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| 1 | Anti-angiogenesis in hepatocellular carcinoma treatment: Current evidence and future perspectives显示文摘Hepatocellular carcinoma(HCC) is among the most common cancer diseases worldwide.Arterial hypervascularisation is an essential step for HCC tumorigenesis and can be targeted by transarterial chemoembolization(TACE).This interventional method is the standard treatment for patients with intermediate stage HCC,but is also applied as 'bridging' therapy for patients awaiting liver transplantation in many centers worldwide.Usually the devascularization effect induced by TACE is transient,consequently resulting in repeated cycles of TACE every 4-8 wk.Despite documented survival benefits,TACE can also induce the up-regulation of proangiogenic and growth factors,which might contribute to accelerated progression in patients with incomplete response.In 2007,sorafenib,a multi-tyrosine kinase and angiogenesis inhibitor,was approved as the first systemic treatment for advanced stage HCC.Other active targeted compounds,either inhibitors of angiogenesis and/or growth factors,are currently being investigated in numerous clinical trials.To overcome revascularisation or tumor progression under TACE treatment it seems therefore attractive to combine TACE with systemic targeted agents,which might theoretically block the effects of proangiogenic and growth factors.Over the last 12 mo,several retrospec-tive or prospective cohort studies combining TACE and sorafenib have been published.Nevertheless,robust results of the efficacy and tolerability of such combination strategies as proven by randomized,controlled trials are awaited in the next two years. | Martin-Walter Welker Joerg Trojan | 2011 | World Journal of Gastroenterology2011，17，26： | 14 |
| 2 | Social disclosure, financial disclosure and the cost of equity capital显示文摘 | Alan J. Richardson Michael Welker | 2001 | Accounting, Organizations and Society2001，，7： | 3 |
| 3 | Concise review: Interferon-free treatment of hepatitis C virus-associated cirrhosis and liver graft infection显示文摘Chronic hepatitis C is a major reason for development of cirrhosis and hepatocellular carcinoma and a leading cause for liver transplantation. The development of direct-acting antiviral agents lead to(pegylated) interferon-alfa free antiviral therapy regimens with a remarkable increase in sustained virologic response(SVR) rates and opened therapeutic options for patients with advanced cirrhosis and liver graft recipients. This concise review gives an overview about most current prospective trials and cohort analyses for treatment of patients with liver cirrhosis and liver graft recipients. In patients with compensated cirrhosis Child-Pugh-Turcotte(CTP) class A, all approved agents are safe and SVR rates do not significantly differ from patients without cirrhosis in general. In patients with decompensated cirrhosis CTP class B or C, daclastasvir, ledipasvir, velpatasvir, and sofosbuvir are approved, and SVR rates higher than 90% can be achieved. Especially for patients with a model of end stage liver disease score higher than 15 and therefore eligible for liver transplantation, data is scarce. Reported SVR rates in patients with cirrhosis CTP class C are lower compared to patients with a less severe liver disease. In liver transplant recipients with a maximum of CTP class A, SVR rates are comparable to patients without LT. Patients with decompensated graft cirrhosis should be treated on an individual basis. | Nina Weiler Stefan Zeuzem Martin-Walter Welker | 2016 | World Journal of Gastroenterology2016，22，41： | 2 |
| 4 | Recurrent hepatocellular carcinoma after liver transplantation – an emerging clinical challenge显示文摘 | Martin‐Walter Welker Wolf‐Otto Bechstein Stefan Zeuzem Joerg Trojan | 2012 | Transplant International2012，，2： | 2 |
| 5 | Related pharmacokinetic interaction between oral cyclosporin and mibefradil in stabilized post-renal- transplant patients显示文摘 | Spoendlin M Peters J Welker H | 1998 | Nephrol Dial Transplant1998，13，7： | 2 |
| 6 | Serum microRNA-1 and microRNA-122 are prognostic markers in patients with hepatocellular carcinoma显示文摘 | Verena K?berle Bernd Kronenberger Thomas Pleli J?rg Trojan Esther Imelmann Jan Peveling-Oberhag Martin-Walter Welker Mohammed Elhendawy Stefan Zeuzem Albrecht Piiper Oliver Waidmann | 2013 | European Journal of Cancer2013，，： | 2 |
| 7 | Rates of humic substance photosensitized degradation of microcystin-LR in natural waters 显示文摘 | Welker M Steinberg C | 2000 | Environment Sci & Technol2000，34，8： | 1 |
| 8 | Biochemistry, genetics and applications of exopolysaccharide production in Streptococcus thermophilus: a review 显示文摘 | BROADBENT J R MCMAHON D J WELKER D L | 2003 | Journal of Dairy Science2003，86，： | 1 |
| 9 | Social Disclosure,Financial Disclosure and the Cost of Equity Capital显示文摘 | Richardson A J Welker M | 2001 | Accounting Organiza- tions and Society2001，26，7： | 1 |
| 10 | Effect of granulocyte macrophage colony-stimulating factor in a patient with benign systemic mastocytosis显示文摘 | Welker P Grabbe J | 2001 | Br J Dermatol2001，145，4： | 1 |
| 11 | Indirect photolysis of cyanotoxins: one possible mechanism for their low persistence 显示文摘 | Welker M Steinberg C | 1999 | Wat Res1999，33，5： | 1 |
| 12 | Expression of cloned homologous fermentative genes in Clostridium acetobutyli- cure ATCC 824 显示文摘 | Mermelstein LD Welker NE Bennett GN | 1992 | Biotechnology ( NY )1992，10，2： | 1 |
| 13 | Catalytic cracking of n-octane on small-pore zeolites显示文摘 | ALTWASSER S WELKER C TRAA Y WEITKAMP J | 2005 | Micropor Mesopor Mater2005，83，13： | 1 |
| 14 | A basic investigation in origins of AOX substances in paper sludge 显示文摘 | WELKER A SCHMITF T G | 1997 | Water Research1997，31，4： | 1 |
| 15 | Social disclosure, financial disclosure and the cost of equity capital 显示文摘 | Richardson A J Welker M | 2001 | Account- ing Organizations and Society2001，26，7： | 1 |
| 16 | Intramolecular versus in termolecular disulfide bonds in prion proteins显示文摘 | Raymond L D Scheraga H A | 2002 | J Biol Chem2002，277，33： | 1 |
| 17 | Transforming growth factor-β receptor type Ⅰ and type Ⅱ expression during murine hair follicle development and cycling显示文摘 | Paus R Foitzik K Welker P | 1997 | J Invest Dermatol1997，109，： | 1 |
| 18 | Thyroid nodules显示文摘 | Welker MJ Orlov D | 2003 | Am Fam Physician2003，67，3： | 1 |
| 19 | Role of redox metabolism for adaptation of aquatic animals to drastic changes in oxygen availability显示文摘 | Alexis F. Welker Daniel C. Moreira élida G. Campos Marcelo Hermes-Lima | 2013 | Comparative Biochemistry and Physiology, Part A2013，，： | 1 |
| 20 | Design of antisense RNA constructs for down regulation of the acetone formation pathway of Clostridium acetobutylicum显示文摘 | Tummala SB Welker NE Papoutsakis ET | 2003 | J Bacteriol2003，185，6： | 1 |
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