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| 1 | Biomarkers in diabetic nephropathy: Present and future显示文摘Diabetic nephropathy(DN) is the leading cause of end stage renal disease in the Western world. Microalbuminuria(MA) is the earliest and most commonly used clinical index of DN and is independently associated with cardiovascular risk in diabetic patients. Although MA remains an essential tool for risk stratification and monitoring disease progression in DN, a number of factors have called into question its predictive power. Originally thought to be predictive of future overt DN in 80% of patients, we now know that only around 30% of microalbuminuric patients progress to overt nephropathy after 10 years of follow up. In addition, advanced structural alterations in the glomerular basement membrane may already have occurred by the time MA is clinically detectable.Evidence in recent years suggests that a significant proportion of patients with MA can revert to normoalbuminuria and the concept of nonalbuminuric DN is well-documented, reflecting the fact that patients with diabetes can demonstrate a reduction in glomerular filtration rate without progressing from normo-to MA. There is an unmet clinical need to identify biomarkers with potential for earlier diagnosis and risk stratification in DN and recent developments inthis field will be the focus of this review article. | Gemma Currie Gerard Mc Kay Christian Delles | 2014 | World Journal of Diabetes2014，5，6： | 26 |
| 2 | Effects of urea and(NH_4)_2 SO_4 on nitrification and acidification of Ultisols from Southern China显示文摘The mechanisms for the effects of ammonium-based fertilizers on soil acidification in subtropical regions are not well understood.Two Ultisols collected from cropland and a tea garden in Anhui and Jiangxi Provinces in subtropical southern China,respectively,were used to study the effects of urea and(NH 4) 2 SO 4 on the nitrification and acidification of soils with incubation experiments.Nitrification occurred at very low pH with no N fertilizer added and led to lowering of the soil pH by 0.53 and 0.30 units for the soils from Jiangxi and Anhui,respectively.Addition of urea accelerated nitrification and soil acidification in both Ultisols;while nitrification was inhibited by the addition of(NH 4) 2 SO 4,and greater input of(NH 4) 2 SO 4 led to greater inhibition of nitrification.Ammonia-oxidizing bacteria(AOB) played an important role in nitrification in cropland soil under acidic conditions.Addition of urea increased the soil pH at the early stages of incubation due to hydrolysis and stimulated the increase in the AOB population,and thus accelerated nitrification and soil acidification.At the end of incubation,the pH of Ultisol from Jiangxi had decreased by 1.25,1.54 and 1.84 units compared to maximum values for the treatments with 150,300 and 400 mg/kg of urea-N added,respectively;the corresponding figures were 0.95,1.25 and 1.69 for the Ultisol from Anhui.However,addition of(NH 4) 2 SO 4 inhibited the increase in the AOB population and thus inhibited nitrification and soil acidification.Soil pH for the treatments with 300 and 400 mg/kg of(NH 4) 2 SO 4-N remained almost constant during the incubation.AOB played an important role in nitrification of the cropland soil under acidic conditions.Addition of urea stimulated the increase in the AOB population and thus accelerated nitrification and soil acidification;while addition of(NH 4) 2 SO 4 inhibited the increase in the AOB population and thus inhibited nitrification. | Dell Tong Renkou Xu | 2012 | Journal of Environmental Sciences2012，24，4： | 21 |
