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| 1 | Diagnosis of pancreatic tumors by endoscopic ultrasound-guided fine-needle aspiration显示文摘AIM: To evaluate the diagnostic accuracy of endoscopic ultrasound-guided fi ne-needle aspiration (EUS-FNA) for pancreatic solid tumors larger or smaller than 3 cm, and cystic lesions. METHODS: From January/1997 to December/2006, 611 patients with pancreatic tumors were subjected to EUS-FNA. The fi nal diagnosis was obtained either by surgery (356 cases) or after a mean clinical follow-up of 11.8 mo in the remaining patients. RESULTS: There were 405 solid tumors, 189 cystic lesions and 17 mixed. Pancreatic specimens for cytological assessment were successfully obtained by EUS-FNA in 595 (97.4/) cases. There were 352 (57.6/) malignancies and 259 (42.4/) benign tumors. Among the malignancies, pancreatic adenocarcinomas accounted for 67/ of the lesions. Overall, the sensitivity, specifi city, positive and negative predictive values, and accuracy of EUS-FNA were, respectively, 78.4/, 99.2/, 99.3/, 77.2/ and 87.2/. Specif ically for solid tumors, the same parameters for neoplasms larger and smaller than 3 cm were, respectively, 78.8/ vs 82.4/, 100/ vs 98.4/, 100/ vs 99/, 54.8/ vs 74.1/ and 83.1/ vs 87.8/. For cystic lesions, the values were, respectively, 72.2/, 99.3/, 97.5/, 91/ and 92.2/. CONCLUSION: EUS-FNA can be used to sample pancreatic tumors in most patients. Even though the negative predictive value is inadequate for large solid tumors, the results are rather good for small solid tumors, especially concerning the sensitivity, negative predictive value and diagnostic accuracy. Among all pancreatic lesions, EUS-FNA for cystic lesions canreveal the best negative predictive value and diagnostic accuracy, both higher than 90/. | José Celso Ardengh César Vivian Lopes Luiz Felipe Pereira de Lima Juliano Rodrigues de Oliveira Filadélfi o Venco Giulio Cesare Santo José Luiz Pimenta Módena | 2007 | World Journal of Gastroenterology2007，13，22： | 17 |
| 2 | Transcriptome and Metabolic Profiling Provides Insigh into Betalain Biosynthesis and Evolution in Mirabilis jalapa显示文摘 | Guy Polturak Uwe Heinig Noam Grossman Maor Battat Dena Leshkowitz Sergey Malitsky liana Rogachev~ and Asaph Aharoni | 2018 | Molecular Plant2018，11，1： | 10 |
| 3 | Preparation of multi-color quantum dots and its application to immunohistochemical analysis显示文摘Quantum dots (QDs) have the potential to be used in the multiplexed bioanalysis for their unique property:multi-color QDs can be excited at the same single wavelength light. In this work,high quan-tum yield multi-color core/shell QDs were prepared. After being water-solubilized by amphiphilic polymer based on self-assembling,the QDs would be labeled by two different IgGs and used in the multiplexed biodetection. Fluorescence resonance energy transfer (FRET) should be avoided in the multiplexed biodetection. In this work,spectral analysis showed that no FRET appeared in water-soluble QDs modified by amphiphilic polymer. The immunofluorescence in vitro indicated that the QDs-IgGs bioconjugates had excellent species-specific detection ability with nearly non-specific binding. The setting of this model will help to support the application of multi-color QDs in the multiplexed bioanalysis communities. | ZHANG BingBo LIU XuHui LI DeNa TIAN Hui MA GuiPing CHANG Jin | 2008 | Chinese Science Bulletin2008，53，13： | 6 |
