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| 1 | How the Bcl-2 family of proteins interact to regulate apoptosis显示文摘到 apoptosis 的房间的承诺主要被在 Bcl-2 蛋白质家庭的成员之间的蛋白质蛋白质相互作用管理。它的三个亚科有不同角色:BH3 仅仅,蛋白质经由他们的 BH3 领域由绑定触发 apoptosis 到支持幸存的亲戚,当 pro-apoptotic Bax 和 Bak 有一个必要下游的角色包含 organellar 膜和 caspase 激活的正式就职的混乱时。BH3 仅仅,蛋白质充当损坏传感器,由压力信号保持惰性直到他们的激活。一旦激活,他们被认为杂乱地绑在支持幸存的蛋白质目标,但是意外选择最近从他们的相互作用的分析出现了。BH3 仅仅,蛋白质也绑在 Bax 和 Bak 的一些。Bax 和 Bak 是否被这些 BH3 仅仅直接激活蛋白质,或间接地作为后果 BH3 仅仅蛋白质抵销他们的支持幸存的目标是强烈争论的题目。不管这,在家庭成员之间的相互作用的详细理解,经常选择,为设计反癌症药指向 Bcl-2 家庭有著名含意。 | Mark F van Delft David CS Huang | 2006 | Cell Research2006，16，2： | 38 |
| 2 | A decision-making model of development intensity based on similarity relationship between land attributes intervened by urban design显示文摘The paper presents a dynamic model intervened by urban design for the decision-making of land development intensity, which expresses the inherent interaction mechanism between lands based on the evaluation of land attributes and their similarity relationship. Each land unit is described with several factors according to their condition and potential for development, such as land function, accessibility, historical site control, landscape control, and so on. Then, the dynamic reference relationship between land units is established according to the similarity relationship between their factors. That means lands with similar conditions tend to have similar development intensities, which expresses the rule of the spontaneous urban development. Therefore, the development intensities of the pending lands can be calculated by the confirmed ones. Furthermore, the system can be actively intervened by adjusting the parameters according to urban design or planning intentions. And the reaction of the system offers effective support and reference for reasonable decision. The system with multiple intervention input is not only a credible tool for deriving development intensities, but also a platform to activate urban design conception. Above all, the system as a socio-technical tool integrates the optimization of form, function and environment, and embodies the principle of impersonality, justice and flexibility in the decision of land development intensity. | WANG JianGuo1, ZHANG Yu2 & FENG Han3 1 School of Architecture, Southeast University Key Laboratory for Urban and Architectural Heritage Conservation, Ministry of Education, Nanjing 210096, China 2 School of Architecture, Southeast University, Nanjing 210096, China 3 Faculty of Architecture, Delft University of Technology, 2628 CR Delft, Netherlands | 2010 | Science China(Technological Sciences)2010，53，7： | 12 |
| 3 | Training and transfer of colonoscopy skills: a multinational, randomized, blinded, controlled trial of simulator versus bedside training显示文摘 | Adam Haycock Arjun D. Koch Pietro Familiari Foke van Delft Evelien Dekker Lucio Petruzziello Jelle Haringsma Siwan Thomas-Gibson | 2010 | Gastrointestinal Endoscopy2010，，2： | 2 |
| 4 | Intra‐ and interobserver reliability of levator ani muscle biometry and avulsion using three‐dimensional endovaginal ultrasonography显示文摘 | K. van Delft S. A. Shobeiri R. Thakar N. Schwertner‐Tiepelmann A. H. Sultan | 2014 | Ultrasound Obstet Gynecol2014，，2： | 1 |
| 5 | Crystal structure of fibroblast growth factors receptor ectodomain bound to ligand and hepararin显示文摘 | PELLEGRINI L BURKE D F VON DELFT F | 2000 | Nuture2000，407，： | 1 |
