6篇
您的检索式：作者名="C.David Allis"
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| 1 | Histone methylation versus histone acetylation: new insights into epigenetic regulation显示文摘 | Judd C Rice C.David Allis | 2001 | Current Opinion in Cell Biology2001，，3： | 1 |
| 2 | Phosphorylation of Serine 10 in Histone H3 Is Functionally Linked In Vitro and In Vivo to Gcn5-Mediated Acetylation at Lysine 14显示文摘 | Wan-Sheng Lo Raymond C Trievel Jeannie R Rojas Laura Duggan Jer-Yuan Hsu C.David Allis Ronen Marmorstein Shelley L Berger | 2000 | Molecular Cell2000，，6： | 1 |
| 3 | Synergistic Coupling of Histone H3 Phosphorylation and Acetylation in Response to Epidermal Growth Factor Stimulation显示文摘 | Peter Cheung Kirk G Tanner Wang L Cheung Paolo Sassone-Corsi John M Denu C.David Allis | 2000 | Molecular Cell2000，，6： | 1 |
| 4 | AF9YEATS结构域在分子层面偶联组蛋白巴豆酰化和活跃转录显示文摘染色质结合蛋白质模块(“阅读器”)识别组蛋白共价修饰构成表观遗传调控的主要方式之一,例如溴域识别乙酰化赖氨酸修饰。除乙酰化之外,近来研究发现组蛋白赖氨酸还能发生巴豆酰化、丁酰化、丙酰化等酰基化修饰.但能够偏好识别这些新型酰基化修饰的阅读器尚未见报道。 | Yuanyuan Li Benjamin R.Sabari Tatyana Panchenko Hong Wen Dan Zhao Haipeng Guan Liling Wan He Huang Zhanyun Tang Yingming Zhao Robert G.Roeder Xiaobing Shi C.David Allis 李海涛 | 2017 | 科学新闻2017，19，4： | 0 |
| 5 | 组蛋白修饰通过促成相分离机制来调节染色质区室化显示文摘文章简介真核染色体包含各种功能的区室,这些区室由特定的组蛋白修饰标记。但是,人们对这些组蛋白标记在染色体区室化中起作用的分子机制了解甚少。组成型异染色质是一个高度沉默的染色体区室,部分特征在于组蛋白H3K9的二甲基化和三甲基化修饰标记(H3K9me2/3)。 | 王亮 郜一飞 郑向东 Cuifang Liu Shuangshuang Dong Ru Li Guanwei Zhang Yixuan Wei Hongyuan Qu Yuhan Li C.David Allis Guohong Li 李海涛 李丕龙 | 2020 | 科学新闻2020，，2： | 0 |
| 6 | Dual role of lipids for genome stability and pluripotency facilitates full potency of mouse embryonic stem cells显示文摘While Mek1/2 and Gsk3βinhibition('2i')supports the maintenance of murine embryonic stem cells(EsCs)in a homogenous naive state,prolonged culture in 2i results in aneuploidy and DNA hypomethylation that impairs developmental potential.Additionally,2i fails to support derivation and culture of fully potent female ESCs.Here we find that mouse ESCs cultured in 2i/LIF supplemented with lipid-rich albumin(AlbuMAx)undergo pluripotency transition yet maintain genomic stability and full potency over long-term culture.Mechanisticaily,lipids in AlbuMAx impact intracellular metabolism including nucleotide biosynthesis,lipid biogenesis,and TCA cycle intermediates,with enhanced expression of DNMT3s that prevent DNA hypomethylation.Lipids induce a formative-like pluripotent state through direct stimulation of Erk2 phosphorylation,which also alleviates X chromosome loss in female ESCs.Importantly,both male and female'all-ESc'mice can be generated from de novo derived ESCs using AlbuMAXbased media.Our findings underscore the importance of lipids to pluripotency and link nutrient cues to genome integrity in early development. | Liangwen Zhong Miriam Gordillo Xingyi Wang Yiren Qin Yuanyuan Huang Alexey Soshnev Ritu Kumar Gouri Nanjangud Daylon James C.David Allis Todd Evans Bryce Carey Duancheng Wen | 2023 | Protein & Cell2023，14，8： | 0 |
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