|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 亚太地区炎症性肠病处理共识意见(一)显示文摘虽然目前亚太地区尚无炎症性肠病(IBD)的大规模流行病学资料,但一系列研究显示其发病率和患病率呈上升趋势,与西方国家相比仍呈滞后现象,溃疡性结肠炎(UC)的发病率仍较克罗恩病(CD)高。除地域差异外,在一些多民族国家中,IBD尚可见种族差异。亚太地区IBD的遗传背景有异于西方国家,如据报道该地区CD患者未检出NOD2/CARD15变异。一般而言,该地区IBD患者的临床过程似不如西方国家严重。亚太地区IBD的诊断存在一些特殊问题。如缺乏IBD诊断金标准,存在多种小肠结肠炎,与IBD临床表现相似,使鉴别诊断特别困难。迄今为止,亚太地区IBD的诊断标准多采用西方国家的诊断标准。诊断必须逐步排除非IBD的小肠结肠炎,确诊应有典型的组织学表现,某些患者需借助随访和诊断性治疗才能确诊。进一步研究IBD发病机制将有助于开发更好的诊断标记物。亚太地区IBD的治疗亦存在特殊问题。由于诊断困难,IBD患者常未能及时接受适当的药物治疗,但该地区仍广泛采用药物治疗方案。结合西方指南和本地经验可制定类似的处理原则,以利诱导缓解和维持缓解。提倡逐级使用基于病变范围、活动性和严重度的阶梯式治疗方案,对不同病例采用综合性、个体化的方法。随着对IBD发病机制和亚太地区IBD独特性的深入理解,合理、实用的药物治疗指南和应用生物制剂治疗将改善该地区IBD的治疗前景。 | 欧阳钦 Rakesh Tandon KL Goh 潘国宗 KM Fock Claudio Fiocchi SK Lam 萧树东 张虎 梁红亮 王玉芳 | 2006 | 胃肠病学2006，11，4： | 123 |
| 2 | 慢性乙肝患者阿德福韦治疗的病毒学应答和耐药性显示文摘背景:HBV感染患者的阿德福韦耐药性发生率和危险因素尚未明确。目的:探讨阿德福韦病毒学应答的特征、明确阿德福韦耐药的发生率并研究起始病毒学应答(Initial Virologic Response,IVR)和阿德福韦耐药的相关因素。 | Fung SK Chae HB Fontana RJ | 2006 | 中国处方药2006，5，3： | 63 |
| 3 | 香港华人妇女产后抑郁危险因素的前瞻性研究显示文摘目的:产后抑郁是一种常见的精神障碍,对产妇、新生儿和其它家庭成员导致广泛的伤害。产后抑郁的病因学研究大多是基于西方样本,对其中的社会文化原因也缺乏实证研究。本研究从人口学、心理社会及种族文化因素等方面探讨中国妇女产后抑郁症状学的决定因素。方法:在大学附属综合医院产前门诊连续收集登记的中国孕妇959例,从她们第一次产前检查开始评估(基线),以后分别在孕期的最后3个月、产后即刻和产后3个月时评估。调查涉及的危险因素分6个方面:人口学和社会经济背景,躯体疾病及精神疾病病史, 产前抑郁情绪,围生期应激源,人际关系,和种族文化环境。采用等级回归进行分析。因变量是产后3个月时的抑郁评分。结果:决定产后抑郁症状学的因素有:目前的生活事件,缺乏社会支持,婚姻不满意,既往有故意自伤史,以及产前存在抑郁情绪。婆媳关系不好和没有陪月在产后阶段也与抑郁评分高有关联。结论:西方研究所确立的产后抑郁危险因素大体适用于中国妇女。产褥期的社会文化特点同样对产妇情绪有影响。 | Dominic TS Lee Alexander SK Yip Sandra SM Chan Fiona FY Lee Tony YS Leung Tony KH Chung | 2005 | 中国心理卫生杂志2005，19，9： | 50 |
| 4 | 亚太地区炎症性肠病处理共识意见(二)显示文摘 | 欧阳钦 Rakesh Tandon KL Goh 潘国宗 KM Fock Claudio Fiocchi SK Lam 萧树东 张虎(翻译) 梁红亮(翻译) 王玉芳(翻译) 欧阳钦(审校) | 2006 | 胃肠病学2006，11，5： | 47 |
| 5 | Immune therapy including dendritic cell based therapy in chronic hepatitis B virus infection显示文摘肝炎 B (HBV ) 感染是一个全球公共卫生问题。全球被感染了的约 20 亿个人,超过 4 亿是 HBV 的慢性带菌者。长期的 HBV 搬运人的可观的数字患进步的肝疾病。另外,所有 HBV 搬运人是这个病毒的永久来源。为长期的 HBV 搬运人没有药品治疗。然而,抗病毒的药为大约 10% 病人被推荐这些药是昂贵的,限制了功效,并且拥有可观的副作用。最近的研究证明了到 HBV 的主人的有免疫力的回答非常在长期的 HBV 感染的每个阶段被包含:(1 ) 这些影响长期的 HBV 带菌状态的获得,(2 ) 他们在肝损坏的上下文是重要的,(3 ) 从长期的 HBV 相关的肝疾病的恢复依赖于 HBV 特定的有免疫力的回答的自然和程度。然而,在长期的 HBV 搬运人的 HBV 特定的有免疫力的回答的足够的层次的正式就职是困难的。在最后一十年期间,肝炎 B 疫苗作为一条治疗学的途径(疫苗的治疗) 予长期的 HBV 搬运人被以。疫苗的治疗的现在的政体是安全、便宜,然而并非那么有效。一支树枝状的基于房间的治疗学的疫苗最近为治疗长期的 HBV 感染被开发了。在这评论,我们将为治疗长期的 HBV 感染包括疫苗的治疗和树枝状的基于房间的疫苗的治疗关于 HBV 特定的有免疫力的治疗的开发的概念,科学逻辑,策略和技术讨论。 | Sk Md Fazle Akbar Norio Horiike Morikazu Onji | 2006 | World Journal of Gastroenterology2006，12，18： | 35 |
| 6 | An Archean continental block in the Taihangshan and Hengshan regions: Constraints from geochronology and geochemistry显示文摘Recent research on the tectonothermal evolution and geochronology in the Fuping, Hengshan and Wutaishan metamorphic complexes, together with the discoveries of a high-pressure granulite belt in the northern margin of the North China Craton (NCC) and high-pressure metapelites in the Jingangku Group of the Wutaishan complex, suggests that there