肝素组。入选对象为不稳定性心绞痛或非Q波心肌梗死 ,入选前 4 8小时以内至少有一次心绞痛发作 ,ST段无抬高。肝素 10 0IU/kg静注 ,续 10 0 0IU/h ,维持活化的部分凝血活酶时间 (APTT)或活化的全血凝固时间 (ACT)于正常的 1 5~ 2 0倍 ,连续 7日。低分子量肝素 0 4~ 0 6ml,每日两次皮下注射 ,连续 7日。主要观察终点 :随访治疗 3 0日内发生急性心肌梗死、心脏性或非心脏性死亡和药物治疗无法控制心绞痛 ,需行急性血运重建术。住院至少 7日 ,随访至治疗后 3 0日。结果 本研究共入选符合条件的患者 4 0 2例 ,两组在性别、年龄、心血管危险因素和心绞痛发作方面差异无显著性。治疗后 7日 ,两组用药期间平均胸痛发作次数差异无显著性 ,但肝素组有更多的患者需口服硝酸甘油缓解胸痛 ;病死率在低分子量肝素组较普通肝素组低 ,两组比较P值为 0 0 62 ,复合终点事件 (死亡、心肌梗死和紧急血管重建 )在低分子量肝素组明显下降。低分子量肝素组出血事件明显少于肝素组。治疗开始后 3 0日 ,低分子量肝素组死亡和复合终点事? | Clinical Collaborative Study Group of Low Molecular Weight Heparin (Correspondent: HU Dayi, XU Juntang. Beijing Red Cross Chaoyang Hospital, Beijing University of Medical Sciences, Beijing 100020, China) | 2000 | 中华心血管病杂志2000，28，1： | 172 |
| 3 | 2008中西方BNP专家共识显示文摘1.前言
2008年6月,来自中国、美国、欧洲的急诊科、心血管科、实验室及内科临床专家相聚在中国上海。 | Alan Maise Christian Mueller W. Frank Peacock Gerasimos Filippatos Hu Dayi 胡大一(主译) 刘梅颜(主译) 吴寸草(翻译) 王博雅(翻译) 黄睿(翻译) | 2009 | 中国医药导刊2009，11，10： | 76 |
| 4 | A Multicentre Prospective Evaluation of the Impact of Renal Insufficiency on In-hospital and Long-term Mortality of Patients with Acute ST-elevation Myocardial Infarction显示文摘 | Chao Li Dayi Hu Xubo Shi Li Li Jingang Yang Li Song Changsheng Ma | 2015 | Chinese Medical Journal2015，，1： | 18 |
| 5 | 90分钟冠状动脉造影评价急性心肌梗塞血管开通及临床再通指标价值显示文摘通过经静脉溶栓开始后90分钟冠状动脉造影(CAG),观察国产尿激酶(天普洛欣,UKTP)静脉溶栓治疗急性心肌梗塞(AMI)血管开通疗效,并评价临床再灌注标准的判断价值如何。方法:从UKTP多中心治疗AMI1406例中,汇集其中所行冠状动脉造影(CAG)共124例资料。结果提示:(1)124例AMI患者,在溶栓开始后90分钟时的梗塞相关血管的血流达TIMIⅢ级者52例(41.9%)、Ⅱ级38例(30.7%),梗塞相关血管再开通率为72.6%;(2)溶栓距起病时间愈早,具有愈高的开通趋势,但差异无统计学意义;(3)以CAG为金标准,临床标准对血管开通判断敏感性为88%,特异性为69%,准确性为83%。结论:UKTP静脉溶栓治疗AMI血管开通疗效肯定,临床标准判断血管再通的敏感性较高,但特异性欠佳,有待提高。 | The multicentre investigating group of thrombolytic therapy on acute myocardial infarction with Urokinase Techpool Correspondence: Hu Dayi, Xu Zhimin. Chaoyang Red Cross Hospital, Capital University of Medical Sciences, Beijing 100020 | 1997 | 中华心血管病杂志1997，25，4： | 11 |
| 6 | Dynamic behavior of aero-engine rotor with fusing design suffering blade off显示文摘Fan blade off(FBO) from a running turbofan rotor will introduce sudden unbalance into the dynamical system,which will lead to the rub-impact,the asymmetry of rotor and a series of interesting dynamic behavior.The paper first presents a theoretical study on the response excited by sudden unbalance.The results reveal that the reaction force of the bearing located near the fan could always reach a very high value which may lead to the crush of ball,journal sticking,high stress on the other components and some other failures to endanger the safety of engine in FBO event.Therefore,the dynamic influence of a safety design named ‘‘fusing' is investigated by mechanism analysis.Meantime,an explicit FBO model is established to simulate the FBO event,and evaluate the effectiveness and potential dynamic influence of fusing design.The results show that the fusing design could reduce the vibration amplitude of rotor,the reaction force on most bearings and loads on mounts,but the sudden change of support stiffness induced by fusing could produce an impact effect which will couple with the influence of sudden unbalance.Therefore,the implementation of the design should be considered carefully with optimized parameters in actual aero-engine. | Cun WANG Dayi ZHANG Yanhong MA Zhichao LIANG Jie HONG | 2017 | Chinese Journal of Aeronautics2017，30，3： | 11 |
| 7 | Modal characteristics analysis for a flexible rotor with non-smooth constraint due to intermittent rub-impact显示文摘Intermittent rub-impact, during which the contact between rotor and stator is characterized by a ‘‘bouncing' or intermittent type of behavior, is one of the most common rubbing forms in rotating machinery. When the intermittent rub-impact occurs, the non-smooth constraint, which is the phenomenon that the system stiffness changes with respect to the state of contact and noncontact, will appear. The paper aims at discovering the possible effects of the non-smooth constraint on the flexible rotor's modal characteristics by theoretical and experimental methods. The qualitative description for non-smooth constraint is given for the intermittent rub-impact process, and the dynamic modeling for a rotor system with non-smooth constraint is carried out. Meanwhile, the analysis method is developed by Floquet theory and