| 3 | Molecular pathogenesis of bone metastases in breast cancer: Proven and emerging therapeutic targets显示文摘Metastatic occurrence is the principal cause of death in breast cancer patients. The high osteotropism makes breast cancer the most common primary tumor type associated with metastatic bone disease. The peculiar clinical aspects associated with metastases limited to the skeletal system suggest considering these cases as a distinctive subset of metastatic patients with a better prognosis. Because bone is frequently the first metastatic site in disease relapse, it is feasible that the next improvement in therapeutic options for bone metastatic disease could be associated with an improvement of survival expectation and quality of life in breast cancer patients. Study of the molecular basis of bone remodeling and breast cancer osteotropism has allowed identification of several therapeutic candidates involved in formation and progression of bone metastases. These targets are frequently the determinants of positive feedback between the tumor and bone cells whose clinical outcome is osteolytic lesions. In this review, we discuss the physiopathologic features underlying targeted therapeutic strategies aimed at interfering with the aberrant bone remodeling associated with breast cancer metastases. | Nadia Rucci Patrizia Sanità Simona Delle Monache Edoardo Alesse Adriano Angelucci | 2014 | World Journal of Clinical Oncology2014，5，3： | 18 |
| 4 | 最优集合预报订正方法在客观温度预报中的应用显示文摘数值模式的直接输出预报在实际应用时常与实况产生一定的偏差,对模式预报进行有效的本地化订正是提高预报准确率的重要手段。以欧洲中期天气预报中心(ECMWF)模式细网格资料,采用最优集合(anolog ensemble,AnEn)预报订正方法对北京市各站1~7 d的日最高气温和日最低气温进行订正,并对相关参数进行了本地化。采用了滑动训练期、优化变量权重两种方案进行训练。检验评估结果表明:(1)滑动训练期采用60 d时能同时保证计算效率和预报准确率;采用最优变量权重方案后,与预报员主观预报准确率对比,AnEn的最低气温优于预报员主观预报,最高气温基本相当;增加训练期的长度(引入多年的历史资料)相比优化变量权重方案能更有效地提高预报准确率。(2)AnEn预报订正方法在改善数值模式预报的固有偏差(如对由数值模式对局地地形、边界层日变化等形成的误差)效果显著,有较好的应用价值;对于因局地天气(如霾、降水、大风等)影响下,AnEn的温度预报准确率虽优于ECMWF,但不如主观预报,未来还有改进空间。还对检验结果进行了时间和空间验证,确保在以后的业务尤其是智能网格预报业务中的运行效果。 | 郝翠 张迎新 王在文 付宗钰 DELLE MONACHE Luca | 2019 | 气象2019，45，8： | 18 |
| 5 | Exocrine pancreatic insufficiency in adults:A shared position statement of the Italian association for the study of the pancreas显示文摘This is a medical position statement developed by the Exocrine Pancreatic Insufficiency collaborative group which is a part of the Italian Association for the Study of the Pancreas(AISP).We covered the main diseases associated with exocrine pancreatic insufficiency(EPI)which are of common interest to internists/gastroenterologists,oncologists and surgeons,fully aware that EPI may also occur together with many other diseases,but less frequently.A preliminary manuscript based on an extended literature search(Medline/PubMed,Cochrane Library and Google Scholar)of published reports was prepared,and key recommendations were proposed.The evidence was discussed at a dedicated meeting in Bologna during the National Meeting of the Association in October 2012.Each of the proposed recommendations and algorithms was discussed and an initial consensus was reached.The final draft of the manuscript was then sent to the AISP Council for approval and/or modification.All concerned parties approved the final version of the manuscript in June 2013. | Raffaele Pezzilli Angelo Andriulli Claudio Bassi Gianpaolo Balzano Maurizio Cantore Gianfranco Delle Fave Massimo Falconi Luca Frulloni the Exocrine Pancreatic Insufficiency collaborative(EPIc) Group | 2013 | World Journal of Gastroenterology2013，19，44： | 16 |
| 6 | 相似集合预报方法在北京区域地面气温和风速预报中的应用显示文摘相似集合是近年来提出的一种基于相似理论、大数据挖掘和集合预报思路的统计释用方法。文中首先介绍了相似集合的基本原理,并应用该方法对北京快速更新循环数值预报系统(BJ-RUC)v3.0预报地面要素开展了订正释用试验。结果表明,相似集合订正后,在0-36 h预报时段内,10 m风速的均方根误差降低44%,2 m气温的均方根误差降低22%,均方根误差均显著减小。对比测站预报误差的水平分布,相似集合方法的应用对于提升非城区站点的10 m风速预报、复杂地形区域的2 m气温预报具有更为明显的效果。相同预报因子的相似集合和支持向量机方法对模式10 m风速和2 m气温预报均具有显著且相似的订正效果,但相似集合方法具有计算资源需求较少、不需要大量人工干预的优势。相似集合方法形成的集形成确定性预报的同时,还能够提供预报要素的不确定性或概率信息。因此,相似集合方法在模式预报订正及释用方面具有广阔的应用前景。 | 王在文 陈敏 Luca Delle Monache 卢冰 张涵斌 | 2019 | 气象学报2019，77，5： | 16 |
