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| 1 | Chinese deserts and sand fields in Last Glacial Maximum and Holocene Optimum显示文摘The Last Glacial Maximum (LGM, c. 26-16 ka) and the Holocene Optimum (HO, c. 9-5 ka) were characterized by cold-dry and warm-wet climates respectively in the recently geological Earth. How Chinese deserts and sand fields responded to these distinctive climatic changes is still not clear, however. To reconstruct environments of the deserts and sand fields during the LGM and HO is helpful to understand the forcing mechanisms of environment change in this arid region, and to test paleoclimatic modeling results. Through our long-term field and laboratory investigations, 400 optically stimulated luminescence (OSL) ages and more than 100 depositional records in the Chinese deserts and sand fields were obtained; on the basis of these data, we reconstruct spatial distributions of the deserts and sand fields during the LGM and HO. Our results show that the sand fields of Mu Us, Hunshandake, Horqin and Hulun Buir in northern and northeastern China had expanded 25%, 37%, 38% and 270%, respectively, during the LGM; the sand fields of Gonghe in the northeastern Qinghai-Tibetan Plateau had expanded 20%, and the deserts of Badain Jaran, Tengger in central northern China had expanded 39% and 29% separately during the LGM; the deserts of Taklimakan, Gurbantünggüt and Kumtag in northwestern China had expanded 10%-20% respectively, compared to their modern areas. On the other hand, all of the sand fields were nearly completely covered by vegetation during the HO; the deserts in northwestern and central northern China were reduced by around 5%-20% in area during this time. Lakes in this arid region were probably expanded during the HO but this conclusion needs more investigation. Compared with the geological distributions of deserts and sand fields, human activity has clearly changed (expanded) the area of active sand dunes at the present time. Our observations show that environmental conditions of Chinese deserts and sand fields are controlled by regional climate together with human activity. | LU HuaYu YI ShuangWen XU ZhiWei ZHOU YaLi ZENG Lin ZHU FangYing FENG Han DONG LiNa ZHUO HaiXin YU KaiFeng MASON Joseph WANG XiaoYong CHEN YingYong LU Qi WU Bo DONG ZhiBao QU JianJun WANG XunMing GUO ZhengTang | 2013 | Chinese Science Bulletin2013，58，23： | 40 |
| 2 | Identification of coastal wetlands of international importance for waterbirds:a review of China Coastal Waterbird Surveys 2005–2013显示文摘Background:China's coastal wetlands belong to some of the most threatened ecosystems worldwide.The loss and degradation of these wetlands seriously threaten waterbirds that depend on wetlands.Methods:The China Coastal Waterbird Census was organized by volunteer birdwatchers in China's coastal region.Waterbirds were surveyed synchronously once every month at 14 sites,as well as irregularly at a further 18 sites,between September 2005 and December 2013.Results:A total of 75 species of waterbirds met the 1 % population level Ramsar listing criterion at least once at one site.The number of birds of the following species accounted for over 20 % of the total flyway populations at a single site:Mute Swan(Cygnus olor),Siberia Crane(Grus leucogeranus),Far Eastern Oystercatcher(Haematopus osculans),Bar-tailed Godwit(Limosa lapponica),Spotted Greenshank(Tringa guttifer),Great Knot(Calidris tenuirostris),Spoon-billed Sandpiper(Calidris pygmeus),Saunders' s Gull(Larus saundersi),Relict Gull(Larus relictus),Great Cormorant(Phalacrocorax carbo),Eurasian Spoonbill(Platalea leucorodia),Black-faced Spoonbill(Platalea minor) and Dalmatian Pelican(Pelecanus crispus).A total of 26 sites supported at least one species of which their number met the1 % criterion.Forty-two species met the 1 % criterion in the Yellow River Delta,Shandong;29 at the Cangzhou coast,Hebei and 26 species at the Lianyungang