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| 1 | 常见呼吸道病毒分子鉴别诊断技术的建立显示文摘目的建立一种常见呼吸道感染病毒的快速检测方法,为尽早诊断、减少疾病的传播以及为临床提供良好的治疗依据。方法采用液体芯片检测技术结合靶向多重RT-PCR技术建立可以同时检测13种呼吸道病原的检测技术。结果该方法特异性方面检测13种常见呼吸道病毒没有交叉,标本的检出率为100%;灵敏度方面达到10e2-10e1(pfu/ml)。结论该分子鉴别诊断可应用常见呼吸道病毒的检测,协助诊断病毒引起的病毒性呼吸道感染。 | 邹淑梅 韩健 温乐英 Kassi Cronin 舒跃龙 | 2006 | 中华实验和临床病毒学杂志2006，20，2： | 15 |
| 2 | Imaging of bone metastasis: An update显示文摘Early detection of skeletal metastasis is critical for accurate staging and optimal treatment. This paper briefly reviews our current understanding of the biological mechanisms through which tumours metastasise to bone and describes the available imaging methods to diagnose bone metastasis and monitor response to treatment. Among the various imaging modalities currently available for imaging skeletal metastasis, hybrid techniques whichfuse morphological and functional data are the most sensitive and specific, and positron emission tomography(PET)/computed tomography and PET/magnetic resonance imaging will almost certainly continue to evolve and become increasingly important in this regard. | Gerard J O'Sullivan Fiona L Carty Carmel G Cronin | 2015 | World Journal of Radiology2015，7，8： | 10 |
| 3 | Thermoelectric transport across graphene/hexagonal boron nitride/graphene heterostructures显示文摘我们越过 graphene/hexagonal 硼氮化物(h-BN ) 报导热电的运输大小 /graphene heterostructure 设备。用一种交流占据技术,我们能分开热电的贡献到这些重要设备结构的 IV 特征。温度坡度用拉曼光谱学光学地被测量,它使我们能探索在材料接口生产的热电的运输,越过就 12 nm 的长度规模。基于观察热电的电压(V) 和温度坡度(T) , 99.3 V/K 的一个 Seebeck 系数为 heterostructure 设备被查明。获得的 Seebeck 系数能为在新兴的 2D heterostructure 设备的跨飞机的 IV 行为理解热电的部件是有用的。这些结果提供一条途径给在二维的分层的 heterostructures 探查热电的精力变换。 | Chun-Chung Chen Zhen Li Li Shi Stephen B. Cronin | 2015 | Nano Research2015，8，2： | 8 |
| 4 | Assessing the effects of quality, value, and customer satisfaction on consumer behavioral intentions in service environments显示文摘 | J.Joseph Cronin Michael K Brady G.Tomas M Hult | 2000 | Journal of Retailing2000，，2： | 7 |
| 5 | Free radicals and antioxidants in normal physiological functions and human disease显示文摘 | Marian Valko Dieter Leibfritz Jan Moncol Mark T.D. Cronin Milan Mazur Joshua Telser | 2006 | International Journal of Biochemistry and Cell Biology2006，，1： | 6 |
| 6 | Free radicals and antioxidants in normal physiological functions and human disease显示文摘 | Marian Valko Dieter Leibfritz Jan Moncol Mark T.D. Cronin Milan Mazur Joshua Telser | 2006 | International Journal of Biochemistry and Cell Biology2006，，1： | 5 |
| 7 | 急性心肌缺血综合征中国地区现状调查显示文摘目的研究分析中国地区急性心肌缺血综合征病人的临床特点和治疗现状.方法此项研究为国际多中心关于急性心肌缺血综合征登记试验(OASIS)的一部分.采用填写加拿大心血管合作协会统一设计的病例记录表(CRF)的方法,自1999年4月开始,收集了各中心因急性心肌缺血入院病人的资料,记录了病人主要临床特征和院内事件.结果共注册急性心肌缺血综合征(包括不稳定心绞痛及非Q波心肌梗死)病人1509例,来自全国范围内34所医院.病人平均年龄62.3岁,其中男性62.2%,就诊时持续胸痛47.8%,心电图异常89.5%,入院诊断不稳定心绞痛91.3%,非Q波心肌梗死8.7%.住院期间溶栓3.3%,冠状动脉造影35.0%,经皮冠状动脉腔内成形术(PTCA)16.8%,冠状动脉旁路移植术(CABG)4.1%,应用硝酸酯制剂96.8%,抗血小板治疗95.5%.院内发生重要并发症18.8%,其中死亡1.2%,主要原因为严重心律失常或猝死.结论中国地区急性心肌缺血病人以不稳定心绞痛就诊居多.我国病人住院期间PTCA治疗率相对较高,CABG治疗率较低.院内死亡最主要的原因为严重心律失常或猝死. | 无 Tan HQ Liang Y Zhu J Liu LS Cronin L | 2002 | Chinese Medical Journal2002，，8： | 3 |
| 8 | 地质学家震源机制解入门显示文摘本文的目的是帮助学生提高识别和解释"海滩球"图(地震学家推导的矩张量几何形状的图形表示)的技能。笔者把有关获取矩张量过程的大部分定量细节描述留给地震学教程或文献中讲述。然而,笔者发现有关如何手工获得震源机制解(FMS)的一些知识对学生很有用,因此整个过程并不具有多少黑箱艺术。 | Vince Cronin 李万金 李永华 吕春来 | 2015 | 世界地震译丛2015，46，1： | 3 |
| 9 | The burden of selected digestive diseases in the United States显示文摘 | Robert S. sandler James E. Everhart Mark Donowitz Elizabeth Adams Kelly Cronin Clifford Goodman Eric Gemmen Shefali Shah Aida Avdic Robert Rubin | 2002 | Gastroenterology2002，，5： | 2 |
