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| 1 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 2 | Circulating miR-29a, Among Other Up-Regulated MicroRNAs, Is the Only Biomarker for Both Hypertrophy and Fibrosis in Patients With Hypertrophic Cardiomyopathy显示文摘 | Roberta Roncarati Chiara Viviani Anselmi Maria Angela Losi Laura Papa Elena Cavarretta Paula Da Costa Martins Carla Contaldi Gloria Saccani Jotti Anna Franzone Laura Galastri Michael V.G. Latronico Massimo Imbriaco Giovanni Esposito Leon De Windt Sandro B | 2014 | Journal of the American College of Cardiology2014，，9： | 2 |
| 3 | Interleukin-6-174G/C polymorphism is associated with a decreased risk of type 2 diabetes in patients with chronic hepatitis C virus显示文摘BACKGROUND Chronic hepatitis C(CHC)is associated with type 2 diabetes mellitus.Although the pathogenesis remains to be elucidated,a growing evidence has suggested a role of pro-inflammatory immune response.Increased serum concentrations of Interleukin 6(IL-6)have been associated with insulin resistance,type 2 diabetes mellitus as well as advanced forms of liver disease in chronic hepatitis C infection.AIM To investigate the frequency of IL-6-174G/C(rs1800795)single nucleotide polymorphism(SNP)in CHC patients and in healthy subjects of the same ethnicity.Associations between type 2 diabetes mellitus(dependent variable)and demographic,clinical,nutritional,virological and,IL-6 genotyping data were also investigated in CHC patients.METHODS Two hundred and forty-five patients with CHC and 179 healthy control subjects(blood donors)were prospectively included.Type 2 diabetes mellitus was diagnosed according to the criteria of the American Diabetes Association.Clinical,biochemical,histological and radiological methods were used for the diagnosis of the liver disease.IL-6 polymorphism was evaluated by Taqman SNP genotyping assay.The data were analysed by logistic regression models.RESULTS Type 2 diabetes mellitus,blood hypertension and liver cirrhosis were observed in 20.8%(51/245),40.0%(98/245)and 38.4%(94/245)of the patients,respectively.The frequency of the studied IL-6 SNP did not differ between the CHC patients and controls(P=0.81)and all alleles were in Hardy-Weinberg equilibrium(P=0.38).In the multivariate analysis,type 2 diabetes mellitus was inversely associated with GC and CC genotypes of IL-6-174(OR=0.42;95%CI=0.22-0.78;P=0.006)and positively associated with blood hypertension(OR=5.56;95%CI=2.79-11.09;P<0.001).CONCLUSION This study was the first to show that GC and CC genotypes of IL-6-174 SNP are associated with a decreased risk of type 2 diabetes mellitus in patients chronically infected with hepatitis C virus.The identification of potential inflammatory mediators involved in the crosstalk between hepatitis C virus and the axis pancreas-liver remains important issues that deserve further investigations. | Cliviany Borges da Silva Diego Alves Vieira Luisa Freitas de Melo Anna Luiza Soares Chagas Adriana Dias Gomes César Lúcio Lopes de Faria Jr Rosangela Teixeira Dulciene Maria de Magalh?es Queiroz Gifone Aguiar Rocha Maria Marta Sarquis Soares Juliana Maria Trindade Bezerra Luciana Diniz Silva | 2020 | World Journal of Hepatology2020，12，4： | 2 |
