|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Molecular aspects of intestinal calcium absorption显示文摘Intestinal Ca2+ absorption is a crucial physiological process for maintaining bone mineralization and Ca2+ homeostasis. It occurs through the transcellular and paracellular pathways. The first route comprises 3steps: the entrance of Ca2+ across the brush border membranes(BBM) of enterocytes through epithelial Ca2+ channels TRPV6, TRPV5, and Cav1.3; Ca2+ movement from the BBM to the basolateral membranes by binding proteins with high Ca2+ affinity(such as CB9k); and Ca2+ extrusion into the blood. Plasma membrane Ca2+ ATPase(PMCA1b) and sodium calcium exchanger(NCX1) are mainly involved in the exit of Ca2+ from enterocytes. A novel molecule, the 4.1R protein, seems to be a partner of PMCA1 b, since both molecules colocalize and interact. The paracellular pathway consists of Ca2+ transport through transmembrane proteins of tight junction structures, such as claudins 2, 12, and 15. There is evidence of crosstalk between the transcellular and paracellular pathways in intestinal Ca2+ transport. When intestinal oxidative stress is triggered, there is a decrease in the expression of several molecules of both pathways that inhibit intestinal Ca2+ absorption. Normalization of redox status in the intestine with drugs such as quercetin, ursodeoxycholic acid, or melatonin return intestinal Ca2+ transport to control values. Calcitriol [1,25(OH)2D3] is the major controlling hormone of intestinal Ca2+ transport. It increases the gene and protein expression of most of the molecules involved in both pathways. PTH, thyroid hormones, estrogens, p ro l a c t i n, g ro w t h h o r m o n e, a n d g l u c o c o r t i c o i d s apparently also regulate Ca2+ transport by direct action, indirect mechanism mediated by the increase of renal 1,25(OH)2D3 production, or both. Different physiological conditions, such as growth, pregnancy, lactation, and aging, adjust intestinal Ca2+ absorption according to Ca2+ demands. Better knowledge of the molecular details of intestinal Ca2+ absorption could lead to the development of nutritional and medical strategies for optimizing the efficiency of intestinal Ca2+ absorption and preventing osteoporosis and other pathologies related to Ca2+ metabolism. | Gabriela Diaz de Barboza Solange Guizzardi Nori Tolosa de Talamoni | 2015 | World Journal of Gastroenterology2015，21，23： | 20 |
| 2 | Oxidative stress, antioxidants and intestinal calcium absorption显示文摘The disequilibrium between the production of reactive oxygen(ROS) and nitrogen(RNS) species and their elimination by protective mechanisms leads to oxidative stress. Mitochondria are the main source of ROS as by-products of electron transport chain. Most of the time the intestine responds adequately against the oxidative stress, but with aging or under conditions that exacerbate the ROS and/or RNS production, the defenses are not enough and contribute to developing intestinal pathologies. The endogenous antioxidant defense system in gut includes glutathione(GSH) and GSH-dependent enzymes as major