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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Refining pathological evaluation of neoadjuvant therapy for adenocarcinoma of the esophagus显示文摘AIM:To assess tumour regression grade(TRG)and lymph node downstaging to help define patients who benefit from neoadjuvant chemotherapy.METHODS:Two hundred and eighteen consecutive patients with adenocarcinoma of the esophagus or gastro-esophageal junction treated with surgery alone or neoadjuvant chemotherapy and surgery between 2005and 2011 at a single institution were reviewed.Triplet neoadjuvant chemotherapy consisting of platinum,fluoropyrimidine and anthracycline was considered for operable patients(World Health Organization performance status≤2)with clinical stage T2-4 N0-1.Response to neoadjuvant chemotherapy(NAC)was assessed using TRG,as described by Mandard et al.In addition lymph node downstaging was also assessed.Lymph node downstaging was defined by cN1 at diagnosis:assessed radiologically(computed tomography,positron emission tomography,endoscopic ultrasonography),then pathologically recorded as N0 after surgery;ypN0 if NAC given prior to surgery,or pN0if surgery alone.Patients were followed up for 5 years post surgery.Recurrence was defined radiologically,with or without pathological confirmation.An association was examined between t TRG and lymph node downstaging with disease free survival(DFS)and a comprehensive range of clinicopathological characteristics.RESULTS:Two hundred and eighteen patients underwent esophageal resection during the study interval with a mean follow up of 3 years(median follow up:2.552,95%CI:2.022-3.081).There was a 1.8%(n=4)inpatient mortality rate.One hundred and thirty-six(62.4%)patients received NAC,with 74.3%(n=101)of patients demonstrating some signs of pathological tumour regression(TRG 1-4)and 5.9%(n=8)having a complete pathological response.Forty four point one percent(n=60)had downstaging of their nodal disease(cN1 to ypN0),compared to only 15.9%(n=13)that underwent surgery alone(pre-operatively overstaged:cN1 to pN0),(P<0.0001).Response to NAC was associated with significantly increased DFS(mean DFS;TRG 1-2:5.1years,95%CI:4.6-5.6 vs TRG 3-5:2.8 years,95%CI:2.2-3.3,P<0.0001).Nodal down-staging conferred a significant DFS advantage for those patients with a poor primary tumour response to NAC(median DFS;TRG 3-5 and nodal down-staging:5.533 years,95%CI:3.558-7.531 vs TRG 3-5 and no nodal down-staging:1.114 years,95%CI:0.961-1.267,P<0.0001).CONCLUSION:Response to NAC in the primary tumour and in the lymph nodes are both independently associated with improved DFS. | Fergus Noble Luke Nolan Adrian C Bateman James P Byrne Jamie J Kelly Ian S Bailey Donna M Sharland Charlotte N Rees Timothy J Iveson Tim J Underwood Andrew R Bateman | 2013 | World Journal of Gastroenterology2013，19，48： | 4 |
| 3 | Tools for chloroplast transformation in Chlan,ydomonas: expression vectors and a new dominant selectable marker 显示文摘 | Bateman J M Purton S | 2000 | Molecular General Genetetic2000，263，： | 1 |
| 4 | Assignment of credit and blame for performance outcomes显示文摘 | Crant J M Bateman T S | | 0，，01： | 1 |
| 5 | Diagnosis and remediation of learning disabilities显示文摘 | Kirk S A Bateman B | 1962 | Exceptional Children1962，，2： | 1 |
| 6 | Influence of vascular endothelial growth factor single nucleotide polymorphisms on tumour development in cutaneous malignant melanoma显示文摘 | HOWELL W M BATEMAN A C TURNER S J | 2002 | Hums Immun2002，3，： | 1 |
| 7 | Rising prevalence of aller-gy to peanut in children:data from 2 sequential cohorts显示文摘 | Grundy J Matthews S Bateman B | 2002 | J Allergy ClinImmunol2002，110，5： | 1 |
| 8 | Effect of Nitinol implant porosity on Cranialbone ingrowth and apposition after 6 weeks显示文摘 | Ayers R Simske S Bateman T | 1999 | Biomed Mater Res1999，45，： | 1 |
| 9 | The proactive component of organi- zational behavior: A measure and correlates 显示文摘 | Bateman T S Crant J M | 1993 | Journal of Organizational Behavior1993，14，2： | 1 |
| 10 | A longitudinal analysis of the antecedents of organizational commitment显示文摘 | Bateman TS Strasser S | 1984 | Academy of Management Journal1984，27，1： | 1 |
| 11 | Rising prevalence of allergy to peanut in children:data from 2 sequential cohorts显示文摘 | Grundy J Matthews S Bateman B | 2002 | J Allergy Clin Immunol2002，110，： | 1 |
| 12 | Viral fusogenic membrane glycoprotein expression causes syncytia formation with bioenergetic cell death:implications for gene therapy显示文摘 | HIGUCHI H BRONK S F BATEMAN A | 2000 | Cancer Res2000，60，： | 1 |
| 13 | Sensor measurements for Wi-Fi location with emphasis on time-of-arrival ranging显示文摘 | GOLDEN S A BATEMAN S S | 2007 | IEEE Trans on Mobile Computing2007，6，10： | 1 |
| 14 | A longitudinal analysis of the antecedents of organizational commitment显示文摘 | Bateman T S Strasser S | | 0，，01： | 1 |
| 15 | The proactive component of organizational behavior: A measure and corre- lates显示文摘 | Bateman T S Crant J M | 1993 | Journal of Organizational Behavior1993，14，2： | 1 |
| 16 | Modem experincents in telepathy显示文摘 | Soal S G Bateman F Lenzen V F | 1955 | American Journal of Physics1955，23，： | 1 |
| 17 | Simultaneous production and pathogenesis by Sclerotium rolfsii显示文摘 | BEER S V | 1965 | Phytopathology1965，58，： | 1 |
| 18 | Evaluation of Ruminally Protected Methionine and Lysine or Blood Meal and Fishmeal as Protein Sources for Lactating Holsteins显示文摘 | Bateman H D Spain J N Kerley M S | 1999 | J Dairy Sci1999，82，8： | 1 |
| 19 | Evaluation of ruminally protected methionine and lysine or blood meal and fish meal as protein sources for lactating Holsteins显示文摘 | Bateman H D Spain J N Kerley M S | 1999 | J Dairy Sci1999，82，： | 1 |
| 20 | Molecular diagnosis of Stickler syndrome:a COL2A1 stop codon mutation screening strategy that is not compromised by mutant mRNA instability显示文摘 | Freddi S Savarirayan R Bateman JF | 2000 | Am J Med Genet2000，90，： | 1 |
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