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| 1 | Sarcopenia in heart failure: mechanisms and therapeutic strategies显示文摘长期的心失败(CHF ) 是一个高度流行的条件在之中老并且与可观的病态, institutionalization 和死亡被联系。在它的先进阶段, CHF 被肌肉质量和力量的损失经常伴随。Sarcopenia 是活跃地与大量不利健康结果由于它的协会在最近的年里被学习了的衰老老人症候群。这评论的目标是讨论在 CHF 和 sarcopenia 之间的关系,与分享的 pathophysiological 小径和处理的一个焦点。营养不良,全身的发炎,内分泌的不平衡,和氧化应力看起来连接 sarcopenia 和 CHF。在肌肉发达的水平, ubiquitin proteasome 系统,发信号的 myostatin,和 apoptosis 的改变在 sarcopenia 和 CHF 被描述了并且能在肌肉质量和功能的损失起一个作用。阻碍肌肉在 CHF 病人浪费的前进的可能的治疗学的策略包括变换血管收缩素的酶禁止者和 β 的蛋白质和维生素 D 补充,结构化的物理锻练,和管理; -blockers。有生长荷尔蒙,睾丸激素,和 ghrelin 的神经质的补充也作为潜在的治疗被讨论。 | Agnese Collamati Emanuele Marzetti Riccardo Calvani Matteo Tosato Emanuela D'Angelo Alex N Sisto Francesco Landi | 2016 | Journal of Geriatric Cardiology2016，13，7： | 25 |
| 2 | 一种miRNA标记在胶质瘤侵袭性表型的确定与预后评估中的价值(英文)显示文摘Gliomas represent a disparate group of tumours for which there are to date no cure. Thus,there is a recognized need for new diagnostic and therapeutic approaches based on increased understanding of their molecular nature. We performed the comparison of the microRNA( miRNA) profile of 8 WHO grade II gliomas and 24 higher grade tumours( 2 WHO grade III and 22 glioblastomas) by using the Affymetrix Gene Chip miRNA Array v. 1. 0. A relative quantification method( RT-q PCR) with standard curve was used to confirm the 22 miRNA signature resulted by array analysis. The prognostic performances of the confirmed miRNAs were estimated on the Tumor Cancer Genome Atlas( TCGA) datasets. We identified 22 miRNAs distinguishing grade II gliomas from higher grade tumours.RT-q PCR confirmed the differential expression in the two patients' groups for 13 out of the 22 miRNAs. The analysis of the Glioblastoma Multiforme( GBM) and Lower Grade Glioma( LGG) datasets from TCGA demonstrated the association with prognosis for 6 of those miRNAs. Moreover,in the GBM dataset miR-21 and miR-210 were predictors of worse prognosis in both univariable and multivariable Cox regression analyses( HR 1. 19,P = 0. 04,and HR 1. 18,P = 0. 029 respectively). Our results support a direct contribution of miRNAs to glioma cancerogenesis and suggest that miR-21 and miR-210 may play a role in the aggressive clinical behaviour of glioblastomas. | Barbano R Palumbo O Pasculli B Galasso M Volinia S D'Angelo V Icolaro N Coco M Dimitri L Graziano P Copetti M Valori VM Maiello E Carella M Fazio VM Parrella P | 2014 | 中华神经外科疾病研究杂志2014，13，5： | 6 |
| 3 | TIPS for Budd-Chiari Syndrome: Long-Term Results and Prognostics Factors in 124 Patients显示文摘 | Juan Carlos Garcia–Pagán Mathis Heydtmann Sebastian Raffa Aurélie Plessier Sarwa Murad Federica Fabris Giovanni Vizzini Juan Gonzales Abraldes Simon Olliff Antonio Nicolini Angelo Luca Massimo Primignani Harry L.A. Janssen Dominique Valla Elwyn Elias Jaum | 2008 | Gastroenterology2008，，3： | 3 |
| 4 | Essential role of TRPC1 channels in cardiomyoblasts hypertrophy mediated by 5-HT 2A serotonin receptors显示文摘 | Cécile Vindis Romina D’Angelo Elodie Mucher Anne Nègre-Salvayre Angelo Parini Jeanne Mialet-Perez | 2009 | Biochemical and Biophysical Research Communications2009，，1： | 2 |
| 5 | 在肝的 G6PT-H6PDH-11HSD1 三个一组和它在新陈代谢的症候群的 pathomechanism 的含意显示文摘 The metabolic syndrome, one of the most common clinical conditions in recent times, represents a combination of cardiometabolic risk determinants, including central obesity, glucose intolerance, insulin resistance, dyslipidemia, non-alcoholic fatty liver disease and hypertension. Prevalence of the metabolic syndrome is rapidly increasing worldwide as a consequence of common overnutrition and consequent obesity. Although a unifying picture of the pathomechanism is still missing, the key role of