coast,Jiangsu.Conclusions:The results highlight the international importance of China's coastal wetlands for waterbirds.This study also demonstrates that participation of local birdwatchers in waterbird surveys results in data that are invaluable not only for understanding the current status of waterbirds in China's coastal regions but also for waterbird conservation and management. | Qingquan Bai Jianzhong Chen Zhihong Chen Guotai Dong Jiangtian Dong Wenxiao Dong Vivian Wing Kan Fu Yongxiang Han Gang Lu Jing Li Yang Liu Zhi Lin Derong Meng Jonathan Martinez Guanghui Ni Kai Shan Renjie Sun Suixing Tian Fengqin Wang Zhiwei Xu Yat-tung Yu Jin Yang Zhidong Yang Lin Zhang Ming Zhang Xiangwu Zeng | 2015 | Chinese Birds2015，，3： | 20 |
| 3 | 中西医对肾纤维化发病机制的研究进展显示文摘文章通过文献研究的方法,从中西医两方面分别对肾纤维化的病因及发病机制进行了回顾。分析了西医学方面肾纤维化发病机制是多种致病因子共同作用的最终途径以及中医学认为其病机多属'正虚邪实'的特点。阐明了对肾纤维化的治疗应致力于把中西医两者从病因病机及治疗有机结合,做到辨病与辨证有机结合,以探求一条中西医结合一体化的治疗之路。 | 陈凤 LU Zhiwei 戴恩来 | 2016 | 辽宁中医杂志2016，43，6： | 20 |
| 4 | Dense coding scheme using superpositions of Bell-states and its NMR implementation显示文摘Dense coding using superpositions of Bell-states is proposed. The generalized Grover's algorithm is used to prepare the initial entangled states, and the reverse process of the quantum algorithm is used to determine the entangled state in the decoding measurement. Compared with the previous schemes, the superpositions of two Bell-states are exploited. Our scheme is demonstrated using a nuclear magnetic resonance (NMR)quantum computer. The corresponding manipulations are obtained. Experimental results show a good agreement between theory and experiment. We also generalize the scheme to transmit eight messages by introducing an additional two-state system. | ZHANG Jingfu, XIE Jingyi, DENG Zhiwei & LU Zhiheng Key Laboratory for Quantum Information and Measurements, Department of Physics, Tsinghua University, Beijing 100084, China Center for Quantum Information, Tsinghua University, Beijing 100084, China Department of Materials Science and Engineering, Beijing Normal University, Beijing 100875, China Testing and Analytical Center, Beijing Normal University, Beijing 100875, China Department of Physics, Beijing Normal University, Beijing 100875, China | 2005 | Science China(Physics,Mechanics & Astronomy)2005，48，1： | 18 |
| 5 | A review of ecological restoration techniques in fluvial rivers显示文摘Rivers play an important role in people's living and agricultural production,however,intense human activities have broken the original ecological balance,and affected structures and functions of the river ecosystem.To restore the damaged river ecosystem back to a healthy status,effective ecological restoration measures need to be implemented.The main problems that the damaged rivers face are either the locally altered hydrological processes affected by construction of hydraulic facilities,or the deterioration of water quality resulted from pollution emissions,or both.In this study,ecological restoration techniques of the rivers affected by engineering control or pollution are reviewed respectively.In addition,three kinds of methods,i.e.physical,chemical and biological-ecological methods are introduced in details for the rivers affected by water pollution.At present,the development of river restoration techniques shows the following trends:1) the scale of ecological restoration is becoming larger;2) ecological restoration measures are required to meet multiple objectives;and 3) the management of water environment is changing from water quality management to aquatic ecosystem management. | Baozhu Pan Jianping Yuan Xinhua Zhang Zhaoyin Wang Jiao Chen Jinyou Lu Wenjun Yang Zhiwei Li Na Zhao Mengzhen Xu | 2016 | International Journal of Sediment Research2016，31，2： | 18 |