components. When the ROS and/or RNS production is exacerbated, oxidative stress occurs and the intestinal Ca2+ absorption is inhibited. GSH depleting drugs such as DLbuthionine-S,R-sulfoximine, menadione and sodium deoxycholate inhibit the Ca2+ transport from lumen to blood by alteration in the protein expression and/or activity of molecules involved in the Ca2+ transcellular and paracellular pathways through mechanisms of oxidative stress, apoptosis and/or autophagy. Quercetin, melatonin, lithocholic and ursodeoxycholic acids block the effect of those drugs in experimental animals by their antioxidant, anti-apoptotic and/or anti-autophagic properties. Therefore, they may become drugs of choice for treatment of deteriorated intestinal Ca2+ absorption under oxidant conditions such as aging, diabetes, gut inflammation and other intestinal disorders. | Gabriela Diaz de Barboza Solange Guizzardi Luciana Moine Nori Tolosa de Talamoni | 2017 | World Journal of Gastroenterology2017，23，16： | 18 |
| 3 | Role of immunosuppression and tumor differentiation in predicting recurrence after liver transplantation for hepatocellular carcinoma: A multicenter study of 412 patients显示文摘AIM: To assess pre-orthotopic liver transplantation (OLT) factors that could be evaluated pre-operatively or con- trolled post-operatively associated with hepatocellular carcinoma (HCC) recurrence and disease-free survival after liver transplantation (LT).METHODS: Four hundred and twelve patients trans- planted for HCC between 1988 and 1998 in 14 French centers, who survived the postoperative period were studied. Kaplan Meier estimates were calculated for 24 variables potentially associated with recurrence of HCC. Uni- and multivariate analyses were conducted to iden- tify independent predictors of recurrence. RESULTS: Overall 5-year disease-free survival was 57.1%. By univariate analysis, variables associated with disease-free survival were: presence of cirrhosis (P = 0.001), etiology of liver disease (P = 0.03), α fetoprotein level (< 200, 200 to 2000, or > 2000; P < 0.0001), γ-GT activity (N, N to 2N or > 2N; P = 0.02), the number of nodules (1, 2-3 or ≥ 4; P = 0.02), maximal diameter of the largest nodule (< 3 cm, 3 to 5 cm or > 5 cm; P < 0.0001), the sum of the diameter of the nodules (< 3 cm, 3 to 5 cm, 5 to 10 cm or >10 cm; P < 0.0001), bi- lobar location (P = 0.01), preoperative portal thrombosis (P < 0.0001), peri-operative treatment of the tumor (P = 0.002) and chemoembolization (P = 0.03), tumor differentiation (P = 0.01), initial type of calcineurin inhibitor (P = 0.003), the use of antilymphocyte antibodies (P = 0.02), rejection episodes (P = 0.003) and period of LT (P < 0.0001). By multivariate analysis, 6 variables were independently associated with HCC recurrence: maximal diameter of the largest nodule (P < 0.0001), time of LT (P < 0.0001), tumor differentiation (P < 0.0001), use of anti-lymphocyte antibody (ATG) or anti-CD3 antibody (OKT3) (P = 0.005), preoperative portal thrombosis (P = 0.06) and the number of nodules (P = 0.06). CONCLUSION: This study identif ies immunosuppression, through the