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| 1 | Guanylyl cyclase C signaling axis and colon cancer prevention显示文摘Colorectal cancer(CRC) is a major cause of cancerrelated mortality and morbidity worldwide. While improved treatments have enhanced overall patient outcome, disease burden encompassing quality of life, cost of care, and patient survival has seen little benefit. Consequently, additional advances in CRC treatments remain important, with an emphasis on preventative measures. Guanylyl cyclase C(GUCY2C), a transmembrane receptor expressed on intestinal epithelial cells, plays an important role in orchestrating intestinal homeostatic mechanisms. These effects are mediated by the endogenous hormones guanylin(GUCA2A) and uroguanylin(GUCA2B), which bind and activate GUCY2 C to regulate proliferation, metabolism and barrier function in intestine. Recent studies have demonstrated a link between GUCY2 C silencing and intestinal dysfunction, including tumorigenesis. Indeed, GUCY2 C silencing by the near universal loss of its paracrine hormone ligands increases colon cancer susceptibility in animals and humans. GUCY2C's role as a tumor suppressor has opened the door to a new paradigm for CRC prevention by hormone replacement therapy using synthetic hormone analogs, such as the FDA-approved oral GUCY2 C ligand linaclotide(Linzess^(TM)). Here we review the known contributions of the GUCY2 C signaling axis to CRC, and relate them to a novel clinical strategy targeting tumor chemoprevention. | Amanda M Pattison Dante J Merlino Erik S Blomain Scott A Waldman | 2016 | World Journal of Gastroenterology2016，22，36： | 2 |
| 2 | 初始降压治疗策略与治疗惰性:基于人群的大型队列研究证据显示文摘尽管由于治疗惰性导致血压控制不佳,但许多高血压患者的治疗并未升级。在实际诊疗中,这种现象有多普遍还没有具体的数据。研究者纳入来自Lombardy地区(意大利)开始降压治疗采用1种(100982例)或2种药物固定剂量或自由联合(24653例)的患者125635例(年龄40~85岁)。采用对数二项式回归模型评估联合治疗所占比例与初始治疗策略的关系。 | 赵狄 练桂丽 Rea F Corrao G Merlino L Mancia G | 2018 | 中华高血压杂志2018，26，10： | 2 |
| 3 | Overexpression of NK2 inhibits liver regeneration after partial hepatectomy in mice显示文摘AIM: To investigate the in vivo effects of NK2 on liver regeneration after partial hepatectomy (PH). METHODS: Survival after PH was observed with 21 NK2 transgenic mice and 23 wild-type (WT) mice over 10 d. Liver regeneration was analyzed using histology and immunohistochemistry. Expressions of genes were analyzed using Northern blot analysis, immunoprecipitation and immunoblotting, and reverse transcriptase polymerase chain reaction assay. KaplanMeier method and the log-rank test were used for ahalyzing the survival after PH. Differences in the resultsof immunohistochemistry and percentage of liver regeneration was determined by the Student's t-test. RESULTS: More than half of NK2 transgenic mice died within 48 h after PH. After PH, increased deposition of small lipid droplets in hepatocytes was evident and hepatic proliferation was inhibited in NK2 transgenic mice. The hepatic expression and kinase activity of HGF receptor, c-Met, were unchanged among WT mice and NK2 transgenic mice after PH. The expression of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in liver tissues were prolonged in NK2 transgenic mice that died after PH.CONCLUSION: Our findings indicate that overexpression of NK2 inhibits liver regeneration after PH. | Toshiyuki Otsuka Norio Horiguchi Daisuke Kanda Takashi Kosone Yuichi Yamazaki Kazuhisa Yuasa Naondo Sohara Satoru Kakizaki Ken Sato Hitoshi Takagi Glenn Merlino Masatomo Mori | 2005 | World Journal of Gastroenterology2005，11，47： | 2 |