| 7 | Growth and nutrient dynamics of Betula alnoides seedlings under exponential fertilization显示文摘Betula alnoides is a fast-growing hardwood species grown in large plantations in Southeast Asia and South China.Nitrogen requirements for producing robus seedlings,growth and nutrient dynamics were investigated using exponential fertilization treatments.Root collar diameter,height,dry mass and nutrient contents of seedlings increased exponentially in all fertilization treatments as time progressed.Moreover,with water soluble fertilizer(Plant Products plus microelements N–P_2O_5–K_2O:20–20–20),300 mg N seedling^(-1)was adequate.Vector analysis revealed that P was the most responsive nutrient element followed by N and K.Dilutions of N and K were evident in the plants without N addition,which induced initial P sufficiency and then luxury consumption probably due to the antagonistic interaction between N and P.However deficiencies of N,P and K were mostly observed in al exponential regimes during the experiment because seedling growth rate exceeded nutrient uptake rate,inferring that further study on improving the nutrient uptake efficiency is needed.Analysis of relationships among nutrient supply,dry mass,N content and N concentration demonstrated that 100–400 mg N seedling^(-1)induced sufficiency to luxury consumption of nitrogen without significant change in dry mass,and 400 mg N seedling^(-1)is recommended to apply for nutrient loading of seedlings before outplanting.The findings will help improve seedling quality and enhance the production of robust seedlings for plantation forestry of this species. | Lin Chen Chunsheng Wang Bernard Dell Zhigang Zhao Junjie Guo Daping Xu Jie Zeng | 2018 | Journal of Forestry Research2018，29，1： | 14 |
| 8 | Nasogastric or nasointestinal feeding in severe acute pancreatitis显示文摘AIM:To assess the rate of spontaneous tube migration and to compare the effects of naso-gastric and nasointestinal(NI)(beyond the ligament of Treitz) feeding in severe acute pancreatitis(SAP).METHODS:After bedside intragastric insertion,tube position was assessed,and enteral nutrition(EN) started at day 4,irrespective of tube localization.Patients were monitored daily and clinical and laboratory parameters evaluated to compare the outcome of patients with nasogastric(NG) or NI tube.RESULTS:Spontaneous tube migration to a NI site occurred in 10/25(40%) prospectively enrolled SAP patients,while in 15(60%) nutrition was started with a NG tube.Groups were similar for demographics and pancreatitis aetiology but computed tomography(CT) severity index was higher in NG tube patients than in NI(mean 6.2 vs 4.7,P=0.04).The CT index seemed a risk factor for failed obtainment of spontaneous distal migration.EN trough NG or NI tube were similar in terms of tolerability,safety,clinical goals,complications and hospital stay.CONCLUSION:Spontaneous distal tube migration is successful in 40% of SAP patients,with higher CT severity index predicting intragastric retention;in such cases EN by NG tubes seems to provide a pragmatic alternative opportunity with similar outcomes. | Matteo Piciucchi Elettra Merola Massimo Marignani Mari-anna Signoretti Roberto Valente Lucia Cocomello Flavia Baccini Francesco Panzuto Gabriele Capurso Gianfranco Delle Fave | 2010 | World Journal of Gastroenterology2010，16，29： | 13 |
| 9 | Simultaneous intraductal papillary neoplasms of the bile duct and pancreas treated with chemoradiotherapy显示文摘Some authors have suggested that intraductal papillary mucinous neoplasms of the bile duct(IPMN-B) could be the the biliary counterpart of IPMN of the pancreas(IPMN-P) since they share several clinical-pathological features.These include prominent intraductal papil-lary proliferation pattern,a gastrointestinal phenotype,frequent mucin hyper-secretion and progression to mu-cinous carcinoma.To date there are just four reported cases of patients with synchronous IPMN-B and IPMN-P all of which were treated surgically.We hereby report the case of a 76-year-old woman who was incidentally diagnosed with both an asymptomatic 3 cm bulky uid lesion obstructing the bile duct lumen,diagnosed as a malignant IPMN-B,and synchronous multiple pancreatic cystic lesions(10-13 mm) communicating with an irreg-ular Wirsung,diagnosed