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| 1 | Deeper Chemical Perceptions for Better Traditional Chinese Medicine Standards显示文摘Traditional Chinese medicines (TCMs), a complex system of natural resources with many diverse components, are widely used as approved medicinal agents in China. Quality control of TCMs is a huge challenge for the government and for testing institutes and is associated with numerous scientific issues. Among these considerations include the following questions: How many components are in TCMs? How can the multiple components in TCMs be comprehensively delineated and subsequently characterized? What is the level and range of these (active) metabolites within these multiple-component TCMs, in order to recommend standards? and What are the qualities required for a marker constituent to be selected, and from a practical perspective, how can these components be assessed with low cost and in a short time? All of these factors require significant and deep thinking in order to understand the individualistic chemistry of TCM in order to develop enhanced TCM quality standards for improved and consistent patient care. In this review, the latest exploratory research in TCM chemistry analytical techniques and methods is summarized in order to begin to develop responses to these scientific issues. Advances in these methods have included multidimensional separation for liquid chromatography–high-resolution mass spectrometry (LC–HRMS), smart triggering data-dependent acquisition of LC–HRMS, target analysis with liquid chromatography–mass spectrometry (LC–MS), supercritical fluid chromatography, and data mining of large mass spectrometry (MS) datasets. In addition, two quality strategies have been introduced in order to save reference standards and the analysis time for a TCM quality standard, including the application of the single standard to determine multi-components (SSDMC) and monomethodheterotrait matrix methods. Finally, a series of future improvements for analytical methods for TCMs are proposed. | Jin-Jun Hou Jian-Qing Zhang Chang-Liang Yao Rudolf Bauer Ikhlas A. Khan Wan-Ying Wu De-an Guo | 2019 | Engineering2019，5，1： | 9 |
| 2 | Development and evaluation of a safe and effective sugar-free herbal lollipop that kills cavity-causing bacteria显示文摘Dental caries (tooth decay) is caused by a specific group of cariogenic bacteria, like Streptococcus mutans, which convert dietary sugars into acids that dissolve the mineral in tooth structure. Killing cariogenic bacteria is an effective way to control or prevent tooth decay. In a previous study, we discovered a novel compound (Glycyrrhizol A), from the extraction of licorice roots, with strong antimicrobial activity against cariogenic bacteria. In the current study, we developed a method to produce these specific herbal extracts in large quantities, and then used these extracts to develop a sugar-free lollipop that effectively kills cariogenic bacteria like Streptococcus mutans. Further studies showed that these sugar-free lollipops are safe and their antimicrobial activity is stable. Two pilot human studies indicate that a brief application of these lollipops (twice a day for ten days) led to a marked reduction of cariogenic bacteria in oral cavity among most human subjects tested. This herbal lollipop could be a novel tool to promote oral health through functional foods. | Chu-hong Hu Jian He Randal Eckert Xiao-yang Wu Li-na Li Yan Tian Renate Lux Justin A. Shuffer Faina Gelman Janet Mentes Sue Spackman Janet Bauer Maxwell H. Anderson Wen-yuan Shi | 2011 | International Journal of Oral Science2011，3，1： | 3 |
| 3 | Regional Ischemic ?Preconditioning? Protects Remote Virgin Myocardium From Subsequent Sustained Coronary Occlusion显示文摘 | Karin Przyklenk Barbara Bauer Michel Ovize Robert A. Kloner Peter Whittaker | 1993 | Circulation1993，，3： | 3 |
| 4 | 心率的减速能力是心肌梗死后死亡发生的预测因素:队列研究 | Bauer A. Kantelhardt J.W. Barthel P. G. Schmidt 任付先 | 2006 | 世界核心医学期刊文摘(心脏病学分册)2006，0，11： | 3 |
| 5 | C-Reactive Protein Elevation in Patients With Atrial Arrhythmias: Inflammatory Mechanisms and Persistence of Atrial Fibrillation显示文摘 | Mina K. Chung David O. Martin Dennis Sprecher Oussama Wazni Anne Kanderian Cynthia A. Carnes John A. Bauer Patrick J. Tchou Mark J. Niebauer Andrea Natale David R. Van Wagoner | 2001 | Circulation: Journal of the American Heart Association2001，，24： | 3 |
| 6 | Proton Pump Inhibitors and Risk of Fractures: A Meta-Analysis of 11 International Studies显示文摘 | Elaine W. Yu Scott R. Bauer Paul A. Bain Douglas C. Bauer | 2011 | The American Journal of Medicine2011，，6： | 2 |
| 7 | Impaired Myofibrillar Energetics and Oxidative Injury During Human Atrial Fibrillation显示文摘 | Michael J. Mihm Fushun Yu Cynthia A. Carnes Peter J. Reiser Patrick M. McCarthy David R. Van Wagoner John Anthony Bauer | 2001 | Circulation: Journal of the American Heart Association2001，，2： | 2 |