| 6 | Composition, origin and weathering process of surface sediment in Kumtagh Desert, Northwest China显示文摘Kumtagh 沙漠是在中国的八最大的沙漠之一,但是因为存取的困难,以前糟糕调查我们的学科交差的学习。在这份报纸, 33 件代表性的表面沉积样品从在实验室荒芜、分析的 Kumtagh 被收集获得重矿物质部件和 geochemical 元素内容。结果证明重矿物质的各种各样的类型在这些样品是在场的,与绿帘石和角闪石的高水平。Si 和艾尔收起化学作文的大部分。与上面的大陆人外壳(UCC ) 的 geochemical 元素的平均作文相比,除了 Si 和 Ca,所有元素被弄空到某个度;Fe, Mg, Ca, P, Ti 和 Mn 在他们的内容有高关联系数。矿物质和 Kumtagh 荒芜的沉积的 geochemical 作文在 Altyn Tagh 山脉和 Taklamakan 沙漠的附近与 Altyn Tagh 山脉,和冲积/洪水的扇子的表面沉积的岩石的有类似,显示 Kumtagh 荒芜的沉积的一主要来源位于 Altyn Tagh 山脉。在 Aqik 山谷和 Shule 河的更低的活动范围的冲积沉积物和湖沉积是容易的被侵蚀并且搬运由强壮在东北弯屈进 Kumtagh 沙漠,形成沙漠的另一来源扔。一张 A-CN-K 第三的图证明由 Na 和 K 的损失捱过的弱度化学药品发生在这些沉积,而 A-CNK-FM 第三的图建议 Fe 和 Mg 经历了重要化学区别。物理捱过过程为 mafic 矿物质在好粒子引起容易的侵蚀和丰富,这样粗糙的荒芜的沙粒子能相对在 Fe 和 Mg 被弄空。在经历不太化学的捱过的干旱区域的沉积的矿物质和 geochemical 作文被物理捱过主要影响。 | XU Zhiwei LU Huayu ZHAO Cunfa WANG Xianyan SU Zhizhu WANG Zhenting LIU Hongyi WANG Lixin LU Qi | 2011 | Journal of Geographical Sciences2011，21，6： | 13 |
| 7 | Earth surface processes and their effects on human behavior in monsoonal China during the Pleistocene-Holocene epochs显示文摘There is a wide diversity of landforms in China.The topography of three major terraces,decreasing in height stepwise from west to east,was formed by the early Miocene.With the commencement of the Great Northern Hemisphere Glaciations(GHGs)and the glacial-interglacial cycles in the Pleistocene,thick loess deposits accumulated in north China,and fluvial terraces were formed and lakes expanded and contracted in eastern and central China.The earliest evidence of hominins in China is dated to ~1.7 Ma;they occupied the monsoon-dominated region for a long interval,until the late Pleistocene,~50 ka.In this study,we investigated a large area rich in the relics and artifacts of early man.The results indicate that the early humans occupied riverine areas,especially medium-sized fluvial basins,and lake shores.Even in the relatively recent geological past,the occupation and abandonment of settlements were directly forced by the shifting of sand dune fields in the desert-loess transitional zone,which in turn was closely associated with variations in the monsoon climate and vegetation patterns.Our observations indicate that landforms were one of the main determinants of early human behavior,in that loess tableland,large alluvial plains,desert-Gobi areas,and the Tibetan Plateau,were not suitable environments for early human settlement.We infer that the early humans in China adapted their behavior to specific landforms and landform processes.The monsoon climate,which shapes the large-scale step-like pattern of fluvial landforms,promotes vegetation coverage and dominates soil formation,provides a crucial context for early human adaptation.The adaptation of early humans to earth surface processes in East Asia is investigated for the first time in this study.Future investigations will provide further information that will increase our understanding of the linkage between early human behavior and landform processes in East Asia. | LU Huayu ZHUO Haixin ZHANG Wenchao WANG Shejiang ZHANG Hongyan SUN Xuefeng JIA Xin XU Zhiwei WANG Xianyan | 2017 | Journal of Geographical Sciences2017，27，11： | 12 |
| 8 | Single-shot BOTDA based on an optical chirp chain probe wave for distributed ultrafast measurement显示文摘Brillouin optical time-domain analysis(BOTDA)requires frequency mapping of the Brillouin spectrum to obtain environmental information(e.g.,temperature or strain)over the length of the sensing fiber,with the finite frequencysweeping time-limiting applications to only static or slowly varying strain or temperature environments.To solve this problem,we propose the use of an optical chirp chain probe wave to remove the requirement of frequency sweeping for the Brillouin spectrum,which enables distributed ultrafast strain measurement with a single pump pulse.The optical chirp chain is generated using a frequency-agile technique via a fast-frequency-changing microwave,which covers a larger frequency range around the Stokes frequency relative to the pump wave,so that a distributed Brillouin gain spectrum along the fiber is realized.Dynamic strain measurements for periodic mechanical vibration,mechanical shock,and a switch event are demonstrated at sampling rates of 25 kHz,2.5 MHz and 6.25 MHz,respectively.To the best of our knowledge,this is the first demonstration of distributed Brillouin strain sensing with a wide-dynamic range at a sampling rate of up to the MHz level. | Dengwang Zhou Yongkang Dong Benzhang Wang Chao Pang Dexin Ba Hongying Zhang Zhiwei Lu Hui Li Xiaoyi Bao | 2018 | Light(Science & Applications)2018，7，1： | 11 |
