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| 1 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 2 | Simulation and analysis of the carrying capacity for road networks using a grid-based approach显示文摘The number of vehicles that a road network can carry is limited.When the limit is exceeded,the network system is not able to function effectively.In this paper,an updated cellular automaton model for grid networks with all-way stop-controlled intersections is proposed to simulate the network level critical density and carrying capacity under different conditions,which essentially indicates the limit number of vehicles that the network can handle before going into gridlock.In the proposed model,two update rules,including lane-changing and the longitudinal location update,are adopted to describe the vehicle’s movements on road segments according to the driving condition on the road and the vehicle’s direction in the downstream intersection.The vehicle’s movements in intersection areas are prioritized based on vehicle’s position,so as to prevent collisions within the intersection area.The simulation results show that an increase in network size is able to expand the carrying capacity of a road network,whereas the expansion rate is lower than the change rate in the network size.The carrying capacity is also associated with the structure of road network.The carrying capacity is inversely proportional to the number of intersections,and proportional to the length of the road in the network.Also,optimizing the origin-destination(O-D)distribution can increase the carrying capacity of an urban road network. | Junqing Shi Linwu Chen Fengxiang Qiao Lei Yu Qing Li Guilian Fan | 2020 | Journal of Traffic and Transportation Engineering(English Edition)2020，7，4： | 3 |
| 3 | NDRG2 in rat liver regeneration: Role in proliferation and apoptosis显示文摘 | JiandongYang YanLi LinWu ZhaoxiaZhang TenglongHan HangGuo NingJiang KaishanTao ZhenyuTi XinpingLiu LiboYao KefengDou | 2010 | Wound Repair and Regeneration2010，，5： | 1 |
| 4 | Structural characteristics of water-soluble polysaccharides from Rabdosia serra (MAXIM.) HARA leaf and stem and their antioxidant capacities显示文摘 | Lianzhu Lin Mingzhu Zhuang Linwu Zou Fenfen Lei Bao Yang Mouming Zhao | 2012 | Food Chemistry2012，，2： | 1 |
| 5 | Development and evaluation of an online monitoring single-particle optical particle counter with polarization detection显示文摘We developed a single-particle optical particle counter with polarization detection(SOPC)for the real-time measurement of the optical size and depolarization ratio(defined as the ratio of the vertical component to the parallel component of backward scattering)of atmospheric particles,the polarization ratio(DR)value can reflect the irregularity of the particles.The SOPC can detect aerosol particles with size larger than 500 nm and the maximum particle count rate reaches~1.8×10^(5)particles per liter.The SOPC uses a modulated polarization laser to measure the optical size of particles according to forward scattering signal and the DR value of the particles by backward S and P signal components.The sampling rate of the SOPC was 106#/(sec·channel),and all the raw data were processed online.The calibration curve was obtained by polystyrene latex spheres with sizes of 0.5-10μm,and the average relative deviation of measurement was 3.96% for sub 3μm particles.T-matrix method calculations showed that the DR value of backscatter light at 120°could describe the variations in the aspect ratio of particles in the above size range.We performed insitu observations for the evaluation of the SOPC,the mass concentration constructed by the SOPC showed good agreement with the PM_(2.5)measurements in a nearby state-controlled monitoring site.This instrument could provide useful data for source appointment and regulations against air pollution. | Weijie Yao Xiaole Pan Yu Tian Hang Liu Yuting Zhang Shandong Lei Junbo Zhang Yinzhou Zhang LinWu Yele Sun Zifa Wang | 2024 | Journal of Environmental Sciences2024，，4： | 0 |
| 6 | A DEA Model with an AHP Restraint Cone显示文摘 | Yuhua Wu Linwu Zhang | 2006 | Journal of Systems Science and Information2006，4，4： | 0 |
| 7 | MODIFICATION OF ETHYLENE-VINYL ACETATE COPOLYMER AND ITS EFFECTS ON THE PERMEABILITY OF SOME STEROIDS显示文摘Ethyleae-vinyl acetate copolymer ( EVA ) was mechanically blended with methylvinyl siloxane in order to increase the permeability of some steroids and to obtain an ideal material with membrane-controlled release of steroids from the intrauterine | LINWu FANGZhen JINZhao-Ying | 1989 | Journal of Reproduction and Contraception1989，1，1： | 0 |
| 8 | PREPARATION AND RELEASE RATE OF A LEVONORGESTREL-RELEASING INTRAUTERINE DEVICE显示文摘A key-shaped lcvonorgcstrcl-rclcasing intrauterine device ( LNG-IUD ) was designed and fabricated. The IUD with a hollow vcrtlcal arm was made of modified ethylene-vinyl acetate copolymcr ( EVA ). The LNG paste was cncapsulcd in the vertical arm | LINWu JINGZhao-Ying ZHUGeng-Geng | 1989 | Journal of Reproduction and Contraception1989，1，1： | 0 |
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