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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Mass Spectral Analyses of Microcystins from Toxic Cyanobacteria Using on-line Chromatographic and Electrophoretic Separations显示文摘 | Bateman K P Thibault P Douglas D J | 1995 | J Chromatogr A1995，712，： | 1 |
| 3 | Diseases and pathogens associated with mortality in Ontario beef feedlots 显示文摘 | Gagea M I Bateman K G van Dreumel T | 2006 | J Vet Diagn Invest2006，18，： | 1 |
| 4 | Complications of laparoscopy-operative and diagnostic 显示文摘 | Bateman BG Kolp LA Hoeger K | 1996 | Fertil Steril1996，66，1： | 1 |
| 5 | Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2)显示文摘 | Bentley SD Chater KF Cerdeno-Tarraga AM Challis GL Thomson NR James KD Harris DE Quail MA Kieser H Harper D Bateman A Brown S Chandra G Chen CW Collins M Cronin A Fraser A Goble A Hidalgo J Hornsby T Howarth S Huang CH Kieser T Larke L Murphy L Oliver K O | | 0，，： | 1 |
| 6 | Road transport conditions of slaughter cattle: Effects on the prevalence of dark, firm and dry beef显示文摘 | WARREN L A MANDELL I B BATEMAN K G | 2010 | Canadian Journal of Animal Science2010，90，4： | 1 |
| 7 | Elicitation and trun-cation effects in contingent valuation studies显示文摘 | BATEMAN I J LANGFORD I H TURNER R K | 1999 | Ecological Economics1999，12，： | 1 |
| 8 | Origins of Nd-Sr-Pb isotopic variations in single scheelite grains from Arehaean gold deposits, Western Australia 显示文摘 | Brugger J Mass R Lahaye Y McRae C Ghaderi M Costa S Lam-bert D Bateman R Prince K | 2002 | Chemical Geology2002，182，： | 1 |
| 9 | Gene therapy for prostate cancer: current status and future prospects显示文摘 | Harrington K J Spitzweg C Bateman AR | 2001 | J Urol2001，166，4： | 1 |
| 10 | Roflumilast-anoral anti-inflammatory treatment for chronic obstructive pulmonary disease: a randomised controlled trial 显示文摘 | Rabe K F Bateman E D O'Donnell D D | 2005 | Lancet2005，366，4985： | 1 |
| 11 | Naturally occurring Mycoplasma bovis-associated pneumonia and polyarthritis in feedlot beef calves显示文摘 | Gagea M I Bateman K G Shanahan R A | | 0，，： | 1 |
| 12 | Infection by a Hematodinium -like parasitic dinoflagellate causes Pink Crab Disease (PCD) in the edible crab Cancer pagurus显示文摘 | G.D Stentiford M Green K Bateman H.J Small D.M Neil S.W Feist | 2002 | Journal of Invertebrate Pathology2002，，3： | 1 |
| 13 | Antibodies to type Ⅱ collagen in SLE : a role in the pathogenesis of deforming arthristis 显示文摘 | Choi E K Gatenby P A Bateman J F | 1990 | Immunol Cell Biol1990，，： | 1 |
| 14 | Postictal generalized EEG suppression is linked to seizure-associated respiratory dysfunction but not postictal apnea显示文摘 | Seyal M Hardin K A Bateman L M | 2012 | Epilepsia2012，53，5： | 1 |
| 15 | Microvascular resuscitation as a therapeutic goal in severe sepsis 显示文摘 | Bateman R M Walley K R | 2005 | Crit Care2005，9，4： | 1 |
| 16 | The Pfam protein families database 显示文摘 | Punta M Coggill P C Eberhardt R Y Mistry J Tate J Boursnell C Pang N Forslund K Ceric G Clements J Hcger A Holm L Sonnhammer E L Eddy S R Bateman A Finn R D | 2012 | Nucleic Acids Research2012，40，： | 1 |
| 17 | Monitoring copopulated conformational states during protein folding events using electrospray ionization-ion mobility spectrometry-mass spectrometry显示文摘 | SMITH D P GILES K BATEMAN R H | 2007 | J Am Soc Mass Speetrom2007，18，12： | 1 |
| 18 | A single-blinded trial of methotrexate versus azathioprine as steroid-sparing agents in gener- alized myasthenia gravis 显示文摘 | Heckmann JM Rawoot A Bateman K | 2011 | BMC Neuro12011，11，： | 1 |
| 19 | 显示文摘 | Dean K M Bateman S A | 2007 | Polymer2007，48，8： | 1 |
| 20 | An Overview of Degradable and Biodegradable Polyolefins显示文摘 | Ammala A Bateman S Dean K | 2011 | Progress in Polymer Science2011，36，8： | 1 |
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