| 10 | Advanced multimodality imaging of inflammatory bowel disease in 2015: An update显示文摘The diagnosis and effective management of inflammatory bowel disease(IBD) requires a combination clinical, endoscopic, histological, biological, and imaging data. While endoscopy and biopsy remains the gold standard for diagnosis of IBD, imaging plays a central role in the assessment of extra mural disease, in disease surveillance and in the assessment of response to medical treatments, which are often expensive. Imaging is also vital in the detection and diagnosis of disease related complications, both acute and chronic. In this review, we will describe, with illustrative images, the imaging features of IBD in adults, with emphasis on upto-date imaging techniques focusing predominantly on cross sectional imaging and new magnetic resonance imaging techniques. | Emma Stanley Heather K Moriarty Carmel G Cronin | 2016 | World Journal of Radiology2016，8，6： | 2 |
| 11 | Enhanced photocurrent and photoluminescence spectra in MoS2 under ionic liquid gating显示文摘 | Zhen Li Shun-Wen Chang Chun-Chung Chen Stephen B. Cronin | 2014 | Nano Research2014，7，7： | 2 |
| 12 | Nanoscopy reveals surface-metallic black phosphorus显示文摘Black phosphorus(BP)is an emerging two-dimensional material with intriguing physical properties.It is highly anisotropic and highly tunable by means of both the number of monolayers and surface doping.Here,we experimentally investigate and theoretically interpret the near-field properties of a-few-atomic-monolayer nanoflakes of BP.We discover near-field patterns of bright outside fringes and a high surface polarizability of nanofilm BP consistent with its surface-metallic,plasmonic behavior at mid-infrared frequencies o1176 cm−1.We conclude that these fringes are caused by the formation of a highly polarizable layer at the BP surface.This layer has a thickness of~1 nm and exhibits plasmonic behavior.We estimate that it contains free carriers in a concentration of n≈1.1×10^(20) cm^(−3).Surface plasmonic behavior is observed for 10–40 nm BP thicknesses but absent for a 4-nm BP thickness.This discovery opens up a new field of research and potential applications in nanoelectronics,plasmonics and optoelectronics. | Yohannes Abate Sampath Gamage Zhen Li Viktoriia Babicheva Mohammad H Javani Han Wang Stephen B Cronin Mark I Stockman | 2016 | Light(Science & Applications)2016，5，1： | 2 |
| 13 | AIF-regulated oxidative phosphorylation supports lung cancer development显示文摘Cancer is a major and still increasing cause of death in humans. Most cancer cells have a fundamentally different metabolic profile from that of normal tissue. This shift away from mitochondrial ATP synthesis via oxidative phosphorylation towards a high rate of glycolysis, termed Warburg effect, has long been recognized as a paradigmatic hallmark of cancer, supporting the increased biosynthetic demands of tumor cells. Here we show that deletion of apoptosis-inducing factor (AIF) in a Kras^G12D-driven mouse lung cancer model resulted in a marked survival advantage, with delayed tumor onset and decreased malignant progression. Mechanistically, Aif deletion leads to oxidative phosphorylation (OXPHOS) deficiency and a switch in cellular metabolism towards glycolysis in non-transformed pneumocytes and at early stages of tumor development. Paradoxically, although Aif-deficient cells exhibited a metabolic Warburg profile, this bioenergetic change resulted in a growth disadvantage of Kras^G12D-driven as well as Kras wild-type lung cancer cells. Cell-autonomous re-expression of both wild-type and mutant AIF (displaying an intact mitochondrial, but abrogated apoptotic function) in Aif-knockout Kras^G12D mice restored OXPHOS and reduced animal survival to the same level as AIF wild-type mice. In patients with non-small cell lung cancer, high AIF expression was associated with poor prognosis. These data show that AIF-regulated mitochondrial respiration and OXPHOS drive the progression of lung cancer. | Shuan Rao Laura Mondragon Blanka Pranjic Toshikatsu Hanada Gautier Stoll Thomas Kocher Peng Zhang Alexander Jais Alexander Lercher Andreas Bergthaler Daniel Schramek Katharina Haigh Valentina Sica Marion Leduc Nazanine Modjtahedi Tsung-Pin Pai Masahiro Onji Iris Uribesalgo Reiko Hanada Ivona Kozieradzki Rubina Koglgruber Shane J. Cronin Zhigang She Franz Quehenberger Helmut Popper Lukas Kenner Jody J. Haigh Oliver Kepp Malgorzata Rak Kaican Cai Guido Kroemer Josef M. Penninger | 2019 | Cell Research2019，29，7： | 2 |
