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| 1 | Biomechanics and mechanobiology of the bone matrix显示文摘The bone matrix plays an indispensable role in the human body,and its unique biomechanical and mechanobiological properties have received much attention.The bone matrix has unique mechanical anisotropy and exhibits both strong toughness and high strength.These mechanical properties are closely associated with human life activities and correspond to the function of bone in the human body.None of the mechanical properties exhibited by the bone matrix is independent of its composition and structure.Studies on the biomechanics of the bone matrix can provide a reference for the preparation of more applicable bone substitute implants,bone biomimetic materials and scaffolds for bone tissue repair in humans,as well as for biomimetic applications in other fields.In providing mechanical support to the human body,bone is constantly exposed to mechanical stimuli.Through the study of the mechanobiology of the bone matrix,the response mechanism of the bone matrix to its surrounding mechanical environment can be elucidated and used for the health maintenance of bone tissue and defect regeneration.This paper summarizes the biomechanical properties of the bone matrix and their biological significance,discusses the compositional and structural basis by which the bone matrix is capable of exhibiting these mechanical properties,and studies the effects of mechanical stimuli,especially fluid shear stress,on the components of the bone matrix,cells and their interactions.The problems that occur with regard to the biomechanics and mechanobiology of the bone matrix and the corresponding challenges that may need to be faced in the future are also described. | Chunyang Ma Tianming Du Xufeng Niu Yubo Fan | 2022 | Bone Research2022，10，4： | 2 |
| 2 | 老年股骨粗隆间骨折的中西医结合治疗新进展显示文摘股骨粗隆间骨折主要采取手术治疗,可在短期内取得良好效果,但手术创伤面积大,术中出血量多:牵引治疗费用较低,适合不能耐受手术的患者,但并发症多。中西医结合治疗老年股骨粗隆间骨折患者能取得较满意的效果,并减少术后并发症。 | 杨文华 | 2016 | 按摩与康复医学2016，0，5： | 1 |
| 3 | 影响骨小梁微有限元模型最大应力的骨微结构指标显示文摘背景:基于Micro-CT微有限元可以研究骨小梁在载荷下的力学响应,通常认为在动物骨小梁标本上骨体积分数是决定骨小梁抗压缩能力的最重要指标,但在微有限元模型中,导致应力集中或决定最大应力的骨微结构指标尚不明确。目的:探究影响骨小梁微有限元模型最大应力的骨微结构指标。方法:获取10只正常大鼠双侧股骨干骺端感兴趣区域骨小梁微观结构指标,比较双侧感兴趣区域骨小梁差异性;构建20个骨小梁微有限元模型并对模型进行加载,以微有限元模型中应力值最大的前5%,2%,1%,0.5%个单元的应力平均值作为最大应力值,根据模型应力、应变验证模型的真实可靠性;最后,以最大应力值为因变量,感兴趣区域骨小梁微观结构指标为自变量,通过多元线性逐步回归法挖掘影响骨小梁微有限元模型最大应力的关键影响因素。结果与结论:双侧股骨干骺端感兴趣区域骨小梁微结构存在同质性(P> 0.05),进而对数据进行合并;20个骨小梁微有限元模型平均单元数232813,节点数60682;前5%,2%,1%,0.5%个单元应力平均值分别为31.91,41.96,50.86,61.23MPa,平均有效应变为3.28%;多元线性逐步回归分析结果提示骨小梁结构模型指数是影响骨小梁微有限元模型最大应力的最重要的骨微结构指标(P <0.001,R^(2)=0.807)。提示:骨小梁结构模型指数是影响骨小梁微有限元模型应力集中的最重要骨微结构指标,骨小梁结构模型指数值越大,杆状骨小梁越多,应力集中范围越大。 | 钟毅征 黄培镇 蔡群斌 郑利钦 何兴鹏 董航 | 2023 | 中国组织工程研究2023，27，9： | 0 |
| 4 | 三维有限元分析在治疗股骨转子间骨折的研究进展显示文摘综合国内外文献关于生物力学及计算机有限元分析对于股骨转子间骨折在临床的研究进展,通过模拟生物力学环境,分析股骨转子间骨折生物力学特点、骨折机制、以及其内固定装置的选择,对股骨转子间骨折在有限元分析上的应用进行综述。 | 韩亮 卢向东 张晋峰 | 2018 | 世界最新医学信息文摘2018，18，43： | 0 |
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