| 4 | Rifaximin,but not growth factor 1,reduces brain edema in cirrhotic rats显示文摘AIM:To compare rifaximin and insulin-like growth factor(IGF)-1 treatment of hyperammonemia and brain edema in cirrhotic rats with portal occlusion.METHODS:Rats with CCl4-induced cirrhosis with ascites plus portal vein occlusion and controls were randomized into six groups:Cirrhosis;Cirrhosis + IGF-1;Cirrhosis + rifaximin;Controls;Controls + IGF-1;and Controls + rifaximin.An oral glutamine-challenge test was performed,and plasma and cerebral ammonia,glucose,bilirubin,transaminases,endotoxemia,brain water content and ileocecal cultures were measured and liver histology was assessed.RESULTS:Rifaximin treatment significantly reduced bacterial overgrowth and endotoxemia compared with cirrhosis groups,and improved some liver function parameters(bilirubin,alanine aminotransferase and aspartate aminotransferase).These effects were associated with a significant reduction in cerebral water content.Blood and cerebral ammonia levels,and area-underthe-curve values for oral glutamine-challenge tests were similar in rifaximin-treated cirrhotic rats and control group animals.By contrast,IGF-1 administration failed to improve most alterations observed in cirrhosis.CONCLUSION:By reducing gut bacterial overgrowth,only rifaximin was capable of normalizing plasma and brain ammonia and thereby abolishing low-grade brain edema,alterations associated with hepatic encephalopathy. | Gemmaòdena Mireia Miquel Anna Serafín Amparo Galan Rosa Morillas Ramon Planas Ramon Bartolí | 2012 | World Journal of Gastroenterology2012，18，17： | 6 |
| 5 | Preparation of monodisperse, superparamagnetic, luminescent, and multifunctional PGMA microspheres with amino-groups显示文摘Micron-sized, monodisperse, superparamagnetic, luminescent composite poly(glycidyl methacrylate) (PGMA) microspheres with functional amino-groups were successfully synthesized in this study. The process of preparation was as follows: preparation of monodisperse poly(glycidyl methacrylate) mi- crospheres by dispersion polymerization method; modification of poly(glycidyl methacrylate) micro- spheres with ethylene diamine to form amino-groups; impregnation of iron ions (Fe2+ and Fe3+) inside the microspheres and subsequently precipitating them with ammonium hydroxide to form magnetite (Fe3O4) nanoparticles within the polymer microspheres; infusion of CdSe/CdS core-shell quantum dots (QDs) into magnetic polymer microspheres. Scanning electron microscopy (SEM) was used to char- acterize surface morphology and size distribution of composite microspheres. The average size of mi- crospheres was 1.42 μm with a size variation of 3.8%. The composite microspheres were bright enough and easily observed using a conventional fluorescence microscope. The composite microspheres were easily separated from solution by magnetic decantation using a permanent magnet. The new multi- functional composite microspheres are promising to be used in a variety of bioanalytical assays in- volving luminescence detection and magnetic separation. | WANG WeiCai ZHANG Qi ZHANG BingBo LI DeNa DONG XiaoQing ZHANG Lei CHANG Jin | 2008 | Chinese Science Bulletin2008，53，8： | 5 |
| 6 | Ghrelin attenuates gastrointestinal epithelial damage induced by doxorubicin显示文摘AIM:To examine the influence of ghrelin on the regenerative potential of gastrointestinal(GI)epithelium.METHODS:Damage to GI epithelium was induced in mice by two intravenous injections of doxorubicin(10 and 6 mg/kg).Some of the doxorubicin-treated mice received a continuous subcutaneous infusion of ghrelin(1.25μg/h)for 10 d via implanted mini-osmotic pumps.To label dividing stem cells in the S-phase of the cell cycle,all mice received a single intraperitoneal injection of 5'-bromo-2'-deoxyuridine(BrdU)one hour before sacrifice.The stomach along with the duodenum were then removed and processed for histological examination and immunohistochemistry using anti-BrdU antibody.RESULTS:The results showed dramatic damage to the GI epithelium 3 d after administration of chemotherapy which began to recover by day 10.In ghrelintreated mice,attenuation of GI mucosal damage was evident in the tissues examined postchemotherapy.Immunohistochemical analysis showed an increase in the number of BrdUlabeled cells and an alteration in their distribution along the epithelial lining in response to damage by doxorubicin.In mice treated with both doxorubicin and ghrelin,the number of BrdUlabeled cells was reduced when compared with mice treated with doxorubicin alone.CONCLUSION:The present study suggests that ghrelin enhances the regenerative potential of the GI epithelium in doxorubicintreated mice,at least in part,by modulating cell proliferation. | Mohamed A Fahim Hazem Kataya Rkia El-Kharrag Dena AM Amer Basel al-Ramadi Sherif M Karam | 2011 | World Journal of Gastroenterology2011，17，33： | 3 |