| 9 | Total mesopancreas excision for pancreatic head cancer: analysis of 120 cases显示文摘Objective: To evaluate the feasibility and safety of total mesopancreas excision(TMpE) in the treatment of pancreatic head cancer. Methods: The clinical and pathological data of 120 patients with pancreatic head cancer who had undergone TMpE in our center from May 2010 to January 2014 were retrospectively analyzed. Results: The mean operative time was(275.0±50.2) min and the average intra-operative blood loss was(390.0±160.5) mL. Post-operative complications were reported in 45 patients, while no peri-operative death was noted. The specimen margins were measured in three dimensions, and 86 patients(71.6%) achieved R0 resection. Conclusions: TMpE is safe and feasible for pancreatic head cancer and is particularly helpful to increase the R0 resection rate. | Wenguang Wu Xu'an Wang Xiangsong Wu Maolan Li Hao Weng Yang Cao Ruifa Bao Sijun Su Jianhua Lu Wei Gong Weibin Shi Jun Gu Xuefeng Wang Yingbin Liu Zhiwei Quan Shuyou Peng | 2016 | Chinese Journal of Cancer Research2016，28，4： | 10 |
| 10 | Preparation of carbon-coated iron oxide nanoparticles dispersed on graphene sheets and applications as advanced anode materials for lithium-ion batteries显示文摘 | Huilong Fei Zhiwei Peng Lei Li Yang Yang Wei Lu Errol L. G. Samuel Xiujun Fan James M. Tour | 2014 | Nano Research2014，7，4： | 10 |
| 11 | Reservoir Characteristics of Lacustrine Shale and Marine Shale:Examples from the Songliao Basin,Bohai Bay Basin and Qiannan Depression显示文摘Lacustrine shale from the Qingshankou Formatin of Songliao basin and the Shahejie Formation of Bohai Bay basin, and marine shale from the lower Cambrian Jiumenchong Formation of Qiannan depression were analysed by using rock pyrolysis, TOC(total organic carbon), XRD(X-ray diffraction), SEM(scanning electron microscope), FE-SEM(field emission scanning electron microscope), high pressure mercury intrusion, and low pressure N_2 and CO_2 gas adsorption experiments, in aim to reveal their reservoir features. The results show that:(1) the width of micro-pores of all the studied samples mainly ranges from 0.45 to 0.7 nm indicated by CO_2 isotherms, and the width of meso-pores is less than 10 nm, with type IV adsorption isotherms and type H2 hysteresis loop, indicative of 'ink-bottle'-shaped pores. Good correlations exist among pore volume, surface area and averaged pore diameter, and a good positive correlation exists between micro-pore volume and TOC content; however, there is no obvious correlation between meso-pore volume and TOC content;(2) interparticle pores, pores among the edge of mineral grains and organic matter pores were all identified in marine and lacustrine shale, among which the interparticle pores may be influence by dissolution effect. Not all bitumen develops organic matter pore, and only high to over mature bitumen present pores. Now the description methods of micrometer scale pores developed in shale are very lack. Microfractures developed in Jiyang depression and dissolution interparticle pores developed in Songliao Basin should be the accumulation sites for shale oil in lacustrine shale, and can be as sweet spots. | WANG Min LU Shuangfang WANG Zhiwei LIU Yang HUANG Wenbiao CHEN Fangwen XU Xingyou LI Zheng LI Jijun | 2016 | Acta Geologica Sinica(English Edition)2016，90，3： | 10 |