was a Neoarchean to Paleoproterozoic orogenic belt related to collision between the Eastern and Western continental blocks. Comparison of geological, geochronological, tectonothermal and geochemical data between the Fuping and Hengshan complexes suggests these two complexes most likely originated and evolved as a single lithotectonic domain (i.e., the Taihangshan-Hengshan block) during the early evolution of the North China Craton, probably as an active margin to the Eastern Continental Block. The Taihangshan-Hengshan block has been subjected to intensive and extensive tectono-magmatism and high-grade metamorphism related to collision between the Eastern and Western continental blocks at ~1.80 Ga. | LIU Shuwen , LI Jianghai, PAN Yuanming, ZHANG Jian and LI Qiugen(1. The Key Laboratory of Orogenic Belts and Crustal Evolution, School of Earth and Space Sciences, Peking University, Beijing 100871, China 2. Department of Geological Sciences, University of Saskatchewan, Saskatoon, SK S7N 5E2, Canada) | 2002 | Progress in Natural Science:Materials International2002，12，8： | 32 |
| 7 | 聚合酶链反应检测乙型肝炎患者肝外组织中的乙型肝炎病毒DNA显示文摘应用巢式聚合酶链(PCR)技术对18例石蜡包埋的胆囊、肾、脾、肾上腺、心、睾丸、胰腺及肝脏组织的乙型肝炎病毒(HBV)DNA进行了检测,并与其免疫组化及原位杂交方法作比较。二组引物检测的结果表明:肝组织中均有HBV感染,其中5例有HBV的复制。肝外组织中HBV检出率分别为胆囊85.7%、75.0%、肾72.7%、肾上腺66.7%、心脏55.6%、睾丸55.6%和胰腺54.5%,但均未检测出HBV的复制,PCR检测发现与免疫组化及原位杂交结果基本一致。HBV可以感染肝外组织但并不在这些组织中复制的发现可以解释受感染的肝外组织可以作为肝外感染源,但并不引起这些脏器出现明显的病理变化。 | 郎振为 闫惠平 黄德在 王健 吴和 Zhang JL Perry A Byrne SK Stiver GH | 1994 | 中华内科杂志1994，33，4： | 33 |
| 8 | Antidiabetic and in vitro antioxidant potential of Hybanthus enneaspermus(Linn) F.Muell in streptozotocin—induced diabetic rats显示文摘Objective:To evaluate antidiabetic and antioxidant potential of Hybanthus enneaspermus in different models.Methods:The oral glucose tolerance test(OGTT) and normoglycemic effect of alcoholic extract of Hybanthus enneaspermus(AHE) were evaluated at a dose of 125,250 and 500mg/kg p.o.while hypoglycemic activity and effect on body weight were tested at 250 and 500 mg/kg p.o.per day for 21 days in Streptozotocin(STZ) induced diabetic rats.Further,glucose uptake by hemidiaphram was also evaluated.The total polyphenolic and flavonoid were determined and their correlation with various antioxidant assays was also determined.Results:The results showed high level of phenolic content in AHE.AHE also exhibited higher total antioxidant capacity,good reducing power and a significant scavenger of reactive oxygen species like DPPH radical,nitric oxide,hydrogen peroxide and deoxyribose.Furthermore there was a significant increase in the body weight and decrease in the blood glucose level on treatment with the AHE.AHE increased glucose uptake on isolated rat hemi-diaphragm compared to control group.Conclusions:AHE reduce blood glucose level in STZ-induced diabetic model.It does not show significant effect in normoglycemic study but showes significant effect in OGT.AHE has significant antioxidant activity,which may be attributed to high phenolic content. | Patel DK Kumar R Prasad SK Sairam K Hemalatha S | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，4： | 22 |