| 4 | Dual-polarization wavelength conversion of 16-QAM signals in a single silicon waveguide with a lateral p-i-n diode[Invited]显示文摘A polarization-diversity loop with a silicon waveguide with a lateral p-i-n diode as a nonlinear medium is used to realize polarization insensitive four-wave mixing. Wavelength conversion of seven dual-polarization 16-quadrature amplitude modulation(QAM) signals at 16 GBd is demonstrated with an optical signal-to-noise ratio penalty below 0.7 dB. High-quality converted signals are generated thanks to the low polarization dependence(≤0.5 dB) and the high conversion efficiency(CE) achievable. The strong Kerr nonlinearity in silicon and the decrease of detrimental free-carrier absorption due to the reverse-biased p-i-n diode are key in ensuring high CE levels. | FRANCESCO DA Ros ANDRZEJ GAJDA ERIK LIEBIG EDSON P.DA SILVA ANNA PECZEK PETER D.GIROUARD ANDREAS MAI KLAUS PETERMANN LARS ZIMMERMANN MICHAEL GALILI LEIF K.OXENLOWE | 2018 | Photonics Research2018，6，5： | 1 |
| 5 | Oxidation efficiency in the electro-Fenton process显示文摘 | Anna Da Pozzo Paola Ferrantelli Carlo Merli | 2005 | J Appl Electrochem2005，35，： | 1 |
| 6 | Contents of polyphenols in fruit and vegetables显示文摘 | Ewa Cieslik Anna Gre'da Wiktor Adamus | 2006 | Food Chemistry2006，，94： | 1 |
| 7 | An experimental comparison of a graphite electrode and a gas diffusion electrode for the cathodic production of hydrogen peroxide显示文摘 | Anna Da Pozzo Luca Di Palma Carlo Merli Elisabetta Petrucci | 2005 | Journal of Applied Electrochemistry2005，，4： | 1 |
| 8 | Oxidation efficiency in the electro-Fenton process显示文摘 | Anna da Pozza Paola Ferrantelli Carlo Merli Elisabetta Petrucci | 2005 | Journal of Applied Electrochemistry2005，，4： | 1 |
| 9 | Speckle reduction in polarimetric SAR imagery with stochastic dis- tances and nonlocal means 显示文摘 | TORRES L SANT'ANNA S J S da COSTA FREITAS C | 2014 | Pattern Recognition2014，47，1： | 1 |
| 10 | Oxidation efficiency in the electro-Fenton process显示文摘 | ANNA DA POZZO PAOLA FERRANTELLI | 2005 | Journal of Applied Electrochemistry2005，，35： | 1 |
| 11 | Proposed nomenclature for Pseudallescheria,Scedosporium and related genera显示文摘As a result of fundamental changes in the International Code of Nomenclature on the use of separate names for sexual and asexual stages of fungi,generic names of many groups should be reconsidered.Members of the ECMM/ISHAM working group on Pseudallescheria/Scedosporium infections herein advocate a novel nomenclature for genera and species in Pseudallescheria,Scedosporium and allied taxa.The generic names Parascedosporium,Lomentospora,Petriella,Petriellopsis,and Scedosporium are proposed for a lineage within Microascaceae with mostly Scedosporium anamorphs producing slimy,annellidic conidia.Considering that Scedosporium has priority over Pseudallescheria and that Scedosporium prolificans is phylogenetically distinct from the other Scedosporium species,some name changes are proposed.Pseudallescheria minutispora and Petriellidium desertorum are renamed as Scedosporium minutisporum and S.desertorum,respectively.Scedosporium prolificans is renamed as Lomentospora prolificans. | Michaela Lackner G.Sybren de Hoog Liyue Yang Leandro Ferreira Moreno Sarah A.Ahmed Fritz Andreas Josef Kaltseis Markus Nagl Cornelia Lass-Florl Brigitte Risslegger Gunter Rambach Cornelia Speth Vincent Robert Walter Buzina Sharon Chen Jean-Philippe Bouchara Jose F.Cano-Lira Josep Guarro Josepa Gené Fabiola Fernández Silva