| 12 | CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells显示文摘In face of the everlasting battle toward COVID-19 and the rapid evolution of SARS-CoV-2,no specific and effective drugs for treating this disease have been reported until today.Angiotensin-converting enzyme 2(ACE2),a receptor of SARS-CoV-2,mediates the virus infection by binding to spike protein.Although ACE2 is expressed in the lung,kidney,and intestine,its expressing levels are rather low,especially in the lung.Considering the great infectivity of COVID-19,we speculate that SARS-CoV-2 may depend on other routes to facilitate its infection.Here,we first discover an interaction between host cell receptor CD147 and SARS-CoV-2 spike protein.The loss of CD147 or blocking CD147 in Vero E6 and BEAS-2B cell lines by anti-CD147 antibody,Meplazumab,inhibits SARSCoV-2 amplification.Expression of human CD147 allows virus entry into non-susceptible BHK-21 cells,which can be neutralized by CD147 extracellular fragment.Viral loads are detectable in the lungs of human CD147(hCD147)mice infected with SARS-CoV-2,but not in those of virus-infected wild type mice.Interestingly,virions are observed in lymphocytes of lung tissue from a COVID-19 patient.Human T cells with a property of ACE2 natural deficiency can be infected with SARS-CoV-2 pseudovirus in a dosedependent manner,which is specifically inhibited by Meplazumab.Furthermore,CD147 mediates virus entering host cells by endocytosis.Together,our study reveals a novel virus entry route,CD147-spike protein,which provides an important target for developing specific and effective drug against COVID-19. | Ke Wang Wei Chen Zheng Zhang Yongqiang Deng Jian-Qi Lian Peng Du Ding Wei Yang Zhang Xiu-Xuan Sun Li Gong Xu Yang Lei He Lei Zhang Zhiwei Yang Jie-Jie Geng Ruo Chen Hai Zhang Bin Wang Yu-Meng Zhu Gang Nan Jian-Li Jiang Ling Li Jiao Wu Peng Lin Wan Huang Liangzhi Xie Zhao-Hui Zheng Kui Zhang Jin-Lin Miao Hong-Yong Cui Min Huang Jun Zhang Ling Fu Xiang-Min Yang Zhongpeng Zhao Shihui Sun Hongjing Gu Zhe Wang Chun-Fu Wang Yacheng Lu Ying-Ying Liu Qing-Yi Wang Huijie Bian Ping Zhu Zhi-Nan Chen | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 9 |
| 13 | KIF18B promotes tumor progression in osteosarcoma by activating β-catenin显示文摘Objective:Osteosarcoma is a common primary highly malignant bone tumor.Kinesin family member 18B(K1F18B)has been identified as a potential oncogene involved in the development and metastasis of several cancer types.While KIF18B overexpression in osteosarcoma tissue is clearly detected,its specific function in the disease process remains to be established.Methods:K IF18B expression was assessed in osteosarcoma tissues and cells.We additionally evaluated the effects of KIF18B on proliferation,migration,and invasion of osteosarcoma cells,both in vitro and in vivo.Results:Our results showed overexpression of KIF18B in osteosarcoma tissues and cells.Knockdown of K IF18B induced G1/S phase arrest and significantly inhibited proliferation,migration,and invasion of osteosarcoma cells,both in vitro and in vivo.K IF18B regulated P-catenin expression at the transcriptional level by controlling nuclear aggregation of ATF2 and at the post-transcriptional level by interacting with the adenomatous polyposis coli(APC)tumor suppressor gene in osteosarcoma cells.Conclusions:KIF18B plays a carcinogenic role in osteosarcoma by regulating expression ofβ-catenin transcriptionally via decreasing nuclear aggregation of ATF2 or post-transcriptionally through interactions with APC.Our collective findings support the potential utility of KIF18B as a novel prognostic biomarker for osteosarcoma. | Tian Gao Ling Yu Zhiwei Fang Jiayong Liu Chujie Bai Shu Li Ruifeng Xue Lu Zhang Zhichao Tan Zhengfu Fan | 2020 | Cancer Biology & Medicine2020，17，2： | 7 |
