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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | 城市垃圾焚烧过程中重金属释放行为的试验研究显示文摘以城市垃圾为研究对象,在流化床试验装置上进行焚烧试验,并采用电感耦合等离子体发射光谱仪在线测量烟气中的重金属浓度,研究不同气氛条件(空气、混合气和氮气)下Cd、Pb及Zn3种重金属的释放特性.试验发现,城市垃圾焚烧过程中,在还原气氛及HCl存在的情况下,Cd及Pb较易挥发释放,而Zn释放程度较低,且基本不受气氛条件的影响.研究结果对揭示城市垃圾流化床焚烧过程中重金属释放行为有一定的意义. | 孙路石 陆继东 张娟 Abanades S Flamant G Gauthier D | 2003 | 燃烧科学与技术2003，9，6： | 9 |
| 3 | Cerebrospinal fluid phosphorylated tau,visinin-like protein-1,and chitinase-3-like protein 1 in mild cognitive impairment and Alzheimer’s disease显示文摘Background:Visinin-like protein-1(VILIP-1)and chitinase-3-like protein 1(CHI3L1 or YKL-40)in cerebrospinal fluid(CSF)are newly discovered markers indicating neuronal damage and microglial activation,respectively.Phosphorylated tau(p-tau)reflects the neuropathology of Alzheimer’s disease(AD)and is useful as diagnostic markers for AD.However,it is unknown whether these biomarkers have similar or complementary information in AD.Methods:We stratified 121 participants from the Alzheimer’s Disease Neuroimaging Initiative(ADNI)database into cognitively normal(CN),stable mild cognitive impairment(sMCI),progressive MCI(pMCI),and dementia due to AD.Analysis of covariance(ANOVA)and chi-square analyses,Spearman correlation,and logistic regression models were performed to test the demographic,associations between biomarkers,and diagnostic accuracies,respectively.Linear mixed-effects models were used to evaluate the effects of CSF amyloid-β(Aβ)on above biomarkers within diagnostic groups,the combination of diagnostic group and Aβstatus as predictor,and CSF biomarkers as predictors of AD features,including cognition measured by Mini–Mental State Examination(MMSE)and brain structure and white matter hyperintensity(WMH)measured by magnetic resonance imaging(MRI).Results:P-tau,VILIP-1,and YKL-40 were all predictors of AD diagnosis,but combinations of biomarkers did not improve the diagnostic accuracy(AUC 0.924 for p-tau,VILIP-1,and YKL-40)compared to p-tau(AUC 0.922).P-tau and VILIP-1 were highly correlated(r=0.639,p<0.001)and strongly associated with Aβpathology across clinical stages of AD,while YKL-40 was correlated with Aβpathology in CN and AD groups.VILIP-1 was associated with acceleration of cognitive decline,hippocampal atrophy,and expansion of ventricles in longitudinal analyses.YKL-40 was associated with hippocampal atrophy at baseline and follow-up,while p-tau was only associated with worsening WMH at baseline.Conclusions:CSF levels of p-tau,VILIP-1,and YKL-40 may have utility for discriminating between cognitively normal subjects and patients with AD.Increased levels of both VILIP-1 and YKL-40 may be associated with disease degeneration.These CSF biomarkers should be considered for future assessment in the characterization of the natural history of AD. | Hua Zhang Kok Pin Ng Joseph Therriault Min Su Kang Tharick APascoal Pedro Rosa-Neto Serge Gauthier the Alzheimer’s Disease Neuroimaging Initiative | 2018 | Translational Neurodegeneration2018，7，1： | 5 |
