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| 1 | Thyroid hormones and thyroid hormone receptors: Effects of thyromimetics on reverse cholesterol transport显示文摘Reverse cholesterol transport (RCT) is a complex process which transfers cholesterol from peripheral cells to the liver for subsequent elimination from the body via feces. Thyroid hormones (THs) affect growth, develop- ment, and metabolism in almost all tissues. THs exert their actions by binding to thyroid hormone receptors (TRs). There are two major subtypes of TRs, TRα and TRβ, and several isoforms (e.g. TRα1, TRα2, TRβ1, and TRβ2). Activation of TRα1 affects heart rate, whereas activation of TRβ1 has positive effects on lipid and lipoprotein metabolism. Consequently, particular interest has been focused on the development of thyromimetic compounds targeting TRβ1, not only because of their ability to lower plasma cholesterol but also due their ability to stimulate RCT, at least in pre-clinical models. In this review we focus on THs, TRs, and on the effects of TRβ1-modulating thyromimetics on RCT in various animal models and in humans. | Matteo Pedrelli Camilla Pramfalk Paolo Parini | 2010 | World Journal of Gastroenterology2010，16，47： | 4 |
| 2 | 胆固醇结石病人肝脏脂质代谢异常的分子生物学研究显示文摘目的:研究导致胆石病人胆汁胆固醇过饱和的肝脏胆固醇和胆汁酸代谢途径中的分子生物学改变。方法:收集22例胆石病人和13例无胆石病的对照病人肝脏活检组织、胆囊胆汁和血浆。采用实时定量PCR检测肝脏基因表达,采用Western印迹法测定蛋白含量。结果:胆石病人较对照组ABCG5/ABCG8和LXRα基因的mRNA表达水平分别增加51%、59%和102%。肝脏SRBI的mRNA和蛋白含量均增加。结论:胆石病人ABCG5/ABCG8基因表达上调,可能与LXRα表达增加促进相关,这些异常是导致胆汁胆固醇过饱和的原因。此外,胆汁中过多的胆固醇可能来源于经肝脏高密度脂蛋白受体SRBI的摄取,而不是由于肝脏合成和酯化的异常。 | 蒋兆彦 姜翀弋 胡海 所广军 Paolo Parini Gsta Eggertsen Matthew A Davis Lawrence L Rudel Curt Einarsson 韩天权 张圣道 | 2007 | 外科理论与实践2007，12，5： | 4 |
| 3 | Essential role of TRPC1 channels in cardiomyoblasts hypertrophy mediated by 5-HT 2A serotonin receptors显示文摘 | Cécile Vindis Romina D’Angelo Elodie Mucher Anne Nègre-Salvayre Angelo Parini Jeanne Mialet-Perez | 2009 | Biochemical and Biophysical Research Communications2009，，1： | 2 |
| 4 | 儿童Fabry病的临床表现:来自Fabry病转归调查的数据显示文摘Background:Fabry disease is a rare X-linked disorder caused by deficient activity of the enzyme α-galactosidase A.This produces progressive lysosomal accumulation of globotriaosylceramide throughout the body,leading to organ failure and premature death.Aim:Here,we present the clinical manifestations of Fabry disease in children enrolled in FOS-the Fabry Outcome Survey-a European database of the natural history of Fabry disease and the effects of enzyme replacement therapy with agalsidase alfa(Replagal(tm)).Methods:Currently,there are 545 patients in FOS,from 11 European countries.We analysed the baseline demographic and clinical characteristics of 82 of these patients(40 boys,42 girls)who were below 18 y of age.The median age at evaluation(defined as the median age at entry into FOS)was 12.5 and 13.2 y for boys and girls,respectively.Results:The most frequent early clinical manifestations of Fabry disease were neurological(acroparaesthesiae,altered temperature sensitivity)and gastrointestinal symptoms(altered bowel habits and abdominal pain),which were documented in about 80%and 60%of patients,respectively,at the time of evaluation and subsequent entry into FOS.Tinnitus,vertigo,fatigue and angiokeratoma were present in over 40%of patients.Symptoms were noted in early childhood and occurred with similar frequency in boys and girls,although the onset of symptoms was 2-5 y later in girls than in boys.There was an approximately 3-y delay from onset of symptoms to diagnosis,and patients were frequently misdiagnosed.Conclusion:Although the life-threatening complications of Fabry disease,such as stroke and renal and heart failure,are not seen in children,the present analysis shows that other symptoms are common and may have an impact on quality of life. | Ramaswami U. Whybra C. Parini R. 郭战宏(译) | 2006 | 世界核心医学期刊文摘(儿科学分册)2006，2，8： | 1 |
