|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Preparation of monolayer-assembled fluorescent film and its sensing performances to hidden nitroaromatic explosives显示文摘Pyrene was chemically assembled on a glass plate surface in a monolayer manner via spacers con-taining triethylenetetramine (TETA) subunits. It has been demonstrated that the fluorescence emission of the film is sensitive to the presence of trace amount of nitroaromatic compound (NAC) vapors. As discovered in the present work, the response selectivity of the pyrene-functionalized film depends on the length of the spacer, the vapor pressure of a given NAC, and the quencher size. The film shows faster response to those quenchers which have higher vapor pressure and smaller size. Compared to the film with shorter spacers, the present film with longer flexible spacers shows a slower response to the NACs, but higher selectivity to the quencher size. Additionally, the detection limits to common ex-plosives in vapor phase, 2,4,6-trinitrotoluene (TNT) and 2,4-dinitrotoluene (DNT), are 7.14×10-12 and 5.49×10-11 g·mL-1, respectively. Further examinations indicated that the sensing process is fully re-versible, and the vapors of those common interference such as benzene, toluene, ethanol, and perfume have little effect upon the sensing performances of the film. | LI HuiHui LU FengTing ZHANG ShuJuan HE Gang FANG Yu | 2008 | Chinese Science Bulletin2008，53，11： | 4 |
| 2 | Expression profiles of miRNAs in human pancreatic cancer cell lines显示文摘目的将开始由微数组技术在人的胰腺的癌症房间线分析 miRNAs 表示侧面的差别。743 根探针全部的方法 A 根据人,老鼠,和老鼠的已知的 miRNAs 序列被设计。miRNAs 微数组被生产,它的可靠被验证。全部的 RNA 被提取, miRNAs 与胰腺的癌症房间衬里的人(SW1990, Capan-2, BxPC-3, Aspc-1,和 Panc1 ) 和不朽的人被分开胰腺的管上皮的房间线 H6C7。他们用 T4 RNA ligase 被标记,当时是有微数组的 hybridized。通过数组扫描和分析,在胰腺的癌症的 miRNAs 表达式侧面被获得。结果被北弄污和 RT-PCR 验证。与胰腺的癌症有关的 63 miRNAs 全部的结果 A 被发现是在 5 根胰腺的癌症房间线表示的差别,包括 25 下面调整并且 38 起来调整的 miRNAs。mir-21 和 let-7 的表情也被证实。结果建议了侧面能在胰腺的癌症房间被发现的那 miRNAs 表情的结论。 | Shineng Zhang Haijun Zuo Zhong Yu Fengting Huang Wa Zhong | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，2： | 3 |
| 3 | Solar-Driven Producing of Value-Added Chemicals with Organic Semiconductor-Bacteria Biohybrid System显示文摘Photosynthetic biohybrid systems exhibit promising performance in biosynthesis;however,these systems can only produce a single metabolite and cannot further transform carbon sources into highly valuable chemical production.Herein,a photosynthetic biohybrid system integrating biological and chemical cascade synthesis was developed for solar-driven conversion of glucose to value-added chemicals.A new ternary cooperative biohybrid system,namely bacterial factory,was constructed by self-assembling of enzyme-modified light-harvesting donor-acceptor conjugated polymer nanoparticles(D-A CPNs)and genetically engineered Escherichia coli(E.coli).The D-A CPNs coating on E.coli could effectively generate electrons under light irradiation,which were transferred into E.coli to promote the 37%increment of threonine production by increasing the ratio of nicotinamide adenine dinucleotide phosphate(NADPH).Subsequently,the metabolized threonine was catalyzed by threonine deaminase covalently linking with D-A CPNs to obtain 2-oxobutyrate,which is an important precursor of drugs and chemicals.The 2-oxobutyrate yield under light irradiation is increased by 58%in comparison to that in dark.This work provides a new organic semiconductor-microorganism photosynthetic biohybrid system for biological and chemical cascade synthesis of highly valuable chemicals by taking advantage of renewable carbon sources and solar energy. | Wen Yu Haotian Bai Yue Zeng Hao Zhao Shengpeng Xia Yiming Huang Fengting Lv Shu Wang | 2022 | Research2022，，3： | 2 |