as branch duct IPMN-P.Since surgery was ruled-out because of the patient's age and preferences,she underwent a conservative manage-ment regimen comprising both chemotherapy and radio-therapy.This was effective in decreasing the mass size and in resolving subsequent jaundice.This is also the f irst reported case of IPMN-B successfully treated with chemoradiotherapy.Clinicians should consider medical treatment as an option in this clinical scenario,in pa-tients who may be unf it for surgery. | Roberto Valente Gabriele Capurso Paola Pierantognetti Elsa Iannicelli Matteo Piciucchi Adriana Romiti Paolo Mercantini Alberto Larghi Giulia Francesca Federici Viola Barucca Maria Falchetto Osti Emilio Di Giulio Vincenzo Ziparo Gianfranco Delle Fave | 2012 | World Journal of Gastrointestinal Oncology2012，4，2： | 13 |
| 10 | 施P肥和外生菌根菌接种对蓝桉林产量和养分积累的影响显示文摘主要研究施P肥和接种外生菌根菌对蓝桉生长、生物量和养分积累的影响。在云南楚雄的试验表明:接种外生菌根菌只能在幼林期促进树木生长,3a后这种促进作用不显著。施P肥能在幼林期促进蓝桉树高和胸径的生长,但4 5a后这种促进作用也变得不显著。由于施P肥提高了蓝桉的保存率,所以也显著地提高了蓝桉林的生物量。低P处理时,树木保存率低,较大的生长空间促进了树木的后期生长,可能会导致施P肥对后期单株蓝桉树高和胸径生长作用不显著。施P肥还增加了树木N、P和K的养分积累量,提高了上述养分的利用效率。施P肥同时还明显增加了林下植被和林下凋落物P的积累量,但不能明显增加N和K的养分积累量。树木叶片和土壤分析结果进一步说明施P肥对蓝桉幼林作用明显。试验表现出接种外生菌根菌只能在低P情况下促进树木生长,不能在高P情况下促进树木生长的基本趋势。 | 徐大平 Bernie Dell 弓明钦 Nick Malajczuk 王志和 | 2004 | 林业科学研究2004，17，1： | 10 |
| 11 | 可持续服装的情感化设计显示文摘时尚行业在获得巨大经济利益的同时,也引发了全球生态危机,为创造一个可持续的时尚系统,服装设计师开始寻求更具环保性的设计策略。基于人类基本需求发展理论,对服装消费者的情感进行研究,挖掘服装设计中综合情感因素和可持续设计之间的联系,从材料的情感表现、适应性设计、参与式设计、模块化设计和定制设计5个方面,提出满足人类情感需求的设计方法,为消费者提供更好的用户体验,达到延长服装生命周期的目的,为可持续性服装设计提供新的方向。 | 唐颖 刘伦伦 刘妍兵 ARTURO Dell'Acqua Bellavitis | 2020 | 服装学报2020，5，6： | 9 |
| 12 | Area under the curve of methotrexate and creatinine clearance are outcome - determining factors in primary CNS lymphomas显示文摘Although high-dose methotrexate(HD-MTX)is the most effective drug against primary CNS lymphomas(PCNSL),outcome-de-termining variables related to its administration schedule have not been defined.The impact on toxicity and outcome of the area under thecurve(AUC(MTX)),dose intensity(DI(MTX))and infusion rate(IR(MTX))of MTX and plsamatic creatinine clearance(CL(crea))was investigated in a retrospective series of 45 PCNSL patients treated with three different HD-MTX-basedcombinations.Anticon-vulsants were administered in 31 pts(69%).Age>60 years,anticonvulsant therapy,slow IR(MTX)( | FerreriAJ GuerraE RegazziM PasiniF AmbrosettiA PivnikA GubkinA CalderoniA SpinaM BrandesA FerrareseF RognoneA GoviS Dell’OroS LocatelliM VillaE ReniM | 2004 | 中国神经肿瘤杂志2004，2，1： | 9 |
| 13 | Optimal management of a patient with recurrent nasopharyngeal carcinoma显示文摘Nasopharyngeal carcinoma is rare in western countries, accounting for less than 1% of all malignancies. Despite prognosis is satisfactory for newly diagnosed, non-metastatic disease, management of recurrent disease is challenging, with a survival expectancy of approximately 6 mo with the use of chemotherapy as the sole salvage treatment. We report a case of recurrent nasopharyngeal carcinoma treated with a combination of chemotherapy, radiotherapy and surgery in the context of a multidisciplinary approach. A durable complete response was achieved. | Francesco Perri Italo Dell’Oca Paolo Muto Concetta Schiavone Corrado Aversa Franco Fulciniti Raffaele Solla Giuseppina Della Vittoria Scarpati Carlo Buonerba Giuseppe Di Lorenzo Francesco Caponigro | 2014 | World Journal of Clinical Cases2014，2，7： | 8 |
| 14 | Gastroenteropancreatic neuroendocrine tumours显示文摘 | Irvin M Modlin Kjell Oberg Daniel C Chung Robert T Jensen Wouter W de Herder Rajesh V Thakker Martyn Caplin Gianfranco Delle Fave Greg A Kaltsas Eric P Krenning Steven F Moss Ola Nilsson Guido Rindi Ramon Salazar Philippe Ruszniewski Anders Sundin | 2008 | Lancet Oncology2008，，1： | 8 |
