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| 1 | MicroRNA-21 as a potential colon and rectal cancer biomarker显示文摘Colorectal cancer(CRC)is one of the most common malignant diseases worldwide and the prognosis is still poor although much progress has been achieved in recent years.In order to reduce CRC-related deaths,many studies are aimed at identifying novel screeningand prognosis-related biomarkers.MicroRNAs(miRNAs)are a class of 18-27-nucleotide single-stranded RNA molecules that regulate gene expression at the posttranscriptional level.It has been demonstrated that miRNAs regulate a variety of physiological functions,including development,cell differentiation,proliferation,and apoptosis.They play important roles in various physiologic and developmental processes and in the initiation and progression of various human cancers.It has been shown that miRNAs can critically regulate tumor cell gene expression,and evidence suggests that they may function as both oncogenes and tumor suppressor genes.In CRC,miRNAs-21 is one of the most important miRNAs and is rapidly emerging as a novel biomarker in CRC,with good potential as a diagnostic and therapeutic target.In this review,we summarize the latest research findings of the clinicopathological relevance of miRNAs-21 in CRC initiation,development,and progress,highlighting its potential diagnostic,prognostic,and therapeutic application,as well as discuss-ing future prospects. | Tao Li Mei Ha Leong Bruce Harms Gregory Kennedy Lin Chen | 2013 | World Journal of Gastroenterology2013，19，34： | 16 |
| 2 | TALEN-based generation of a cynomolgus monkey disease model for human microcephaly显示文摘基因在非人类的首领编辑可以为在人探索病原学和遗传上基于的神经病学的混乱的治疗学的策略导致珍贵模型。然而,仔细在人模仿病理学、行为的赤字的神经病学的混乱的一个猴子模型成功地还没被产生了。Microcephalin 1 (MCPH1 ) 在人的大脑,和智力迟钝伴随的 MCPH1 变化原因头小畸型的进化被含有。这里,我们产生了用抄写带 biallelic MCPH1 变化的一只 cynomolgus 猴子(Macaca fascicularis ) 像使活跃之物的受动器核酸酶。猴子概括了大多数在病人观察的重要临床的特征,包括在头圆周,早熟的染色体冷凝作用(PCC ) ,语料库 callosum 的发育不全和上面的手足 spasticity 的显著减小。而且,在变异的真皮的成纤维细胞的 MCPH1 的 overexpression 救了 PCC 症候群。这个猴子模型可以帮助我们阐明在人的头小畸型并且更好的致病的 MCPH1 的角色在首领大脑尺寸的进化理解这蛋白质的功能。 | Qiong Ke Weiqiang Li Xingqiang Lai Hong Chen Lihua Huang Zhuang Kang Kai Li Jie Ren Xiaofeng Lin Haiqing Zheng Weijun Huang Yunhan Ma Dongdong Xu Zheng Chen Xinming Song Xinyi Lin Min Zhuang Tao Wang Fengfeng Zhuang Jianzhong Xi Frank Fuxiang Mao Huimin Xia Bruce T Lahn Qi Zhou Shihua Yang Andy Peng Xiang | 2016 | Cell Research2016，26，9： | 13 |
| 3 | A STUDY OF STRUCTURE AND PROPERTY CHANGES OF BIODEGRADABLE POLYGLYCOLIDE AND POLY(GLYCOLIDE-co-LACTIDE)FIBERS DURING PROCESSING AND IN VITRO DEGRADATION显示文摘Structure and properties of bioabsorbable polyglycolide (PGA) and poly(glycolide-co-lactide) (PGA-co-PLA)fibers were investigated during several industrial processing stages and in vitro degradation by means of wide-angle X-ray diffraction (WAXD), dynamic mechanical analysis (DMA) and mechanical property tests. In the orientation stage, the PGA fibers were found to have higher degrees of crystallinity than corresponding PGA-co-PLA samples produced under similar conditions. In the hot-stretching and post-annealing stages, after fibers were braided, PGA samples were found to gain more crystallinity and higher Tg than PGA-co-PLA samples. The higher crystallinity in PGA fibers resulted in a slower rate of degradation. DMA