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| 1 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 2 | Circulating miR-29a, Among Other Up-Regulated MicroRNAs, Is the Only Biomarker for Both Hypertrophy and Fibrosis in Patients With Hypertrophic Cardiomyopathy显示文摘 | Roberta Roncarati Chiara Viviani Anselmi Maria Angela Losi Laura Papa Elena Cavarretta Paula Da Costa Martins Carla Contaldi Gloria Saccani Jotti Anna Franzone Laura Galastri Michael V.G. Latronico Massimo Imbriaco Giovanni Esposito Leon De Windt Sandro B | 2014 | Journal of the American College of Cardiology2014，，9： | 2 |
| 3 | microRNAs in cardiovascular diseases: current knowledge and the road ahead显示文摘 | Gianluigi Condorelli Michael V. G Latronico Elena Cavarretta | 2014 | Journal of the American College of Cardiology2014，，： | 2 |
| 4 | Integrin-targeting with peptide-bioconjugated semiconductor-magnetic nanocrystalline heterostructures显示文摘二进制不对称的 nanocrystals (BNC ) ,加入的光敏的 TiO 2 nanorod 填写了 superparamagnetic -Fe2O3 球形的领域,在聚乙烯乙二醇被嵌入修改 phospholipid micelle 并且成功地 bioconjugated 到包含一个 RGD 主题的合适设计的肽。BNC 表示由于在一个粒子的二个不同领域的共存,相关多功能的 nanomaterial 由高 photoactivity 和磁性描绘了,那特别地在生物成像用作光线疗法和过高热代理人以及一根磁性的探针被适合。我们选择了 RGD 主题以便指向在激活的 endothelial 房间和癌症房间的几种类型上表示的 integrin。准备 RGD-peptide/BNC 结合,包括地由使用互补光、结构的技术监视了,在生物媒介表明了高稳定性和一致可分散性。RGD-peptide/BNC 的 cytotoxicity 结合在 vitro 被学习。RGD 肽的细胞的举起在房间结合,在房间 lysates 借助于二条不同途径,也就是共焦的显微镜学分析和排放光谱学决心估计了, RGD-peptide-BNC 的显示的选择为 v3 integrin 结合。这些 RGD-peptide-BNC 结合为癌症的 theranostic 治疗有一个高潜力。 | Gianpiero Valente Nicoletta Depalo Ivan de Paola Rosa Maria lacobazzi Nunzio Denora Valentino Laquintana Roberto Comparelli Emiliano Altamura Tiziana Latronico Michele Altomare Elisabetta Fanizza Marinella Striccoli Angela Agostiano Michele Saviano Annarita Del Gatto Laura Zaccaro Maria Lucia Curri | 2016 | Nano Research2016，9，3： | 2 |
| 5 | MicroRNAs in heart disease : putative novel therapeutic targets? 显示文摘 | Condorelli G Latronico MV Dorn GW | 2010 | Eur Heart J2010，31，6： | 1 |
| 6 | Polymorphismsin the bovine follicle-stimulating hormone receptorgeue 显示文摘 | Ahal P Latronico A C Kohek M B | 2000 | Animal Genetics2000，31，4： | 1 |
| 7 | Impact of mutations in kisspeptin and neurokinin B signaling pathways on human reproduction显示文摘 | Silveira LG Tusset C Latronico AC | 2010 | Brain Res2010，1364，： | 1 |
| 8 | Genetics basis for GnRH dependent pubertal disorders in humans显示文摘 | Silveira L F Trarbach E B Latronico A C | 2010 | Mol Cell Endocrinol2010，324，： | 1 |
| 9 | Emerging role of microRNAs in cardiovascular biology显示文摘 | Latronico MV Catalueci D Condorelli G | 2007 | Circ Res2007，101，12： | 1 |
| 10 | Critical illness polyneuropathy and myopathy:a major cause of muscle weakness and paralysis显示文摘 | Latronico N Bolton CF | 2011 | Lancet Neurol2011，10，10： | 1 |
| 11 | Critical illness myopathy and neuropathy显示文摘 | Latronico N Peli E Botteri M | 2005 | Current Opinion In Critical Care2005，11，： | 1 |
| 12 | Neuromuscular sequelae of critical illness显示文摘 | Latronico N Shehu I Seghelini E | 2005 | Curr Opin Crit Care2005，11，4： | 1 |
| 13 | Critical illness myopathy and neuropathy 显示文摘 | Latronico N Guameri B | 2008 | Minerva Anestesiol2008，74，6： | 1 |
| 14 | Role of ACTH receptor in adrenocortical tumor formation显示文摘 | Latronico AC | 2000 | Braz J Med Biol Res2000，33，10： | 1 |
| 15 | Advanced' generation lentiviruses as efficient vectors for cardiomyocyte gene transduction in vitro and in vivo显示文摘 | Bonci D Cittadini A Latronico MY | 2003 | Gene Ther2003，10，： | 1 |
| 16 | Critical illness polyneuropathy and myopathy: a major cause of muscle weakness and paralysis显示文摘 | Latronico N Bolton CF | 2011 | Lancet Neurol2011，10，： | 1 |
| 17 | Criticai illness myopathy and neurop?athy显示文摘 | Latronico N Guarneri B | 2008 | Minerva Anestesiol2008，74，6： | 1 |
| 18 | Critical illness myopathy and neuropathy显示文摘 | Latronico N Peli E Botteri M | 2005 | Curr Opin Crit Care2005，11，2： | 1 |
| 19 | Approach to the patient withhypogonadotropic hypogonadism显示文摘 | Silveira LF Latronico AC | 2013 | J Clin Endocrinol Metab2013，98，5： | 1 |
| 20 | A single lute- inizing hormone determination 2 hours after depot leupro- lide is useful for therapy monitoring of gonadotropin-de- pendent precocious puberty in girls显示文摘 | Brito VN Latronico AC Arnhold IJ | 2004 | J Clin Endoerinol Metab2004，89，9： | 1 |
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