| 9 | High-intensity focused ultrasound ablation:An effective bridging therapy for hepatocellular carcinoma patients显示文摘AIM:To analyze whether high-intensity focused ultrasound(HIFU) ablation is an effective bridging therapy for patients with hepatocellular carcinoma(HCC).METHODS:From January 2007 to December 2010,49 consecutive HCC patients were listed for liver transplantation(UCSF criteria).The median waiting time for transplantation was 9.5 mo.Twenty-nine patients received transarterial chemoembolization(TACE) as a bringing therapy and 16 patients received no treatment before transplantation.Five patients received HIFU ablation as a bridging therapy.Another five patients with the same tumor staging(within the UCSF criteria) who received HIFU ablation but not on the transplant list were included for comparison.Patients were comparable in terms of Child-Pugh and model for end-stage liver disease scores,tumor size and number,and cause of cirrhosis.RESULTS:The HIFU group and TACE group showed no difference in terms of tumor size and tumor number.One patient in the HIFU group and no patient in the TACE group had gross ascites.The median hospital stay was 1 d(range,1-21 d) in the TACE group and two days(range,1-9 d) in the HIFU group(P < 0.000).No HIFU-related complication occurred.In the HIFU group,nine patients(90%) had complete response and one patient(10%) had partial response to the treatment.In the TACE group,only one patient(3%) had response to the treatment while 14 patients(48%) had stable disease and 14 patients(48%) had progressive disease(P = 0.00).Seven patients in the TACE group and no patient in the HIFU group dropped out from the transplant waiting list(P = 0.559).CONCLUSION:HIFU ablation is safe and effective in the treatment of HCC for patients with advanced cirrhosis.It may reduce the drop-out rate of liver transplant candidate. | Tan To Cheung Sheung Tat Fan See Ching Chan Kenneth SH Chok Ferdinand SK Chu Caroline R Jenkins Regina CL Lo James YY Fung Albert CY Chan William W Sharr Simon HY Tsang Wing Chiu Dai Ronnie TP Poon Chung Mau Lo | 2013 | World Journal of Gastroenterology2013，19，20： | 23 |
| 10 | 涎腺类乳腺分泌性癌:对25例标准RT-PCR法未能检出ETV6-NTRK3融合基因病例的进一步分子分析:4例存在ETV6-X融合基因显示文摘ETV6基因异常在肿瘤病理学已有完整描述,据文献报道不同的上皮性肿瘤和血液系统恶性肿瘤可检出多种ETV6融合基因伴侣。在涎腺肿瘤病理中,ETV6-NTRK3易位被认为是乳腺分泌性癌的特异性改变,而在其他类型的涎腺肿瘤中均木见报道。 | Skálová A Vanecek T Simpson R H 胡舜 余英豪 | 2016 | 临床与实验病理学杂志2016，32，5： | 21 |
| 11 | 聚合酶链反应检测乙型肝炎患者心肌组织中 HBV DNA显示文摘应用巢式聚台酶链反应(PCR)技术检测了18例乙型肝炎(乙肝)患者石蜡包埋心、肝组织中的HBVDNA,并与其免疫组化及原位杂交结果作了比较。二组引物检测的结果表明:在肝组织中均有HBV感染,其中5例有HBV复制。心肌组织HBVDNA的检出率为55.6%,不存在HBV的复制。心脏病理检查可见一些非特异性改变,如脂变、水肿和纤维素样坏死等。病理变化与心电图、临床症状、体征及PCR检测结果无相关件。以上结果提示:乙肝患者心脏出现的一些病变可能是由于沉积于心肌内的免疫复合物介导损伤的结果。 | 郎振为 阎惠平 李俊强 Zhang JL Perry A Byrne SK Stiver GH | 1994 | 中华传染病杂志1994，12，1： | 19 |
