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| 1 | Mixed adenoneuroendocrine carcinoma of gastrointestinal tract: Report of two cases显示文摘Mixed adenoneuroendocrine carcinoma(MANEC) is a rare tumor of the gastrointestinal tract that consists of a dual adenocarcinomatous and neuroendocrine differentiation, each component representing at least 30% of the tumor. To date, only seven cases have been reported in the cecum, and less than 40 in the stomach. Our first case was diagnosed in a 74-years-old female as a polypoid lesion of the cecum with direct invasion in the transverse colon, without lymph node metastases. The second case was diagnosed in the stomach of a 46-years-old male as a polypoid tumor of the antral region that invaded the pancreas and presented metastases in 22 regional lymph nodes. The metastatic tissue was represented by the glandular component. In both cases, the tumor consisted of a moderately-differentiated tubular adenocarcinoma(with mucinous component in Case 1) intermingled with neuroendocrine carcinoma. Ki67 index was lower than 20% in Case 1, respectively higher than 20% in Case 2. The neuroendocrine component was marked by synaptophysin and neuron specific enolase, being negative for Keratins 7/20. The neuroendocrine component represented 60% in Case 1, and 40% in Case 2, respectively. The glandular components were marked by carcinoembryonic antigen, maspin and keratin 20/7(Case 1/2). Both cases were proved to be microsatellite stable. Independently by the localization and tumor stage, MANECs appear to be highly malignant tumors, with high risk for distant metastases. The aggressiveness seems to depend on the endocrine component, independent of its proportion. The neuroendocrine component could be a dedifferentiated adenocarcinoma with a neuroendocrine phenotype. | Simona Gurzu Zoltan Kadar Tivadar Bara Tivadar Jr. Bara Adrian Tamasi Leonard Azamfirei Ioan Jung | 2015 | World Journal of Gastroenterology2015，21，4： | 14 |
| 2 | Single skip metastasis in sentinel lymph node: In an early gastric cancer显示文摘Lymph node status is considered a key prognostic and predictive factor in patients with gastric cancer(GC).Although there is a practical approach to the intraoperative detection of sentinel lymph nodes(SLNs),such a procedure is not included in the European surgical protocol.In this report,we present a practical approach to SLN mapping in a representative case with early gastric cancer(EGC).A 74-year-old female was hospitalized with an endoscopically observed,superficially ulcerated tumor located in the antral region.Subtotal gastrectomy with D2 lymphadenectomy and SLN mapping was performed by injecting methylene blue dye into the peritumoral submucosal layer.An incidentally detected blue-stained lymph node located along the middle colic artery was also removed.This was detected 40 min after injection of the methylene blue.Histopathologic examination showed a p T1b-staged well-differentiated HER-2-negative adenocarcinoma.All of the 41 LNs located at the first,third,and fifth station of the regional LN compartments were found to be free of tumor cells.The only lymph node with metastasis was located along the middle colicartery and was considered a non-regional lymph node.This incidentally identified skip metastasis indicated stage Ⅳ GC.A classic chemotherapy regimen was given,and no recurrences were observed six months after surgery.In this representative case,low-cost SLN mapping,with a longer intraoperative waiting time,totally changed the stage of the tumor in a patient with EGC. | Tivadar Jr Bara Simona Gurzu Ioan Jung Zoltan Kadar Haruhiko Sugimura Tivadar Bara | 2015 | World Journal of Gastroenterology2015，21，33： | 8 |
