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| 1 | EZH2, an epigenetic driver of prostate cancer显示文摘The histone methyltransferase EZH2 has been in the limelight of the fi eld of cancer epigenetics for a decade now since it was fi rst discovered to exhibit an elevated expression in metastatic prostate cancer.It persists to attract much scientifi c attention due to its important role in the process of cancer development and its potential of being an effective therapeutic target.Thus here we review the dysregulation of EZH2 in prostate cancer,its function,upstream regulators,downstream effectors,and current status of EZH2-targeting approaches.This review there-fore provides a comprehensive overview of EZH2 in the context of prostate cancer. | Yeqing Angela Yang Jindan Yu | 2013 | Protein & Cell2013，4，5： | 9 |
| 2 | Current perspectives on FOXA1 regulation of androgen receptor signaling and prostate cancer显示文摘FOXA1(also known as hepatocyte nuclear factor 3a,or HNF-3a)is a protein of the FKHD family transcription factors.FOXA1 has been termed as a pioneer transcription factor due to its unique ability of chromatin remodeling in which the chromatin can be decompacted to allow genomic access by nuclear hormone receptors,including androgen receptor(AR)and estrogen receptor(ER).In this review,we discuss our current understanding of FOXA1 regulation of prostatic and non-prostatic AR-chromatin targeting.We present an updated model wherein FOXA1:AR equilibrium in the nuclei defines prostatic AR binding profile,which is perturbed in prostate cancer with FOXA1 and/or AR de-regulation.Finally,we discuss recent efforts in exploring new horizons of AR-independent functions of FOXA1 in prostate cancer and interesting directions to pursue in future studies. | Yeqing Angela Yang Jindan Yu | 2015 | Genes & Diseases2015，2，2： | 5 |
| 3 | Cardiopulmonary Comorbidity, Radiomics and Machine Learning, and Therapeutic Regimens for a Cerebral fMRI Predictor Study in Psychotic Disorders显示文摘Recently, two researches by Doucet et al. and Collin et al. used functional neuroimaging as a tool to improve the management of schizophrenia and other psychotic disorders [1, 2]. We would like to highlight several issues in relation to cardiopulmonary comorbidity, radiomics and machine learning, and therapeutic regimens, along with their clinical implications. | Xiao-Hui Wang Angela Yu Xia Zhu Hong Yin Long-Biao Cui | 2019 | Neuroscience Bulletin2019，35，5： | 4 |
| 4 | Ten‐Day Quadruple Therapy Comprising Proton‐Pump Inhibitor, Bismuth, Tetracycline, and Levofloxacin Achieves a High Eradication Rate for H elicobacter pylori Infection after Failure of Sequential Therapy显示文摘 | Ping‐I Hsu Wen‐Chi Chen Feng‐Woei Tsay Chih‐An Shih Sung‐Shuo Kao Huay‐Min Wang Hsien‐Chung Yu Kwok‐Hung Lai Hui‐Hwa Tseng Nan‐Jing Peng Angela Chen Chao‐Hung Kuo Deng‐Chyang Wu | 2014 | Helicobacter2014，，1： | 3 |
| 5 | A 10-miRNA risk score-based prediction model for pathological complete response to neoadjuvant chemotherapy in hormone receptor-positive breast cancer显示文摘Patients with hormone receptor(HR)-positive tumors breast cancer usually experience a relatively low pathological complete response(p CR)to neoadjuvant chemotherapy(NAC).Here,we derived a 10-micro RNA risk score(10-mi RNA RS)-based model with better performance in the prediction of p CR and validated its relation with the disease-free survival(DFS)in 755 HRpositive breast cancer patients(273,265,and 217 in the training,internal,and external validation sets,respectively).This model,presented as a nomogram,included four parameters:the 10-mi RNA RS found in our previous study,progesterone receptor(PR),human epidermal growth factor receptor 2(HER2)status,and volume transfer constant(K).Favorable calibration and discrimination of 10-mi RNA RS-based model with areas under the curve(AUC)of 0.865,0.811,and 0.804 were shown in the training,internal,and external validation sets,respectively.Patients who have higher nomogram score(>92.2)with NAC treatment would have longer DFS(hazard ratio=0.57;95%CI:0.39–0.83;P=0.004).In summary,our data showed the 10-mi RNA RS-based model could precisely identify more patients who can attain p CR to NAC,which may help clinicians formulate the personalized initial treatment strategy and consequently achieves better clinical prognosis for patients with HRpositive breast cancer. | Chang Gong Ziliang Cheng Yaping Yang Jun Shen Yingying Zhu Li Ling Wanyi Lin Zhigang Yu Zhihua Li Weige Tan Chushan Zheng Wenbo Zheng Jiajie Zhong Xiang Zhang Yunjie Zeng Qiang Liu RStephanie Huang Andrzej LKomorowski Eddy SYang François Bertucci Francesco Ricci Armando Orlandi Gianluca Franceschini Kazuaki Takabe Suzanne Klimberg Naohiro Ishii Angela Toss Mona PTan Mathew A Cherian Erwei Song | 2022 | Science China(Life Sciences)2022，65，11： | 3 |
