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| 1 | High-density SNP-based genetic maps for the parents of an outcrossed and a selfed tetraploid garden rose cross, inferred from admixed progeny using the 68k rose SNP array显示文摘Dense genetic maps create a base for QTL analysis of important traits and future implementation of marker-assisted breeding.In tetraploid rose,the existing linkage maps include<300 markers to cover 28 linkage groups(4 homologous sets of 7 chromosomes).Here we used the 68k WagRhSNP Axiom single-nucleotide polymorphism(SNP)array for rose,in combination with SNP dosage calling at the tetraploid level,to genotype offspring from the garden rose cultivar‘Red New Dawn’.The offspring proved to be not from a single bi-parental cross.In rose breeding,crosses with unintended parents occur regularly.We developed a strategy to separate progeny into putative populations,even while one of the parents was unknown,using principle component analysis on pairwise genetic distances based on sets of selected SNP markers that were homozygous,and therefore uninformative for one parent.One of the inferred populations was consistent with self-fertilization of‘Red New Dawn’.Subsequently,linkage maps were generated for a bi-parental and a self-pollinated population with‘Red New Dawn’as the common maternal parent.The densest map,for the selfed parent,had 1929 SNP markers on 25 linkage groups,covering 1765.5 cM at an average marker distance of 0.9 cM.Synteny with the strawberry(Fragaria vesca)genome was extensive.Rose ICM1 corresponded to F.vesca pseudochromosome 7(Fv7),ICM4 to Fv4,ICM5 to Fv3,ICM6 to Fv2 and ICM7 to Fv5.Rose ICM2 corresponded to parts of F.vesca pseudochromosomes 1 and 6,whereas ICM3 is syntenic to the remainder of Fv6. | Mirjana Vukosavljev Paul Arens Roeland E Voorrips Wendy P C van't Westende G D Esselink Peter M Bourke Peter Cox W Eric van de Weg Richard G F Visser Chris Maliepaard Marinus J M Smulders | 2016 | Horticulture Research2016，3，1： | 6 |
| 2 | On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials. | Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong | 2005 | World Journal of Gastroenterology2005，11，35： | 4 |
| 3 | Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials显示文摘 | Naveed Sattar David Preiss Heather M Murray Paul Welsh Brendan M Buckley Anton JM de Craen Sreenivasa Rao Kondapally Seshasai John J McMurray Dilys J Freeman J Wouter Jukema Peter W Macfarlane Chris J Packard David J Stott Rudi G Westendorp James Shepherd | 2010 | The Lancet2010，，9716： | 2 |
| 4 | Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials显示文摘 | Naveed Sattar David Preiss Heather M Murray Paul Welsh Brendan M Buckley Anton JM de Craen Sreenivasa Rao Kondapally Seshasai John J McMurray Dilys J Freeman J Wouter Jukema Peter W Macfarlane Chris J Packard David J Stott Rudi G Westendorp James Shepherd | 2010 | The Lancet2010，，9716： | 2 |
| 5 | Besifloxacin,a novel fluoroquinolone,has broad-spectrum in vitro activity against aerobic and anaerobic bacteria显示文摘 | Haas W Chris M P Gary E Z | 2009 | Antimicrob Agents Chemother2009，53，8： | 1 |
| 6 | The interactive effects of feeding and exercise on oxygen consumption,swimming performance and protein usage in Juvenile rainbow trout (Oncorhynchus mykiss) 显示文摘 | Derek H A Chris M W | 1997 | The Journal of Experimental Biology1997，200，： | 1 |
| 7 | What is the biochemi- cal and physiological rationale for using clod water immersion in sports recovery显示文摘 | Chris M Bleakley Gareth W Davison | 2010 | Sports Med2010，44，： | 1 |
| 8 | Modelling the formation of maillard reaction intermediates for the generation of flavour 显示文摘 | GUILLAUME D TAHIR I M CHRIS W | 2006 | Developments in Food Science2006，，43： | 1 |
| 9 | Gene therapy for cerebrovascular disease显示文摘 | Chris W Macdonald ML Stoodley M | 1999 | Neurosurgery1999，44，2： | 1 |
| 10 | A scalable formulation of probabilistic linear discirminant analysis: Applied to face recognition显示文摘 | Laurent E S Chris M Roy W | 2013 | IEEE Transactions on Pattern Recognition and Machine Learning2013，35，7： | 1 |
| 11 | Identification of the sex pheromone of Holotrichia reynaudi显示文摘 | Andrew W Chris M Anitha V | 2002 | Journal of Chemical Ecology2002，28，3： | 1 |
| 12 | The behaviour of al in MSW incinerator fly ash during thermal treatment显示文摘 | Chris C Y Chan D W K Hilary M | 2000 | Journal of Hazardous Materials2000，76，1： | 1 |
| 13 | Effect of cortisol on the physiology of cultured pavement cell epithelia from freshwater trout gills显示文摘 | scott P K CHRIS M W | 2001 | Regulatory Integrative and Comparative Physiology2001，281，3： | 1 |
| 14 | Chromium behavior during thermal treatment of MSW fly ash显示文摘 | Donald W K Chris C Y Hilary M | 2002 | J Hazard Mater2002，90，： | 1 |
| 15 | T - DNA vector backbone sequences are frequently integrated into the ge- nome of transgenic plants obtained by Agrobacterium - mediated transformation显示文摘 | Sylvie D B Chris D W Marc V M at al | 2000 | Molecular Breeding2000，6，5： | 1 |
| 16 | Reduced lignin content and altered lignin composition in transgenic tobacco down-regulated in expression of L-phenylalanine ammonia-lyase or cinnamate 4-hydroxylase显示文摘 | Vincent J H S Weiting N Jack W B Hans G J Sameer A M Paul A H Chris L and Richard A D | | 0，，： | 1 |
| 17 | Modeling the prehistoric arrival of the sweet potato in Polynesia显示文摘 | Alvaro M Chris A Andrew W | 2007 | Journal of Archaeological Science2007，，4： | 1 |
| 18 | Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials显示文摘 | Naveed Sattar David Preiss Heather M Murray Paul Welsh Brendan M Buckley Anton JM de Craen Sreenivasa Rao Kondapally Seshasai John J McMurray Dilys J Freeman J Wouter Jukema Peter W Macfarlane Chris J Packard David J Stott Rudi G Westendorp James Shepherd | 2010 | 2010 (9716)2010，，9716： | 1 |
| 19 | A dose-response study following in utero and lactationalexposure todi-(2-ethylhexyl)-phthalate (DEHP): Non-monotonicdose-response and low dose effects on rat brain aromatase activity 显示文摘 | Anderson J M A Simone W G Chris E | 2006 | Toxicology2006，227，3： | 1 |
| 20 | A dose-response study following in utero and lactational exposure to di-(2-ethylhexyl) phthalate (DEHP): Reproductive effects on adult female offspring rats 显示文摘 | Simone W G Anderson J M A Chris E T | 2007 | Toxicology2007，229，12： | 1 |
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