the pre-receptor glucocorticoid activation has emerged recently. Local glucocorticoid activation is catalyzed by a triad composed of glucose-6-phosphate-transporter, hexose-6-phosphate dehydrogenase and 11β-hydroxysteroid dehydrogenase type 1 in the endoplasmic reticulum. The elements of this system can be found in various cell types, including adipocytes and hepatocytes. While the contribution of glucocorticoid activation in adipose tissue to the pathomechanism of the metabolic syndrome has been well established, the relative importance of the hepatic process is less understood. This review summarizes the available data on the role of the hepatic triad and its role in the metabolic syndrome, by confronting experimental findings with clinical observations. | Ibolya Czegle Miklós Csala József Mandl Angelo Benedetti István Karádi Gábor Bánhegyi | 2012 | World Journal of Hepatology2012，4，4： | 2 |
| 6 | Artemisinin derivatives inhibit Toxoplasma gondii in vitro at multiple steps in the lytic cycle显示文摘 | D'ANGELO J G BORD N C POSNER GH | 2009 | J Antimicrob Chemother2009，63，1： | 1 |
| 7 | Distributed simulation of modular time Petri nets: an approach and a case study exploiting temporal uncertainty显示文摘 | Franco C Angelo F Libero N | 2007 | Real-time System2007，35，1： | 1 |
| 8 | Quantitative fluorescence cytometric measurement of estrogen and progesterone receptors: correlation with the hormone binding assay 显示文摘 | Angelos D Gritzapis Constantin N | 2003 | Breast Cancer Res and Tre2003，80，： | 1 |
| 9 | Late-onset rheumatoid arthritis and late-onset spondyloarthritis 显示文摘 | Olivieri I Pipitone N D'Angelo S | 2009 | Cliu Exp Rheumatol2009，27，4： | 1 |
| 10 | Delayed ischemic preconditioning is mediated by opening of ATPsensitive potassium channels in rabbit heart显示文摘 | Bernado N D' angelo M Okubo S | 1999 | Am J Physiol Heart Circ Physiol1999，276，： | 1 |
| 11 | Comparing SF-6D and EQ-5D utilities across groups differing in health status显示文摘 | Kontodimopoulos N Pappa E Angelos A | | 0，，： | 1 |
| 12 | Laboratory observation of the dust-acoustic wave mode显示文摘 | Barkan A Merlino R L D′Angelo N | 1995 | Physics of Plasma1995，2，10： | 1 |
| 13 | Experimental deformation of partially melted granitic aggregates显示文摘 | Dell'Angelo L N Tullis J | 1988 | Journal of Metamorphic Geology1988，6，： | 1 |
| 14 | Salivary duct carcinoma arising inIgG4-related autoimmune disease of the parotid gland显示文摘 | Gill J Angelo N Yeong ML | 2009 | Hum Pathol2009，40，6： | 1 |
| 15 | Discovery and optimization of a series of benzothiazole phosphoinositide 3-kinase(PI3K)/mammalian target of rapamycin(m TOR)dual inhibitors显示文摘 | D'ANGELO N D KIM T S ANDREWS K | 2011 | J Med Chem2011，54，6： | 1 |
| 16 | Oncogenic RAS alters the global and gene-specific histone modification pattern during epithelial–mesenchymal transition in colorectal carcinoma cells显示文摘 | Ignacio Mazón Peláez Margarita Kalogeropoulou Angelo Ferraro Angeliki Voulgari Tibor Pankotai Imre Boros Alexander Pintzas | 2010 | International Journal of Biochemistry and Cell Biology2010，，6： | 1 |
| 17 | Discovery and optimization of a series of benzothiazole phosphoinositide 3-kinase(PI3K)/mammalian target of rapamycin(mTOR)dual inhibitors显示文摘 | D'ANGELO N D KIM T S ANDREWA K | 2011 | J Med Chem2011，54，6： | 1 |
| 18 | Experimental deformation of partially melted granitic aggregates显示文摘 | Dell'Angelo L N Tullis J | 1988 | Journal of Metamorphic Geology1988，6，： | 1 |
| 19 | 查看详情显示文摘 | Barkan A Merlino R L Angelo N D | | 0，，： | 1 |
| 20 | Scheduling real-time mixed-criticality jobs显示文摘 | Baruah SK Bonifaci V D'Angelo G Li H Marchetti-Spaccamela A Megow N Stougie L | | 0，，08： | 1 |
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