| 4 | Oligo(p-phenylenevinylene)-rhodium complex as intracellular catalyst for enhancing biosynthesis of polyhydroxybutyrate biomaterials显示文摘Microbial synthesis utilizes sustainable resources to produce valuable chemicals,as a potential alternative to petroleum-based chemical industry.Although metabolic engineering is an efficient method to enhance the biosynthesis efficacy of microorganisms,it requires complicated biological procedures.Herein,we report a facile intracellular catalysis system for augmenting the production of bio-based material in microorganism.Covalent linking of oligo(p-phenylenevinylene)(OPV)and cyclopentadienyl rhodium(Ⅲ)bipyridine offers intracellular metal catalyst(OPV-Rh).The OPV-Rh complex displayed certain resistance to toxic biomolecules,which guaranteed its catalytic activity in complicated biological systems.With uptake by Gramnegative bacterium Ralstonia eutropha H16(R.eutropha H16),the OPV-Rh complex promotes the transformation of intracellular NADP+to NADPH,which further enhances the biosynthesis of polyhydroxybutyrate(PHB)by this microorganism.This work demonstrates that synthetic metal catalyst can be employed for regulating microbial biosynthesis intracellularly. | Nan Dai Hao Zhao Wen Yu Fengting Lv Libing Liu Shu Wang | 2021 | Science China Chemistry2021，64，1： | 2 |
| 5 | Immobilization of pyrene on quartz plate surface via a flexible long spacer and its sensing properties to dicarboxylic acids显示文摘A novel photo-induced luminescence film has been prepared by immobilizing pyrene on quartz plate surface via a flexible long spacer, 1,3-diaminopropane and 3-glycidoxypropyl trimethoxysilane. The film shows combined monomer and excimer emission of pyrene in both wet and dry states. Steady-state and time-resolved fluorescence emission meas-urements demonstrated that the excimer emission mainly came from direct excitation of ground state dimers, and/or monomers in aggregated state. Classical Birks?scheme plays little role in the formation of the excimers. The structures of the excimers formed during the excitation are complex. Both standard excimer of sandwich-like fully overlapped structure and distorted ex-cimer of partially overlapped structure exist in the excited state of the fluorophore. The emission of the film is sensitive to the presence of dicarboxylic acids, including ethanedioic acid, malonic acid, succinic acid, etc. The emission in the monomer and excimer region increases along with increasing the concentration of the dicarboxylic acids. The time needed for the emission to reach equilibrium depends on the nature of the acids. It has been shown that the longer the chain length of the acids, the more the time needed. This observation is explained by considering the conformational reorganization of the immobilized pyrene due to insertion of the dicarboxylic acids into the space between neighboring spacers. Experimental results from similar studies using formic acid and acetic acid are in support of this explanation. Furthermore, the response of the film to dicarboxylic acids is reversible. | GAO Lining FANG Yu Lü Fengting DING Liping | 2004 | Science China Chemistry2004，47，3： | 1 |
| 6 | Synergistic corrosion inhibition of environment-friendly inhibitors on the corrosion of carbon steel in soft water显示文摘 | Bingru Zhang Chengjun He Cheng Wang Peidi Sun Fengting Li Yu Lin | 2015 | Corrosion Science Volnme942015，，： | 1 |
| 7 | COVID-19 reinfection in the presence of neutralizing antibodies显示文摘Due to the high transmissibility of the SARS-CoV-2 virus,it continues to infect over 300000 people worldwide per day(WHO statistics,December 2020),even almost one year after the first COVID-19 cases were confirmed[1,2].One of the most important public health discussions being undertaken currently concerns the protective nature of the immune response and the possibility of reinfection in recovered individuals. | Ju Zhang Nan Ding Lili Ren Rui Song Danying Chen Xuesen Zhao Budong Chen Junyan Han Jiarui Li Yangzi Song Lin Di Kai Han Fengting Yu Ruming Xie Zhihai Chen Wen Xie Jingyuan Liu Shan Cen Yuhai Bi Angela R.Wu Fujie Zhang Chen Chen Hui Zeng | 2021 | National Science Review2021，8，4： | 1 |
