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| 1 | Pancreatic regenerating protein (regⅠ) and regⅠreceptor mRNA are upregulated in rat pancreas after induction of acute pancreatitis显示文摘AIM: Pancreatic regenerating protein (regⅠ) stimulates pancreatic regeneration after pancreatectomy and is mitogenic to ductal andβ-cells. This suggests that regⅠand its receptor may play a role in recovery after pancreatic injury. We hypothesized that regⅠand its receptor are induced in acute pancreatitis. METHODS: Acute pancreatitis was induced in male Wistar rats by retrograde injection of 3% sodium taurocholate into the pancreatic duct. Pancreata and serum were collected 12, 24, and 36 hours after injection and from normal controls (4 rats/group). RegⅠreceptor mRNA, serum regⅠprotein, and tissue regⅠprotein levels were determined by Northern analysis, enzyme-linked immunosorbent assay (ELISA), and Western analysis, respectively. Immunohistochemistry was used to localize changes in regⅠand its receptor. RESULTS: Serum amylase levels and histology confirmed necrotizing pancreatitis in taurocholate treated rats. There was no statistically significant change in serum regⅠconcentrations from controls. However, Western blot demonstrated increased tissue levels of regⅠat 24 and 36 h. This increase was localized primarily to the acinar cells and the ductal cells by immunohistochemistry. Northern blot demonstrated a significant increase in regⅠreceptor mRNA expression with pancreatitis. Immunohistochemistry localized this increase to the ductal cells, islets, and acinar cells. CONCLUSION: Acute pancreatitis results in increased tissue regⅠprotein levels localized to the acinar and ductal cells, and a parallel threefold induction of regⅠreceptor in the ductal cells, islets, and acinar cells. These changes suggest that induction of reg I and its receptor may be important for recovery from acute pancreatitis. | Martin H Bluth Sameer A Patel Brian K Dieckgraefe Hiroshi Okamoto Michael E Zenilman | 2006 | World Journal of Gastroenterology2006，12，28： | 19 |
| 2 | Spontaneous fungal peritonitis: Micro-organisms, management and mortality in liver cirrhosis-A systematic review显示文摘BACKGROUND Spontaneous peritonitis is an infection of ascitic fluid without a known intraabdominal source of infection. spontaneous fungal peritonitis (SFP) is a potentially fatal complication of decompensated cirrhosis, defined as fungal infection of ascitic fluid in the presence of ascitic neutrophil count of greater than 250 cells/mL. AIM To determine the prevalence of fungal pathogens, management and outcomes (mortality) of SFP in critically ill cirrhotic patients. METHODS Studies were identified using PubMed, EMBASE, Cochrane Central Register of Controlled Trials and Scopus databases until February 2019. Inclusion criteria included intervention trials and observation studies describing the association between SFP and cirrhosis. The primary outcome was in-hospital, 1-mo, and 6- mo mortality rates of SFP in cirrhotic patients. Secondary outcomes were fungal microorganisms identified and in hospital management by anti-fungal medications. The National Heart, Lung and Blood Institute quality assessment tools were used to assess internal validity and risk of bias for each included study. RESULTS Six observational studies were included in this systematic review. The