| 7 | YAP1对颗粒细胞的重编程可导致具间质谱系和浆液性特征的高级别卵巢癌显示文摘高级别浆液性卵巢癌(HGSC)是临床中最常见、且恶性程度最高的卵巢癌.深入了解高级别浆液性卵巢癌的起源细胞可对该亚型卵巢癌进行有效预防和早期诊断.最近TCGA和AOCS通过分子分型研究发现了一种具有间充质特征的高级别浆液性卵巢癌亚型,并且表明该亚型是所有新发现的亚型中预后最差的一种,而且目前大家对于这种卵巢癌新亚型的起源细胞一无所知.在研究Hippo信号通路在卵巢颗粒细胞生理和病理中的作用时,意外地发现Hippo信号传导途径的主要效应分子YAP1的高度激活可以诱导具有间质谱系和高可塑性的卵巢颗粒细胞的去分化与重编程,最终导致具有浆液性特征的高级别卵巢癌的发生.本文的研究结果揭示了具间质特征的高级别浆液性卵巢癌的一种潜在起源细胞. | 吕向民 何春波 黄聪 滑国华 陈骍程 Barbara K.Timm Victoria M.Maclin Abigail A.Haggerty Shelly K.Aust Denae M.Golden Bhavana J.Dave Yun-An Tseng 陈利 王洪波 陈培超 David L.Klinkebiel Adam R.Karpf Jixin Dong Ronny I.Drapkin Bo R.Rueda John S.Davis 王诚 | 2020 | Science Bulletin2020，65，15： | 2 |
| 8 | Understanding chemical reactions between carbons and NaOH and KOH显示文摘 | M.A Lillo-Ródenas D Cazorla-Amorós A Linares-Solano | 2002 | Carbon2002，，2： | 2 |
| 9 | Ribosomal ribonucleic acid gene typing for species identification显示文摘 | Naito E Dena K and Ymanouchi H | 1992 | Journal of Forensic Sciences1992，37，2： | 1 |
| 10 | Parentage determination of Kuruma shrimp Penaeus (Marsupenaeus) japonicus using microsatellite markers (Bate)显示文摘 | DENA R J NIGEL P PRESTON P J | 2004 | Aquaculture2004，235，： | 1 |
| 11 | High surface area materials prepared from sewage sludge-based precursors显示文摘 | Ros A Lillo-Ró denas M A Fuente E | 2006 | Chemosphere2006，17，2： | 1 |
| 12 | Brain Volume and Neurobehavior in Newborns with Complex Congenital Heart Defects显示文摘 | Mallory Owen Michael Shevell Mary Donofrio Annette Majnemer Robert McCarter Gilbert Vezina Marine Bouyssi-Kobar Iordanis Evangelou Dena Freeman Neil Weisenfeld Catherine Limperopoulos | 2013 | The Journal of Pediatrics2013，，： | 1 |
| 13 | 显示文摘 | Denae M Smit I Musil V | 2005 | Composites:Part A: Applied Sci- ence and Manufacturing2005，36，8： | 1 |
| 14 | Mutational spectra of PTEN/MMAC1 gene: a tumor suppressor with lipid phosphatase activity显示文摘 | Ali IU Schriml LM Dena M | 1999 | J Natl Cancer Inst1999，91，22： | 1 |
| 15 | Rosiglitazone increased heart failure but did not differ from metformin plus sulphonylurea for other CV outcomes at interim analysis 显示文摘 | Mark A Hlatky MD Dena M | 2007 | Evid Based Med2007，12，6： | 1 |
| 16 | Population-Based Genome-wide Association Studies Reveal Six Loci Influencing Plasma Levels of Liver Enzymes显示文摘 | Xin Yuan Dawn Waterworth John R.B. Perry Noha Lim Kijoung Song John C. Chambers Weihua Zhang Peter Vollenweider Heide Stirnadel Toby Johnson Sven Bergmann Noam D. Beckmann Yun Li Luigi Ferrucci David Melzer Dena Hernandez Andrew Singleton James Scott Paul | 2008 | The American Journal of Human Genetics2008，，4： | 1 |
| 17 | High surface area materials prepared from sewage sludge-based precursors 显示文摘 | ROS A LILLO-RO' M A DENAS FUENTE E | 2006 | Chemosphere2006，65，： | 1 |
| 18 | A procedure for efficient bayesian reliability demonstration, presented to the operations research society of america显示文摘 | Schick G J Denas T M | 1972 | New Orleans Louisiana April1972，26，： | 1 |
| 19 | Parentage determination of Kuruma shrimp Penaeus ( Marsupenaeus ) japonicus using microsatellite markers (Bate) 显示文摘 | Dena R J Nigel P P Peter J | 2004 | Aquaculture2004，235，： | 1 |
| 20 | The IL-33/ST2 pathway controls coxsackievirus B5-Induced experimental pancreatitis显示文摘 | Sesti-Costa R Silva GK Proenca-Módena JL | | 0，，： | 1 |
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