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| 1 | Cytoreductive surgery and hyperthermic intraperitonealchemotherapy in gastric cancer显示文摘Gastric cancer associated peritoneal carcinomatosis(GCPC) has a poor prognosis with a median survival of less than one year. Systemic chemotherapy including targeted agents has not been found to significantly increase the survival in GCPC. Since recurrent gastric cancer remains confined to the abdominal cavity in many patients, regional therapies like aggressive cytoreductive surgery( CRS) and hyperthermic intraperitoneal chemotherapy(HIPEC) have been investigated for GCPC. HIPEC has been used for three indications in GC- as an adjuvant therapy after a curative surgery, HIPEC has been shown to improve survival and reduce peritoneal recurrences in many randomised trials in Asian countries; as a definitive treatment in established PC, HIPEC along with CRS is the only therapeutic modality that has resulted in longterm survival in select groups of patients; as a palliative treatment in advanced PC with intractable ascites, HIPEC has been shown to control ascites and reduce the need for frequent paracentesis. While the results of randomised trials of adjuvant HIPEC from western centres are awaited, the role of HIPEC in the treatment of GCPC is still evolving and needs larger studies before it is accepted as a standard of care. | Ramakrishnan Ayloor Seshadri Olivier Glehen | 2016 | World Journal of Gastroenterology2016，22，3： | 34 |
| 2 | 结直肠癌腹膜转移高风险患者进行二次探查手术加腹腔热灌注化疗与随访的比较(PRO⁃PHYLOCHIP–PRODIGE15):一项随机的3期研究显示文摘背景:如果在结直肠癌腹膜转移出现症状之前就能够早期诊断和治疗,可以提高患者生存率。我们研究的目的是在结直肠癌腹膜转移的高风险患者中,探究进行有计划的二次探查手术加腹腔热灌注化疗(hyperthermic intraperitoneal chemo-therapy,HIPEC)是否可以给患者带来生存获益。 | 张荣欣 GOéRé D GLEHEN O QUENET F | 2020 | 结直肠肛门外科2020，26，5： | 9 |
| 3 | Intra-operative peritoneal lavage for colorectal cancer显示文摘Free cancer cells can be detected in peritoneal fluid at the time of colorectal surgery.Peritoneal lavage in colorectal surgery for cancer is not used in routine,and the prognostic significance of intraperitoneal free cancer cells(IPCC)remains unclear.Data concerning the technique of peritoneal lavage to detect IPCC and its timing regarding colorectal resection are scarce.However,positive IPCC might be the first step of peritoneal spread in colorectal cancers,which could lead to early specific treatments.Because of the important heterogeneity of IPCC determination in reported studies,no treatment have been proposed to patients why positive IPCC.Herein,we provide an overview of IPCC detection and its impact on recurrence and survival,and we suggest further multi-institutional studies to evaluate new treatment strategies. | Guillaume Passot Kayvan Mohkam Eddy Cotte Olivier Glehen | 2014 | World Journal of Gastroenterology2014，20，8： | 5 |
| 4 | Intraperitoneal Chemohyperthermia Using a Closed Abdominal Procedure and Cytoreductive Surgery for the Treatment of Peritoneal Carcinomatosis: Morbidity and Mortality Analysis of 216 Consecutive Procedures显示文摘 | O. Glehen MD D. Osinsky MD E. Cotte MD F. Kwiatkowski MS G. Freyer MD PhD S. Isaac MD V. Trillet-Lenoir MD PhD A. C. Sayag-Beaujard MD Y. Fran?ois MD J. Vignal MD F. N. Gilly MD PhD | 2003 | Annals of Surgical Oncology2003，，8： | 4 |
| 5 | Selection of patients and staging of peritoneal surface malignancies显示文摘Peritoneal carcinomatosis (PC) is a common evolution of cancer of the gastrointestinal tract, and has been traditionally regarded as a terminal disease with short median survival. During the last 20 years, thanks to its favourable oncologic results, a new loco-regional therapeutic approach, combining cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC), has an important development. Due to its significant, but acceptable, morbidity and mortality, and high cost, this comprehensive management plan requires knowledgeable patient selection. Quantitative prognostic indicators are required to assess a patient’s eligibility. Large multicenter studies have identified several prognostic factors, which can be used for a better selection of patients who would benefit from the combination of cytoreductive surgery with HIPEC. Indications for treatment of PC with cytoreduction and HIPEC are now validated for several diseases: peritoneal mesothelioma, pseudomyxoma peritonei, PC from the appendix, and colorectal