Hill's method to obtain the rotor's modal characteristics. The results reveal that the non-smooth constraint produced by the intermittent rubimpact will increase the modal frequencies and critical speeds of the rotor system significantly.Due to the time-varying features of the constraint stiffness, the modal frequencies for the intermittent rub-impact rotor present fluctuant changes with the increase of rotation speed, which is different from the general linear rotor system. The non-smooth constraint is possible to lead the rotor's instability, and the rotor's instable regions can be expanded significantly for the increase of average constraint stiffness, constraint amplitude and contact time ratio. Non-smooth constraint could also expand the resonance speed and resonance sideband of the rotor system, which sometimes results in amplitude jump phenomenon. | Jie HONG Pingchao YU Dayi ZHANG Zhichao LIANG | 2018 | Chinese Journal of Aeronautics2018，31，3： | 8 |
| 8 | Investigation on nonlinear lateral-torsional coupled vibration of a rotor system with substantial unbalance显示文摘Substantial unbalance may be caused by fan blade off during the operation period of gas turbine engines,and related dynamic problems are very critical to the safety design of rotor system in aero-engine.This article aims to understand lateral-torsional coupled vibration of the rotor system with substantial unbalance.The governing equation of a modified unbalanced rotor system is established based on Lagrangian approach.Then,a mathematical analytical method is proposed in which a linear approximation is derived and the Floquet theory and Hill’s method are incorporated,from which the modal characteristics of the unbalanced rotor are obtained.The modal characteristics of the unbalanced rotor system are revealed comprehensively for the first time.Furthermore,the relation between the modes and responses of the unbalanced rotor is discussed in detail.The results show that the lateral vibration and torsional vibration of the unbalanced rotor are coupled through the inertial terms in the governing equations.Due to the coupling,veering and lock-in phenomena occur between the frequencies of the forward whirl mode and the torsional mode.Furthermore,lock-in can lead to a kind of principal instability.With regard to the response of the unbalanced rotor,both natural vibration components and enforced vibration components appear in the lateral response,while only natural vibration components appear during torsional vibration.Moreover,natural vibration components play a crucial role in the response within the principal instability region and cause divergence of the vibration amplitudes in the lateral and torsional directions. | Jie HONG Pingchao YU Yanhong MA Dayi ZHANG | 2020 | Chinese Journal of Aeronautics2020，33，6： | 8 |
| 9 | Experimental investigation on shape memory alloy metal rubber显示文摘Shape memory alloy metal rubber(SMAMR)is a novel intelligent elastic damping material which can realize the integration of structure and function.The investigations on the anisotropic mechanical characteristics which depended on shaping craft and working temperature were conducted by quasi-static tests.Comparative experiments indicated that the heat setting temperature affect the elastic modulus non-monotonously but has little effect on the loss factor of SMAMR in both martensite and austenite phases.With the increase of the heat setting time,the elastic modulus of SMAMR monotonously decreases and the reduction of loss factor is unobvious.With the present shaping craft,SMAMR exhibits the anisotropy in moulding and non-moulding directions,which is affected by the heat setting process and working temperature.It was proved that the mechanical properties have approximately linear relationship with temperature during the phase transition process.Due to its temperature-dependent mechanical properties,SMAMR that experiences the heat setting procedure is expected to be used in active vibration control systems with varying temperature-dependent stiffness and damping coefficients to provide superior vibration control performance. | MA YanHong ZHU HaiXiong ZHANG DaYi LIU BaoLong HONG Jie | 2013 | Science China(Technological Sciences)2013，56，8： | 6 |