| 12 | 不同种植密度和施肥水平对大豆籽粒品质的影响显示文摘本试验自2002年开始至2004年止,从种植密度和施肥水平两方面对大豆脂肪、蛋白质含量的影响进行了分析。结果表明:种植密度对大豆籽粒的脂肪、蛋白质含量具有显著的影响,相关性分析结果显示,种植密度与大豆籽粒的脂肪含量存在着负相关性,与籽粒中的蛋白质含量之间为正相关。中国品种的脂肪含量受种植密度的影响大于美国品种,而中国品种的蛋白质含量受种植密度的影响小于美国品种。蛋脂总含量受种植密度的影响较小,并且不存在品种间的差异性。磷酸二铵的施用量与大豆籽粒脂肪含量和蛋白质含量之间没有显著的相关性,但是中美品种的品质对磷酸二铵施用量的反应不同。磷酸二铵的施用量与中国品种的脂肪含量、蛋白质含量和蛋脂总含量呈正相关,而与美国品种的脂肪、蛋白质含量和蛋脂总含量呈负相关,但相关程度均不显著。 | 谢志涛 谢甫绨 王海英 张惠君 王智权 丁雪丽 Steven SK Martin | 2006 | 种子2006，25，3： | 19 |
| 13 | A review on medicinal importance,pharmacological activity and bioanalytical aspects of beta-carboline alkaloid 'Harmine'显示文摘Harmine,a beta-carboline alkaloid,is widely distributed in the plants,marine creatures,insects, mammalians as well as in human tissues and body fluids.Harmine was originally isolated from seeds of Peganum harmal in 1847 having a core indole structure and a pyridine ring.Harmine has various types of pharmacological activities such as antimicrobial,antifungal,antitumor,cytotoxic, antiplasmodial,antioxidaant,antimutagenic,antigenotoxic and hallucinogenic properties.It acts on gamma-aminobutyric acid type A and monoamine oxidase A or B receptor,enhances insulin sensitivity and also produces vasorelaxant effect.Harmine prevents bone loss by suppressing osteoclastogenesis.The current review gives an overview on pharmacological activity and analytical techniques of harmine,which may be useful for researcheres to explore the hidden potential of harmine and and will also help in developing new drugs for the treatment of various diseases. | K Patel M Gadewar R Tripathi SK Prasad Dinesh Kumar Patel | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，8： | 17 |
| 14 | An overview on antidiabetic medicinal plants having insulin mimetic property显示文摘Diabetes mellitus is one of the common metabolic disorders acquiring around 2.8%of the world's population and is anticipated to cross 5.4%by the year 2025.Since long back herbal medicines have been the highly esteemed source of medicine therefore,they have become a growing part of modern,high-tech medicine.In view of the above aspects the present review provides profiles of plants(65 species) with hypoglycaemic properties,available through literature source from various database with proper categorization according to the parts used,mode of reduction in blood glucose(insulinomimetic or insulin secretagugues activity) and active phyloconsliluents having insulin mimetics activity.From the review it was suggested that,plant showing hypoglycemic potential mainly belongs to the family Leguminoseae,Lamiaceae,Liliaceae,Cucurbitaceae, Asteraceae,Moraceae,Rosaceae and Araliaceae.The most active plants are Allium sativum. Gymnema sylvestre,Citrullus colocynthis,Trigonella foenum greacum,Momordica charantia and Ficuts bengalensis.The review describes some new bioactive drugs and isolated compounds from plants such as roseoside,epigallocatechin gallate,beta-pyrazol-1-ylalanine,cinchonain Ib,leucocyandin 