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| 1 | Collaboration for success:the value of strategic collaborations for precision medicine and biomarker discovery显示文摘Precision medicine aims to provide the precise treatment for the patient with the right dose at the right point of time.Biomarkers(BM)are vital for the identification of patients who would benefit the most from individualized treatment.In addition,they help to enable the prediction of prognosis,the detection of early therapeutic and adverse effects,and may serve as surrogate endpoints in clinical trials.BM are becoming essential tools to increase productivity in drug discovery and impressively enhance the way medicine is practiced.However,the identification,sufficient validation and implementation of such BM are challenging.This process requires expertise from different areas and high resource investments.Collaborations of different partners may be helpful to overcome these challenges.In the past decade,collaborations between diagnostics and pharmaceutical companies as well as industrial–academic collaborations have been increasingly pursued.Moreover,public funding may offer support and open new opportunities to form such consortia.Herein we give an overview of the different types of collaborations,their opportunities and challenges,and describe experiences in forming strategic partnerships with other companies. | Lilla Landeck Monika Lessl Joachim Reischl Andreas Busch Patricia Carrigan Matthias Gottwald Petra Reinke Khusru Asadullah | 2016 | Advances in Precision Medicine2016，1，1： | 3 |
| 2 | Performance of the OTSC System in the endoscopic closure of iatrogenic gastrointestinal perforations: a systematic review显示文摘 | Timo Weiland Marion Fehlker Thomas Gottwald Marc O. Schurr | 2013 | Surgical Endoscopy2013，，7： | 3 |
| 3 | Increase in Gap Junction Conductance by an Antiarrhythmic Peptide 显示文摘 | Muller A Gottwald M Tudyka T | 1997 | Eur J Pharmacol1997，327，1： | 1 |
| 4 | Die Bedeutung der Rasterefektronemikroskopie ftir die Entwiklung yon Phsphatierunggsverfahren 显示文摘 | Puderbach H Gotta H Gottwald K H | 1977 | Metall1977，31，10： | 1 |
| 5 | Long-term survival of endometrioid endometrial cancer patients显示文摘 | Gottwald L Pluta P Piekarski J | 2010 | Arch Med Sci2010，6，6： | 1 |
| 6 | An epidemiological analysis of the spread of citrus canker in urban Miami, Florida, and synergistic interaction with the Asian citrus leafminer显示文摘 | Gottwald T R Graham J H Schubert T S | 1997 | Fruits1997，52，： | 1 |
| 7 | Cultivar-specific interactions for strains of Xanthomonas campestris from Florida that cause citrus canker and citrus bacterial spot显示文摘 | Graham J H Gottwald T R Fardelman D | 1990 | Plant Disease1990，74，： | 1 |
| 8 | Genetic evidence for the in planta role of phloem-specific plasma membrane sucrose transporters显示文摘 | GOTTWALD J R KRYSAN P J YOUNG J C | | PNAS0，97，13： | 1 |
| 9 | TILLING in the two-rowed barley cultivar 'Barke' reveals preferred sites of functional diversity in the gene HvHoxl 显示文摘 | Gottwald S Bauer P Komatsuda T | 2009 | BMC Research Notes2009，2，： | 1 |
| 10 | Serum plant sterols asa potential risk factor for coronary heart disease 显示文摘 | Sudhop T Gottwald B M von Bergmann K | 2002 | Metabolism2002，51，12： | 1 |
| 11 | Testing for chaos in deterministic systems with noise 显示文摘 | GOTTWALD G A MELBOURNE L | 2005 | Physica D2005，212，12： | 1 |
| 12 | Comparison of FIGO 1989 and 2009 recommendations on staging of endometrial carcinoma:Pathologic analysis and cervical status in 123 consecutive cases显示文摘 | Korczynski J Jesionek-Kupnicka D Gottwald L | 2011 | lnt J Gynecol Pathol2011，30，4： | 1 |
| 13 | Semiquantitative reverse transcrip tion-polymerase chain reaction with the Agilent 2100 Bioanalyzer显示文摘 | Gottwald E Muller O Polten A | | Electrophoresis0，22，18： | 1 |
| 14 | 3-D high-frequency ultrasound backscatter analysis of human articular cartilage显示文摘 | Mnnicke N Schne M Gottwald M | 2014 | Ultrasound Med Biol2014，40，1： | 1 |
| 15 | Connections:the hard wiring of the plant cell for perception, signaling,and response显示文摘 | Miller D Hable W Gottwald J | 1997 | Plant Cell1997，9，： | 1 |
| 16 | Current epidemiological understanding of citrus显示文摘 | Gottwald T | 2010 | Annual Review of Phytopathology2010，，48： | 1 |
| 17 | New pharma- cotherapy for Parkinson's disease 显示文摘 | Gottwald MD Bainbridge JL Dowling GA | 1997 | Am Pharmacother1997，31，10： | 1 |
| 18 | Terminological difficulties in fuzzy set theory - the case of 'intuitionistic fuzzy sets' 显示文摘 | Dubois D Gottwald S Hajek J Kaeprzyk J Prade H | 2005 | Fuzzy Sets and Systems2005，156，： | 1 |
| 19 | Anal-ysis of disease progress of citrus canker in nurseries in Ar-gentina显示文摘 | GOTTWALD T R TIMMER L W MCGUIRE R G | 1989 | Phytopathology1989，79，： | 1 |
| 20 | Actions of the antiarrhythmic peptide AAP10 on intercellular coupling显示文摘 | A. Müller Thomas Schaefer Werner Linke Tatjana Tudyka Michaela Gottwald Wolfgang Klaus Stefan Dhein | 1997 | Naunyn - Schmiedeberg’s Archives of Pharmacology1997，，1： | 1 |
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