overall quality of included studies was good. A meta-analysis of results could not be performed because of differences in reporting of outcomes and heterogeneity of the included studies. There were 82 patients with SFP described across all the included studies. Candida species, predominantly Candida albicans was the fungal pathogen in majority of the cases (48%-81.8%) followed by Candida krusei (15%- 25%) and Candida glabrata (6.66%-20%). Cryptococcus neoformans (53.3%) was the other major fungal pathogen. Antifungal therapy in SFP patients was utilized in 33.3% to 81.8% cases. The prevalence of in hospital mortality ranged from 33.3% to 100%, whereas 1-mo mortality ranged between 50% to 73.3%. CONCLUSION This systematic review suggests that SFP in end stage liver disease patient is associated with high mortality both in the hospital and at 1-mo, and that antifungal therapy is currently underutilized. | Tooba Tariq Furqan B Irfan Mehdi Farishta Brian Dykstra Eric Martin Sieloff Archita P Desai | 2019 | World Journal of Hepatology2019，11，7： | 7 |
| 3 | Penile revascularization--contemporary update显示文摘为可勃起的机能障碍的当代的治疗通常向老人被指向并且普遍雇佣药理学或设备相关治疗选择。阴茎 revascularization,用 microvascular 动脉绕过外科的技术,是非药理学, non-device-related,和为有被瓦克拉夫·米查尔博士首先在 1973 描述的可勃起的机能障碍的人的改造外科的策略。当代的阴茎 revascularization 尝试到 ‘ cure' 纯 arteriogenic 在有在远侧的内部 pudendal 的动脉的闭塞的病理的年轻人的可勃起的机能障碍,对从钝骨盆、会阴或阴茎的损伤的焦点的 endothelial 损害第二等的普通阴茎或近似的 cavernosal 动脉。microvascular 吻合在腹上部的施主晚辈和接受者之间被塑造背面的阴茎动脉。增加的灌注压力理论上经由穿孔被传达到 cavernosal 动脉从背面的动脉的分支。这篇文章将与可勃起的机能障碍,利用的当前的外科的技术和外科的结果在年轻人考察钝导致损伤的焦点的动脉的闭塞的疾病的历史,指示和 pathophysiology。阴茎 revascularization 的当代的使用是一种逻辑、想要的治疗学的选择试图在支撑了钝骨盆、会阴或阴茎的损伤的年轻人颠倒可勃起的机能障碍。 | Brian Dicks Martin Bastuba Irwin Goldstein | 2013 | Asian Journal of Andrology2013，15，1： | 4 |
| 4 | Suppression of tumour-specific CD4+ T cells by regulatory T cells is associated with progression of human colorectal cancer显示文摘 | Gareth Betts Emma Jones Syed Junaid Tariq El-Shanawany Martin Scurr Paul Mizen Mayur Kumar Sion Jones Brian Rees Geraint Williams Awen Gallimore Andrew Godkin | 2012 | Gut2012，，8： | 3 |
| 5 | Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial显示文摘 | Brian I Rini Bernard Escudier Piotr Tomczak Andrey Kaprin Cezary Szczylik Thomas E Hutson M Dror Michaelson Vera A Gorbunova Martin E Gore Igor G Rusakov Sylvie Negrier Yen-Chuan Ou Daniel Castellano Ho Yeong Lim Hirotsugu Uemura Jamal Tarazi David Cella | 2011 | The Lancet . 2011 (9807)2011，，9807： | 2 |
| 6 | Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial显示文摘 | Brian I Rini Bernard Escudier Piotr Tomczak Andrey Kaprin Cezary Szczylik Thomas E Hutson M Dror Michaelson Vera A Gorbunova Martin E Gore Igor G Rusakov Sylvie Negrier Yen-Chuan Ou Daniel Castellano Ho Yeong Lim Hirotsugu Uemura Jamal Tarazi David Cella | 2011 | The Lancet2011，，9807： | 2 |
| 7 | Soluble TNF-α receptor 1 and IL-6 plasma levels in humans subjected to the sleep deprivation model of spaceflight显示文摘 | William T. Shearer James M. Reuben Janet M. Mullington Nicholas J. Price Bang-Ning Lee E.O’Brian Smith Martin P. Szuba Hans P.A. Van Dongen David F. Dinges | 2001 | The Journal of Allergy and Clinical Immunology2001，，1： | 2 |
| 8 | Prevalence, Demographics, and Treatment Characteristics of Visual Impairment due to Diabetic Macular Edema in a Representative Canadian Cohort显示文摘 | Robert J. Petrella Julie Blouin Brian Davies Martin Barbeau Andrew G. Lee | 2012 | Journal of Ophthalmology2012，，： | 1 |