3-O-beta-d-galactosyl cellobioside,leucopelargonidin-3- O-alpha-L rhamuoside,glycyrrhetinic acid,dehydrotrametenolic acid,strictinin,isostrictinin,pedunculagin, epicatechin and christinin-A showing significant insulinomimetic and antidiabetic activity with more efficacy than conventional hypoglycaemic agents.Thus,from the review majorly,the antidiabetic activity of medicinal plants is attributed to the presence of polyphenols,flavonoida, terpenoids,coumarins and other constituents which show reduction in blood glucose levels.The review also discusses the management aspect of diabetes mellitus using these plants and their active principles. | Patel DK Prasad SK Kumar R Hemalatha S | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，4： | 15 |
| 15 | Serum and urine metabolomic fingerprinting in diagnostics of inflammatory bowel diseases显示文摘AIM:To evaluate the utility of serum and urine metabolomic analysis in diagnosing and monitoring of inflammatory bowel diseases(IBD).METHODS:Serum and urine samples were collected from 24 patients with ulcerative colitis(UC),19 patients with the Crohn’s disease(CD)and 17 healthy controls.The activity of UC was assessed with the Simple Clinical Colitis Activity Index,while the activity of CD was determined using the Harvey-Bradshaw Index.The analysis of serum and urine samples was performed using proton nuclear magnetic resonance(NMR)spectroscopy.All spectra were exported to Matlab for preprocessing which resulted in two data matrixes for serum and urine.Prior to the chemometric analysis,both data sets were unit variance scaled.The differences in metabolite fingerprints were assessed using partial least-squaresdiscriminant analysis(PLS-DA).Receiver operating characteristic curves and area under curves were used to evaluate the quality and prediction performance of the obtained PLS-DA models.Metabolites responsible for separation in models were tested using STATISTICA10 with the Mann-Whitney-Wilcoxon test and the Student’s t test(α=0.05).RESULTS:The comparison between the group of patients with active IBD and the group with IBD in remission provided good PLS-DA models(P value 0.002for serum and 0.003 for urine).The metabolites that allowed to distinguish these groups were:N-acetylated compounds and phenylalanine(up-regulated in serum),low-density lipoproteins and very low-density lipoproteins(decreased in serum)as well as glycine(increased in urine)and acetoacetate(decreased in urine).The significant differences in metabolomic profiles were also found between the group of patients with active IBD and healthy control subjects providing the PLS-DA models with a very good separation(P value<0.001 for serum and 0.003 for urine).The metabolites that were found to be the strongest biomarkers included in this case:leucine,isoleucine,3-hydroxybutyric acid,N-acetylated compounds,acetoacetate,glycine,phenylalanine and lactate(increased in serum),creatine,dimethyl