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| 1 | Anticancer immunotherapy by CTLA-4 blockade: obligatory contribution of IL-2 receptors and negative prognostic impact of soluble CD25显示文摘堵住抗体 ipilimumab 的细胞毒素的 T 淋巴细胞 antigen-4 (CTLA-4 ) 在很少的病人导致变形黑瘤的调停免疫者的长期的控制。尽管 ipilimumab 无疑经由 immunostimulation 施加它的治疗学的效果,这样远的临床上有用的、 immunologically 相关的 biomarkers 预言治疗效率是逃犯的。这里,我们显示出 IL-2 的那中立化或堵住 α并且 βIL-2 受体的子单元(CD25 和 CD122,分别地) 否则在现出症状之前的潜的老鼠模型由 CTLA-4 封锁导致了,废除了 antitumor 效果和 intratumoral T 受动器对规章的房间(Tregs ) 的比率的伴随的改进,它是。CTLA-4 封锁导致了在失去了 FoxP3 表示并且在 regressing 肿瘤积累了的 IL-2-producing 受动器房间与伴随物上升表示 Lag3, ICOS, IL-10 和 Egr2 的一个镇压 CD4 + T 房间子集的减小。当 recombinant IL-2 改进了 CTLA-4 封锁的治疗学的功效时,圈套 IL-2 受体 α(IL-2Rα, sCD25 ) 禁止了 CTLA-4 的 anticancer 效果封锁。在收到 ipilimumab 的 262 个变形黑瘤病人, sCD25 的基线浆液集中代表了全面幸存的独立指示物,与预言到治疗的抵抗的高水平。总的来说,这些结果解开为在 CTLA-4 的 anticancer 活动的 IL-2 和 IL-2 受体的一个角色封锁。重要地,我们的学习提供第一 immunologically 相关的 biomarker,也就是提高的浆液 sCD25,那与黑瘤在病人预言抵抗到 CTLA-4 封锁。 | Dalil Hannani Marie Vetizou David Enot Sylvie Rusakiewicz Nathalie Chaput David Klatzmann Melanie Desbois Nicolas Jacquelot Nadege Vimond Salem Chouaib Christine Mateus James P Allison Antoni Ribas Jedd D Wolchok Jianda Yuan Philip Wong Michael Postow Andrzej Mackiewicz Jacek Mackiewicz Dirk Schadendorff Dirk Jaeger Alan J Korman Keith Bahjat Michele Maio Luana Calabro Michele WL Teng Mark J Smyth Alexander Eggennont Caroline Robert Guido Kroemer Laurence Zitvogel | 2015 | Cell Research2015，25，2： | 14 |
| 2 | Multimodality imaging of ovarian cystic lesions: Review with an imaging based algorithmic approach显示文摘Ovarian cystic masses include a spectrum of benign, borderline and high grade malignant neoplasms. Imaging plays a crucial role in characterization and pretreatment planning of incidentally detected or suspected adnexal masses, as diagnosis of ovarian malignancy at an early stage is correlated with a better prognosis. Knowledge of differential diagnosis, imaging features, management trends and an algorithmic approach of such lesions is important for optimal clinical management. This article illustrates a multi-modality approach in the diagnosis of a spectrum of ovarian cystic masses and also proposes an algorithmic approach for the diagnosis of these lesions. | Ashish P Wasnik Christine O Menias Joel F Platt Usha R Lalchandani Deepak G Bedi Khaled M Elsayes | 2013 | World Journal of Radiology2013，5，3： | 7 |
| 3 | Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial显示文摘 | Roger Stupp Monika E Hegi Warren P Mason Martin J van den Bent Martin JB Taphoorn Robert C Janzer Samuel K Ludwin Anouk Allgeier Barbara Fisher Karl Belanger Peter Hau Alba A Brandes Johanna Gijtenbeek Christine Marosi Charles J Vecht Karima Mokhtari Piet | 2009 | Lancet Oncology2009，，5： | 4 |
| 4 | Testing for HCV Infection: An Update of Guidance for Clinicians and Laboratorians显示文摘 | Getchell Jane P Wroblewski Kelly E DeMaria Alfred Bean Christine L Parker Monica M Pandori Mark Dufour D Robert Busch Michael P Brecher Mark E Meyer William A Pesano Rick L Teo Chong-Gee Beckett Geoffrey A Araujo Aufra C Branson Bernard M D | 2013 | MMWR. Morbidity and Mortality Weekly Report2013，，18： | 3 |
| 5 | Implications of phytoestrogen intake for breast cancer显示文摘 | Christine D Kimberly P Ann P | 2007 | CA Cancer Clin2007，57，5： | 1 |