| 9 | Preservation and Incorporation of Valuable Endoscopic Innovations (PIVI) on the use of endoscopy simulators for training and assessing skill显示文摘 | Jonathan Cohen Brian P. Bosworth Amitabh Chak Brian J. Dunkin Dayna S. Early Lauren B. Gerson Robert H. Hawes Adam V. Haycock Juergen H. Hochberger Joo Ha Hwang John A. Martin Peter R. McNally Robert E. Sedlack Melina C. Vassiliou | 2012 | Gastrointestinal Endoscopy2012，，3： | 1 |
| 10 | Donor Site Morbidity After Anterior Iliac Crest Bone Harvest for Single-Level Anterior Cervical Discectomy and Fusion显示文摘 | Jeff S. Silber D. Greg Anderson Scott D. Daffner Brian T. Brislin J. Martin Leland Alan S. Hilibrand Alexander R. Vaccaro Todd J. Albert | 2003 | Spine2003，，： | 1 |
| 11 | Loss of Heterozygosity for Loci on Chromosome Arms 1p and 10q in Oligodendroglial Tumors: Relationship to Outcome and Chemosensitivity显示文摘 | Brian Thiessen John A. Maguire Kelly McNeil David Huntsman Montgomery A. Martin Doug Horsman | 2003 | Journal of Neuro - Oncology2003，，3： | 1 |
| 12 | Measuring the effectiveness of heart transplant programmes:quality of life data and their relationship to survival analysis 显示文摘 | Bernie JO Martin JB Brian AB | 1987 | J Chron Dis1987，40，： | 1 |
| 13 | Tacrolimus for the treatment of fistulas in patients with crohn’s disease: a randomized, placebo-controlled trial显示文摘 | William J Sandborn Daniel H Present Kim L Isaacs Douglas C Wolf Eugene Greenberg Stephen B Hanauer Brian G Feagan Lloyd Mayer Therese Johnson Joseph Galanko Christopher Martin Robert S Sandler | 2003 | Gastroenterology2003，，2： | 1 |
| 14 | Under specification and Aspectual Coercion显示文摘 | MARTIN J PICKERING BRIAN MCELREE STEVEN FRISSON | 2006 | Discourse Processes2006，，2： | 1 |
| 15 | Dynamic Hepatitis C Virus Genotypic and Phenotypic Changes in Patients Treated With the Protease Inhibitor Telaprevir显示文摘 | Christoph Sarrazin Tara L. Kieffer Doug Bartels Brian Hanzelka Ute Müh Martin Welker Dennis Wincheringer Yi Zhou Hui–May Chu Chao Lin Christine Weegink Henk Reesink Stefan Zeuzem Ann D. Kwong | 2007 | Gastroenterology2007，，5： | 1 |
| 16 | The critique of science becomes academic显示文摘 | Brian Martin | 1993 | Science Technology & Human Values1993，，18： | 1 |
| 17 | Lake and catchment management in Denmark显示文摘 | Erik Jeppesen Martin S?ndergaard Brian Kronvang Jens P. Jensen Lars M. Svendsen Torben L. Lauridsen | 1999 | Hydrobiologia1999，，0： | 1 |
| 18 | Teacher behavior, student interest and affective learning: putting theory to practice显示文摘 | Keith Weber Matthew Martin Brian Patterson | 2001 | Journal of Applied Com- munication Research2001，29，1： | 1 |
| 19 | Predictors of Change in Pain and Physical Functioning Among Post-Menopausal Women With Recurrent Pain Conditions in the Women’s Health Initiative Observational Cohort显示文摘 | Jennifer Brennan Braden Alicia Young Mark D. Sullivan Brian Walitt Andrea Z. LaCroix Lisa Martin | 2012 | Journal of Pain2012，，： | 1 |
| 20 | Are Transthoracic Echocardiographic Parameters Associated With Atrial Fibrillation Recurrence or Stroke?显示文摘 | Brian Olshansky Eliot N. Heller L. Brent Mitchell Mary Chandler William Slater Martin Green Michael Brodsky Patrick Barrell H. Leon Greene | 2005 | Journal of the American College of Cardiology2005，，： | 1 |
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