| 8 | Amplification and up-regulation of microRNA-30b in oral squamous cell cancers显示文摘 | Chenying Shao Yili Yu Liying Yu Yuan Pei Qiping Feng Fengting Chu Zhengyu Fang Yi Zhou | 2012 | Archives of Oral Biology2012，，8： | 1 |
| 9 | Phylogenomic tracing of asymptomatic transmission in a COVID-19 outbreak显示文摘SARS-CoV-2 has caused over 100 million deaths and continues to spread rapidly around the world.Asymptomatic transmission of SARS-CoV-2 is the Achilles’heel of COVID-19 public health control measures.Phylogenomic data on SARS-CoV-2 could provide more direct information about asymptomatic transmission.In this study,using a novel MINERVA sequencing technology,we traced asymptomatic transmission of COVID-19 patients in Beijing,China.One hundred and seventy-eight close contacts were quarantined,and 14 COVID-19 patients were laboratory confirmed by RT-PCR.We provide direct phylogenomic evidence of asymptomatic transmission by constructing the median joining network in the cluster.These data could help us to determine whether the current symptom-based screening should cover asymptomatic persons. | Ju Zhang Nan Ding Yangzi Song Rui Song Yang Pan Linghang Wang Shuo Yan Qi Wang Shanfang Ma Lirong Wei Fengting Yu Lianhe Lu Fujie Zhang Chen Chen Hui Zeng | 2021 | The Innovation2021，2，2： | 1 |
| 10 | Controllable assembly of nitrogen-doped mesoporous carbon with different pore structures onto CNTs for excellent lithium storage显示文摘Mesoporous carbon nanomaterials have shown a great application potential in energy storage and conversion fields due to their outstanding conductivity,tunable pore structure,and good chemical stability.Nevertheless,how to accurately control the pore structure,especially directly assembling the mesoporous carbon onto different substrates remains a big challenge.Herein,we have successfully assembled two kinds of highly nitrogen-doped mesoporous carbon onto carbon nanotubes(NMC/CNTs)based on a facile cooperative assembly process assisted by triblock PEO_(20)PPO_(70)PEO_(20)(P123)and PEO_(106)PPO_(70)PEO_(106)(F127)copolymers.The experimental results indicate that the P_(123)/F_(127)mass ratio has a profound effect on the pore structure,leading to the formation of NMC/CNTs composites with spherical pore structure(S-NMC/CNTs)and cylindrical pore structure(CNMC/CNTs).In virtue of fast electron/ion transfer kinetics,the as-prepared S-NMC/CNTs anode demonstrates an excellent electrochemical performance for lithium-ion batteries,and it delivers a high reversible capacity of 588.1 mAh∙g^(−1)at the current of 0.1 A∙g^(−1)after 100 cycles,along with a superior cycling stability.Specifically noted,the controlled assembly route developed in our work can also be applied to other support materials with different structures and compositions. | Haitao Li Xiao Fang Fengting Lv Wei Yu Hui Cheng Haijiao Zhang | 2023 | Nano Research2023，16，3： | 0 |
| 11 | Simulation of Passenger Behavior in Virtual Subway Station Based on Multi-Agent显示文摘According to architectural structure of underground station and condition of passengers,the emergency evacuations are extremely important during emergency accidents caused in the stations.Based on the architectural features and situation of passengers in the station,Multi-Agent system is proposed to analyze passengers’behavior and elements which affect passengers’behavior.Base on the crowd mentality,the model of selective behavior of passengers’route was established to simulate passengers’actions during emergency accidents.It is feasible to find out the influence brought by crowd mentality affect the emergency evacuations,and the influence of remitting the situation from external factor through WebVR.At last,it provides references for emergency evacuation strategy. | Yan Li Zequn Li Fengting Yan Yu Wei Linghong Kong Zhicai Shi Lei Qiao | 2020 | 国际计算机前沿大会会议论文集2020，，2： | 0 |