| 6 | Membrane-type 1 matrix metalloproteinase expression is regulated by zonula occludens-1 in human breast cancercells显示文摘 | Myriam P Christine C Beatrice NR | 2005 | Cancer Res2005，65，： | 1 |
| 7 | Whole animal measurements of shear and ahesive forces in adult tree frogs: insights into underlying mechanisms of adhesion obtained from studying the effects of size and scale显示文摘 | BARNES W J P CHRISTINE O JOANNA M S | 2006 | Journal of Comparative Physiology A2006，192，11： | 1 |
| 8 | Oligocene CO2decline promoted C4 photosynthesis in grasses 显示文摘 | Christin P A Besnard G Samaritani E | 2008 | Curr Biol2008，18，1： | 1 |
| 9 | The new market for federal judicial law clerks显示文摘 | Avery C Christine J Richard P and Alvin E R | 2007 | University of Chicago Law Review2007，，： | 1 |
| 10 | The Writing Assignments and Writing Problems of Doctoral Students:Faculty Perceptions, Pedagogical Issues,and Needed Research显示文摘 | Christine P C Philip H | 1992 | English for Specific Purposes1992，，11： | 1 |
| 11 | Charalerization of lacti' andbacteria isolated from a Thai low-salt fermented fish producl and th role of garlic as substrate for fermertation 显示文摘 | Christine P M Hans H H Lone G | 1999 | International JotJrrttl of Food MicrobioLogy1999，46，3： | 1 |
| 12 | Isolation of a cDNA Encoding a β-1,4 endoglucanase in the root knot nematode Meloidogyne incognita and expression analysis during plant parasitism显示文摘 | MARIE N R BRUNO F CHRISTINE P | 1999 | Mol Plant-Microbe Interact1999，12，7： | 1 |
| 13 | Root decomposition across a barrier island chronosequence:Litter quality and environmental controls显示文摘 | Christine E Conn Frank P Day Jr | 1997 | Plant and Soil1997，195，2： | 1 |
| 14 | Hearl rate as a risk factor for cardiovascular disease 显示文摘 | CHRISTINE P G LAURE J ATHANASE B | 2009 | Pro- gress in Cardiovascular Diseases2009，52，1： | 1 |
| 15 | Digital watermarking, al- gorithms and applieations显示文摘 | Christine I P Edward J D | 2001 | IEEE Signal Processing Magazine2001，，7： | 1 |
| 16 | Comparision of basal insulin added to oral agents versus twice-daily premixed insulin as initial therapy for type 2 diabetes 显示文摘 | Hans U J Christine K F Gerd P | 2005 | Diabetes Care2005，28，2： | 1 |
| 17 | [11C] Methionine and [18F] Fluorodeoxyglucose PET in the follow-up of glioblastoma multiforme显示文摘 | Christian P?tzi Alexander Becherer Christine Marosi Georgios Karanikas Monika Szabo Robert Dudczak Kurt Kletter Susanne Asenbaum | 2007 | Journal of Neuro - Oncology2007，，3： | 1 |
| 18 | Hydrologic modeling analysis of a passive, residential rainwater harvesting program in an urbanized, semi-arid watershed 显示文摘 | Thomas C W Christine A P Steven J B | 2014 | J Hydrol2014，420，： | 1 |
| 19 | Evaluation of a sequential extraction procedure for the speciation of heavy metals in sediments显示文摘 | Rhodri P Thomas Sharon E Mc Vey | 1994 | Anal Chim Acta1994，291，： | 1 |
| 20 | Effects of early childhood psychosocial stimulation and nutritional supplementation on cognition and education in growth-stunted Jamaican children: prospective cohort study显示文摘 | Susan P Walker Susan M Chang Christine A Powell Sally M Grantham-McGregor | 2005 | The Lancet2005，，9499： | 1 |
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