| 14 | Crescentic dune migration and stabilization: Implications for interpreting paleo-dune deposits as paleoenvironmental records显示文摘Paleo-dune deposits have been widely used as a proxy indicator of past dune activity, which is further used to reconstruct paleoclimates. However, recent studies have critically examined the reproducibility of dune chronologies and the complexity of paleo-dune deposits as paleoenvironmental records. This paper addresses questions on the paleoenvironmental implications of dune chronostratigraphies that have been raised by those reviews, in the specific case of crescentic dunes, using a case study from the Mu Us dune field, north-central China. The processes of turn-over and stabilization of relatively small crescentic dunes are first investigated by observational evidence. In combination with the analysis of a simplified sand preservation model and stratigraphic records, the effect of dune morphodynamics on sand preservation is demonstrated. It is especially evident that thick, nearly instantaneously deposited sand units record dune stabilization near the very end of a dune activity episode, while thin sand units may signal the preservation of sand deposited earlier in episodes of activity. Interpreting the distribution of luminescence ages that indicate sand deposition over time is not as simple as assumed in some previous work. Low frequency of sand ages could indicate an interval of either dune field stabilization or extensive dune activity but poor sand preservation. A peak of sand age frequency likely represents a shift in dune field activity towards stabilization, not a peak of active dune extent, especially if it partially overlaps with an independently identified interval of stabilization(e.g. one recorded by paleosols). The nature and magnitude of these biases in the distribution of sand ages over time are strongly affected by the magnitude of net sand accumulation, which is in turn related to sand supply, transport capacity and sand availability, and ultimately climate change. Relatively short dune stabilization and turn-over time(10~1 to 10~2 yrs) indicate that dune geomorphic processes can quickly respond to short-term disturbance, but the chronology of that response must be interpreted in light of how those processes influence age distributions. | XU Zhiwei Joseph A. MASON LU Huayu YI Shuangwen ZHOU Yali WU Jiang HAN Zhiyong | 2017 | Journal of Geographical Sciences2017，27，11： | 7 |
| 15 | Industrialization prospects for hydrogen production by coal gasification in supercritical water and novel thermodynamic cycle power generation system with no pollution emission显示文摘Energy conversion and utilization, particularly carbon-based fuel burning in air phase, have caused great environmental pollution and serious problems to society. The reactions in water phase may have the potential to realize clean and efficient energy conversion and utilization. Coal gasification in supercritical water is a typical carbon-based fuel conversion process in water phase, and it takes the advantages of the unique chemical and physical properties of supercritical water to convert organic matter in coal to H2 and CO2. N, S, P, Hg and other elements are deposited as inorganic salts to avoid pollution emission. The State Key Laboratory of Multiphase Flow in Power Engineering has obtained extensive experimental and theoretical results based on coal gasification in supercritical water. Supercritical water fluidized bed reactor was developed for coal gasification and seven kinds of typical feedstock were selected. The hydrogen yield covers from 0.67 to 1.74 Nm3/kg and the carbon gasification efficiency is no less than 97%. This technology has a bright future in industrialization not only in electricity generation but also in hydrogen production and high value-added chemicals. Given the gas yield obtained in laboratory-scale unit, the hydrogen production cost is U.S.$ 0.111 Nm3 when the throughput capacity is 2000 t/d. A novel thermodynamic cycle power generation system based on coal gasification in supercritical water was proposed with the obvious advantages of high coal-electricity conversion efficiency and zero pollutant emission. The cost of U.S.