| 4 | 流化床内重金属蒸发特性的动力学模型显示文摘在流化床内煤燃烧烟气中重金属浓度的实时监测基础上,发展动力学模型来研究重金属蒸发释放的动力学特性。该方法包括出口烟气中的重金属浓度变化的实验数据和一个反应器尺度的模型。在反应器的气体出口安装了在线分析系统,该在线分析系统可连续测量烟气中的重金属浓度变化规律。将烟气重金属在线分析的实验结果作为模型的输入参数,根据重金属的蒸发率和固体颗粒中重金属浓度的关系得到其蒸发的动力学规律,对于煤得到2级反应动力学规律。 | 刘晶 D Gauthier S Abanades G Flamant 郑楚光 | 2009 | 工程热物理学报2009，30，2： | 2 |
| 5 | Efficacy of galantamine improbable vascular dementia and Alzheimer's disease combined with cerebrovascular disease: a randomised trial显示文摘 | Erkinjuntti Kurz A Gauthier S | 2002 | Lancet2002，359，9314： | 1 |
| 6 | Bircle is the gene within the Lgnl locus associated with resistance to Legionella pneumophila显示文摘 | Diez E Lee S H Gauthier S | 2003 | Nat Genet2003，33，1： | 1 |
| 7 | AMP-activated protein kinase is activated as a consequence of lipolysis in the adipocyte: potential mechanism and physiological relevance显示文摘 | Gauthier M S Miyoshi H Souza S C | 2008 | J Biol Chem2008，283，24： | 1 |
| 8 | A strategy for greenhouse climate control,Part Ⅰ:Model development显示文摘 | Trigui M Barrington S Gauthier L | 2001 | Journal of Agricultural Engineering Research2001，78，4： | 1 |
| 9 | Fire impacts and crowning in the boreal forest:study of a large wildfire in western Quebec显示文摘 | Kafka V Gauthier S and Bergeron Y | 2001 | International Journal of Wildland Fire2001，10，2： | 1 |
| 10 | Fractionation of whey' protein hydrolysates using charged UF/NF membranes显示文摘 | Pouliot Y Wijers M C Gauthier S F | 1999 | Journal of Membrane Science1999，158，： | 1 |
| 11 | A strategy for greenhouse climate control, Part Ⅰ: Model development显示文摘 | Trigui M Barrington S Gauthier M | 2001 | Journal of Agricultural Engineering Research2001，78，4： | 1 |
| 12 | An in situ target strength model for Atlantic redfish 显示文摘 | Gauthier S Rose G A | 1998 | Journal of the Acoustical Society of America1998，103，5： | 1 |
| 13 | Polymerase chain reaction detection of deformed wing virus(DWV)in Ap~ melliferaand Varroa destructor显示文摘 | TENTCHEVA D GAUTHIER L JOUVE S | | 0，，： | 1 |
| 14 | Current evidence for subjective cognitive impairment (SCI) as the pre-mild cognitive impairment (MCI) stage of subsequently manifest Alzheimer's disease 显示文摘 | Reisberg B Gauthier S | 2008 | Int Psycho- geriatr2008，20，1： | 1 |
| 15 | Emerging therapies for vascular dementia and vascular cognitive impairment显示文摘 | Erkinjuntti T Roman G Gauthier S | 2004 | Stroke2004，35，4： | 1 |
| 16 | Emerging therapiesfor vascular dementia and vascular cognitive impairment显示文摘 | Erkinjuntti T Romn G Gauthier S | 2004 | Stroke2004，35，4： | 1 |
| 17 | Comparison of bifidobacterial growth-promoting activity of ultrafiltered casein hydrolyzate fractions 显示文摘 | Proulx M Ward P Gauthier S F | 1994 | Lait1994，74，： | 1 |
| 18 | Variation in virulence of cereal cyst nematode popula- tions from North Africa and Asia 显示文摘 | MOKABLI A VALETTE S GAUTHIER J P | 2002 | Nematology2002，4，： | 1 |
| 19 | Genetic diversity among a complex of cereal cyst nematode inferred from RFLP analysis of the ribosomal internal transcribed spacer region显示文摘 | Bekal S Gauthier J P Rivoal R | 1997 | Genome1997，40，： | 1 |
| 20 | A 24-week,randomized double-blind study of donepezil in moderate to severe Alzheimer's disesse显示文摘 | Feldman H Gauthier S Hecker J | 2001 | Neurology2001，57，： | 1 |
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