use of ATG or OKT3, as a predictive factor of tumor recurrence, and confi rms the prognostic value of tumor differentiation. | Thomas Decaens Franoise Roudot-Thoraval Solange Bresson-Hadni Carole Meyer Jean Gugenheim Francois Durand Pierre-Henri Bernard Olivier Boillot Philippe Compagnon Yvon Calmus Jean Hardwigsen Christian Ducerf Georges Philippe Pageaux Sébastien Dharancy Olivier Chazouillères Daniel Cherqui Christophe Duvoux | 2006 | World Journal of Gastroenterology2006，12，45： | 10 |
| 4 | The Effects of a Multiple Family Therapy on Adolescents with Eating Disorders: An Outcome Study显示文摘 | Zoé Gelin Silvana Fuso Stephan Hendrick Solange Cook‐Darzens Yves Simon | 2015 | Fam. Proc2015，，1： | 5 |
| 5 | A historical view of alveolar echinococcosis, 160 years after the discovery of the first case in humans: part 1. What have we learnt on the distribution of the disease and on its parasitic agent?显示文摘自从著名科学家鲁道夫·弗乔在 1855 在疾病的起源在南部的德国和一个寄生虫的正确鉴定观察的开始的 2 个盒子,牙槽的包虫病(AE ) 的地方性的区域的边阶从来没停下来过膨胀。寄生虫连续地在瑞士被认出,然后为疾病在长的俄国,奥地利和法国考虑了同样唯一的地方性的区域。盒子在 1939 在土耳其被揭示;然后,许多注意对阿拉斯加并且到北海道被给予,在日本。状况完全由科学家的国际社区在中国地方性的区域的识别以后在 1991 变化了。世界地图被 AE 的鉴定,并且由盒子的识别在中亚在大多数中央 / 东方的欧洲和波罗的语州的国家在第 21 世纪的开始完成。直到现在,疾病从来然而没在南方半球并且在英国被报导过。在 mid-1950s ,由在阿拉斯加的 Rausch 和德国诗人,并且由在德国的 Vogel 的示范,在 2 寄生虫种类之间的区别负责分别地为膀胱的包虫病(“胞虫疾病”)和 AE 结束在“二元论者”之间的长持续的争论,谁相信了那最后证明了真的理论,和“ unicists ”,相信了为两疾病负责的单个种。在第 20 世纪的结束,分子的生物学充分证实了“二元论者”理论当把几新种加到开始描述的 E 时。granulosus;在过去的十年以内,它也证实很少变化在西藏的高原上在一些中间的动物宿主在包虫(E.) multilocularis 种类,和那 AE-Iooking 感染以内存在确实由于新种,从 E 不同。multilocularis,命名 E。shiquicus。自从 1970 年代,在风景之间的唯一的生态的相互作用,主人,和 E。multilocu/aris 日益增多地被描出。为寄生虫周期的维护的啮齿类动物 / 兔类动物水库尺寸的重要角色在第 20 世纪的最后 2 十年以内被认出了。并且在在由农业 / 林地的陆地使用的小哺乳动物和个性的高密度之间的一种靠近的关系的发现在污染压力上强调了政治 / 经济的决定的责任。在欧洲和日本和在中国的狗的主要角色的狐狸的都市化关于权威的主人和预防措施在 21 st 世纪的开始代表新买卖。 | Dominique Angele Vuitton WANG Qian ZHOU Hong-xia Francis Raoul Jenny Knapp Solange Bresson-Hadni WEN Hao Patrick Giraudoux | 2011 | Chinese Medical Journal2011，，18： | 5 |
| 6 | Factors Associated With Response to Therapy and Outcome of Patients With Primary Biliary Cirrhosis With Features of Autoimmune Hepatitis显示文摘 | Ersan Ozaslan Cumali Efe Alexandra Heurgué–Berlot Taylan Kav Chiara Masi Tugrul Purnak Luigi Muratori Yücel Ustündag Solange Bresson–Hadni Gérard Thiéfin Thomas D. Schiano Staffan Wahlin Paolo Muratori | 2014 | Clinical Gastroenterology and Hepatology2014，，： | 3 |
| 7 | Helicobacter pylori-negative Russell body gastritis:Case report显示文摘Russell body gastritis is an unusual form of chronic gastritis characterized by the permeation of lamina propria by numerous plasma cells with eosinophilic cytoplasmic inclusions.Very few cases have been reported in the literature;the majority of which have shown Helicobacter Pylori(H.pylori)infection,thus suggesting a correlation between plasma cell presence and antigenic stimulation by H.pylori.We present a case of Russell body gastritis in a 78-year-old woman who was undergoing esophagogastroduodenoscopy for epigastric pain.Gastric biopsy of the gastroesophageal junction showed the presence of cells with periodic acid-Schiff-positive hyaline pink bodies.Giemsa staining