| 12 | Unexpected Photocatalytic Degeneration of NAD^(+) for Inducing Apoptosis of Hypoxia Cancer Cells显示文摘Developing customized chemical reactions that could regulate a specific biological process on demand is regarded as an advanced and promising strategy for treating diseases.However,conventional chemical reactions become challenging in complex physiological environments,which demand mild reaction conditions,high efficiency,good biocompatibility,and strong controllability.Moreover,the effects of the achieved reactions on the real biological system are usually further lessened.Herein,we describe an advanced photocatalytic reaction that irreversibly converted nicotinamide adenine dinucleotide(NAD+)to nicotinamide and adenosine diphosphate(ADP)-ribose by the cationic conjugated poly(fluorene-co-phenylene)(PFP).This reaction was introduced to tumor cells and triggered cell apoptosis.Under white-light illumination,the photocatalytic reaction decreased the NAD+ratio in tumor cells,disrupted the mitochondrial membrane potential,inhibited the synthesis of adenosine triphosphate(ATP),and effectively induced apoptosis.We propose a mechanism of the reaction where PFP is photoexcited to PFP*,and the obtained photoelectrons are transferred from PFP*to NAD+to produce nicotinamide and another unstable intermediate,ADP-ribosyl radical.ADP-ribosyl radical quickly reacts with triethanolamine to form ADP-ribose.This intracellular utilization of a specific photocatalytic reaction could offer a new approach to affect biological function for efficient cancer treatment. | Shengpeng Xia Haotian Bai Endong Zhang Wen Yu Zhiqiang Gao Fengting Lv Yiming Huang Daoben Zhu Shu Wang | 2023 | CCS Chemistry2023，5，10： | 0 |
| 13 | Distinct durability of IgM/IgG antibody responses in COVID-19 patients with differing severity显示文摘Dear Editor,The coronavirus disease 2019(COVID-19)pandemic is generating a demand for simultaneous vaccine development,which is expected to prevent future outbreaks by eliciting sufficient and protective immunity. | Junyan Han Ning Zhang Danying Chen Yuhuan Gong Guoli Li Yaxian Kong Lin Pu Chen Chen Jingyuan Liu Qi Wang Ju Zhang Xuesen Zhao Juan Du Kai Han Chuan Song Linghang Wang Mingxi Hua Yu Hao Rui Song Yangzi Song Fengting Yu Siyuan Yang Haofeng Xiong Wei Zhang George F.Gao Fujie Zhang Ang Li Hui Zeng Yuhai Bi | 2022 | Science China(Life Sciences)2022，65，1： | 0 |
| 14 | Development of a UHPLC-MS/MS method for the quantification of ilaprazole enantiomers in rat plasma and its pharmacokinetic application显示文摘In Korea and China,ilaprazole is a widely used proton pump inhibitor in the treatment of gastric ulcers.In this study,a specific and sensitive LC-MS/MS method has been developed and validated for the quantification of ilaprazole enantiomers in the rat plasma,using R-lansoprazole as the internal standard.The enantioseparation was achieved on a CHIRALPAK AS-RH column(4.6 mm×150 mm,i.d.5 mm),with a mobile phase composed of 10 m M ammonium acetate aqueous solution and acetonitrile(60:40,V/V),at a flow-rate of 0.5 m L/min.The method was validated over the concentration range of 0.5 e300 ng/m L for both,R-and S-ilaprazole.The lower limit of quantification was 0.5 ng/m L for both enantiomers.The relative standard deviation(RSD)of intra-and inter-day precision of R-ilaprazole and S-ilaprazole was less than 10.9%,and the relative error accuracy(RE)ranged fromà0.5%e2.0%.Finally,the method was successfully evaluated in rats in a stereoselective pharmacokinetic study of the ilaprazole racemate. | Fengting Ou Ying Zhou Jinxiu Lei Su Zeng Fuhai Wu Ning Zhang Lushan Yu | 2020 | Journal of Pharmaceutical Analysis2020，10，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员