results showed that a great deal of internal stress that was built during orientation and hot-stretching stages was released in the post-annealing stage for all PGA and PGA-co-PLA samples. During earlier stages ofin vitro degradation, both PGA and PGA-co-PLA samples exhibited the typical cleavage-induced crystallization mechanism. The heat shrinkage in the glass transition area was found to disappear after 6-8 days of degradation for all PGA and PGA-co-PLA samples, indicating the amorphous portions of the polymers lost orientation after a short period in the buffer solution, most likely due to relaxation of the cleaved chains. | Bruce X.Fu Benjamin S.Hsiao Gavin Chen Jack Zhou Susan Lin Jenny Yuan Ilya Koyfman Dennis D Jamiolkowski Edward Dormier | 2003 | Chinese Journal of Polymer Science2003，21，2： | 9 |
| 4 | ALDH2 contributes to melatonin-induced protection against APP/PS1 mutation-prompted cardiac anomalies through cGAS-STING-TBK1-mediated regulation of mitophagy显示文摘Ample clinical evidence suggests a high incidence of cardiovascular events in Alzheimer’s disease(AD),although neither precise etiology nor effective treatment is available.This study was designed to evaluate cardiac function in AD patients and APP/PS1 mutant mice,along with circulating levels of melatonin,mitochondrial aldehyde dehydrogenase(ALDH2)and autophagy.AD patients and APP/PS1 mice displayed cognitive and myocardial deficits,low levels of circulating melatonin,ALDH2 activity,and autophagy,ultrastructural,geometric(cardiac atrophy and interstitial fibrosis)and functional(reduced fractional shortening and cardiomyocyte contraction)anomalies,mitochondrial injury,cytosolic mtDNA buildup,apoptosis,and suppressed autophagy and mitophagy.APP/PS1 mutation downregulated cyclic GMP-AMP synthase(cGAS)and stimulator of interferon genes(STING)levels and TBK1 phosphorylation,while promoting Aβaccumulation.Treatment with melatonin overtly ameliorated unfavorable APP/PS1-induced changes in cardiac geometry and function,apoptosis,mitochondrial integrity,cytosolic mtDNA accumulation(using both immunocytochemistry and qPCR),mitophagy,and cGAS-STING-TBK1 signaling,although these benefits were absent in APP/PS1/ALDH2−/−mice.In vitro evidence indicated that melatonin attenuated APP/PS1-induced suppression of mitophagy and cardiomyocyte function,and the effect was negated by the nonselective melatonin receptor blocker luzindole,inhibitors or RNA interference of cGAS,STING,TBK1,and autophagy.Our data collectively established a correlation among cardiac dysfunction,low levels of melatonin,ALDH2 activity,and autophagy in AD patients,with compelling support in APP/PS1 mice,in which melatonin rescued myopathic changes by promoting cGAS-STING-TBK1 signaling and mitophagy via an ALDH2-dependent mechanism. | Shuyi Wang Lin Wang Xing Qin Subat Turdi Dongdong Sun Bruce Culver Russel JReiter Xiaoming Wang Hao Zhou Jun Ren | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 9 |
| 5 | Association Between Early Adverse Life Events and Irritable Bowel Syndrome显示文摘 | Kara Bradford Wendy Shih Elizabeth J. Videlock Angela P. Presson Bruce D. Naliboff Emeran A. Mayer Lin Chang | 2012 | Clinical Gastroenterology and Hepatology2012，，4： | 3 |