$ 3.69 billion for desulfuration, denitration and dust removal in China in 2013 would have been saved with this technology. Five kinds of heat supply methods are analyzed and the rates of return of investment are roughly estimated. An integrated cooperative innovation center called a new type of high-efficient coal gasification technology and its large-scale utilization was founded to enhance the industrialization of the technology vigorously. | GUO LieJin JIN Hui GE ZhiWei LU YouJun CAO ChangQing | 2015 | Science China(Technological Sciences)2015，58，12： | 7 |
| 16 | Peripheral CD4^(+) T cell signatures in predicting the responses to anti-PD-1/PD-L1 monotherapy for Chinese advanced non-small cell lung cancer显示文摘Limited benefit population of immune checkpoint inhibitors makes it urgent to screen predictive biomarkers for stratifying the patients.Herein,we have investigated peripheral CD4^(+) T cell signatures in advanced non-small cell lung cancer(NSCLC)patients receiving anti-PD-1/PD-L1 treatments.It was found that the percentages of IFN-γand IL-17A secreting naïve CD4^(+) T cells(Tn),and memory CD4^(+) T cells(Tm)expressing PD-1,PD-L1 and CTLA-4 were significantly higher in responder(R)than non-responder(NonR)NSCLC patients associated with a longer progression free survival(PFS).Logistic regression analysis revealed that the baseline IFN-γ-producing CD4^(+) Tn cells and PD-1^(+)CD4^(+) Tm cells were the most significant signatures with the area under curve(AUC)value reaching 0.849.This was further validated in another anti-PD-1 monotherapy cohort.Conversely,high percentage of CTLA-4^(+)CD4^(+) Tm cells was associated with a shorter PFS in patients receiving anti-PD-L1 monotherapy.Our study therefore elucidates the significance of functional CD4^(+) Tn and Tm subpopulations before the treatment in predicting the responses to anti-PD-1 treatment in Chinese NSCLC patients.The fact that there display distinct CD4^(+) T cell signatures in the prediction to anti-PD-1 and anti-PD-L1 monotherapy from our study provides preliminary evidence on the feasibility of anti-PD-1 and anti-PD-L1 combination therapy for advanced NSCLC patients. | Liliang Xia Hui Wang Mingjiao Sun Yi Yang Chengcheng Yao Sheng He Huangqi Duan Weimin Xia Ruiming Sun Yaxian Yao Zhiwei Chen Qiong Zhao Hong Li Shun Lu Ying Wang | 2021 | Science China(Life Sciences)2021，64，10： | 7 |
| 17 | Diamond Raman laser:a promising high-beam-quality and low-thermal-effect laser显示文摘Stimulated Raman-scattering-based lasers provide an effective way to achieve wavelength conversion.However,thermally induced beam degradation is a notorious obstacle to power scaling and it also limits the applicable range where high output beam quality is needed.Considerable research efforts have been devoted to developing Raman materials,with diamond being a promising candidate to acquire wavelength-versatile,high-power,and high-quality output beam owing to its excellent thermal properties,high Raman gain coefficient,and wide transmission range.The diamond Raman resonator is usually designed as an external-cavity pumped structure,which can easily eliminate the negative thermal effects of intracavity laser crystals.Diamond Raman converters also provide an approach to improve the beam quality owing to the Raman cleanup effect.This review outlines the research status of diamond Raman lasers,including beam quality optimization,Raman conversion,thermal effects,and prospects for future development directions. | Yulan Li Jie Ding Zhenxu Bai Xuezong Yang Yuqi Li Jingling Tang Yu Zhang Yaoyao Qi Yulei Wang Zhiwei Lu | 2021 | High Power Laser Science and Engineering2021，9，3： | 7 |
