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| 1 | Inflammatory colonic carcinogenesis: A review on pathogenesis and immunosurveillance mechanisms in ulcerative colitis显示文摘Ulcerative colitis(UC)is characterized by repeated flare-ups of inflammation that can lead to oncogenic insults to the colonic epithelial.UC-associated carcinogenesis presents a different sequence of tumorigenic events compared to those that contribute to the development of sporadic colorectal cancer.In fact,in UC,the early events are represented by oxidative DNA damage and DNA methylation that can produce an inhibition of oncosuppressor genes,mutation of p53,aneuploidy,and microsatellite instability.Hypermethylation of tumor suppressor and DNA mismatch repair gene promoter regions is an epigenetic mechanism of gene silencing that contribute to tumorigenesis and may represent the first step in inflammatory carcinogenesis.Moreover,p53 is frequently mutated in the early stages of UC-associated cancer.Aneuploidy is an independentrisk factor for forthcoming carcinogenesis in UC.Epithelial cell-T-cell cross-talk mediated by CD80 is a key factor in controlling the progression from low to high grade dysplasia in UC-associated carcinogenesis. | Marco Scarpa Ignazio Castagliuolo Carlo Castoro Anna Pozza Melania Scarpa Andromachi Kotsafti Imerio Angriman | 2014 | World Journal of Gastroenterology2014，20，22： | 22 |
| 2 | Mitochondrial uncoupling protein 2 and pancreatic cancer:A new potential target therapy显示文摘Overall 5-years survival of pancreatic cancer patients is nearly 5%,making this cancer type one of the most lethal neoplasia.Furthermore,the incidence rate of pancreatic cancer has a growing trend that determines a constant increase in the number of deceases caused by this pathology.The poor prognosis of pancreatic cancer is mainly caused by delayed diagnosis,early metastasis of tumor,and resistance to almost all tested cytotoxic drugs.In this respect,the identification of novel potential targets for new and efficient therapies should be strongly encouraged in order to improve the clinical management of pancreatic cancer.Some studies have shown that the mitochondrial uncoupling protein 2(UCP2) is over-expressed in pancreatic cancer as compared to adjacent normal tissues.In addition,recent discoveries established a key role of UCP2 in protecting cancer cells from an excessive production of mitochondrial superoxide ions and in the promotion of cancer cell metabolic reprogramming,including aerobic glycolysis stimulation,promotion of cancer progression.These observations together with the demonstration that UCP2 repression can synergize with standard chemotherapy to inhibit pancreatic cancer cell growth provide the molecular rationale to consider UCP2 as a potential therapeutic target for pancreatic cancer.In this editorial,recent advances describing the relationship between cancer development and mitochondrial UCP2 activity are critically provided. | Massimo Donadelli Ilaria Dando Elisa Dalla Pozza Marta Palmieri | 2015 | World Journal of Gastroenterology2015，21，11： | 9 |
| 3 | Effects of percutaneous varicocele repair on testicular volume:results from a 12-month follow-up显示文摘Varicocele is a comm on fin ding in men. Varicocele correcti on has bee n advocated for young patients with testicular hypotrophy, but there is a lack of morphofunctional follow-up data. We assessed whether percutaneous treatment of left varicocele is associated with testicular 'catch-up growth' in the following 12 months by retrospectively reviewing data from an electronic database of 10 656 patients followed up in our clinic between 2006 and 2016. We selected all young adults (<35 years) with left varicocele who un derwe nt percuta neous treatment, had a minimum of 12 mon ths' ultraso und imagi ng follow-up, and had no other con ditions affecting testicular volume. One hundred and fourteen men (mean±standard deviation [s.d.] of age: 22.8 ± 5.4 years) met the inclusion and exclusion criteria. Left testicular hypotrophy (LTH), defined as a >20% difference between left and right testicular volume at baseline, was observed in 26 (22.8%) men. Participants with LTH (mean±s.d.: 14.5 ± 2.7 ml) had lower baseline testicular volume compared to those without LTH (mean±s.d.: 15.7 ± 3.8 ml;P= 0.032). Repeated measures mixed models showed a sign ifica nt in teraction betwee n LTH and time posttreatme nt when correcting for baseli ne left testicular volume (β= 0.114, 95% confidence interval [Cl]: 0.018-0.210, P=0.020), resulting in a catch-up growth of up to 1.37 ml per year (95% Cl: 0.221- 2.516). Age at intervention was also associated with reduced testicular volume (-0.072 ml per year, 95% Cl:-0.135--0.009;P = 0.024). Percutaneous treatment of left varicocele in young adults with LTH can result in catch-up growth over 1 year of follow-up. The reproductive and psychological implicati ons of these findings n eed to be confirmed in Ion ger and larger prospective studies. | Andrea Sansone Danilo Alunni Fegatelli Carlotta Pozza Giorgio Fattorini Rosa Lauretta Marianna Minnetti Francesco Romanelli Pierleone Lucatelli Mario Corona Mario Bezzi Francesco Lombardo Andrea Lenzi Daniele Gianfrilli | 2019 | Asian Journal of Andrology2019，21，4： | 8 |
