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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 3 | Bench-to-bedside review:microvascular dysfunction in sepsis-hemodynamics,oxygen transport,and nitric oxide显示文摘 | Bateman R M Sharpe M D Ellis C G | 2003 | Crit Care2003，7，： | 1 |
| 4 | Computer simulation of the impact performance of a wire rope safety fence显示文摘 | Bateman M B Howard I C Johnson A R | | 0，，1： | 1 |
| 5 | Origins of Nd-Sr-Pb isotopic variations in single scheelite grains from Arehaean gold deposits, Western Australia 显示文摘 | Brugger J Mass R Lahaye Y McRae C Ghaderi M Costa S Lam-bert D Bateman R Prince K | 2002 | Chemical Geology2002，182，： | 1 |
| 6 | Stable epigenetic effects impact adaptation in allopolyploid Orchids (Dac- tylorhiza: Orchidaceae ) 显示文摘 | Paun O Bateman R M Fay M F | 2010 | Mol Biol Evol2010，27，11： | 1 |
| 7 | Naturally occurring Mycoplasma bovis-associated pneumonia and polyarthritis in feedlot beef calves显示文摘 | Gagea M I Bateman K G Shanahan R A | | 0，，： | 1 |
| 8 | Mixing of cordierit granitoid and proxene gabbro, and fractionation, in the Santa Olallatonlite (Andaluc) 显示文摘 | MART M P CASTRO A | 1992 | Lithos1992，28，： | 1 |
| 9 | Microvascular resuscitation as a therapeutic goal in severe sepsis 显示文摘 | Bateman R M Walley K R | 2005 | Crit Care2005，9，4： | 1 |
| 10 | The Pfam protein families database 显示文摘 | Punta M Coggill P C Eberhardt R Y Mistry J Tate J Boursnell C Pang N Forslund K Ceric G Clements J Hcger A Holm L Sonnhammer E L Eddy S R Bateman A Finn R D | 2012 | Nucleic Acids Research2012，40，： | 1 |
| 11 | Bringing ecosystem services into economic decision-making: Landuse in the United Kingdom 显示文摘 | Bateman I J Harwood A R Mace G M | 2013 | Science2013，341，6141： | 1 |
| 12 | A low-noise, microprocessor-controlled,internally digitizing rotating-vane electric field mill for airborne platforms显示文摘 | BATEMAN B G STEWART M F BLAKESLEE R J | 2007 | Jornal of Atmospheric and Oceanic Technology2007，24，7： | 1 |
| 13 | Developmental bases for key innovations in the seed-plant microgametophyte 显示文摘 | Rudall P J Bateman R M | 2007 | Trends Plant Sci2007，12，7： | 1 |
| 14 | Org Identification and structural analysis of synthetic oligosaccharides of shigella sonnei using MALDI-TOFMS显示文摘 | Harvey D J Rudd P M Bateman R H | 1994 | Mass Spectrom1994，29，： | 1 |
| 15 | Quantifica tion of bone ingrowth into porous block hydroxyapatite in humans 显示文摘 | Ayers R A Wolford L M Bateman T A | 1999 | BiomedMaterRes1999，47，： | 1 |
| 16 | Evaluation of ruminally protected methionine and lysine or blood meal and fish meal as protein sources for lactating Holsteins显示文摘 | Spain J N Kerley M S Belyea R L and Marshall R T | 1999 | J Dairy Sci1999，82，： | 1 |
| 17 | Proteinase inhibitors from Nicotiana alata enhance plant resistance to insect pests显示文摘 | Heath RL Mcdonald G Christeller JT Lee M Bateman K West J Vanheeswuck R Anderson MA | | 0，，9： | 1 |
| 18 | Development of a system to predict feed protein flow to the small intestine of cattle显示文摘 | Bateman H G Clark J H Murphy M R | 2005 | J Dairy Sci2005，88，： | 1 |
| 19 | MSE with mass defect filtering for in vitro and in vivo metabolite identification显示文摘 | Bateman KP Castro-Perez J Wrona M Shockcor JP Yu K Oballa R | 2007 | Rapid Commun Mass Spectrom2007，21，9： | 1 |
| 20 | The enhanced infectivity of Metarhizium Flavoviride in oil formulations to desert locusts at low humidities显示文摘 | Bateman R P Carey M Moore D | 1993 | Annals of Applied Biology1993，122，： | 1 |
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