| 8 | ERCP-Directed Radiofrequency Ablation and Photodynamic Therapy Are Associated with Comparable Survival in the Treatment of Unresectable Cholangiocarcinoma显示文摘 | Daniel S. Strand Natalie D. Cosgrove James T. Patrie Dawn G. Cox Todd W. Bauer Reid B. Adams James A. Mann Bryan G. Sauer Vanessa M. Shami Andrew Y. Wang | 2014 | Gastrointestinal Endoscopy2014，，： | 2 |
| 9 | Sarcopenia: An Undiagnosed Condition in Older Adults. Current Consensus Definition: Prevalence, Etiology, and Consequences. International Working Group on Sarcopenia显示文摘 | Roger A. Fielding Bruno Vellas William J. Evans Shalender Bhasin John E. Morley Anne B. Newman Gabor Abellan van Kan Sandrine Andrieu Juergen Bauer Denis Breuille Tommy Cederholm Julie Chandler Capucine De Meynard Lorenzo Donini Tamara Harris Aimo Kannt F | 2011 | Journal of the American Medical Directors Association2011，，4： | 2 |
| 10 | Highlights of the 2nd International Symposium on Tribbles and Diseases: tribbles tremble in therapeutics for immunity, metabolism, fundamental cell biology and cancer显示文摘The Tribbles(TRIB) family of pseudokinase proteins has been shown to play key roles in cell cycle, metabolic diseases, chronic inflammatory disease, and cancer development. A better understanding of the mechanisms of TRIB pseudokinases could provide new insights for disease development and help promote TRIB proteins as novel therapeutic targets for drug discovery. At the 2 nd International Symposium on Tribbles and Diseases held on May 7–9, 2018 in Beijing, China, a group of leading Tribbles scientists reported their findings and ongoing studies about the effects of the different TRIB proteins in the areas of immunity, metabolism, fundamental cell biology and cancer. Here, we summarize important and insightful overviews from 4 keynote lectures, 13 plenary lectures and 8 short talks that took place during this meeting. These findings may offer new insights for the understanding of the roles of TRIB pseudokinases in the development of various diseases. | Bing Cui Patrick A. Eyers Leonard L. Dobens Nguan Soon Tan Peter D. Mace Wolfgang A. Link Endre Kiss-Toth Karen Keeshan Takuro Nakamura Warren S. Pear Yodit Feseha Jessica Johnston Arkatiz Carracedo Marcel Scheideler Zabran llyas Robert C. Bauer Jorge D. Erusalimsky Dominika Grzesik Juan Salamanca-Viloria Xiaoxi Lv Yishi Jin Ke Li Guillermo Velasco Shuang Shang Jose M. Lizcano Xiaowei Zhang Jichao Zhou Jiaojiao Yu Fang Hua Feng Wang Shanshan Liu Jinmei Yu Zhuowei Hu | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 2 |
| 11 | Maligne Tumoren der Hepaticusgabel – Ergebnisse der chirurgischen Therapie und Prognosefaktoren显示文摘 | K. T. E. Beckurts A. H. H?lscher T. H. Bauer J. R. Siewert | 1997 | Der Chirurg1997，，4： | 1 |
| 12 | Regional Ischemic ?Preconditioning? Protects Remote Virgin Myocardium From Subsequent Sustained Coronary Occlusion显示文摘 | Karin Przyklenk Barbara Bauer Michel Ovize Robert A. Kloner Peter Whittaker | 1993 | Circulation1993，，3： | 1 |
| 13 | Effects of watershed land use on sources and nutritional value of particulate organic matter in temperate headwater streams显示文摘 | Yue Han Lu Elizabeth A. Canuel James E. Bauer R. M. Chambers | 2014 | Aquatic Sciences2014，，3： | 1 |
| 14 | ATP citrate lyase inhibition can suppress tumor cell growth显示文摘 | Georgia Hatzivassiliou Fangping Zhao Daniel E. Bauer Charalambos Andreadis Anthony N. Shaw Dashyant Dhanak Sunil R. Hingorani David A. Tuveson Craig B. Thompson | 2005 | Cancer Cell2005，，4： | 1 |
| 15 | C-Reactive Protein Elevation in Patients With Atrial Arrhythmias: Inflammatory Mechanisms and Persistence of Atrial Fibrillation显示文摘 | Mina K. Chung David O. Martin Dennis Sprecher Oussama Wazni Anne Kanderian Cynthia A. Carnes John A. Bauer Patrick J. Tchou Mark J. Niebauer Andrea Natale David R. Van Wagoner | 2001 | Circulation: Journal of the American Heart Association2001，，24： | 1 |
| 16 | Brain resuscitation by extracorporeal circulation after prolonged cardiac arrest in cats显示文摘 | T. Iijima R. Bauer Prof. Dr. K. -A. Hossmann | 1993 | Intensive Care Medicine1993，，2： | 1 |
| 17 | Linking Transgene Expression of Engineered Mesenchymal Stem Cells and Angiopoietin-1–induced Differentiation to Target Cancer Angiogenesis显示文摘 | Claudius Conrad Yves Hüsemann Hanno Niess Irene von Luettichau Ralf Huss Christian Bauer Karl-Walter Jauch Christoph A. Klein Christiane Bruns Peter J. Nelson | 2011 | Annals of Surgery2011，，3： | 1 |
| 18 | Chronic Cerebral Ischemia: Where “Evidence-Based Medicine” Fails Patients显示文摘 | Andrew M. Bauer Mark D. Bain Peter A. Rasmussen | 2015 | World Neurosurgery2015，，： | 1 |
| 19 | Optimized N-mineralization parameters of loess soils from incubation experiments显示文摘 | J. Richter A. Nuske W. Habenicht J. Bauer | 1982 | Plant and Soil1982，，3： | 1 |
| 20 | The impact of portal vein resection on outcomes for hilar cholangiocarcinoma显示文摘 | Mechteld C. de Jong Hugo Marques Bryan M. Clary Todd W. Bauer J. Wallis Marsh Dario Ribero Pietro Majno Ioannis Hatzaras Dustin M. Walters Andrew S. Barbas Raquel Mega Richard D. Schulick Michael A. Choti David A. Geller Eduardo Barroso Gilles Mentha Lore | 2012 | Cancer2012，，19： | 1 |
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