| 4 | pregnane X receptor and constitutive androstane receptor modulate differently CYp3A-mediated metabolism in earlyand late-stage cholestasis显示文摘AIM To ascertain whether cholestasis affects the expression of two CYP3 A isoforms(CYP3 A1 and CYP3 A2) and of pregnane X receptor(PXR) and constitutive androstane receptor(CAR).METHODS Cholestasis was induced by bile duct ligation in 16 male Wistar rats; whereas 8 sham-operated rats were used as controls. Severity of cholestasis was assessed on histological examination of liver sections, and serum concentrations of albumin, AST, ALT, GGT, ALPK and bilirubin. Gene and protein expressions of PXR, CAR, CYP3 A1 and CYP3 A2 were assessed by means of q RT-PCR and Western blot, respectively. Alterations in CYP3 A activity were measured by calculating the kinetic parameters of 4-OH and 1'-OH-midazolam hydroxylation, marker reactions for CYP3 A enzymes.RESULTS The m RNA and protein expression of CYP3 A1 increased significantly in mild cholestasis(P < 0.01). At variance, m RNA and protein expression of CYP3 A2 didn't change in mild cholestasis, whereas the expression and activity of both CYP3 A1 and CYP3 A2 decreased dramatically when cholestasis became severe. Consistently with these observations, the nuclear expression of both PXR and CAR, which was measured because they both translocate into the cell nucleus after their activation, virtually disappeared in the late stage of cholestatic injury, after an initial increase. These results indicate that early-and late-stage cholestasis affects CYP3 Amediated drug metabolism differently, probably as consequence of the different activation of PXR and CAR.CONCLUSION Early-and late-stage cholestasis affects CYP3 Amediated drug metabolism differently. PXR and CAR might be targeted therapeutically to promote CYP3 Amediated liver detoxification. | Daniela Gabbia Arianna Dalla Pozza Laura Albertoni Roberta Lazzari Giorgia Zigiotto Maria Carrara Vincenzo Baldo Tatjana Baldovin Annarosa Floreani Sara De Martin | 2017 | World Journal of Gastroenterology2017，23，42： | 5 |
| 5 | Para-aortic node involvement is not an independent predictor of survival after resection for pancreatic cancer显示文摘AIM To analyze the importance of para-aortic node status in a series of patients who underwent pancreaticoduodenectomy(PD)in a single Institution.METHODS Between January 2000 and December 2012,151patients underwent PD with para-aortic node dissection for pancreatic adenocarcinoma in our Institution.Patients were divided into two groups:patients with negative PALNs(PALNs-),and patients with metastatic PALNs(PALNs+).Pathologic factors,including stage,nodal status,number of positive nodes and lymph node ratio,invasion of para-aortic nodes,tumor’s grading,and radicality of resection were studied by univariate and multivariate analysis.Survival curves were constructed with Kaplan-Meier method and compared with Log-rank test:significance was considered as P<0.05.RESULTS A total of 107 patients(74%)had nodal metastases.Median number of pathologically assessed lymph nodes was 26(range 14-63).Twenty-five patients(16.5%) had para-aortic lymph node involvement.Thirty-three patients(23%)underwent R1 pancreatic resection.Onehundred forty-one patients recurred and died for tumor recurrence,one is alive with recurrence,and 9 are alive and free of disease.Overall survival was significantly influenced by grading(P=0.0001),radicality of resection(P=0.001),stage(P=0.03),lymph node status(P=0.04),para-aortic nodes metastases(P=0.02).Multivariate analysis showed that grading was an independent prognostic factor for overall survival(P=0.0001),while grading(P=0.0001)and radicality of resection(P=0.01)were prognostic parameters for disease-free survival.Number of metastatic nodes,node ratio,and para-aortic nodes involvement were not independent predictors of disease-free and overall survival.CONCLUSION In this experience,lymph node status and para-aortic node metastases were associated with poor survival at univariate analysis,but they were not independent prognostic factors. | Cosimo Sperti Mario Gruppo Stella Blandamura Michele Valmasoni Gioia Pozza Nicola Passuello Valentina Beltrame Lucia Moletta | 2017 | World Journal of Gastroenterology2017，23，24： | 5 |
