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| 1 | High-density SNP-based genetic maps for the parents of an outcrossed and a selfed tetraploid garden rose cross, inferred from admixed progeny using the 68k rose SNP array显示文摘Dense genetic maps create a base for QTL analysis of important traits and future implementation of marker-assisted breeding.In tetraploid rose,the existing linkage maps include<300 markers to cover 28 linkage groups(4 homologous sets of 7 chromosomes).Here we used the 68k WagRhSNP Axiom single-nucleotide polymorphism(SNP)array for rose,in combination with SNP dosage calling at the tetraploid level,to genotype offspring from the garden rose cultivar‘Red New Dawn’.The offspring proved to be not from a single bi-parental cross.In rose breeding,crosses with unintended parents occur regularly.We developed a strategy to separate progeny into putative populations,even while one of the parents was unknown,using principle component analysis on pairwise genetic distances based on sets of selected SNP markers that were homozygous,and therefore uninformative for one parent.One of the inferred populations was consistent with self-fertilization of‘Red New Dawn’.Subsequently,linkage maps were generated for a bi-parental and a self-pollinated population with‘Red New Dawn’as the common maternal parent.The densest map,for the selfed parent,had 1929 SNP markers on 25 linkage groups,covering 1765.5 cM at an average marker distance of 0.9 cM.Synteny with the strawberry(Fragaria vesca)genome was extensive.Rose ICM1 corresponded to F.vesca pseudochromosome 7(Fv7),ICM4 to Fv4,ICM5 to Fv3,ICM6 to Fv2 and ICM7 to Fv5.Rose ICM2 corresponded to parts of F.vesca pseudochromosomes 1 and 6,whereas ICM3 is syntenic to the remainder of Fv6. | Mirjana Vukosavljev Paul Arens Roeland E Voorrips Wendy P C van't Westende G D Esselink Peter M Bourke Peter Cox W Eric van de Weg Richard G F Visser Chris Maliepaard Marinus J M Smulders | 2016 | Horticulture Research2016，3，1： | 6 |
| 2 | Colonoscopic yield of colorectal neoplasia in daily clinical practice显示文摘AIM:To assess the prevalence and location of ad-vanced neoplasia in patients undergoing colonoscopy,and to compare the yield per indication.METHODS:In a multicenter colonoscopy survey (n = 18 hospitals) in the Amsterdam area (Northern Holland),data of all colonoscopies performed during a three month period in 2005 were analyzed. The location and the histological features of all colonic neoplasia were recorded. The prevalence and the distribution ofadvanced colorectal neoplasia and differences in yield between indication clusters were evaluated. Advanced neoplasm was defi ned as adenoma > 10 mm in size,with > 25% villous features or with high-grade dyspla-sia or cancer.RESULTS:A total of 4623 eligible patients underwent a total colonoscopy. The prevalence of advanced neo-plasia was 13%,with 281 (6%) adenocarcinomas and 342 (7%) advanced adenomas. Sixty-seven percent and 33% of advanced neoplasia were located in the distal and proximal colon,respectively. Of all patients with right-sided advanced neoplasia (n = 228),51% had a normal distal colon,whereas 27% had a syn-chronous distal adenoma. Ten percent of all colono-scopies were performed in asymptomatic patients,7% of whom had advanced neoplasia. In the respective procedure indication clusters,the prevalence of right-sided advanced neoplasia ranged from 11%-57%. CONCLUSION:One out of every 7-8 colonoscopies yielded an advanced colorectal neoplasm. Colonoscopy is warranted for the evaluation of both symptomatic and asymptomatic patients. | Jochim S Terhaar sive Droste Mike E Craanen Rene WM van der Hulst Joep F Bartelsman Dick P Bezemer Kim R Cappendijk Gerrit A Meijer Linde M Morsink Pleun Snel Hans ARE Tuynman Roy LJ van Wanrooy Eric IC Wesdorp Chris JJ Mulder | 2009 | World Journal of Gastroenterology2009，15，9： | 6 |