for H.pylori infection was nega-tive,as well as immunohistochemical detection.The cells with eosinophilic inclusions stained positive for CD138,CD79a,andκand lambda light chains,which confirmed plasma cell origin.In particular,κand lambda light chains showed a polyclonal origin and the patient was negative for immunological dyscrasia.The histological observations were confirmed by ultrastructural examination.The cases reported in the literature associated with H.pylori infection have shown regression of plasma cells after eradication of H.pylori.Nothing is known about the progression of H.pylori-negative cases.The unusual morphological appearance of this type of chronic gastritis should not be misinterpreted during routine examination,and it should be distinguished from other common forms of chronic gastritis.It is mandatory to exclude neoplastic diseases such as gastric carcinoma, lymphoma and plasmocytoma by immunohistochemistry and electron microscopy,which can help with differential diagnosis.The long-term effects of plasma cells hyperactivation are still unknown,because cases of gastric tumor that originated in patients affected by Russell body gastritis have not been described in the literature.We are of the opinion that these patients should be scheduled for endoscopic surveillance. | Alessandro Del Gobbo Luca Elli Paola Braidotti Franca Di Nuovo Silvano Bosari Solange Romagnoli | 2011 | World Journal of Gastroenterology2011，17，9： | 3 |
| 8 | Starch Digestibility and Physicochemical and Cooking Properties of Irradiated Rice Grains显示文摘This study evaluated the starch digestibility, physicochemical properties and cooking characteristics of polished rice(varieties IRGA417 and IAC202) subjected to the doses of 0(as the control), 1, 2 and 5 k Gy of gamma radiation. The highest dose decreased the apparent amylose content, peak viscosity, water absorption and volume expansion. Irradiation increased the solid loss by 119% and 187% for IAC202 and IRGA417, respectively, when comparing the higher dose with the control. For IAC202, irradiation decreased the rapidly digestible starch and increased the slowly digestible starch(SDS) and resistant starch(RS). IRGA417 showed an elevation of SDS and a reduction in RS. And 1 k Gy dose of gamma radiation generated the highest level of RS for both the two varieties and presented the smallest changes in other physicochemical and cooking properties. | Luís Fernando POLESI Manoel Divino da MATTA JUNIOR Silene Bruder Silveira SARMENTO Solange Guidolin CANNIATTI-BRAZACA | 2017 | Rice science2017，24，1： | 3 |
| 9 | 磷酸蒸馏-离子色谱法测定药物中的氰根总量显示文摘建立了磷酸蒸馏-离子色谱法测定药物中氰根总量的方法。样品在加入磷酸的环境下,加热蒸馏,将氰根转化成氰化氢的形式被蒸馏出来,经过冷凝管后被氢氧化钠溶液吸收。吸收液用离子色谱-安培检测器测定氰根含量。离子色谱条件:IonPac AS11-HC色谱柱(250mm×4mm)和IonPac AG11-HC保护柱(50mm×4mm),流量1.0mL·min^-1,4mmol·L^-1氢氧化钠淋洗液。氰根的质量浓度在0.02~1.0mg·L^-1内与其峰面积之间呈线性关系,相关系数为0.999 7,检出限(3S/N)为0.004 mg·L^-1,样品的加标回收率为100%~102%,相对标准偏差(n=6)为1.0%~2.1%。该方法灵敏度好、精密度和重复性高,有效避免了药物基体的干扰,为难以消除的基体药物中氰根的测定提供新方法和新思路。 | 栾绍嵘 刘鹏宇 张芳芳 SOLANGE Muhayimana 倪力军 | 2020 | 理化检验(化学分册)2020，56，4： | 3 |