| 6 | The landscape epidemiology of echinococcoses显示文摘Echinococcoses are parasitic diseases of major public health importance globally.Human infection results in chronic disease with poor prognosis and serious medical,social and economic consequences for vulnerable populations.According to recent estimates,the geographical distribution of Echinococcus spp.infections is expanding and becoming an emerging and re-emerging problem in several regions of the world.Echinococcosis endemicity is geographically heterogeneous and over time it may be affected by global environmental change.Therefore,landscape epidemiology offers a unique opportunity to quantify and predict the ecological risk of infection at multiple spatial and temporal scales.Here,we review the most relevant environmental sources of spatial variation in human echinococcosis risk,and describe the potential applications of landscape epidemiological studies to characterise the current patterns of parasite transmission across natural and human-altered landscapes.We advocate future work promoting the use of this approach as a support tool for decision-making that facilitates the design,implementation and monitoring of spatially targeted interventions to reduce the burden of human echinococcoses in disease-endemic areas. | Angela M.Cadavid Restrepo Yu Rong Yang Donald P.McManus Darren J.Gray Patrick Giraudoux Tamsin S.Barnes Gail M.Williams Ricardo J.Soares Magalhães Nicholas A.S.Hamm Archie C.A.Clements | 2016 | Infectious Diseases of Poverty2016，5，1： | 2 |
| 7 | Bulk organic δ 13 C and C/N as indicators for sediment sources in the Pearl River delta and estuary, southern China显示文摘 | Fengling Yu Yongqiang Zong Jeremy M. Lloyd Guangqing Huang Melanie J. Leng Christopher Kendrick Angela L. Lamb Wyss W.-S. Yim | 2010 | Estuarine Coastal and Shelf Science2010，，4： | 1 |
| 8 | Removal of pharmaceuticals in secondary wastewater treatment processes in Taiwan显示文摘 | Angela Y L Yu T Shaik K L | 2009 | J Hazard Mater2009，108，1： | 1 |
| 9 | Removal of pharmaceuticals in secondary wastewater treatment processes in Taiwan显示文摘 | Lin Angela Yu Chen Yu Tsung Hsien Lateef Shaik Khaja | 2009 | Journal of Hazardous Materials2009，167，123： | 1 |
| 10 | Occurrence of pharmaceuticals in Taiwan’s surface waters:impact of waste streams from hospitals and pharmaceutical production facilities显示文摘 | Lin Angela Yu Chen Tsai Yu Ting | 2009 | Sci Total Environ2009，407，12： | 1 |
| 11 | Phototransformation of cephalosporin antibiotics in an aqueous environment re- sults in higher toxicity 显示文摘 | Wang Xiao-huan Angela Yu Chen Lin | 2012 | Environmental Science and Tech- nology2012，46，12： | 1 |
| 12 | COVID-19 reinfection in the presence of neutralizing antibodies显示文摘Due to the high transmissibility of the SARS-CoV-2 virus,it continues to infect over 300000 people worldwide per day(WHO statistics,December 2020),even almost one year after the first COVID-19 cases were confirmed[1,2].One of the most important public health discussions being undertaken currently concerns the protective nature of the immune response and the possibility of reinfection in recovered individuals. | Ju Zhang Nan Ding Lili Ren Rui Song Danying Chen Xuesen Zhao Budong Chen Junyan Han Jiarui Li Yangzi Song Lin Di Kai Han Fengting Yu Ruming Xie Zhihai Chen Wen Xie Jingyuan Liu Shan Cen Yuhai Bi Angela R.Wu Fujie Zhang Chen Chen Hui Zeng | 2021 | National Science Review2021，8，4： | 1 |
| 13 | Pharmaceutical Contamination in Residential, Industrial, and Agricultural Waste Streams: Risk to Aqueous Environments in Taiwan显示文摘 | Angela Yu-Chen Lin Tsung-Hsien Yu Cheng-Fang Lin | 2008 | Chemosphere2008，74，： | 1 |
| 14 | Removal of pharmaceuticals in secondary wastewater treatment processes in Taiwan 显示文摘 | ANGELA Y C L YU T SHAIK KL | 2009 | Journal of Hazardous Materials2009，108，1： | 1 |
| 15 | The effect of aprepitant and race on the pharmacokinetics of cyclophosphamide in breast cancer patients显示文摘 | Christine Walko Austin Combest Ivan Spasojevic Angela Yu Shriya Bhushan J. Hull Janelle Hoskins Delma Armstrong Lisa Carey Frances Collicio E. Dees | 2012 | Cancer Chemotherapy and Pharmacology2012，，5： | 1 |
| 16 | Can learning be virtually boosted? An investigation of online social networking impacts显示文摘 | Angela Yan Yu Stella Wen Tian Douglas Vogel Ron Chi-Wai Kwok | 2010 | Computers & Education2010，，4： | 1 |
| 17 | Improvement of Agrobacterium-mediated transformation in Hi-II maize (Zea mays) using standard binary vectors显示文摘 | Juan M. Vega Weichang Yu Angela R. Kennon Xinlu Chen Zhanyuan J. Zhang | 2008 | Plant Cell Reports2008，，2： | 1 |
| 18 | Tumor Necrosis Factor α Induces Sustained Signaling and a Prolonged and Unremitting Inflammatory Response in Rheumatoid Arthritis Synovial Fibroblasts显示文摘 | Angela Lee Yu Qiao Galina Grigoriev Janice Chen Kyung‐Hyun Park‐Min Sung Ho Park Lionel B. Ivashkiv George D. Kalliolias | 2013 | Arthritis & Rheumatism2013，，4： | 1 |
| 19 | N -terminal pro -brain natriuretie peptide: an independent risk predictor of cardiovascular congestion, mortality and adverse cardiovascular outcomes in chronic peritoneal dialysis patients 显示文摘 | Angela Yee - Moon Wang Christopher Wai - Kei Lam Cheuk- Man Yu | 2007 | J Am Soc Nephrol2007，18，： | 1 |
| 20 | Can learning be virtually boosted? An investigation of online social networking impacts显示文摘 | Angela Yah Yu Stella Wen Tiart Douglas Vogel & Ron Chi-Wai Kwok | 2010 | Computers & Education2010，，55： | 1 |
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