| 3 | 针对患者利益的机器学习和人工智能研究:在透明性、可重复性、伦理和有效性等方面的20个关键问题显示文摘机器学习(ML)、人工智能(AI)和其他现代统计方法正为利用先前尚未开发且极速增长的数据资源提供新的机会,以期让患者获益。尽管目前正在进行许多有前景的研究,特别是在图像方面,但就文献整体而言还缺乏透明度、对可重复性清晰的阐述、对潜在伦理问题的探究,以及对有效性的明确验证。这些问题的存在有许多原因,其中最重要的一点(为此我们提供了初步解决方案)就是当前缺乏针对ML和AI的最佳实践指南。我们认为从事研究的跨学科团队和应用ML/AI影响健康的项目,将因解决有关透明度、可重复性、伦理和有效性(TREE)的一系列问题而受益。这里提出的20个关键问题为研究团队提供了一个研究设计、实施和报告框架;帮助编辑和同行评审专家评估文献的贡献;让患者、临床医生和政策制定者评估新发现可能会给患者带来的获益。 | Sebastian Vollmer Bilal A Mateen Gergo Bohner Franz J Kirdly Rayid Ghani Pall Jonsson Sarah Cumbers Adrian Jonas Katherine S L McAllister Puja Myles David Granger Mark Birse Richard Branson Karel G M Moons Gary S Collins John P A Chris Holmes Harry Hemingwayp 李峰(译) 徐磊(校) 赵邑(校) | 2020 | 英国医学杂志中文版2020，23，9： | 5 |
| 4 | Alternative treatments to inhibit VEGF in age-related choroidal neovascularisation: 2-year findings of the IVAN randomised controlled trial显示文摘 | Usha Chakravarthy Simon P Harding Chris A Rogers Susan M Downes Andrew J Lotery Lucy A Culliford Barnaby C Reeves | 2013 | The Lancet2013，，： | 2 |
| 5 | Besifloxacin,a novel fluoroquinolone,has broad-spectrum in vitro activity against aerobic and anaerobic bacteria显示文摘 | Haas W Chris M P Gary E Z | 2009 | Antimicrob Agents Chemother2009，53，8： | 1 |
| 6 | Induced resistance against Sclerotinia sclerotiorum in carrots treated with enzymatically hydrolysed chitosan显示文摘 | Chris M Cheah L H Koolaard J P | 2004 | Postharvest Biology and Technology2004，33，： | 1 |
| 7 | A Compact Optical Flow Cell for Nurse in Aqueous Halide Determination显示文摘 | Chris D G Peter D Christopher P M | | 0，，04： | 1 |
| 8 | Induced resis- tance against Sclerotinia sclerotiorumin carrots treated with en- zymaticallyhydrolysed chitusan显示文摘 | Chris M Cheah L H Koolaard J P | 2004 | Postharvest Biology and Tech- nology2004，33，： | 1 |
| 9 | Organic matter accumulation during maturation of gravel-bed constructed wetlands treating farm dairy wastewater 显示文摘 | Chris C T M James P S S Martin P U | 1998 | WaterRes1998，32，10： | 1 |
| 10 | The ORION statement: guidelines for transparent reporting of outbreak reports and intervention studies of nosocomial infection显示文摘 | Sheldon P Stone Ben S Cooper Chris C Kibbler Barry D Cookson Jenny A Roberts Graham F Medley Georgia Duckworth Rosalind Lai Shah Ebrahim Erwin M Brown Phil J Wiffen Peter G Davey | 2007 | The Lancet Infectious Diseases2007，，4： | 1 |
| 11 | Potential for aind- generated electricity in China显示文摘 | MCELROY M B LU Xi CHRIS P | 2009 | Science2009，，325： | 1 |
| 12 | Dichotomous or categorical response? Analyzing self-rated health and lifetime social class显示文摘 | Orly M Sharon M Chris P | | 0，，01： | 1 |
| 13 | Mechanical energy analysis identifies compensatory strategies in disabled elders' gait 显示文摘 | Chris A M David E K Michael S P | 2001 | J of Biomechanics2001，34，： | 1 |
| 14 | Focal Control System for Laser Welding 显示文摘 | Francis M Haran Duncan P Hand Chris Peters | 1997 | Applied Optics1997，36，21： | 1 |
| 15 | Interlayer structure and bonding in nonswelling primary amine intercalated clays 显示文摘 | Harvey J M Boulet P Chris H G | 2005 | Macromolecules2005，38，14： | 1 |
| 16 | Rapid fluorescence polarization immunoassay for the mycotoxin deoxynivalenol in wheat 显示文摘 | Chris M M Ronald D P | 2002 | Agric Food Chem2002，50，： | 1 |
| 17 | Effect of cortisol on the physiology of cultured pavement cell epithelia from freshwater trout gills显示文摘 | scott P K CHRIS M W | 2001 | Regulatory Integrative and Comparative Physiology2001，281，3： | 1 |
| 18 | Organic matter accumula- tion during maturation of gravel-bed construted wetlands treating farm dairy wastewater显示文摘 | Chris C T M James P S S Martin P U | 1998 | Water Res1998，32，10： | 1 |
| 19 | Plants with increased expression of entkaurene oxidase are resistanf to chemical inhibitors of this gibberellin biosynthesis enzyme 显示文摘 | Swain Stephen M Singh Davinder P Helliwell Chris A | 2005 | Plant and Cell Physiol2005，46，2： | 1 |
| 20 | Effect of cortisol on the physiology of cultured pavement cell epithelia from freshwater trout gills显示文摘 | KELLY Scott P WOOD Chris M | 2001 | Am J Physiol Regulatory Integrative Comp Physiol2001，，281： | 1 |
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