| 6 | Mechanisms of colorectal and lung cancer prevention by vegetables:a genomic approach显示文摘 | van Breda SGJ de Kok TMCM van Delft JHM | 2008 | J NutrBiochem2008，19，3： | 1 |
| 7 | Biological monitoring the exposure to polycyclic aromatic hydrocarbons of coke oven workers in relation to smoking and genetic polymorphisms for GSTM1 and GSTT1显示文摘 | van Delft J H M Steenwinkel M van Asten J G | 2001 | Annals of Occupational Hygiene2001，45，5： | 1 |
| 8 | Flow equation renormalization of a spin-boson Medel with a structured bath显示文摘 | KLEFF S KEHREIN S K DELFT J V | 2003 | Phye E2003，18，： | 1 |
| 9 | Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin显示文摘 | Pellegrini L Burke DF yon Delft F | 2000 | Nature2000，407，6807： | 1 |
| 10 | Biological monitoring the exposure to polycyclic aromatic hydrocarbons of coke oven workers in relation to smoking and genetic pnlymorphisms for GSTM1 and GSTT1 显示文摘 | VAN DELFT JH STEENWINKEL MS VAN ASTEN JG | 2001 | Ann Occup Hyg2001，45，5： | 1 |
| 11 | Gene expression changes induced by Ochratoxin A in renal and hepatic tissues of male F344 rat after oral repeated administration显示文摘 | Arbillaga L Vettorazzi A Gil A G Delft J H García-Jalón J A Cerain A L | 2008 | Toxicology and Applied Pharmacology2008，230，2： | 1 |
| 12 | Activation of RhoA by thrombin in endothelial hyperpermeability:role of Rho kinase andprotein tyrosine kinases显示文摘 | van Nieuw Amerongen GP van Delft S Vermeer MA | 2000 | Circulation research2000，87，4： | 1 |
| 13 | Cost effective large blade components byusing carbon fibers显示文摘 | JOOSSE P A VAN DELFT D R V KENSCHECHR | 2002 | Journal of solar energy engineering:Transactions of theASME2002，，： | 1 |
| 14 | Gene expression changes induced by Ochratoxin A in renal and hepatic tissues of male F344 rat after oral repeated administration显示文摘 | Arbillaga L Vettorazzi A Gil A G Delft J H García-Jalón J A Cerain A L | 2008 | Toxicology and Applied Pharmacology2008，230，2： | 1 |
| 15 | Identification of amidated forms of GLP-1 in rat tissues using a highly sensitive radioimmunoassay显示文摘 | Van Delft J Uttenthal LO Hermida OG | | 0，，： | 1 |
| 16 | Crystal structure of fibroblast growth factors receptor ectodomain bound to ligand and hepararin显示文摘 | Pellegrini L Burke D F von Delft F | | 0，，： | 1 |
| 17 | The crystal structure of shikimate dehydrogenase(aroE) reveals a unique NADPH model显示文摘 | Delft F V Brooun A | 2003 | Journal of Bacteriology2003，185，14： | 1 |
| 18 | Training and transfer of colonoscopy skills: a multinational, randomized, blinded, controlled trial of simulator versus bedside training显示文摘 | Adam Haycock Arjun D. Koch Pietro Familiari Foke van Delft Evelien Dekker Lucio Petruzziello Jelle Haringsma Siwan Thomas-Gibson | 2010 | Gastrointestinal Endoscopy2010，，2： | 1 |
| 19 | Induction of somatic mutations but not methylated DNA adducts in lambdalacZ transgenic mice by dichlorvos显示文摘 | PLETSA V STEENWINKEL M J VAN DELFT J H | 1999 | Cancer Lett1999，146，2： | 1 |
| 20 | Induction of cell scattering by expression of P1 integrins in p1-deficient epithelial cells requires activation of members of the rho family of GTPases and downregulation of cadherin and catenin function显示文摘 | GIMOND C A VAN DER FLIER VAN DELFT S | 1999 | ) cell BioI1999，147，6： | 1 |
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