| 15 | Lack of specific association between gastric autoimmunity hallmarks and clinical presentations of atrophic body gastritis显示文摘AIM: To investigate the possible relationships between gastric autoimmune phenomena and clinical presentations of this disorder, in consecutive atrophic body gastritis patients.METHODS: A total of 140 atrophic body gastritis patients,diagnosed as consecutive outpatients presenting with macrocytic or iron deficiency anemia, or longstanding dyspepsia underwent gastroscopy with antral and body biopsies, assay of intrinsic factor, parietal cells and Helicobacter pylori(H pylori) antibodies. Gastritis was assessed according to Sydney System.RESULTS: Parietal cell antibodies were equally distributed in all clinical presentations, whereas the positivity of intrinsic factor antibodies (49/140, 35%) was significantly higher in pernicious anemia patients (49.2%) than in iron deficiency (21.1%) and dyspeptic patients (27.8%). No specific pattern of autoantibodies was related to the clinical presentations of atrophic body gastritis. A positive correlation was obtained between the body atrophy score and the intrinsic factor antibody levels (r = 0.2216,P = 0.0085). Associated autoimmune diseases were present in 25/140 (17.9%) patients, but the prevalence of autoimmune diseases was comparable, irrespective of the clinical presentations.CONCLUSION: The so-called hallmarks of gastric autoimmunity, particularly in intrinsic factor antibody cannot be usefully employed in defining an autoimmune pattern in the clinical presentations of ABG. | Bruno Annibale Edith Lahner Riccardo Negrini Flavia Baccini Cesare Bordi Bruno Monarca Gianfranco Delle Fave | 2005 | World Journal of Gastroenterology2005，11，34： | 6 |
| 16 | 埃索美拉唑能有效控制内镜阴性胃食管反流症状——6个月“按需治疗”对照试验显示文摘 | Talley NJ Lauritsen K Tunturi-Hihnala H Lind T Moum B Bang C Schulz T Omland TM Delle M Junghard O 钟捷 | 2003 | 中华消化杂志2003，23，1： | 6 |
| 17 | 区域土壤质地层次三维空间分布的地统计模拟方法比较显示文摘为了定量化描述冲积平原区土壤剖面质地层次的复杂变异性,本研究根据华北冲积平原一块面积约15km2区域内的139个土壤剖面(0~2m)观测数据,分别应用顺序指示模拟和多点地统计学模拟方法分析了区域内土壤质地层次的三维空间分布特征。前者的结果显示土壤质地层在水平方向上的分布具有很强的随机特性,而后者的结果表明土壤质地层在水平方向上的分布具有一定的规律性。将转移概率函数得到的各向同性分布比例和各向异性平均长度(厚度)用来生成三维训练图像,然后将生成的训练图像用于多点地统计学模拟,并与传统的顺序指示模拟结果进行了对比。结果表明,多点地统计学模拟在估计精度以及垂直方向上土壤质地层次连贯性的再现性上优于传统顺序指示模拟,所得结果能更好地反映土壤质地层次的空间分布特征。 | 贺勇 胡克林 李保国 黄元仿 Dell Chen | 2010 | 土壤2010，42，3： | 5 |
| 18 | Right ventricular septal pacing: Safety and efficacy in a long term follow up显示文摘AIM: To evaluate the safety and efficacy of the permanent high interventricular septal pacing in a long term follow up, as alternative to right ventricular apical pacing. METHODS: We retrospectively evaluated:(1) 244 patients(74 ± 8 years; 169 men, 75 women) implanted with a single(132 pts) or dual chamber(112 pts) pacemaker(PM) with ventricular screw-in lead placed at the right ventricular high septal parahisian site(SEPTAL pacing);(2) 22 patients with permanent pacemaker and low percentage of pacing(< 20%)(NO pacing);(3) 33 patients with high percentage(> 80%) right ventricular apical pacing(RVA). All patients had a narrow spontaneous QRS(101 ± 14 ms). We evaluated New York Heart Association(NYHA) class, quality of life(Qo L), 6 min walking test(6MWT) and left ventricular function(end-diastolic volume, LV-EDV; end-systolic volume, LVESV; ejection fraction, LV-EF) with 2D-echocardiography. RESULTS: Pacing parameters were stable duringfollow up(21 mo/patient). In SEPTAL pacing group we observed an improvement in NYHA class, Qo L score and 6MWT. While LV-EDV didn't significantly increase(104 ± 40 m L vs 100 ± 37 m L; P = 0.35), LV-ESV slightly increased(55 ± 31 m L vs 49 ± 27 m L; P = 0.05) and LV-EF slightly decreased(49% ± 11% vs 53% ± 11%; P = 0.001) but never falling < 45%. In the RVA pacing control group we observed a worsening of NYHA class and an important reduction of LV-EF(from 56% ± 6% to 43% ± 9%, P < 0.0001).CONCLUSION: Right ventricular permanent high septal pacing is safe and effective in a long term follow up evaluation; it could be a good alternative to the conventional RVA pacing in order to avoid its deleterious effects. | Eraldo Occhetta Gianluca Quirino Lara Baduena Rosaria Nappo Chiara Cavallino Emanuela Facchini Paolo Pistelli Andrea Magnani Miriam Bortnik Gabriella Francalacci Gabriele Dell’Era Laura Plebani Paolo Marino | 2015 | World Journal of Cardiology2015，7，8： | 5 |