| 10 | 粘虫谷氨酰胺转胺酶(MsTGase)活力测定条件的正交优化及其在幼虫体内的分布显示文摘【目的】本研究旨在优化Grossowicz氧肟酸比色法测定粘虫Mythimna separata谷氨酰胺转胺酶(Ms TGase)活力的组合条件,以Ms TGase酶活力为依据分析其在不同龄期幼虫体内的分布规律。【方法】取4龄粘虫幼虫,通过组织匀浆和沉析纯化制备Ms TGase,采用Grossowicz比色法测定Ms TGase酶活力,并对Grossowicz比色法的多重实验因素进行正交优化,进一步结合差速离心法分析不同龄期幼虫体内和亚细胞组分(细胞核和细胞碎片,线粒体,微粒体以及胞质溶胶)中Ms TGase酶活力。【结果】结果表明,酶浓度、底物浓度、反应体系pH值、反应温度及钙离子浓度等实验因素都对Ms TGase酶活力测定结果产生显著影响,其影响大小顺序为:酶浓度>温度> p H>底物浓度>Ca2+浓度。Ms TGase酶比活力测定的最优化条件:酶浓度20 mg/m L、底物浓度0. 04 mol/L、反应体系pH值6. 5、测定温度37℃,不添加钙离子。在1-5龄幼虫中以4龄幼虫的Ms TGase酶活力最高,其比活力也显著高于其他龄期的,且在1-5龄幼虫胞质溶胶中Ms TGase酶活力分别占各亚细胞组分酶活力总和的39%,25%,48%,60%和61%。【结论】所获得的最优化条件适用于粘虫Ms TGase酶活力测定。Ms TGase在粘虫体内呈显著的龄期表达特征和亚细胞分布规律。 | 饶文兵 徐久永 章先飞 Solange MUHAYIMANA 黄青春 | 2019 | 昆虫学报2019，62，1： | 2 |
| 11 | WHO classification of alveolar echinococcosis: Principles and application显示文摘 | Peter Kern Hao Wen Naoki Sato Dominique A. Vuitton Beate Gruener Yinmei Shao Eric Delabrousse Wolfgang Kratzer Solange Bresson-Hadni | 2005 | Parasitology International2005，，： | 2 |
| 12 | 非小细胞肺癌驱动基因HER2插入突变的靶向治疗显示文摘人类表皮生长因子受体2(human epidermal growth factor receptor 2,HER2)基因突变,在框内插入大量的20号外显子,在1%-4%的非小细胞肺癌中,专门针对腺癌组织学类型,已经被认为是一种致癌驱动改变。这些改变的预后性意义仍然未知。I期和II期的试验数据表明:阿法替尼、来那替尼和dacomitinib对这些分子亚型组有一些活性。目前没有任何关于帕妥珠单抗或曲妥单抗-emtansine活性的资料可供使用,HER2的反常可以导致蛋白的过表达或者基因的扩增,迄今为止,有很少的临床相关性研究,曲妥单抗活性的试验研究仅仅表明对于极少数过表达HER2的患者有益,这一亚群占大多数腺癌的2%-6%。 | Solange Peters Stefan Zimmermann 魏建国 许春伟 张博 | 2015 | 临床与病理杂志2015，35，2： | 2 |
| 13 | The Antioxidant Activity of Coumarins and Flavonoids显示文摘 | Guilherme Borges Bubols Damiana da Rocha Vianna Alexander Medina-Remon Gilsane von Poser Rosa Maria Lamuela-Raventos Vera Lucia Eifler-Lima Solange Cristina Garcia | 2013 | Mini-Reviews in Medicinal Chemistry2013，，3： | 1 |
| 14 | Transmission, diagno- sis, and management of hepatitis E: an update显示文摘 | Mirazo Santiago Ramos Natalia Mainardi Victoria Gerona Solange Arbiza Juan | 2014 | Hepatic medicine: evidence and research2014，6，： | 1 |
| 15 | Micro-wave-assisted extraction of sulfated polysaccharides (fu- coidan) from brown seaweed 显示文摘 | ROSA M R SOLANGE I M LORENZO P | 2011 | Carbohydrate Poly- mers2011，86，3： | 1 |
| 16 | Bis (imino)pyridines:Surprisingly Reactive Ligands and a Gateway to New Families of Catalysts显示文摘 | Gibson V C Redshaw C SolanG A | 2007 | Chem Rev2007，107，5： | 1 |
| 17 | Acid hydrolysis and fermentation of brewer’s spent grain to produce xylitol显示文摘 | Solange IMussatto Inês CRoberto | 2005 | J Sci Food Agric2005，，14： | 1 |
| 18 | Imaging aspects and non-surgical interventional treatment in human alveolar echinococcosis显示文摘 | Solange Bresson-Hadni Eric Delabrousse Oleg Blagosklonov Brigitte Bartholomot Stéphane Koch Jean-Philippe Miguet Georges André Mantion Dominique Angèle Vuitton | 2005 | Parasitology International2005，，： | 1 |
| 19 | Relationship between vision and motor impairment in children with spastic cerebral palsy: new vidence from electrophysiology显示文摘 | Marcelo FC Solange RS Asriana B | 2004 | Behav Brain Res2004，149，： | 1 |
| 20 | Profile of cytokine production within the peripara-sitic granuloma in human alveolar echinococcos显示文摘 | Said H Veronique G Solange B | 2003 | Acta Trop2003，85，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员