| 6 | 日粮中添加氨基酸降低粗蛋白含量对6~15kg仔猪生产性能的影响显示文摘为评价添加氨基酸降低粗蛋白(CP)含量对6~15 kg仔猪的影响,共设计两个试验。在性能试验中(试验Ⅰ),21日龄、初始体重为5.95±0.33 kg的断奶仔猪120头被分成5组。试验为完全随机区组试验设计,共8个重复,每个重复3只猪。在5个处理组中,CP含量由21.0%降低到15.0%(分别为21.0%,19.5%,18.0%,16.5%和15.0%),通过添加L-赖氨酸、DL-蛋氨酸、L-苏氨酸、L-色氨酸、L-缬氨酸和L-异亮氨酸来满足日粮中氨基酸的需求。各处理间生产性能无显著差异。因此,以上蛋白质的任何水平都能被有效的合成氨基酸。降低蛋白质的含量可以增加必需氨基酸和非必需氨基酸的比值,且蛋白质含量为15%时比值最佳(5347)。随着蛋白质含量的降低,尿素含量线性下降(试验Ⅰ)。为评估氮平衡(试验Ⅱ),21日龄的杂交阉割商品仔猪20只被随机分成5组,仔猪的平均活重为10.79±2.19kg。5个处理组的所有动物安置在铁笼中,每个处理4个重复,每个重复1只猪。结果血液和尿液中尿素含量随蛋白质含量的减少线性降低(P〈0.05),进而减少了动物向环境中的氮排泄。 | Toledo J B Furlan A C Pozza P C Pianob L M Carvalho P L O Peuela-Sierra L M Huepa L M D | 2014 | 饲料博览2014，0，11： | 3 |
| 7 | Pancreatic resection in very elderly patients:A critical analysis of existing evidence显示文摘The aging of the population results in a rise of number of elderly patients(aged 80 years and older) with pancreatic or periampullary cancer, and more pancreatectomies could eventually be performed in such complex patients. However, early and long-term results after pancreatic resection in octogenarians are still controversial, and may trouble the surgeon when approaching this type of population. Evaluation of reported experiences shows that for almost all Authors, pancreatectomy can be performed safely in elderly population, although overall morbidity and mortality rates were 34.9% and 13.2% respectively, with a mean length of hospital stay of 18 d. These features appear higher in older patients compared to the younger counterpart. Less than 50% of patients underwent adjuvant therapy after operation. Long-term survival is reported not significantly different in aged 80 years and older patients, with a median overall survival time of 17.6 mo. The quality of life after pancreatic resection is only sporadically evaluated but, when considered, it highlights the need of health facility service after operation for these 'frail' patients. Prospective studies on the quality of life of pancreatectomized octogenarians are welcome. Proper selection of patients, geriatric assessment with multidisciplinary approach, centralization of pancreatic surgery in high-volume centres and rehabilitation programs after surgery appear to be crucial points in order to improve surgical treatments of pancreatic tumors in very elderly patients. | Cosimo Sperti Lucia Moletta Gioia Pozza | 2017 | World Journal of Gastrointestinal Oncology2017，9，1： | 2 |
| 8 | UCP2 inhibition triggers ROS-dependent nuclear translocation of GAPDH and autophagic cell death in pancreatic adenocarcinoma cells显示文摘 | Ilaria Dando Claudia Fiorini Elisa Dalla Pozza Chiara Padroni Chiara Costanzo Marta Palmieri Massimo Donadelli | 2013 | BBA - Molecular Cell Research2013，，3： | 2 |
| 9 | Tumor angiogenesis: a new significant and independent prognostic indicator in early -stage breast carcinoma显示文摘 | WEIDNER N FOLKMAN J POZZA F | 1992 | Natl Cancer Inst1992，84，24： | 1 |
| 10 | Tumor angiogenesis:a new significant and independent prognostic indicator in early stage breast carcinoma显示文摘 | Weider N Folknmn J Pozza F | 1992 | J Natl Cancer Inst1992，84，： | 1 |
| 11 | Tumor angiogenesis: a new significant and independent prognostic indicator in early stage breast carcinoma显示文摘 | Weidner N Folkman J Pozza F | 1992 | J Natl Cancer Inst1992，84，24： | 1 |
| 12 | Tumor angiogenosis: A new significant and independent prognosis indicator in early stage breast carcinoma显示文摘 | Weidner N Folkman J Pozza F | 1992 | JNCI1992，84，： | 1 |
| 13 | Tumor angiogenesis : a new significant and independent prognostic indicatorin early - stage breas carcinoma 显示文摘 | Weidner N Folkman J Pozza F | 1992 | J Natl Cancer Inst1992，84，7： | 1 |
| 14 | One-wound laparoscopic cholecystectomy显示文摘 | Navarra G Pozza E Oechionorelli S | 1997 | Br J Surg1997，84，5： | 1 |
| 15 | Tumor angiogenesis a new significant and independent prognostic factor in early-stage breast carcinoma显示文摘 | Weidner N Folkman J Pozza R | 1992 | Journal of the National Cancer Institute1992，84，24： | 1 |
| 16 | Tumor angiogenesis: a new significant and independent prognostic indicator in early- stage breast carcinoma显示文摘 | Weidner N Folkman J Pozza F | 1992 | J Natl Cancer Inst1992，84，24： | 1 |
| 17 | One-wound laparoscopic cholecystectomy显示文摘 | Navarra G Pozza E Occhionorelli S | 1997 | Br J Surg1997，84，5： | 1 |
| 18 | Tumor anglo genesis:a new significant and independent prognostic indictor in early stage breast carcinoma显示文摘 | WEIDNER N FOLKMAN J POZZA F | 1992 | Natl Cancer Inst1992，84，6： | 1 |
| 19 | Medical treatment to improve sperm quality 显示文摘 | Isidori AM Pozza C Gianfrilli D | 2006 | Reprod Biomed Online2006，12，6： | 1 |
| 20 | One-wound laparoscopic cholecystectomy显示文摘 | Navarra G Pozza E Occhionorelli S | | 0，，： | 1 |
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