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| 1 | 一种miRNA标记在胶质瘤侵袭性表型的确定与预后评估中的价值(英文)显示文摘Gliomas represent a disparate group of tumours for which there are to date no cure. Thus,there is a recognized need for new diagnostic and therapeutic approaches based on increased understanding of their molecular nature. We performed the comparison of the microRNA( miRNA) profile of 8 WHO grade II gliomas and 24 higher grade tumours( 2 WHO grade III and 22 glioblastomas) by using the Affymetrix Gene Chip miRNA Array v. 1. 0. A relative quantification method( RT-q PCR) with standard curve was used to confirm the 22 miRNA signature resulted by array analysis. The prognostic performances of the confirmed miRNAs were estimated on the Tumor Cancer Genome Atlas( TCGA) datasets. We identified 22 miRNAs distinguishing grade II gliomas from higher grade tumours.RT-q PCR confirmed the differential expression in the two patients' groups for 13 out of the 22 miRNAs. The analysis of the Glioblastoma Multiforme( GBM) and Lower Grade Glioma( LGG) datasets from TCGA demonstrated the association with prognosis for 6 of those miRNAs. Moreover,in the GBM dataset miR-21 and miR-210 were predictors of worse prognosis in both univariable and multivariable Cox regression analyses( HR 1. 19,P = 0. 04,and HR 1. 18,P = 0. 029 respectively). Our results support a direct contribution of miRNAs to glioma cancerogenesis and suggest that miR-21 and miR-210 may play a role in the aggressive clinical behaviour of glioblastomas. | Barbano R Palumbo O Pasculli B Galasso M Volinia S D'Angelo V Icolaro N Coco M Dimitri L Graziano P Copetti M Valori VM Maiello E Carella M Fazio VM Parrella P | 2014 | 中华神经外科疾病研究杂志2014，13，5： | 6 |
| 2 | Defini-tion of relapse risk and role of nonanthracycline drugsfor consolidation in patients with acute promyelocyticleukemia: A joint study of the PETHEMA andG1MEMA cooperative groups 显示文摘 | SANZ M A LO COCO F MARTIN G | 2000 | Blood2000，96，： | 1 |
| 3 | An empirical approach for ranking environmental and energy saving measures in the hotel sector 显示文摘 | Beccali M La Gennusa M Lo Coco L | 2009 | Renewable Energy2009，34，1： | 1 |
| 4 | ATRA and arsenic trioxide (ATO) versus ATRA and idarubicin (AI- DA) for newly diagnosed, non high-risk acute promyelo- cytie leukemia (APL) : results of the phase III, prospec- tive, randomized, intergroup APL0406 study by the Ital- ian-German cooperative groups GIMEMA-SAL-AMLSG 显示文摘 | Lo Coco F Avvisati G Orlando S M | 2012 | Blood2012，120，1： | 1 |
| 5 | Modeling sorting dynamics of cohesive and non-cohesive sediments on intertidal flats under the effect of tides and wind waves显示文摘 | ZHOU Z COCO G van der WEGEN M | 2015 | Continental Shelf Research2015，104，： | 1 |
| 6 | Definition of relapse risk and role of nonanthracychne drugs for consolidation in patients with acute promyelocytic leukemia: a joint study of the PETHEMA and GIMEMA cooperative groups显示文摘 | SANZ M A LO COCO F MARTIN G | 2000 | Blood2000，96，4： | 1 |
| 7 | Extranodal lymphomas associated with hepatitis C virus infection 显示文摘 | Ascoli V Lo Coco F Artini M | 1998 | Am J CAin Pathol1998，109，5： | 1 |
| 8 | Value of strain-ratio on thyroid real-time sonoelastography 显示文摘 | Guazzaroni M Spinelli A Coco I | 2014 | Radiol Med2014，119，3： | 1 |
| 9 | High-performance liquid chromatographic determination of vancomycin in rabbit senlm, vitreous and aqueous humour after intravitreal injection of the drug显示文摘 | DelNozal M J Bemal JL Pampliega A Marinero P Lopez MI Coco R | 1996 | J Chromatogr A1996，727，2： | 1 |
| 10 | Volatile composition of Baga red wine: assessment of the identification of the would-be impact odoumnts显示文摘 | ROCHA S M RODRIGUES F COCO P | 2004 | Analytica Chimica Acta2004，513，1： | 1 |
| 11 | Front-line treatment of acute promyelocytic leukemia with AIDA induction followed by risk-adapted consolidation : results of the AIDA-2000 trial of the Italian GIMEMA Group显示文摘 | Lo Coco F Avvisati G Vignetti M | 2004 | Blood2004，104，11： | 1 |
| 12 | An empirical approach for ranking environmental and energy sav- ing measures in the hotel sector显示文摘 | Beccali M La Gennusa M Lo Coco L | 2009 | Renewable Energy2009，34，1： | 1 |
| 13 | A hypothesis accounting for the in- consistent benefit of glucocorticoid therapy in closed head trauma显示文摘 | BORSODY M K COCO M L | 2001 | MedHypotheses2001，56，1： | 1 |
| 14 | Increased incidence of hip fractures in dial- ysis patients with low serum parathyroid hormone 显示文摘 | Coco M Rush H | 2000 | Am J Kidney Dis2000，36，6： | 1 |
| 15 | Differences in gastric carcinoma microenvironment stratify according to EBV infec- tion intensity: implications for possible immune adjuvant the- rapy显示文摘 | STRONG M J XU G R COCO J | 2013 | PLoS Pathogens2013，9，10： | 1 |
| 16 | GIMEMA-AIEOP AIDA protocol for the treatment of newly diagnosed acute promyelocytic leukemia (APL) in children显示文摘 | TESTI A M BIONDI A LO COCO F | 2005 | Blood2005，106，： | 1 |
| 17 | Growth factor engineering by degenerate homoduplex gene family recombination显示文摘 | Coco W M Encell L P Levinson W E | 2002 | Nat Biotechnol2002，20，： | 1 |
| 18 | Extramedullary involvement at relapse in acute Incidence of extramedullary disease in acute promyelocytic leukemia patients treated or not with all- trans retinoic acid: a report by the Gruppo Italiano Malattie Ematologiche dell' Adulto 显示文摘 | Specchia G Lo Coco F Vignetti M | 2001 | J Clin Oncol2001，19，20： | 1 |
| 19 | Sediment transport on an estuarine intertidal flat : Measurements and conceptual model of waves, rainfall and exchanges with a tidal creek 显示文摘 | GREEN M O COCO G | 2007 | Estuarine Coastal and Shelf Science2007，72，： | 1 |
| 20 | DNA shuffling method for generating highly recombined genes and evolved enzymes 显示文摘 | Coco W M Levinson W E Crist M J | 2001 | Nat Biotechnol2001，19，4： | 1 |
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