| 3 | Further observations on the doubling time of human chorionic gonadotropin in early asymptomatic pregnancies 显示文摘 | Kadar N Freedman M Zacher M | 1990 | Fertil Steril1990，54，： | 1 |
| 4 | Ground Target Tracking with Variable Structure IMM Estimator显示文摘 | Kirubarajan T Bar-Shalom Y Pattipatik P Kadar I | 2000 | IEEE Transactions on Aerospace and Electronic Systems2000，36，1： | 1 |
| 5 | Prognosis of acute my- eloid leukemia transformed from myelodysplastic syndromes:a multicenter retrospective study显示文摘 | Okuyama N Sperr WR Kadar K | 2013 | Leuk Res2013，37，8： | 1 |
| 6 | Optimal scheduling of a renewable micro-grid in an isolated load area using mixed-integer linear programming显示文摘 | MORAIS H KADAR P FARIA P | 2010 | Renew Energy2010，35，1： | 1 |
| 7 | Detcmination of traces of fipronil and its me- tabolites in pollen by liquid chromatography with clectrospray ion - ization - tandem mass spectromelry 显示文摘 | Kadar A Faucon J P | 2005 | J of Agriculture Food Chemistry2005，54，： | 1 |
| 8 | Using flavonoids,phenolic compounds and headspace volatile profile for botanical authentication of lemon and orange honeys显示文摘 | ESCICHE I KADAR M JUAN-BORRAS M | 2011 | Food Res lnt2011，44，： | 1 |
| 9 | Evaluation of post-thaw DNAintegrity of mouse blastocysts after ultrara- pid and slow freezing显示文摘 | Kadar A Agarwal A Abdelrazik H | 2009 | Fertil Steril2009，91，5： | 1 |
| 10 | Incisional hernias after major laparoscopic gynecologic procedures显示文摘 | Kadar N | 1993 | Am J Obstet Gynecol1993，168，5： | 1 |
| 11 | Laparoscopically assisted hysterectomy for uteri weighing 500 g or more显示文摘 | Kadar N | 1994 | Am Assoc Gynecol Laparosc1994，1，4： | 1 |
| 12 | Positive peritoneal cytology is an adverse factor in endomtrial carcinoma only if there is other evidence of extrauterine disease显示文摘 | Kadar N Homesley HD | 1992 | Gynecol Oncol1992，46，： | 1 |
| 13 | Yields from glucose, xylose, and paper sludge hydrolysate during hydrogen production by the extreme thermophile Caldicellulosiruptor saccharolyticus 显示文摘 | Kadar Z De Vrijek T van Noorden GE | 2004 | Appl Biochem Biotechnol2004，，： | 1 |
| 14 | Phosphorus fertiliza- tion impacts on maize yield and nutritional status with em- phasis on P and Zn in leaves and grain显示文摘 | Kovacevic V Loncaric Z Kadar I | 2011 | Brisbane Australia2011，19，： | 1 |
| 15 | Ezrin interacts with fo- cal adhesion kinase and induces its activation independently of cell-matrix adhesion显示文摘 | Poullet P Gautreau A Kadare G | 2001 | J Biol Chem2001，276，37： | 1 |
| 16 | Determinants of survival of surgically staged patients with endometrial carcinoma histologically confined to the uterus: implications for therapy显示文摘 | Kadar N Malfetano JH Homesley HD | 1992 | Obstel Gynecol1992，80，4： | 1 |
| 17 | Maternal death following cardiopulmonary collapse after delivery: amniotic fluid embolism or septic shock due to intrauterine infection? 显示文摘 | Romero R Kadar N Vaisbuch E | 2010 | Am J Reprod Immnnol2010，64，2： | 1 |
| 18 | Cognitive deficits induced in young rats by long-term corticosterone administration显示文摘 | Kadar T Robinzon B | 1993 | Behav Neural Biol1993，60，2： | 1 |
| 19 | Ground target tracking with variable structure IMM estimator 显示文摘 | T Kirubarajan Bar-Shalom Y L Kadar | 2000 | IEEE Transactions on Aerospace and Electronic Systems2000，36，1： | 1 |
| 20 | Reduction of in-source collision-induced dissociation and thermolysis of sulopenem prodrugs for quantitative liquid chromatography/electrospray ionization mass spectrometric analysis by promoting sodium adduct formation显示文摘 | Wujcik CE Kadar EP | 2008 | Rapid Communications in Mass Spectrometry2008，22，20： | 1 |
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