Rosa Haido Gerhard Haase Vladimir Havlicek Dea Garcia-Hermoso Jacques F.Meis Ferry Hagen Martin Kirchmair Johannes Rainer Katharina Schwabenbauer Mirjam Zoderer Wieland Meyer Felix Gilgado Vania A.Vicente Elena Piecková Monika Regenermel Peter-Michael Rath Joerg Steinmann Xisto Wellington de Alencar Francoise Symoens Kathrin Tintelnot Krzysztof Ulfig Aristea Velegraki Anna Maria Tortorano Sandrine Giraud Sara Mina Kinga Rigler-Hohenwarter Fernando L.Hernando Andoni Ramirez-Garcia Aize Pellon Jashanpreet Kaur Eliana Barreto Bergter Jardel Vieira de Meirelles Ingrid Dutra da Silva Laurence Delhaes Ana Alastruey-Izquerdo Ruo-yu Li Qiaoyun Lu Tarek Moussa Omar Almaghrabi Hassan Al-Zahrani Gen Okada Shuwen Deng Wangqing Liao Jingsi Zeng Jouni Issakainen Livia Cristina Liporagi Lopes | 2014 | Fungal Diversity2014，，4： | 1 |
| 12 | Heavy metal removal from synthetic wasterwaters in an anaerobic bioreactor using stillage from ethanol distilleries as carbon source 显示文摘 | Goncalvas M M M da Costa A C A Leite S G F Sant' Anna Jr G L | 2007 | Chemosphere2007，69，： | 1 |
| 13 | Strapping the spinal cord:An innovative ex- perimental model of CNS injury in rats 显示文摘 | Elizabete Sant Anna da Costa Antonia Lima Carvalho Ana Maria Blanco Martinez | 2008 | Journal of Neuro- science Methods2008，170，1： | 1 |
| 14 | Specklereduction in polarimetric SAR imagery with stochasticdistances and nonlocal means显示文摘 | Torres L Sant’Anna S J S Freitas C da C | 2014 | Pattern Recognition2014，47，1： | 1 |
| 15 | Early apoptosis in peripheral blood mononuclear cells from patients with bipolar disorder显示文摘 | Gabriel Rodrigo Fries Mirela Paiva Vasconcelos-Moreno Carolina Gubert Barbara Tietb?hl Martins Quadros dos Santos André Luiz Schuh Teixeira da Rosa Bárbara Eisele Juliana Sartori Bianca Pfaffenseller Flávio Kapczinski Márcia Kauer-Sant’Anna | 2014 | Journal of Affective Disorders2014，，： | 1 |
| 16 | A2A Adenosine Receptor Binding Parameters in Platelets from Patients Affected by Pathological Gambling显示文摘 | Martini Claudia Daniele Simona Picchetti Michela Panighini Anna Carlini Marina Trincavelli Maria Letizia Cesari Daniela Da Pozzo Eleonora Golia Francesca Dell’osso Liliana | 2011 | Neuropsychobiology2011，，3： | 1 |
| 17 | Evidence for overlapping and Distinct Functions in Protein Transport of Coat Protein Sec24p Family Members显示文摘 | Renwang P Anna DA Dieter G | 2000 | J Biol Chen2000，275，11： | 1 |
| 18 | Ophthalmologic findings in a large pedigree of 11778/Haplogroup J Leber hereditary optic neuropathy显示文摘 | Federico Sadun Anna Maria De Negri Valerio Carelli Solange R. Salomao Adriana Berezovsky Rafael Andrade Milton Moraes Angelo Passos Rubens Belfort Arlon Bastos Da Rosa Peter Quiros Alfredo A. Sadun | 2003 | American Journal of Ophthalmology2003，，： | 1 |
| 19 | Thoracoscopic Water P|eurectomy for the Treatment of Recurrent Spontaneous Pneumo- thorax 显示文摘 | Claudio A Antonio DA Anna MC et al | 2014 | Ann Thorac Surg2014，12，5： | 1 |
| 20 | Evaluation of selected ultrasonographic parameters and marker levels in the preoperative differentiation of borderline ovarian tumors and ovarian cancers显示文摘 | Piotr Sobiczewski Anna Dańska-Bidzińska Jakub Rzepka Jolanta Kupryjańczyk Mariusz Gujski Mariusz Bidziński Wojciech Michalski | 2012 | Archives of Gynecology and Obstetrics2012，，6： | 1 |
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