| 5 | Increased expression of LXR alpha, ABCG5, ABCG8, and SR-BI in the liver from normolipidemic, nonobese Chinese gallstone patients显示文摘 | Jiang ZY Parini P Eggertsen G | 2008 | J Lipid Res2008，49，2： | 1 |
| 6 | Genetic diversity and technological properties of Streptococcus thormophilus strains isolated from dairy products显示文摘 | Mora D Fortina MG Parini C | 2002 | J Appl Microbiol2002，93，2： | 1 |
| 7 | Laparoscopic total mesorectal excision :a consecutive series of 100 patients显示文摘 | Morino M Parini U Giraudo G | 2003 | Ann Surg2003，237，3： | 1 |
| 8 | Diffracted Gaussian beam analysis of quasi-optical muhireflector systems, electronics letters 显示文摘 | Rieckmann C Rayner M R Parini C G | 2000 | Electronics Letters2000，36，19： | 1 |
| 9 | Laparoseopic total mesorectal excision:a consecutive series of 100 patients显示文摘 | Morino M Parini U Giraudo G | 2003 | Ann Surg2003，237，3： | 1 |
| 10 | Novel modular approach based on Gaussian beam diffraction for analysing quasioptical multi-reflector antennas 显示文摘 | Rieckmann C Rayner M R Parini C G | 2002 | IEE Proc-Microw Antennus Propag2002，149，3： | 1 |
| 11 | A small printed quasi-self-com- plementary antenna for uhrawideband systems 显示文摘 | LU G SHENG W PARINI C | 2009 | IEEE Anten- nas and Wireless Propagation Letters2009，8，： | 1 |
| 12 | Laparoscopic total mesorectal excision:a consecutive series of 100 patients显示文摘 | Morino M Parini U Giraudo G | 2003 | Ann Surg2003，237，： | 1 |
| 13 | Low Serum Testosterone Increases Mortality Risk among Male Dialysis Patients显示文摘 | Juan Jesús Carrero Abdul Rashid Qureshi Paolo Parini | 2009 | J Am Soc Nephrol2009，20，3： | 1 |
| 14 | Male sexual and urinary function after laparoscopic total mesorectal excision显示文摘 | Mario Morino Umberto Parini Marco Ettore Allaix Gabriella Monasterolo Riccardo Brachet Contul Corrado Garrone | 2009 | Surgical Endoscopy2009，，6： | 1 |
| 15 | ACAT2 is localized to hepatocytes and is the major cholesterol- esterifying enzyme in human liver显示文摘 | PARINI P DAVIS M LADA A T | 2004 | Circulation2004，110，14： | 1 |
| 16 | ACAT2is localized to hepatoeytes and is the major cholesterolesterifying enzyme in human liver显示文摘 | PARINI P DAVIS M LADA A T | 2004 | Circulation2004，110，14： | 1 |
| 17 | Activation of pro-apoptotic cascade by dopamine in renal epithelial cells is fully dependent on hydrogen peroxide generation by monoamine oxidases显示文摘 | Bianchi P Segulas MH Parini A | 2003 | J Am Soc Nephrol2003，14，： | 1 |
| 18 | Hypocholesterolemic effects of fatty acid bile acid conjugates (FABACs) in mice 显示文摘 | Leikin-Frenkel A Parini P Konikoff FM | 2008 | Arch Biochem Biophys2008，471，1： | 1 |
| 19 | Study of compact antenna for UWB applications显示文摘 | Guo L Wang S Parini C G | 2010 | Electronics Letters2010，46，2： | 1 |
| 20 | Optimisation of cross-po- larisation performance for tri-reflector CATR with spherical main reflector 显示文摘 | Rieckmann C Rayner M R Parini C G | 1999 | Electronics Letter1999，135，17： | 1 |
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