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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)显示文摘 | Bentley SD Chater KF Cerdeno-Tarraga AM Challis GL Thomson NR James KD Harris DE Quail MA Kieser H Harper D Bateman A Brown S Chandra G Chen CW Collins M Cronin A Fraser A Goble A Hidalgo J Hornsby T Howarth S Huang CH Kieser T Larke L Murphy L Oliver K O | | 0，，： | 1 |
| 3 | Genetic linkage analysis of autosomal dominant congenital cataracts 显示文摘 | Bateman J B Spence M A Marazita M L | 1986 | Am J Ophthamlol1986，101，： | 1 |
| 4 | Cynicism in the Workplace:Some Causes and Effects显示文摘 | Andersson L M Bateman T S | 1997 | Journal of Organizational Behavior1997，18，5： | 1 |
| 5 | Postictal generalized EEG suppression is linked to seizure-associated respiratory dysfunction but not postictal apnea显示文摘 | Seyal M Hardin K A Bateman L M | 2012 | Epilepsia2012，53，5： | 1 |
| 6 | The Pfam protein families database 显示文摘 | Punta M Coggill P C Eberhardt R Y Mistry J Tate J Boursnell C Pang N Forslund K Ceric G Clements J Hcger A Holm L Sonnhammer E L Eddy S R Bateman A Finn R D | 2012 | Nucleic Acids Research2012，40，： | 1 |
| 7 | Quantifica tion of bone ingrowth into porous block hydroxyapatite in humans 显示文摘 | Ayers R A Wolford L M Bateman T A | 1999 | BiomedMaterRes1999，47，： | 1 |
| 8 | Evaluation of ruminally protected methionine and lysine or blood meal and fish meal as protein sources for lactating Holsteins显示文摘 | Spain J N Kerley M S Belyea R L and Marshall R T | 1999 | J Dairy Sci1999，82，： | 1 |
| 9 | Reduction of image noise in low tube current dynamic CT myocardial perfusion iraaging using HYPR processing: a time-attenuation curve analysis 显示文摘 | SPEIDEL M A BATEMAN C L TAO Y | 2013 | MedPhys2013，40，01： | 1 |
| 10 | Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)显示文摘 | Bentley SD Chater KF Cerdeno-Tarraga AM Challis GL Thomson NR James KD Harris DE Quail MA Kieser H Harper D Bateman A Brown S Chandra G Chen CW Collins M Cronin A Fraser A Goble A Hidalgo J Hornsby T Howarth S Huang CH Kieser T Larke L Murphy L Oliver K O | | 0，，： | 1 |
| 11 | Cynicism in the Workplace:Some Causes and Effects显示文摘 | Anderson L M Bateman T S | 1997 | Journal of Organizational Behaviour1997，18，05： | 1 |
| 12 | Recent advances in aryl-aryl bond formation by direct arylation显示文摘 | McGlacken G P Bateman L M | | 0，，08： | 1 |
| 13 | Effect of Weaning Age of Dairy Calves Fed a Conventional or More Optimum Milk Replacer Program显示文摘 | Hill T M Bateman H G Aldrich J M Schlotterbeck R L | 2009 | Professional Animal Scientist2009，，： | 1 |
| 14 | Initiation and regulation mechanisms of ribosomal RNA transcription in the eukaryote Acanthamoeba castellanii显示文摘 | Paule M R Bateman E Hoffman L | 1991 | Mol Cell Biochem1991，104，12： | 1 |
| 15 | The epidemiology of postpartum hemorrhage in a large, nationwide sample of deliveries 显示文摘 | Bateman B T Berman M F Riley L E | 2010 | Anesthesia & Analgesia2010，110，5： | 1 |
| 16 | The epidemiology of postpartum hemorrhage in a large,nationwide sample of deliveries显示文摘 | Bateman B T Berman M F Riley L E | 2010 | Anesthesia&Analgesia2010，110，5： | 1 |
| 17 | Budesonide/formoteorl and formoteorol provide similar rapid relief in patients with acute asthma showing refractoriness to salbutamol显示文摘 | BATEMAN E D FAIRALL L LOMBARDI D M | 2006 | Respir Res2006，24，： | 1 |
| 18 | Recent advances in aryl-aryl bond formation by direct arylation显示文摘 | MCGLACKEN G P BATEMAN L M | | 0，，08： | 1 |
| 19 | Mierosomal prostaglandinE2(PC-E2)synthase - 1 reduces inducible and basal PC-E2 pro- duction and alters the gastric Pmstanoid Profile显示文摘 | L Boulet M Ouellet K P Bateman | 2004 | Biol Chern2004，279，23： | 1 |
| 20 | Genetic variegation of clonal architecture and propagating cells in leukaemia显示文摘 | Anderson K Lutz C van Delft FW Bateman CM Guo YP Colman SM Kempski H Moorman AV Titley I Swansbury J Kearney L Enver T Greaves M | | 0，，7330： | 1 |
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