| 6 | The effect of endoscopic sphincterotomy on acute and chronic complications of biliary endoprostheses显示文摘 | Craig Margulies Eduardo Sampaio Siqueira William Bruce Silverman Xue Sen Lin John Anthony Martin Mordechai Rabinovitz Adam Slivka | 1999 | Gastrointestinal Endoscopy1999，，6： | 2 |
| 7 | Data envelopment analysis 1978–2010: A citation-based literature survey显示文摘 | John S. Liu Louis Y.Y. Lu Wen-Min Lu Bruce J.Y. Lin | 2013 | Omega2013，，1： | 1 |
| 8 | Sex-related differences in IBS patients: central processing of visceral stimuli显示文摘 | Bruce D Naliboff Steve Berman Lin Chang Stuart W.G Derbyshire Brandall Suyenobu Brent A Vogt Mark Mandelkern Emeran A Mayer | 2003 | Gastroenterology2003，，7： | 1 |
| 9 | Genetic and physical localization of an anthracnose resistance gene in Medicago truncatula显示文摘 | Shengming Yang Muqiang Gao Shweta Deshpande Shaoping Lin Bruce A. Roe Hongyan Zhu | 2007 | Theoretical and Applied Genetics2007，，1： | 1 |
| 10 | Preoperative versus post- operative endoscopic retrograde cholangiopanereatography in mild to moderate gallstone pancreatitis显示文摘 | Lin C Simon LO Bruce E | 2000 | Ann Surger- y2000，231，1： | 1 |
| 11 | Conditional colorings of graphs显示文摘 | LAI Hongjian LIN Jianliang MONTGOMERY Bruce | 2006 | Disecrete Mathematics2006，306，： | 1 |
| 12 | Gastric pacing improves emptying and symptoms in patients with gastroparesis显示文摘 | Richard W. McCallum Jian De Z. Chen Zhiyue Lin Bruce D. Schirmer Ronald D. Williams Robert A. Ross | 1998 | Gastroenterology1998，，3： | 1 |
| 13 | Conditional colorings of graphs 显示文摘 | Hong- Jian LM Jiardiang LIN Bruce Montgomery Taozld SHUI Suohai FAN | 2006 | Discrete2006，306，2006： | 1 |
| 14 | Preoperative versus postoperative endoscopic retrograde cholangiopancreatography in mild to moderate gallstone panereatitis显示文摘 | Lin Chang Simon Lo Bruce E | 2000 | Ann Surg2000，231，： | 1 |
| 15 | Mammalian mucosal alpha - glucosidases coordinate with alpha - amylase in the initial starch hydrolysis stage to have a role in starch digestion beyond glucogenesis 显示文摘 | Sushil D Amy HM Lin Bruce RH | 2013 | Plos One2013，8，4： | 1 |
| 16 | Castration-Resistant Prostate Cancer: AUA Guideline显示文摘 | Michael S. Cookson Bruce J. Roth Philipp Dahm Christine Engstrom Stephen J. Freedland Maha Hussain Daniel W. Lin William T. Lowrance Mohammad Hassan Murad William K. Oh David F. Penson Adam S. Kibel | 2013 | The Journal of Urology2013，，2： | 1 |
| 17 | Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators显示文摘 | Julie St-Pierre Stavit Drori Marc Uldry Jessica M. Silvaggi James Rhee Sibylle J?ger Christoph Handschin Kangni Zheng Jiandie Lin Wenli Yang David K. Simon Robert Bachoo Bruce M. Spiegelman | 2006 | Cell2006，，2： | 1 |
| 18 | Necessary and sufficient graphical conditions for formation control of unicy- cles显示文摘 | LIN Zhiyun BRUCE Francis MANFREDI Maggiore | 2005 | 1EEE Transactions on Automatic Control2005，50，1： | 1 |
| 19 | Coordinate activation of intracellular signaling pathways by insulin-like growth factor-1 and platelet-derived growth factor in rat hepatic stellate cells显示文摘 | Kim R. Bridle Lin Li Rosemary O’Neill Robert S. Britton Bruce R. Bacon | 2006 | The Journal of Laboratory and Clinical Medicine2006，，5： | 1 |
| 20 | Local control strategies for groups of mobile autonomous agents显示文摘 | Zhiyun Lin Mireille Broucke Bruce Francis | 2004 | IEEE Trans on Automatic Control2004，49，4： | 1 |
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