sulfone,histidine,choline and its derivatives(decreased in serum),as well as citrate,hippurate,trigonelline,taurine,succinate and 2-hydroxyisobutyrate(decreased in urine).No clear separation in PLS-DA models was found between CD and UC patients based on the analysis of serum and urine samples,although one metabolite(formate)in univariate statistical analysis was significantly lower in serum of patients with active CD,and two metabolites(alanine and N-acetylated compounds)were significantly higher in serum of patients with CD when comparing jointly patients in the remission and active phase of the diseases.Contrary to the results obtained from the serum samples,the analysis of urine samples allowed to distinguish patients with IBD in remission from healthy control subjects.The metabolites of importance included in this case up-regulated acetoacetate and down-regulated citrate,hippurate,taurine,succinate,glycine,alanine and formate.CONCLUSION:NMR-based metabolomic fingerprinting of serum and urine has the potential to be a useful tool in distinguishing patients with active IBD from those in remission. | Tomasz Dawiskiba Stanislaw Deja Agata Mulak Adam Zabek Ewa Jawień Dorota Pawelka Miroslaw Banasik Agnieszka Mastalerz-Migas Waldemar Balcerzak Krzysztof Kaliszewski Jan Skóra Piotr Bar Krzysztof Korta Kornel Pormańczuk Przemyslaw Szyber Adam Litarski Piotr Mlynarz | 2014 | World Journal of Gastroenterology2014，20，1： | 15 |
| 16 | 早产儿三元整合式教育方案的构建与实施显示文摘目的建立早产儿三元整合式教育方案,并探讨其培训效果。方法组建三元整合教育团队,按照早产儿的发育发展特点构建教育课程,搭建教育平台,包括开办家长学校、开展家长微课堂、视频引导、家长床旁照护操作培训等。采用NICU家长满意度调查表调查并比较培训前后家长满意度。结果培训后早产儿家长的满意度总分为(191.90±0.20)分,培训前满意度总分为(176.00±4.40)分,差异有统计学意义(t=-41.68,P<0.001);培训前后家长的知识和信息维度、家长参与照护维度、医护人员专业态度维度得分的比较,差异有统计学意义(t1=-20.83,P1<0.001;t2=-27.30,P2<0.001;t3=-27.10,P3<0.001)。结论早产儿三元整合式教育方案能提升家长的照护知识和参与照护能力,提高家长对医护人员专业态度的满意度。 | 胡晓静 李丽玲 刘婵 陆春梅 钱葛平 Lee SK 曹云 | 2019 | 中华护理杂志2019，54，11： | 14 |
| 17 | Prospective validation of %p2PSA and the Prostate Health Index, in prostate cancer detection in initial prostate biopsies of Asian men, with total PSA 4-10 ng ml-1显示文摘尽管有它为屏蔽的前列腺癌症的普遍使用,低特性使 PSA 成为非最优的 biomarker,特别在 4-10 ng ml 1 的诊断灰色的地区。假积极与伴随的病态导致不必要的活体检视。这在与在 4.0 和 10 ng ml 1 之间的全部的 PSA 介绍的亚洲人是 % p2PSA 和前列腺健康索引(PHI ) 的第一未来的确认研究。我们学习了在 50 和 75 岁之间的 157 个亚洲人,与每直肠的前列腺考试的正常,经历他们的第一前列腺活体检视,用一个标准化活体检视协议,为 4-10 ng ml 1 的 PSA 层次。(19.1%) 三十被发现在活体检视上有前列腺癌症。有或没有前列腺癌症的病人之间的统计上重要的差别被作出对有利的裁决全部的 PSA, p2PSA, % p2PSA,和 PHI。在为全部的 PSA, % fPSA, % p2PSA,和 PHI 操作典型曲线的接收装置的曲线下面的区域分别地是 0.479, 0.420, 0.695,和 0.794。PHI 最好预言 prostatic 活体检视结果。在 90% 的敏感, PHI 的特性(95% CI ) 是 58.3% ,多于在 17.3% 点使全部的 PSA 的特性增加两倍,潜在地避免 77 (49%) 不必要的活体检视。类似于研究在主要白种人人口,我们有希望地证明了 % p2PSA 和 PHI 极大地超过总数并且释放总计 PSA 比率,在前列腺癌症的察觉起初活体检视。更高的 PHI 层次也对应于增加检测 GS 7 癌症的风险。我们验证了 PHI 的使用与在 4 和 10 ng ml 1 之间的浆液 PSA 在亚洲人关于前列腺活体检视帮助决策。 | Lincoln GL Tan Yung Khan Tan Bee Choo Tai Karen ML Tan Vineet Gauhar Ho Yee Tiong Robert CW Hawkins Thomas P Thamboo Felicia SK Hong Edmund Chiong | 2017 | Asian Journal of Andrology2017，19，3： | 13 |
