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| 1 | 睾丸后精子成熟,不育与高胆固醇血症显示文摘胆固醇是参与哺乳动物生理活动的重要分子,由于它是固醇类激素合成的通用前体物质,因而对生殖系统尤为重要。胆固醇不仅仅对于配子发生起到重要作用,它也是公认的精子功能的调节分子。胆固醇体内平衡的调节对睾丸后精子的成熟至关重要,胆固醇水平失衡会影响到睾丸后调控事件。代谢性脂质紊乱(血脂异常症)会影响男性的生育能力,但大多数这方面的研究是从内分泌/睾丸的角度进行探讨的,而这篇综述将关注像高胆固醇血症这样的特定血脂异常症在哺乳动物精子的睾丸后成熟过程中的有害影响。 | Marjorie Whitfield Xavier PoUet-Villard Rachel Levy Joel R Drevet Fabrice Saez | 2015 | Asian Journal of Andrology2015，17，5： | 8 |
| 2 | Epididymis cholesterol homeostasis and sperm fertilizing ability显示文摘胆固醇,是类固醇荷尔蒙合成的起点,在性腺的水平特别是女性和男繁殖生理学的一个长已知的调节的人,影响胆固醇穿上 gametogenesis。更少对动态平衡可以在 postgonadic 上有的效果胆固醇被知道繁殖功能。最近,几个数据被报导了显示出 imbalanced 胆固醇层次怎么可以特别地影响精子成熟的 testicular 以后事件导致充分肥沃的男配偶子。这评论将集中于那个方面并且实质上在胆固醇怎么为哺乳动物的 epididymis 和精子的生理学是重要的上集中。 | Fabrice Saez Ouvrier and Joel R Drevet | 2011 | Asian Journal of Andrology2011，13，1： | 7 |
| 3 | The epididymal immune balance:a key to preserving male fertility显示文摘Up to 15%of male in fertility has an immuno logical origi n,either due to repetitive infections or to autoimmune resp on ses mainly affecting the epididymis,prostate,and testis.Clinical observations and epidemiological data clearly contradict the idea that the testis confers immune protection to the whole male genital tract.As a consequenee,the epididymis,in which posttesticular spermatozoa mature and are stored,has raised some in terest in recent years when it comes to its immune mecha nisms.In deed,sperm cells are produced at puberty,long after the establishment of self-toleranee,and they possess unique surface proteins that cannot be recognized as self.These are potential targets of the immune system,with the risk of inducing autoantibodies and consequently male infertility.Epididymal immunity is based on a finely tuned equilibrium between efficient immune responses to pathogens and strong tolerance to sperm cells.These processes rely on incompletely described molecules and cell types.This review compiles recent studies focusing on the immune cell types populating the epididymis,and proposes hypothetical models of the organization of epididymal immunity with a special emphasis on the immune response,while also discussing important aspects of the epididymal immune regulation such as tolerance and tumour control. | Allison Voisin Fabrice Saez Joel R Drevet Rachel Guiton | 2019 | Asian Journal of Andrology2019，21，6： | 4 |
| 4 | High-resolution patterns of palaeoenvironmental changes during the Little Ice Age and the Medieval Climate Anomaly in the northwestern Iberian Peninsula显示文摘to identify plant macrofossils,estimate peat humification and calculate hydroclimatic indices based on current bog species,with the overall aim of determining the climate conditions associated with evolution of the bog during the Medieval Climate Anomaly and the Little Ice Age.These proxies,together with historical and climate data,proved to be good indicators of the changes in bog surface wetness.Analysis:of the core led to identification of 9 different periods:two corresponding to the so-called Medieval Climate Anomaly(930 to 1345 AD,1075–665 calibrated years before present[cal.yr BP]);four corresponding to the Little Ice Age(1345 to 1905 AD;665–105 cal yr BP);and three corresponding to the last century(1905 to 2000 AD).The findings revealed a generally dry climate that lasted until the 14th century,followed by a transition to a long period with a more humid,but characteristically very variable climate,which ended at the beginning of the 20th century and was followed by a rapid transition to more humid conditions and finally,a change to drier conditions.The Medieval Climate Anomaly was indicated by the abundance of dry-adapted mosses(Leucobryum glaucum,Hypnum cupressiforme)and characterized by warm dry conditions and high levels of peat humification,with alternating wet phases.The LIA period was dated by a large abundance of Sphagnum species(an indicator of wetness)and a gradual increase in the humification index.However,four different climate