| 14 | 细胞分离培养在实验室诊断眼部单纯疱疹病毒感染疾病的误诊和漏诊情况(英文)显示文摘目的:对比聚合酶链反应(PCR)和细胞分离培养在实验室诊断眼部单纯疱疹病毒(HSV)感染疾病的作用。方法:我们对连续患者的实验室结果(PCR实验,细胞分离培养及临床诊断)及病历进行回顾性研究在诊断眼部HSV感染疾病过程中,PCR检测结果、细胞分离培养及首诊结果进行了统计比较。结果:患者581例经过检查后,520例PCR检查阴性,细胞培养阴性(89.6%);0例PCR检查阴性,细胞培养阳性(0%);27例PCR检查阳性,细胞培养阴性(4.6%);34例PCR检查阳性,细胞培养阳性(5.8%)。PCR检测阳性率高于细胞分离培养(McNemars,P=0.0001)。47例PCR检查为HSV初诊感染阳性患者中,19例患者中有14例为细胞培养阴性结果(74%),5例HSV患者因缺PCR检测结果将被误诊;28例患者中有25例患者细胞培养阳性(占89%),3例HSV患者因缺PCR检测结果将被漏诊。结论:PCR诊断眼部HSV感染优于细胞分离培养。细胞分离培养对于眼部HSV感染的非典型表现不易诊断。 | Regis P Kowalski Paul P Thompson Tara H Cronin | 2010 | 国际眼科杂志2010，10，11： | 2 |
| 15 | Discrete element modelling of the quasi-static uniaxial compression of individual infant formula agglomerates显示文摘Infant formula is usually produced in an agglomerated powder form. These agglomerates are subjected to many transient forces following their manufacture. These can be difficult to quantify experimentally because of their small magnitudes and short durations. Numerical models have the potential to address this gap in the experimental data. The objective of the research described here was to calibrate a discrete element model for these agglomerates using experimental data obtained for quasi-static loading, and to use this model to study the mechanics of the particle response in detail. The Taguchi method was previously proposed as a viable calibration approach for discrete element models. In this work, the method was assessed for calibration of the model parameters (e.g., bond stiffnesses and strengths) considering three responses: the force at failure, strain at failure and agglomerate stiffness. The Weibull moduli for the simulation results and the experimental data were almost identical following calibration and the 37% characteristic stresses were similar. An analysis of the energy terms in the model provided useful insight into the model response. The bond energy and the normal force exerted on the platens were strongly correlated, and bond breakage events coincided with the highest energy dissipation rates. | Kevin J.Hanley Catherine O'Sullivan Edmond P.Byrne Kevin Cronin | 2012 | Particuology2012，10，5： | 2 |
| 16 | 与久坐者相比,职业运动员的肠道菌群在代谢组分,尤其是功能代谢水平上有所不同显示文摘目的有证据表明肠道菌群以及影响其结构和活性的因素在人类代谢、免疫和发育过程中发挥作用。我们曾报道,与久坐者相比,诸如职业运动员,配有相应饮食的极度体育活动者肠道菌群种属和代谢组分发生了改变。这次我们重点研究这些因素对菌群功能/代谢活动的影响,以进一步揭示运动者和久坐者间的差别。方法对专业国际橄榄球联盟球员(样本数为40例)和对照(样本数为46例)的肠道菌群进行代谢表型和功能宏基因组分析,并将结果与生活方式指标(比如饮食习惯)和临床评估指标(比如血清肌酸激酶)进行关联。结果与对照相比,运动员组中与肌肉更新和整体健康相关的信号通路(比如:氨基酸、抗生素生物合成和碳水化合物代谢)和肠道菌群代谢产物(比如:短链脂肪酸乙酸酯、丙酸酯和丁酸酯)有所增加。结论运动和久坐相比,其肠道菌群在宏基因组和代谢组学上比组织水平显示出更大差异,拓展了饮食.运动.肠道微生态模式新视野。 | Barton W Penney NC Cronin O Garcia-Perez I Molloy MG Holmes E Shanahan F Cotter PD O'Sullivan O 毛玲娜 宋震亚 | 2017 | 英国医学杂志中文版2017，20，7： | 2 |
| 17 | Plasmonic mode mixing in nanoparticle dimers with nm-separations via substrate-mediated coupling显示文摘 | Jesse Theiss Mehmet Aykol Prathamesh Pavaskar Stephen B. Cronin | 2014 | Nano Research2014，7，9： | 2 |
| 18 | Corticosteroid treatment for sepsis:a critical appraisal and meta -analysis of the literature显示文摘 | Cronin L Cook D J Carlet J | 1995 | Crit Care Med1995，23，： | 2 |
| 19 | Metals, toxicity and oxidative streas 显示文摘 | Valko M Morris H Cronin Mr | 2005 | Curr Med Chem2005，12，： | 1 |
| 20 | Tbe stress social support and burnout of critical care nurses显示文摘 | Rooks CA | 1985 | The result of reseach heart & lung1985，14，1： | 1 |
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