| 19 | Endoscopy-guided ablation of pancreatic lesions:Technical possibilities and clinical outlook显示文摘Endoscopic ultrasound(EUS) and endoscopic retrograde cholangiopancreatography(ERCP)-guided ablation procedures are emerging as a minimally invasive therapeutic alternative to radiological and surgical treatments for locally advanced pancreatic cancer(LAPC), pancreatic neuroendocrine tumours(PNETs), and pancreatic cystic lesions(PCLs). The advantages of treatment under endoscopic control are the real-time imaging guidance and the possibility to reach a deep target like the pancreas. Currently, radiofrequency probes specifically designed for ERCP or EUS ablation are available as wel as hybrid cryotherm probe combining radiofrequency with cryotechnology. To date, many reports and case series have confirmed the safety and feasibility of that kind of ablation technique in the pancreatic setting.Moreover, EUS-guided fine-needle injection is emerging as a method to deliver ablative and anti-tumoral agents inside the tumuor. Ethanol injection has been proposed mostly for the treatment of PCLs and for symptomatic functioning PNETs, and the use of gemcitabine and paclitaxel is also interesting in this setting. EUS-guided injection of chemical or biological agents including mixed lymphocyte culture, oncolytic viruses, and immature dendritic cells has been investigated for the treatment of LAPC. Data on the long-term efficacy of these approaches,and large prospective randomized studies are needed to confirm the real clinical benefits of these techniques for the management of pancreatic lesions. | Marianna Signoretti Roberto Valente Alessandro Repici Gianfranco Delle Fave Gabriele Capurso Silvia Carrara | 2017 | World Journal of Gastrointestinal Endoscopy2017，9，2： | 5 |
| 20 | Hepatitis B in patients with hematological diseases: An update显示文摘Hepatitis B virus(HBV) reactivation(HBVr) in patients undergoing immunosuppressive therapy is still a hot topic worldwide. Its prevention and management still represents a challenge for specialists dealing with immunosuppressed patients. Aim of this paper is to provide a critical review of the relevant information emerged in the recent literature regarding HBV reactivation following immunosuppressive treatments for oncohematological tumors. A computerized literature search in MEDLINE was performed using appropriate terms arrangement, including English-written literature only or additional relevant articles. Articles published only in abstract form and case reports not giving considerable news were excluded. Clinical manifestation of HBVr can be manifold, ranging from asymptomatic self-limiting anicteric hepatitis to life-threatening fulminant liver failure. In clusters of patients adverse outcomes are potentially predictable. Clinicians should be aware of the inherent risk of HBVr among the different virological categories(active carriers, occult HBV carriers and inactive carriers, the most intriguing category), and classes of immunosuppressive drugs. We recommend that patients undergoing immunosuppressive treatments for hematological malignancies should undergo HBV screening. In case of serological sign(s) of current or past infection with the virus, appropriate therapeutic or preventive strategies are suggested, according to both virological categories, risk of HBVr by immunosuppressive drugsand liver status. Either antiviral drug management and surveillance and pre-emptive approach are examined, commenting the current international recommendations about this debated issue. | Chiara Coluccio Paola Begini Alfredo Marzano Adriano Pellicelli Barbara Imperatrice Giulia Anania Gianfranco Delle Fave Massimo Marignani | 2017 | World Journal of Hepatology2017，9，25： | 5 |
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