| 10 | Experimental investigation on dynamic response of flat blades with underplatform dampers显示文摘One test rig with three blades and two Under-Platform Dampers(UPDs) is established to better understand the dynamical behavior of blades with UPDs. A pre-loaded spring is used to simulate the centrifugal load acting on the damper, thereby achieving continuous adjustment of the pressing load. UPDs with different forms, sizes and materials are carefully designed as experimental control groups. Noncontact measurement via a laser Doppler velocimeter is employed and contact excitation which is performed by an electromagnetic exciter is adopted to directly obtain the magnitude of the excitation load by a force sensor mounted on the excitation rod. Particular attention is paid to the influence of the contact status of the contact surfaces, e.g. the pressure-sensitive paper is used to measure the effective contact area of the UPDs. The experimental variables are selected as the centrifugal force, the amplitude of the excitation force, the damper mass, the effective contact area, and the damper material. The Frequency Response Function(FRF) of the blade under different experimental parameters is obtained by slow frequency sweep under sinusoidal excitation to study the influence of each parameter on the dynamic characteristics of the blade and the mechanism analysis is carried out combined with the experimental results. | Dayi ZHANG Bin GAO Jie HONG Jianwei FU Xiangyun GE | 2019 | Chinese Journal of Aeronautics2019，32，12： | 5 |
| 11 | 海口云洞图书馆显示文摘1海口城市新愿景作为中国南端重要的港口城市,海口是海上丝绸之路的重要一站。近年,由于海南国际旅游岛、海南自由贸易港陆续建立,海口的城市经济飞速发展,影响力与日俱增。如何通过提升城市公共空间的独特性和艺术性、为居民带来更具人文气质的生活环境、塑造城市的性格和归属感成为了主要议题。大型国际公共艺术项目“海口·海边的驿站”邀请十余位全球顶尖的建筑师、艺术家以及跨学科专家,共同打造了16座地标性公共驿站,是以“自然·共生·未来”为理念的精品民生工程。海口云洞图书馆是此项目首个建成的公共驿站,将为海口市民及游客带来更独特的城市公共和文化空间。 | 无 傅昌瑞 强思旸 尚立 孙菲菲 Dayie Wu Alan Rodríguez Carrillo 解奇霖 Beatrice Bavuso | 2021 | 建筑学报2021，，6： | 5 |
| 12 | The Effect of Home-Based Cardiac Rehabilitation on Functional Capacity,Behavior,and Risk Factors in Patients with Acute Coronary Syndrome in China显示文摘Aim:To investigate the effect of home-based cardiac rehabilitation on functional capacity,health behavior,and risk factors in patients with acute coronary syndrome in China.Methods:Eighty patients with acute coronary syndrome were enrolled in this prospective randomized controlled study.Patients in the cardiac rehabilitation group(n=52)received home-based cardiac rehabilitation with a heart manual and a home exercise video for 3 months and patients in the control group(n=28)received only routine secondary prevention.The 6-min walk distance,laboratory test results,healthy behavior(questionnaire),quality of life(12-item Short Form Health Survey),anxiety(7-item Generalized Anxiety Disorder Questionnaire),and depression(9-item Patient Health Questionnaire)were evaluated at the beginning and after treatment for 3 months.Results:Compared with baseline data,52 patients who participated in cardiac rehabilitation had longer 6-min walk distance(515.26±113.74 m vs 0.445.30±97.92 m,P<0.0002),higher proportions of“always exercise”(78.26% vs.28%,P<0.05),“always limit food with sugar”(65.22% vs 12%,P<0.05),“always eat fruits 200–400 g every day”(82.61% vs.4%,P<0.05).and“always eat vegetables 300–500 g every day”(21.74%vs.12%,P<0.06)after treatment for 3 months.The low-density lipoprotein cholesterol control rate(52.17% vs.28%,P<0.05)and the systolic blood pressure control rate(100%vs.68%,P<0.05)were also signifi cantly increased after treatment for 3 months in the cardiac rehabilitation group.No signifi cant increase was found in the control group after treatment for 3 months.No cardiac-event related to home exercise was reported in both groups.Conclusion:Home-based cardiac rehabilitation is a feasible and available cardiac rehabilitation mode in China. | Rongjing Ding Jianchao Li Limin Gao Liang Zhu Wenli Xie Xiaorong Wang Qin Tang Huili Wang Dayi Hu | 2017 | Cardiovascular Innovations and Applications2017，，B02： | 5 |
