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| 1 | TRPV1 and TRPA1 in cutaneous neurogenic and chronic inflammation: pro-inflammatory response induced by their activation and their sensitization显示文摘皮肤的神经原的发炎(CNI ) 是被导致的发炎(或提高) 在由从感觉神经末端的 neuropeptides 的版本的皮肤。临床的表明主要是象瘙痒和红斑那样的感觉、脉管的混乱。短暂受体潜力 vanilloid 1 并且 ankyrin 1 (TRPV1 和 TRPA1,分别地) 是知道明确地参予疼痛和 CNI 的非选择的阳离子隧道。TRPV1 和 TRPA1 在感觉神经的一个大子集被共同表示,在他们集成众多的有害刺激的地方。两条隧道的表示也在皮肤在感觉神经以外远延长,现在是清楚的,在 keratinocytes,桅杆房间,树枝状的房间,和 endothelial 房间也发生。在这些 non-neuronal 房间, TRPV1 和 TRPA1 也充当 nociceptive 传感器并且加强煽动性的过程。这评论在在感觉神经原和 non-neuronal 皮肤房间导致或维持 CNI 的煽动性的基因的调整讨论 TRPV1 和 TRPA1 的角色。另外,这评论由支持 CNI 的自我维护的另外的内长的煽动性的调停人提供关于两条 TRP 隧道的细胞内部的促进感受性小径的当前的研究的一篇摘要。 | Olivier Gouin Killian L'Herondelle Nicolas Lebonvallet Christelle Le Gall-lanotto Mehdi Sakka Virginie Buhe Emmanuelle PIee-Gautier Jean-Luc Carre Luc Lefeuvre Laurent Misery~,Raphaele Le Garrec | 2017 | Protein & Cell2017，8，9： | 45 |
| 2 | Levels of insecticide resistance to deltamethrin,malathion,and temephos,and associated mechanisms in Aedes aegypti mosquitoes from the Guadeloupe and Saint Martin islands(French West Indies)显示文摘Background:In the Guadeloupe and Saint Martin islands,Aedes aegypti mosquitoes are the only recognized vectors of dengue,chikungunya,and Zika viruses.For around 40 years,malathion was used as a mosquito adulticide and temephos as a larvicide.Since the European Union banned the use of these two insecticide molecules in the first decade of the 21st century,deltamethrin and Bacillus thuringiensis var.israelensis are the remaining adulticide and larvicide,respectively,used in Guadeloupe.In order to improve the management of vector control activities in Guadeloupe and Saint Martin,we investigated Ae.aegypti resistance to and mechanisms associated with deltamethrin,malathion,and temephos.Methods:Ae.aegypti mosquitoes were collected from six different localities of Guadeloupe and Saint Martin.Larvae were used for malathion and temephos bioassays,and adult mosquitoes for deltamethrin bioassays,following World Health Organization recommendations.Knockdown resistance(Kdr)genotyping for V1016I and F1534C mutations,and expression levels of eight enzymes involved in detoxification mechanisms were examined in comparison with the susceptible reference Bora Bora strain.Results:Resistance ratios(RR50)calculated for Ae.aegypti larvae showed high resistance levels to temephos(from 8.9 to 33.1-fold)and low resistance levels to malathion(from 1.7 to 4.4-fold).Adult females displayed moderate resistance levels to deltamethrin regarding the time necessary to affect 50%of individuals,varying from 8.0 to 28.1-fold.Molecular investigations on adult mosquitoes showed high resistant allele frequencies for V1016I and F1534C(from 85 to 96%and from 90 to 98%,respectively),as well as an overexpression of the glutathione S-transferase gene,GSTe2,the carboxylesterase CCEae3a,and the cytochrome genes 014614,CYP6BB2,CYP6M11,and CYP9J23.Conclusions:Ae.aegypti populations from Guadeloupe and Saint Martin exhibit multiple resistance to organophosphates(temephos and malathion),and pyrethroids(deltamethrin).The mechanisms associated with these resistance patterns show strong frequencies of F1534C and V1016I Kdr mutations,and an over-expression of CCEae3a,GSTe2,and four cytochrome P450 genes(014614,CYP9J23,CYP6M11,CYP6BB2).These results will form the baseline for a deeper understanding of the insecticide resistance levels and associated mechanisms of Ae.aegypti populations and will be used to improve vector control strategies in Guadeloupe and Saint Martin. | Daniella Goindin Christelle Delannay Andric Gelasse Cedric Ramdini Thierry Gaude Frederic Faucon Jean-Philippe David Joël Gustave Anubis Vega-Rua Florence Fouque | 2017 | Infectious Diseases of Poverty2017，6，1： | 3 |
| 3 | Prevention of gut leakiness by a probiotic treatment leads to attenuated HPA response to an acute psychological stress in rats显示文摘 | Afifa Ait-Belgnaoui Henri Durand Christel Cartier Gilles Chaumaz Hélène Eutamene Laurent Ferrier Eric Houdeau Jean Fioramonti Lionel Bueno Vassilia Theodorou | 2012 | Psychoneuroendocrinology2012，，11： | 2 |
