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| 1 | Multimode optical fiber transmission with a deep learning network显示文摘Multimode fibers(MMFs)are an example of a highly scattering medium,which scramble the coherent light propagating within them to produce seemingly random patterns.Thus,for applications such as imaging and image projection through an MMF,careful measurements of the relationship between the inputs and outputs of the fiber are required.We show,as a proof of concept,that a deep neural network can learn the input-output relationship in a 0.75 m long MMF.Specifically,we demonstrate that a deep convolutional neural network(CNN)can learn the nonlinear relationships between the amplitude of the speckle pattern(phase information lost)obtained at the output of the fiber and the phase or the amplitude at the input of the fiber.Effectively,the network performs a nonlinear inversion task.We obtained image fidelities(correlations)as high as~98%for reconstruction and~94%for image projection in the MMF compared with the image recovered using the full knowledge of the system transmission characterized with the complex measured matrix.We further show that the network can be trained for transfer learning,i.e.,it can transmit images through the MMF,which belongs to another class not used for training/testing. | Babak Rahmani Damien Loterie Georgia Konstantinou Demetri Psaltis Christophe Moser | 2018 | Light(Science & Applications)2018，7，1： | 9 |
| 2 | Alternative treatments to inhibit VEGF in age-related choroidal neovascularisation: 2-year findings of the IVAN randomised controlled trial显示文摘 | Usha Chakravarthy Simon P Harding Chris A Rogers Susan M Downes Andrew J Lotery Lucy A Culliford Barnaby C Reeves | 2013 | The Lancet2013，，： | 2 |
| 3 | Ranibizumab versus Bevacizumab to Treat Neovascular Age-related Macular Degeneration显示文摘 | Usha Chakravarthy Simon P. Harding Chris A. Rogers Susan M. Downes Andrew J. Lotery Sarah Wordsworth Barnaby C. Reeves | 2012 | Ophthalmology2012，，7： | 2 |
| 4 | Fc-y re- ceptor upregulation is associated with immune-complex inflam- mation in the mouse retina and early age-related macular degen- eration显示文摘 | Murinello S Mullins RF Lotery JA Perry VII Teeling JL | 2014 | Invest Ophthalmol Vis Sci2014，55，1： | 1 |
| 5 | A review of the molecular genetics of congenital Idiopathic Nystagmus ( CIN )显示文摘 | Self J Lotery A | 2007 | Ophthalmic Genet2007，28，4： | 1 |
| 6 | Idiopathic vitreomacular traction andmacular hole : a comprehensive review of pathophysiology,di-agnosis ,and treatment显示文摘 | STEEL DH LOTERY AJ | 2013 | Eye (Lond)2013，27，10： | 1 |
| 7 | The molecular genetics of congenital idiopathic nystagmus显示文摘 | Self J Lotery A | 2006 | Semin Ophthalmol2006，21，2： | 1 |
| 8 | Idiopathic vitreomacular traction and macular hole: a comprehensive review of pathophysiology, diagnosis, and treatment 显示文摘 | Steel D H Lotery A J | 2013 | Eye (Lond)2013，27，1： | 1 |
| 9 | Age-related macular degeneration and the complement system显示文摘 | S. Khandhadia V. Cipriani J.R.W. Yates A.J. Lotery | 2011 | Immunobiology2011，，2： | 1 |
| 10 | Photodynamic therapy for central serous chorioretinopathy 显示文摘 | Erikitola OC Crosby-Nwaobi R Lotery AJ | 2014 | Eye (Lond)2014，28，8： | 1 |
| 11 | Mutation analysis of 3 genes in patients with Leber congenital amaurosis显示文摘 | Namperumalsamy P Jacobson SG | 2000 | Arch Ophthalmol2000，118，： | 1 |
| 12 | Progress in defining the molecular biology of age related macular degeneration 显示文摘 | Lotery A Trump D | 2007 | Hum Genet2007，122，34： | 1 |
| 13 | Alternative treatments to inhibit VEGF in age-related choroidal neovascularisation:2-year findings of the IVAN randomized controlled trial 显示文摘 | Chakravarthy U Harding SP Rogers CA Downes SM Lotery AJ Culliford LA | 2013 | Lancet2013，382，9900： | 1 |
| 14 | Fixed bimonthly aflibercept in nave and switched neovascular age-related macular degeneration patients:one year outcomes显示文摘AIM: To determine real life clinical outcomes in poorly responsive and treatment-nave neovascular age-related macular degeneration(nv AMD) patients using bimonthly fixed dosing aflibercept regimen.METHODS: This was a retrospective study of 165 eyes with nv AMD started on aflibercept at Southampton Eye Unit between June 2013 and June 2014. Patients were either switched from pro re nata(PRN) ranibizumab/bevacizumab due to poor response(107 eyes), or treatment- nave( 58 eyes). Patients initially received 3-monthly intravitreal aflibercept injections followed by 2-monthly fixed doses. Clinic visits were scheduled at month 0, 4, 10 and 12. Mean change in best-corrected visual acuity(BCVA) and central retinal thickness(CRT)from baseline were assessed using the Wilcoxon signedrank test. The proportion of patients maintaining BCVA(<15 letters loss) at 12 mo was also evaluated.RESULTS: Mean BCVA change at month 12 was +3.29 and +4.67 letters in the switched and nave aflibercept groups respectively(P <0.01). BCVA was maintained in 95.3% of switched and 96.6% of nave patients. CRT at month 12 showed a decrease of -6.16 μm in the switched group and -35.36 μm in the nave group(P <0.01).Patients previously treated with ranibizumab/bevacizumab had on average received 7.4 ranibizumab/bevacizumab injections over 12.6 mo, attending 10 clinic visits. The fixed dosing aflibercept regimen required an average of 7.1 injections(nave group), 7.5 injections(switched group) and 4 clinic visits per year.CONCLUSION: Fixed bimonthly aflibercept is effective in both treatment-nave and poorly responsive nv AMD patients. Adopting a fixed dosing regimen can reduce patient burden without compromising on outcomes. | Alasdair N Warwick Hannah H Leaver Andrew J Lotery Srini V Goverdhan | 2016 | International Journal of Ophthalmology(English edition)2016，9，8： | 1 |
| 15 | Central serous chorioretinopathy:an update on pathogenesis and treatment 显示文摘 | Gemenetzi M De Salvo G Lotery AJ | 2010 | Eye2010，24，： | 1 |
| 16 | A review of the molecular genetics of congenital Idiopathic Nystagmus ( CIN ) 显示文摘 | Self J Lotery A | 2007 | Ophthalmic Genet2007，28，4： | 1 |
| 17 | Oxidation and age-related macular degeneration : insights from molecular biology显示文摘 | Khandhadia S Lotery A | 2010 | Expert Rev Mol Med2010，12，： | 1 |
| 18 | Complement factor H Y402H gene polymorphism in coronary artery disease and atherosclero- sis显示文摘 | Goverdhan S V Lotery A J Cree A J | 2006 | Atherosclerosis2006，188，1： | 1 |
| 19 | Current concepts on primary open-angle glaucoma genetics: a contribution to disease pathophysiology and future treatment 显示文摘 | Gemenetzi M Yang Y Lotery AJ | 2012 | Eye (London England)2012，26，3： | 1 |
| 20 | Acute intraoperative suprachoroidal haemorrhage in oc-ular surgery 显示文摘 | Beatty S Lotery A Kent D O ’ Driscoll A Kilmartin DJ Wallace D | 1998 | Eye1998，12，5： | 1 |
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