| 13 | Chinese Guideline on the Primary Prevention of Cardiovascular Diseases显示文摘Cardiovascular disease is the leading cause of mortality in China.Primary prevention of cardiovascular disease with a focus on lifestyle intervention and risk factor control has been shown to effectively delay or prevent the occurrence of cardiovascular events.To promote a healthy lifestyle and enhance the detection,diagnosis,and treatment of cardiovascular risk factors such as hypertension,dyslipidemia,and diabetes,and to improve the overall capacity of primary prevention of cardiovascular disease,the Chinese Society of Cardiology of Chinese Medical Association has collaborated with multiple societies to summarize and evaluate the latest evidence with reference to relevant guidelines and subsequently to develop recommendations for primary cardiovascular disease prevention in Chinese adults.The guideline consists of 10 sections:introduction,methodology for developing the guideline,epidemiology of cardiovascular disease in China and challenges in primary prevention,general recommendations for primary prevention,assessment of cardiovascular risk,lifestyle intervention,blood pressure control,lipid management,management of type 2 diabetes,and use of aspirin.The promulgation and implementation of this guideline will play a key role in promoting the practice of primary prevention for cardiovascular disease in China. | Chinese Society of Cardiology of Chinese Medical Association Cardiovascular Disease Prevention and Rehabilitation Committee of Chinese Association of Rehabilitation Medicine Cardiovascular Disease Committee of Chinese Association of Gerontology and Geriatrics Thrombosis Prevention and Treatment Committee of Chinese Medical Doctor Association Dayi Hu Yaling Han Guang Ning Changsheng Ma | 2021 | Cardiology Discovery2021，1，2： | 4 |
| 14 | Characterization of recuperating talent of white-rot fungi cells to dye-contaminated soil/water显示文摘This study was purposed to explore the decolorization of dyes by fungi on either a soil or in a liquid medium and to determine the application through batch shaking system. Two commercial dyes were decolorized and studied with four fungal strains in three media. Fungal growth is the best in malt extract/glucose medium for all organisms. Decolorization of reactive blue 220 and methyl red was investigated in soil medium by Trametes versicolor. These dyes were removed 91% and 80% for methyl red and reactive blue 220 respectively(dye concentration; 100 mg·L^(-1)) by both organisms. Enzymatic activities were monitored. Laccase(Lac) and manganese peroxidase(Mn P) were detected. MnP enzyme had important role for the dye decolorization. This study demonstrates that it is possible to decolorize some synthetic dyes, which would be highly advanced for dye containing wastewater and soil. These applications could be used for dye bioremediation. | Bugra Dayi Aidai Duishemambet Kyzy Hatice Ardag Akdogan | 2019 | Chinese Journal of Chemical Engineering2019，27，3： | 3 |
| 15 | Neuro-Optimal Guidance Control for Lunar Soft Landing显示文摘Returning to moon has become a top topic recently. Many studies have shown that soft landing is a challenging problem in lunar exploration. The lunar soft landing in this paper beginsfrom a 100km circular lunar parking orbit. Once the landing area has been selected and it is time to deorbit for landing, a burn of 19.4m/s is performed to establish a 100× 15km elliptical orbit. At perilune, the landing jets are ignited, and a propulsive landing is performed. A guidanceand control scheme for lunar soft landing is proposed in the paper, which combines optimal theory with nonlinear neuro-control. Basically, an optimal nonlinear control law based on artificial neural network is presented, on the basis of the optimum trajectory from perilune to lunar surface in terms of Pontryagin’s maximum principle according to the terminal boundary conditions and performanceindex. Therefore some optimal control laws can be carried out in the soft landing system due to thenonlinear mapping function of the neural network. The feasibility and validity of the control laws are verified in a simulation experiment. | Wang, Dayi Li, Tieshou Yan, Hui Ma, Xingrui | 1999 | Journal of Systems Engineering and Electronics1999，10，3： | 3 |
| 16 | Decolourization of the azo dye Orange G in aqueous solution via a heterogeneous Fenton-like reaction catalysed by goethite显示文摘 | Honghai Wu Xiaowen Dou Dayi Deng Yufeng Guan Liguo Zhang Guangping He | 2012 | Environmental Technology2012，，14： | 2 |