| 4 | Follow-up study of the GIGYF2gene in French families with Parkinson’s disease显示文摘 | Suzanne L Christel C Ebba L | 2010 | Neurobiology ofAging2010，31，6： | 1 |
| 5 | Automated nucleic acid probe assays using silicon microstructures for nucleic acid concentration显示文摘 | Christel L A Petersen K McMillan W | 1999 | Journal of Biomechanical Engineering-Transactions of the ASME1999，121，： | 1 |
| 6 | Effects of two proteinase inhibitors on the digestive enzymes and survival of honey bees( Apis mellifera ) 显示文摘 | Belzunces E Malone L A Christeller J T | 1996 | Journal of Insect Physiology1996，42，9： | 1 |
| 7 | Fructose and metabolic diseases: New findings, new questions显示文摘 | Luc Tappy Kim A. Lê Christel Tran Nicolas Paquot | 2010 | Nutrition2010，，11： | 1 |
| 8 | Pathological Response to Neoadjuvant Chemotherapy: A New Prognosis Tool for the Curative Management of Peritoneal Colorectal Carcinomatosis显示文摘 | Guillaume Passot Beno?t You Gilles Boschetti Juliette Fontaine Sylvie Isaac Evelyne Decullier Christele Maurice Delphine Vaudoyer Fran?ois-No?l Gilly Eddy Cotte Olivier Glehen | 2014 | Annals of Surgical Oncology2014，，： | 1 |
| 9 | Arch Microbiol显示文摘 | Christel H | 1990 | 155:56-611990，155，： | 1 |
| 10 | Gelation of skim milk containing anionic exopolysaccharides and recovery of texture after shearing显示文摘 | Maude G Christelle S L | 2007 | Food Hydrocolloids2007，21，10： | 1 |
| 11 | Review on antimicrobial packaging containing essential oils and their active biomolecules显示文摘 | Faten Sadaka Christelle Nguimjeu Claire-Hélène Brachais Isabelle Vroman Lan Tighzert Jean-Pierre Couvercelle | 2014 | Innovative Food Science and Emerging Technologies2014，，： | 1 |
| 12 | Degradation of aniline and monochlorinated anilines by soil-born Pseudomonas acidovorans strains显示文摘 | Michael L Christel H | 1990 | Archives of Microbiology1990，155，： | 1 |
| 13 | Problem -based and project - based learning in engineering and medicine: Determinants of students' engagement and persistance 显示文摘 | Denis B Christelle L Dmliel D | 2012 | Interdisciplinary Journal of Problem - based Learning2012，，2： | 1 |
| 14 | Avidin expressed in transgenic tobacco leaves confers resistance to two noctuid pests, Helicoverpa armigera and Spodoptera litura 显示文摘 | Burgess E P J Malone L A Christeller J T | 2002 | Transgenic Research2002，11，2： | 1 |
| 15 | What Makes Good Antioxidants in Lipid-Based Systems? The Next Theories Beyond the Polar Paradox显示文摘 | Micka?l Laguerre Christelle Bayrasy Atikorn Panya Jochen Weiss D. Julian McClements Jér?me Lecomte Eric A. Decker Pierre Villeneuve | 2015 | Critical Reviews in Food Science and Nutrition2015，，2： | 1 |
| 16 | Epididymis seleno-independent glutathione peroxidase 5 maintains sperm DNA integrity in mice显示文摘 | Chabory Eléonore Damon Christelle Lenoir Alain Kauselmann Gary Kern Hedrun Zevnik Branko Garrel Catherine Saez Fabrice Cadet Rémi Henry-Berger Joelle Schoor Michael Gottwald Ulrich Habenicht Ursula Drevet Jo?l R Vernet Patrick | 2009 | Journal of Clinical Investigation2009，，7： | 1 |
| 17 | Effect of dispersed crude oil exposure upon the aerobic metabolic scope in juvenile golden grey mullet ( Liza aurata )显示文摘 | Thomas Milinkovitch Julie Lucas Stéphane Le Floch Hélène Thomas-Guyon Christel Lefran?ois | 2012 | Marine Pollution Bulletin2012，，4： | 1 |
| 18 | Signal transduction of erythropoietin in endothelial cells 显示文摘 | Haller H Christel C Dannenberg L | 1996 | Kidney Int1996，50，2： | 1 |
| 19 | Simultaneous analysis of 21 elements in foodstuffs by ICP-MS after closed-vessel microwave digestion: Method validation显示文摘 | Sandrine Millour Laurent No?l Ali Kadar Rachida Chekri Christelle Vastel Thierry Guérin | 2010 | Journal of Food Composition and Analysis2010，，1： | 1 |
| 20 | Epididymis seleno-independent glutathione peroxidase 5 maintains sperm DNA integrity in mice显示文摘 | Chabory Eléonore Damon Christelle Lenoir Alain Kauselmann Gary Kern Hedrun Zevnik Branko Garrel Catherine Saez Fabrice Cadet Rémi Henry-Berger Joelle Schoor Michael Gottwald Ulrich Habenicht Ursula Drevet Jo?l R Vernet Patrick | 2009 | Journal of Clinical Investigation2009，，7： | 1 |
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