cancer. Indications are still under discussion for gastric and ovarian carcinomatosis. Computed tomography is the best radiological for staging the disease. The extent of peritoneal carcinomatosis is, however, difficult to evaluate preoperatively, and precise evaluation is most often performed during surgical exploration. Cytoreductive surgery associated with HIPEC for the treatment of peritoneal carcinomatosis should be performed for young patients with limited and resectable carcino-matosis, in specialized institutions involved in the management of peritoneal surface malignancies. | Eddy Cotte Guillaume Passot Franois-Noёl Gilly Olivier Glehen | 2010 | World Journal of Gastrointestinal Oncology2010，2，1： | 4 |
| 6 | Peritoneal Mesothelioma Treated by Cytoreductive Surgery and Intraperitoneal Hyperthermic Chemotherapy: Results of a Prospective Study显示文摘 | C. Brigand MD O. Monneuse MD F. Mohamed MBChB MRCS A. C. Sayag-Beaujard MD S. Isaac MD F. N. Gilly MD PhD O. Glehen MD PhD | 2006 | Annals of Surgical Oncology2006，，3： | 3 |
| 7 | Quality of life after cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy: A prospective study of 216 patients显示文摘 | G. Passot N. Bakrin A.S. Roux D. Vaudoyer F.-N. Gilly O. Glehen E. Cotte | 2013 | European Journal of Surgical Oncology2013，，： | 2 |
| 8 | Pseudomyxoma peritonei: A French multicentric study of 301 patients treated with cytoreductive surgery and intraperitoneal chemotherapy显示文摘 | D. Elias F. Gilly F. Quenet J.M. Bereder L. Sidéris B. Mansvelt G. Lorimier O. Glehen | 2010 | European Journal of Surgical Oncology2010，，5： | 2 |
| 9 | Lack of prognostic significance of conventional peritoneal cytology in colorectal and gastric cancers: Results of EVOCAPE 2 multicentre prospective study显示文摘 | E. Cotte P. Peyrat E. Piaton F. Chapuis M. Rivoire O. Glehen C. Arvieux J.-Y. Mabrut J. Chipponi F.-N. Gilly | 2013 | European Journal of Surgical Oncology2013，，7： | 2 |
| 10 | Peritoneal carcinomatosis from digestive tract cancer: new management by cytoreductive surgery and intraperitoneal chemohyperthermia 显示文摘 | Glehen O Mohamed F Gilly FN | 2004 | Lancet Oncol2004，5，4： | 1 |
| 11 | Peritoneal carcinomatosis from non-gynecologic malignancies: results of the EVOCAPE 1 multicentric prospective study 显示文摘 | Sadeghi B Arvieux C Glehen O | 2000 | Cancer2000，88，2： | 1 |
| 12 | Intraperitoneal chemohyperthermia using a closed abdominal procedure and cytoreductive surgery for the treatment of peritoneal carcinomatosis: morbidity and mortality analysis of 216 consecutive procedures显示文摘 | Glehen O Osinsky D Cotte E | 2003 | Ann Surg Oncol2003，10，8： | 1 |
| 13 | Surgery combined with peritonectomy procedures and intraperitoneal chemohyperthermia in abdominal cancers with peritoneal carcinomatosis: a phase Ⅱ study 显示文摘 | Glehen O Mithieux F Osinsky D | 2003 | J Clin Oncol2003，21，5： | 1 |
| 14 | Hyperthermic intraperitoneal chemothera- py in advanced gastric cancer:the end of skepticism显示文摘 | Glehen O Gilly FN Cotte E | 2011 | Ann Surg On- col2011，18，6： | 1 |
| 15 | Toward curative treatment of peritoneal carcinomatosis from nonovarian origin by cytoreductive surgery combined with perioperative intraperitoneal chemotherapy:a multi-institutional study of 1 290patients显示文摘 | Glehen O Gilly FN Boutitie F | 2010 | Cancer2010，116，： | 1 |
| 16 | Peritoneal carcinomatosis from non-gynecologic malignancies: results of the EVOCAPE 1 multicentric prospective study 显示文摘 | Sadeghi B Arvieux C Glehen O | 2000 | Cancer2000，88，2： | 1 |
| 17 | Cytoreductive surgery and intraperitoneal chemohyperthermia for peritoneal carcinomatosis arising form gastric cancer 显示文摘 | Glehen O Schreiber V Cotte E | 2004 | Arch Surg2004，139，1： | 1 |
| 18 | New perspectives in the management of colorectal cancer: what about peritoneal carcinoma- tosis显示文摘 | Glehen O Gilly FN Sugarbaker PH | 2003 | Scand J Surg2003，92，2： | 1 |
| 19 | Surgery combined with peritonectomy procedures and intraperitoneal chemohyperthermia in abdominal cancers with peritoneal carcinomatosis: a phase II study 显示文摘 | Glehen O Mithieux F Osinsky D | 2003 | J Clin Oncol2003，21，5： | 1 |
| 20 | New perspectives in the management of colorectal cancer:what about peritoneal carcinomatosis 显示文摘 | Glehen O Gilly FN Sugarbaker PH | 2003 | Scand J Surg2003，92，2： | 1 |
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