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| 1 | Population-Based Genome-wide Association Studies Reveal Six Loci Influencing Plasma Levels of Liver Enzymes显示文摘 | Xin Yuan Dawn Waterworth John R.B. Perry Noha Lim Kijoung Song John C. Chambers Weihua Zhang Peter Vollenweider Heide Stirnadel Toby Johnson Sven Bergmann Noam D. Beckmann Yun Li Luigi Ferrucci David Melzer Dena Hernandez Andrew Singleton James Scott Paul | 2008 | The American Journal of Human Genetics2008，，4： | 1 |
| 2 | Analysis of the PINK1 gene in a cohort of patients with sporadic early-onset parkinsonism in Taiwan显示文摘 | Hon-Chung Fung Chiung-Mei Chen John Hardy Andrew B. Singleton Guey-Jen Lee-Chen Yih-Ru Wu | 2005 | Neuroscience Letters2005，，1： | 1 |
| 3 | Association between AKT1 gene and Parkinson’s disease: A protective haplotype显示文摘 | Georgia Xiromerisiou Georgios M. Hadjigeorgiou Alexandros Papadimitriou Evaggelos Katsarogiannis Vasiliki Gourbali Andrew B. Singleton | 2008 | Neuroscience Letters2008，，2： | 1 |
| 4 | Population-Based Genome-wide Association Studies Reveal Six Loci Influencing Plasma Levels of Liver Enzymes显示文摘 | Xin Yuan Dawn Waterworth John R.B. Perry Noha Lim Kijoung Song John C. Chambers Weihua Zhang Peter Vollenweider Heide Stirnadel Toby Johnson Sven Bergmann Noam D. Beckmann Yun Li Luigi Ferrucci David Melzer Dena Hernandez Andrew Singleton James Scott Paul | 2008 | The American Journal of Human Genetics2008，，4： | 1 |
| 5 | Genome-wide Association Study of Vitamin B6, Vitamin B12, Folate, and Homocysteine Blood Concentrations显示文摘 | Toshiko Tanaka Paul Scheet Betti Giusti Stefania Bandinelli Maria Grazia Piras Gianluca Usala Sandra Lai Antonella Mulas Anna Maria Corsi Anna Vestrini Francesco Sofi Anna Maria Gori Rosanna Abbate Jack Guralnik Andrew Singleton Goncalo R. Abecasis David | 2009 | The American Journal of Human Genetics2009，，4： | 1 |
| 6 | Genes and parkinsonism显示文摘 | John Hardy Mark R Cookson Andrew Singleton | 2003 | Lancet Neurology2003，2，： | 1 |
| 7 | Primary hyperhidrosis显示文摘 | Horacio Kaufmann Daniela Saadia Charlene Polin Stephen Hague Amanda Singleton Andrew Singleton | 2003 | Clinical Autonomic Research2003，，2： | 1 |
| 8 | Alkenes from Halides and Epoxides by Reductive Eliminations with CrⅡ in Complexes 显示文摘 | Kochi J K Singleton D M Andrews L J | 1968 | Tetrahedron1968，24，： | 1 |
| 9 | The effect of tailing lipidation on the bioactivity of antimicrobial peptides and their aggregation tendency Special Issue:Emerging Investigators显示文摘Antimicrobial peptides(AMPs)are potentially powerful alternatives to conven-tional antibiotics in combating multidrug resistance,given their broad spectrum of activity.They mainly interact with cell membranes through surface electrostatic potentials and the formation of secondary structures,resulting in permeability and destruction of target microorganism membranes.Our earlier work showed that two leading AMPs,MSI-78(4–20)and pardaxin(1–22),had potent antimicrobial activ-ity against a range of bacteria.It is known that the attachment of moderate-length lipid carbon chains to cationic peptides can further improve the functionality of these peptides through enhanced interactions with the membrane lipid bilayer,inducing membrane curvature,destabilization,and potential leakage.Thus,in this work,we aimed to investigate the antimicrobial activity,oligomerization propensity,and lipid-membrane binding interactions of a range of N-terminal lipidated analogs of MSI-78(4–20)and pardaxin(1–22).Molecular modeling results suggest that aggregation of the N-lipidated AMPs may impart greater structural stability to the peptides in solu-tion and a greater depth of lipid bilayer insertion for the N-lipidated AMPs over the parental peptide.Our experimental and computationalfindings provide insights into how N-terminal lipidation of AMPs may alter their conformations,with subsequent effects on their functional properties in regard to their self-aggregation behavior,membrane interactions,and antimicrobial activity. | Bruce Lin Andrew Hung William Singleton Kevion K.Darmawan Rachael Moses Bicheng Yao Hongkang Wu Anders Barlow Marc-Antoine Sani Alastair J.Sloan Mohammed Akhter Hossain John D.Wade Yuning Hong Neil M.O’Brien-Simpson Wenyi Li | 2023 | Aggregate2023，4，4： | 0 |
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