| 18 | 涎腺类乳腺分泌性癌:采用标准RT-PCR法未能检出25例ETV6-NTRK3融合基因的进一步分子分型(4例存在ETV6-X融合基因)显示文摘ETV6基因异常在肿瘤病理学中已有完整描述。据文献报道,不同的上皮性肿瘤和血液系统恶性肿瘤可检出多种ETV6融合基因伴侣。在涎腺肿瘤病理中,ETV6-NTRK3易位被认为是类乳腺分泌性癌(MASC)的特异性改变,而在其他类型的涎腺肿瘤中均未见报道。 | Skálová A Vanecek T Simpson R H 胡舜 余英豪 | 2016 | 临床与实验病理学杂志2016，32，3： | 13 |
| 19 | 父母参与NICU患儿护理的优势与挑战显示文摘在围产期护理发展之前,新生儿都是在家庭出生并由其父母和助产士进行护理。自20世纪初期,医院开始为新生儿、早产儿提供医疗服务和专业护理,取代了父母的家庭护理。1979年护士出现短缺,爱沙尼亚塔林儿童医院新生儿病房开展了一个新的护理模式,该项目规定:新生儿全天24 h由父母看护,必要的时候医护人员给予帮助;尽可能的提倡母乳喂养;尽量减少医疗技术使用。 | 李变 张欣 Warre R O'Brien K Lee SK | 2015 | 中国新生儿科杂志2015，30，6： | 12 |
| 20 | NCB-02 (standardized Curcumin preparation) protects dinitrochlorobenzene-induced colitis through down-regulation of NFκ-B and iNOS显示文摘AIM: To evaluate the efficacy and mechanism of action of NCB-02, a standardized Curcumin preparation, against 2, 4-dinitrochlorobenzene (DNCB)-induced ulcerative colitis in rats. METHODS: Ulcerative colitis was induced in male rats by sensitizing with topical application of DNCB in acetone for 14 d and intra-colonol challenge with DNCB on day 15. A separate group of animals with vehicle treatment in similar fashion served as control group. Colitis rats were divided into different groups and treated with NCB-02 at doses of 25, 50 and 100 mg/kg b.wt p.o. for 10 d. Sulfasalazine at a dose of 100 mg/kg b.wt for 10 d served as a reference group. On day 10 after respective assigned treatment, all the animals were euthanized and the length of the colon, weight of entire colon and distal 8 cm of the colon were recorded. The distal part of the colon was immediately observed under a stereomicroscope and the degree of damage was scored. Further distal 8 cm of the colon was subject to the determination of colonic myeloperoxidase (MPO), lipid peroxidation (LPO) and alkaline phosphatase (ALP) activities. A small piece of the sample from distal colon of each animal was fixed in 10% neutral buffered formalin and embedded in paraffin wax and sectioned for immunohistochemical examination of NFκ-B and iNOS expression. RESULTS: NCB-02 showed a dose dependent protection against DNCB-induced alteration in colon length and weight. NCB-02 treatment also showed a dose dependent protection against the elevated levels of MPO, LPO and ALP, induced by DNCB. NCB-02 demonstrated a significant effect at a dose of 100 mg/kg b.wt., which was almost equipotent to 100 mg/kg b.wt. of sulfasalazine. Treatment with sulfasalazine and curcuminat a dose of 100 mg/kg b.wt. inhibited the DNCB-induced overexpression of NFκ-B and iNOS in the colon. CONCLUSION: Curcumin treatment ameliorates colonic damage in DNCB-induced colitic rats, an effect associated with an improvement in intestinal oxidative stress and downregulation of colonic NFκ-B and iNOS expression. | MV Venkataranganna Md Rafiq S Gopumadhavan Ghouse Peer UV Babu SK Mitra | 2007 | World Journal of Gastroenterology2007，13，7： | 12 |
您所在的机构暂未开通此部分的功能，请联系管理员