| 4 | Proteomic analysis of amphiphilic proteins of hexaploid wheat kernel显示文摘 | Amiour N Merlino M Leroy P | 2002 | Proteomics2002，2，： | 1 |
| 5 | Investigational approach- es to therapies for restless legs syndrome 显示文摘 | de Blase S Merlino G Lorenzut S | 2014 | Expert Opin Investig Drugs2014，23，： | 1 |
| 6 | A mitochondrial DNA mutation (A3243G mtDNA)in a family with cyclic vomiting 显示文摘 | Salpietro CD Briuglia S Merlino MV | 2003 | Eur J Pediatr2003，162，10： | 1 |
| 7 | Post parathyroidectomy hypocalcemia: incidence, risk factors, and management显示文摘 | Mittendorf EA Merlino JI McHenry CR | 2004 | Am Surg2004，70，2： | 1 |
| 8 | Development of liver tu- mors in transforming growth factor alpha transgenic mice显示文摘 | LEE GH MERLINO G FAUSTO N | 1992 | Can- cer Res1992，52，： | 1 |
| 9 | Nuclear progesterone receptors in the human pregnancy myometrium:Evidence that parturition involves functional progesterone withdrawal mediated by increased expression of progesterone receptor-A显示文摘 | Welsh T N Tan H | 2007 | J Clin Endocrinol Metab2007，92，： | 1 |
| 10 | 显示文摘 | Johnson MD Merlino G | 1995 | Cell Growth Diff1995，6，6： | 1 |
| 11 | Machine learning of event segmentation for news on demand 显示文摘 | Boykin S Merlino A | 2000 | Communications of the ACM2000，43，2： | 1 |
| 12 | Role of calcium-channels in the protective effect of hydrogensulfide in ratcardiomyoblasts显示文摘 | Avanzato D Merlino A Porrera S | 2014 | Cell Physiol Biochem2014，33，4： | 1 |
| 13 | hCMV pp67-mRNA detection by nucleic acid sequence-based amplification in renal transplant patients显示文摘 | Merlino C Bergallo M Gregori G | 2002 | New Microbiol2002，25，1： | 1 |
| 14 | Antioxidant micronutrients and risk of rheumatoidarthritis in a cohort of older women显示文摘 | Cerhan J R Saag K G Merlino L A | 2003 | Am J Epidemiol2003，157，4： | 1 |
| 15 | Evidence for the direct action of thymulin on avian NK cells 显示文摘 | Merlino P G Marsh J A | 2001 | Devel Compar Immunol2001，25，： | 1 |
| 16 | Electrocardiographic score and short-term outcomes of acute pulmonary embolism显示文摘 | TOOSI M S MERLINO J D LEEPER K V | 2007 | Am J Cardiol2007，100，： | 1 |
| 17 | Biofeedback for Fecal Incontinence: Short-Term Outcomes of 513 Consecutive Patients and Predictors of Successful Treatment显示文摘 | Christopher M. Byrne M.B.B.S. B.Sc.(Med.) M.S. F.R.A.C.S. Michael J. Solomon M.B.B.Ch.(Hons.) M.Sc. F.R.A.C.S. Jane M. Young M.B.B.S. M.P.H. Ph.D. F.A.F.P.H.M. Jenny Rex R.N. S.T.N. Christine L. Merlino R.N | 2007 | Diseases of the Colon & Rectum2007，，4： | 1 |
| 18 | Restless legs syndrome: diagnosis, epidemiology, classification and consequences显示文摘 | G. Merlino M. Valente A. Serafini G. L. Gigli | 2007 | Neurological Sciences2007，，1： | 1 |
| 19 | Development of Liver tumor in transforming growth factor_a transgenic mice 显示文摘 | Lee CH Merlino G Tausto N | 1992 | Cancer Res1992，53，： | 1 |
| 20 | Vitamin D intake is inversely associated with rheumatoid arthritis: results from the Iowa Women's Health Study显示文摘 | Merlino LA Curtis J Mikuls TR | 2004 | Arthritis Rheum2004，50，： | 1 |
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