phases were differentiated in this period.High-resolution reconstruction of the evolution of the CVM bog and the multiproxy approach have together enabled a more detailed identification of climatic variations in this area,which are generally consistent with the global models,as well as better definition of the elusive climatic oscillations in the last millennium and confirmation of the importance of local modulation of global models.The study provides new information and a detailed chronology of climatic events that will help to refine local modulation of the climate evolution model in the still quite unexplored region of the NW Iberian Peninsula,a key area for understanding the paleoclimatic dynamics in SW Europe. | Daniel Castro Martin Souto Maria Isabel Fraga Eduardo Garcia-Rodeja Sebastian Perez-Diaz Jose Antonio Lopez Saez Xabier Pontevedra-Pombal | 2020 | Geoscience Frontiers2020，11，5： | 2 |
| 5 | Real-Time PCR for Diagnosing Helicobacter pylori Infection in Patients with Upper Gastrointestinal Bleeding: Comparison with Other Classical Diagnostic Methods显示文摘 | Jesús Saez Sofía Belda Miguel Santibá?ez Juan Carlos Rodríguez Javier Sola-Vera Antonio Galiana Montserrat Ruiz-García Alicia Brotons Elena López-Girona Eva Girona Carlos Sillero Gloria Royo | 2012 | Journal of Clinical Microbiology2012，，10： | 2 |
| 6 | SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β‐catenin显示文摘 | Petra Simic Kayvan Zainabadi Eric Bell David B. Sykes Borja Saez Sutada Lotinun Roland Baron David Scadden Ernestina Schipani Leonard Guarente | 2013 | EMBO Mol Med2013，，3： | 2 |
| 7 | Comparison of different sample treatments for the analysis of ochratoxin A in must, wine and beer by liquid chromatography显示文摘 | SAEZ J M MEDINA A JOSE V | 2004 | Journal of Chromatography A2004，1029，： | 1 |
| 8 | NH ( 2 ) -terminal truncated HER-2 protein but not full-length receptor is associated with nodal metastasis in human breast cancer 显示文摘 | Molina MA Saez R Ramsey EE | 2002 | Clin Cancer Res2002，8，2： | 1 |
| 9 | hPTTG is Over-expressed in Pituitary Adenomas and Other Primary Epithelial neoplasias显示文摘 | SAEZ C JAPON M A ROMOS MORALES F | 1999 | Oncogene1999，18，39： | 1 |
| 10 | Prostasome inhibit the nadph oxidase activity of human neutrophils显示文摘 | Saez F Motta C | 2000 | Molecular human reproduction2000，6，： | 1 |
| 11 | Supermolecular liquid crystals 显示文摘 | SAEZ I GOODBY J | 2005 | J Mater Chem2005，15，： | 1 |
| 12 | The Optimal Treatment of Tax Expenditures显示文摘 | Saez E | 2004 | Journal of Public Economics2004，88，910： | 1 |
| 13 | Up-regulation of microRNA 506 leads to decreased C1-/HCO3- anion exchanger 2 expression in biliary epithelium of patients with primary biliary cirrhosis显示文摘 | Banales JM Saez E Uriz M | 2012 | Hepatology2012，56，2： | 1 |
| 14 | Effect of breed on the muscle glycogen content and dark cutting incidence in stressed young bulls显示文摘 | SANZ M C VERDE M T SAEZ T | 1996 | Meat Science1996，43，1： | 1 |
| 15 | Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a mu, delta or kappa opioid receptor type显示文摘 | Bunzow JR Saez C Mortrud M | 1994 | FEBS Lett1994，347，23： | 1 |
| 16 | Allogeneicbone marrow transplantation in patients who relapseafter autologous transplantation显示文摘 | TSAI T GOODMAN S SAEZ R | 1997 | Bone MarrowTransplant1997，20，： | 1 |
| 17 | Improvement of coagulation-flocculation process using anionic polyacrylamide as coagulant aid显示文摘 | M I Aguilar J Saez | 2005 | Chemosphere2005，58，： | 1 |
| 18 | Hpttg is over-expressed in pituitary adenomas and other primary epithelial neoplasias显示文摘 | Saez C Japon MA Ramos-Morales F | 1999 | Oncogene1999，18，： | 1 |
| 19 | Update of the standard numbering scheme for class 13 beta lactamases显示文摘 | Garau G Garcia Saez I Bebrone C | 2004 | Antimicrob A gents Chemother2004，48，7： | 1 |
| 20 | Multifocal inflammatory pseudotumor of the lung with good response to corticoids显示文摘 | Diez Pina JM Fernandez Vazquez E Saez Roca G | | 0，，02： | 1 |
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