| 18 | Chromosome-level genome of Himalayan yew provides insights into the origin and evolution of the paclitaxel biosynthetic pathway显示文摘Taxus,commonly known as yew,is a well-known gymnosperm with great ornamental and medicinal value.In this study,by assembling a chromosome-level genome of the Himalayan yew(Taxus wallichiana)with 10.9 Gb in 12 chromosomes,we revealed that tandem duplication acts as the driving force of gene family evolution in the yew genome,resulting in the main genes for paclitaxel biosynthesis,i.e.those encoding the taxadiene synthase,P450s,and transferases,being clustered on the same chromosome.The tandem duplication may also provide genetic resources for the nature to sculpt the core structure of taxoids at different positions and subsequently establish the complex pathway of paclitaxel by neofunctionalization.Furthermore,we confirmed that there are two genes in the cluster encoding isoenzymes of a known enzyme in the paclitaxel biosynthetic pathway.The reference genome of the Himalayan yew will serve as a platform for decoding the complete biosynthetic pathway of paclitaxel and understanding the chemodi-versity of taxoids in gymnosperms. | Jian Cheng Xiao Wang Xiaonan Liu Xiaoxi Zhu Zihe Li Huanyu Chu Qian Wang QianQian Lou Bijun Cai Yiqun Yang Xiaoyun Lu Kai Peng Dingyu Liu Yuwan Liu Lina Lu Huan Liu Ting Yang Qijin Ge Chengcheng Shi Guichun Liu Zhiwei Dong Xun Xu Wen Wang Huifeng Jiang Yanhe Ma | 2021 | Molecular Plant2021，14，7： | 6 |
| 19 | A preliminary quantitative reconstruction of precipitation in southern Mu Us sandy land at margin of Asian monsoon-dominated region during late Quaternary显示文摘我们在场季风降水的第一个量的评价在在北中国的沙的陆地的迟了的 glacial-Holocene 期间,基于器官的碳从在亩的边缘的一个黄土沙序列的同位素的作文数据我们沙的土地。我们使用在季风降水和碳之间的关系是的现代土壤的同位素的作文类似物与次要的修正,重建降水回到 c。47 ka 以前。初步的结果显示年度季风降水在 8 ka 以后高,与 435 公里的一般水准;并且它与 194 公里的吝啬的价值在 18 和 8 ka 期间减少了。47-18 ka 的降水价值在二之间变化了。我们把重建的降水与另外的记录和 paleoclimatic 建模结果作比较,证明我们的记录同意从另外的来源,的季风降水的重建甚至捕获象更年轻的 Dryas 那样的短气候的事件。我们建议那太阳的发光,高纬度的温度 / 冰体积和本地蒸发一起在沙的陆地的修改潮湿。 | CHEN Yingyong LU Huayu YI Shuangwen ZHANG Enlou XU Zhiwei YU Kaifeng Joseph A. MASON | 2015 | Journal of Geographical Sciences2015，25，3： | 6 |
| 20 | Efficacy of vinorelbine combined with low-dose methotrexate for treatment of inoperable desmoid tumor and prognostic factor analysis显示文摘Objective: To assess the efficacy of conservative chemotherapy for inoperable desmoid tumor(DT) and analyze the prognostic factors.Methods:From November 2008 to April 2016,71 patients of inoperable DT were treated with vinorelbine and low-dose methotrexate in the Department of Bone and Soft Tissue Tumors,Peking University Cancer Hospital&Institute,and enrolled in this retrospective study.The chemotherapy duration is one year.The efficacy of chemotherapy and the prognosis were observed.Results:Of the 71 patients,55% were female.Age of onset varied from 1 to 47 years,and the median age was 14years.Only 11(15.5%)cases suffered primary tumor.The distribution of the site of tumors was:31(43.7%)in the trunk,36(50.7%)in the limbs,and 4(5.6%)in the peritoneal and pelvic cavity.The size of tumor(the maximum diameter)differed from 2 to 37 cm with a mean of 9.3 cm.The median follow-up duration was 28(range,6–87)months.Common side effects included:nausea and vomiting,liver injury,bone marrow suppression and oral ulcers.When the chemotherapy finished,1(1.4%)case achieved complete response,24(33.8%)achieved partial response,37(52.1%)achieved stable disease and 9(12.7%)had progressive disease.The overall response rate was 87.3%.The progression-free survival(PFS)of the participants were from 6 to 87 months,and the 2-,3-and 5-year PFS was 79.9%,68.4% and 36.3%,respectively.No significant difference was identified in PFS in subgroups of gender,age of onset,age of chemotherapy,tumor site and tumor size.Conclusions:For recurrent,inoperable and progressive DT,enough course of chemotherapy with vinorelbine combined with low-dose methotrexate was an optional choice for local control. | Shu Li Zhengfu Fan Zhiwei Fang Jiayong Liu Chujie Bai Ruifeng Xue Lu Zhang Tian Gao | 2017 | Chinese Journal of Cancer Research2017，29，5： | 6 |
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