| 17 | Bending and vibration of a discontinuous beam with a curvic coupling under different axial forces显示文摘The transverse stiffness and vibration characteristics of discontinuous beams can significantly differ from those of continuous beams given that an abrupt change in stiffness may occur at the interface of the former.In this study,the equations for the deflection curve and vibration frequencies of a simply supported discontinuous beam under axial loads are derived analytically on the basis of boundary,continuity,and deformation compatibility conditions by using equivalent spring models.The equation for the deflection curve is solved using undetermined coefficient methods.The normal function of the transverse vibration equation is obtained by separating variables.The differential equations for the beam that consider moments of inertia,shearing effects,and gyroscopic moments are investigated using the transfer matrix method.The deflection and vibration frequencies of the discontinuous beam are studied under different axial loads and connection spring stiffness.Results show that deflection decreases and vibration frequencies increase exponentially with increasing connection spring stiffness.Moreover,both variables remain steady when connection spring stiffness reaches a considerable value.Lastly,an experimental study is conducted to investigate the vibration characteristics of a discontinuous beam with a curvic coupling,and the results exhibit a good match with the proposed model. | Heng LIU Jie HONG Dayi ZHANG | 2020 | Frontiers of Mechanical Engineering2020，15，3： | 2 |
| 18 | Epidemiology, Risk Factors for Stroke, and Management of Atrial Fibrillation in China显示文摘 | Dayi Hu Yihong Sun | 2008 | Journal of the American College of Cardiology2008，，： | 2 |
| 19 | Dendron-polymer hybrid mediated anticancer drug delivery for suppression of mammary cancer显示文摘Dendron-polymer-based nanoscale and stimuli-responsive drug delivery systems have shown great promise in tumor-targeting accumulation without significant toxicity.Here we report a dendronized polymer-doxorubicin(DOX)hybrid(DPDH)with an improved in vivo drug delivery efficiency for cancer therapy compared with a linear polymer-DOX conjugate(LPDC).The in vitro drug release profile of DOX indicates that DPDH displays pH-responsive drug release due to cleavage of hydrazone bonds since a greater amount of DOX is released at pH 5.2 at a faster rate than at pH 7.4.DPDH efficiently enters 4 T1 cells and releases DOX to induce cytotoxicity and apoptosis.Owing to the dendronzied structure,DPDH has a significantly longer blood circulation time than LPDC.DPDH substantially enhances the therapeutic efficacy to suppress tumor growth in a 4 T1 mammary cancer model than LPDC as well as free drug,evidenced from tumor growth inhibition,TUNEL assessment and histological analysis.Biosafety of DPDH is also confirmed from hemolysis,body weight shifts during treatment and pathological analysis.This study demonstrates the use of dendronized polymer-DOX hybrids for specific drug molecules is a promising approach for drug delivery. | Dayi Pan Xiuli Zheng Miao Chen Qianfeng Zhang Zhiqian Li Zhenyu Duan Qiyong Gong Zhongwei Gu Hu Zhang Kui Luo | 2021 | Journal of Materials Science & Technology2021，，4： | 2 |
| 20 | Thermal comfort models and their developments:A review显示文摘In the past several years,thermal comfort,especially development and application of thermal comfort model,has been a research focus of building environment.Since the 1970s,a series of thermal comfort models based on people’s thermal sensation to environment have been established,and gradually became an important part of the field of thermal comfort research.In this review,the existing thermal comfort models are summarized from various perspectives,such as models applied in different environments like sleeping environment and outdoor environment.Besides,models used for different groups people,such as elderly and different races are discussed.In the part,adaptive models are mentioned.In additions,data-driven models were reviewed.This paper introduced the advantages and disadvantages of each model.Based on the above review,future research work of thermal comfort model is proposed. | Qiantao Zhao Zhiwei Lian Dayi Lai | 2021 | Energy and Built Environment2021，2，1： | 2 |
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