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| 1 | 美国湿地保护制度变迁研究显示文摘本文提出了分析湿地保护制度变迁的理论框架,使不同国家的湿地保护制度研究能在统一语境下比较。首先基于科学计量学和系统研究方法筛选出公众、科学、政府和法律为影响湿地保护制度变迁的四个关键要素,并依赖博弈论工具建立了分析美国湿地保护制度的理论架构。基于这一架构,本文对包括关键利益相关者、政策执行路径、政策工具和管理挑战等内容的美国湿地政策史进行了讨论。对美国湿地保护制度的演化进行了四阶断之划分:'西进运动'与全民开垦(1900年之前)、'水鸟保护'与公众参与(1900-1970年)、核心法律与科学研究(1971-1980年)和完善制度与新的挑战(1980年至今)。分析得出如下结论:在湿地保护制度中,公众是源头、科学是前提、有效的政府管治和将湿地保护的规则和与政策制度化是关键。通过借鉴美国湿地保护制度变迁研究,本文构建了湿地保护制度变迁的'竹节模式'经验性模型,揭示了各动因之间的作用机理。虽然美国湿地保护制度也面临着公众教育、科学定义和政府管辖权等挑战,但中国的湿地管理者与政策制定者仍可从美国湿地政策执行的历史背景中吸取经验。同时本文的理论分析结构也可为自然资源及管理策略的研究提供参考。 | 陈溪 Magdeline Laba Robertson Morgan Barbara Cosens 王子彦 陈雪 James Anderson Marinus Otte Christopher Craft David Feldman 李杨帆 刘晶岚 Patrick Sullivan 吕宪国 | 2016 | 资源科学2016，38，4： | 13 |
| 2 | Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population:Role of serine protease inhibitor Kazal 1type and alcohol显示文摘AIM: To test the hypothesis that calcium sensing receptor (CASR) polymorphisms are associated with chronic pancreatitis (CP), and to determine whether serine protease inhibitor Kazal 1type (SPINK1) N34S oralcohol are necessary co-factors in its etiology. METHODS: Initially, 115 subjects with pancreatitis and 66 controls were evaluated, of whom 57 patients and 21 controls were predetermined to carry the high-risk SPINK1 N34S polymorphism. We sequenced CASR gene exons 2, 3, 4, 5 and 7, areas containing the majority of reported polymorphisms and novel mutations. Based on the initial results, we added 223 patients and 239 controls to analyze three common nonsynonymous single nucleotide polymorphisms (SNPs) in exon 7 (A986S, R990G, and Q1011E). RESULTS: The CASR exon 7 R990G polymorphism was signifi cantly associated with CP (OR, 2.01; 95% CI, 1.12-3.59; P = 0.015). The association between CASR R990G and CP was stronger in subjects who reported moderate or heavy alcohol consumption (OR, 3.12; 95% CI, 1.14-9.13; P = 0.018). There was no association between the various CASR genotypes and SPINK1 N34S in pancreatitis. None of the novel CASR polymorphisms reported from Germany and India was detected. CONCLUSION: Our United States-based study confirmed an association of CASR and CP and for the first time demonstrated that CASR R990G is a signifi cant risk factor for CP. We also conclude that the risk of CP with CASR R990G is increased in subjects with moderate to heavy alcohol consumption. | Venkata Muddana Janette Lamb Julia B Greer Beth Elinoff Robert H Hawes Peter B Cotton Michelle A Anderson Randall E Brand Adam Slivka David C Whitcomb | 2008 | World Journal of Gastroenterology2008，14，28： | 7 |
| 3 | Genotyping-by-sequencing application on diploid rose and a resulting high-density SNP-based consensus map显示文摘Roses,which have been cultivated for at least 5000 years,are one of the most important ornamental crops in the world.Because of the interspecific nature and high heterozygosity in commercial roses,the genetic resources available for rose are limited.To effectively identify markers associated with QTL controlling important traits,such as disease resistance,abundant markers along the genome and careful phenotyping are required.Utilizing genotyping by sequencing technology and the strawberry genome(Fragaria vesca v2.0.a1)as a reference,we generated thousands of informative single nucleotide polymorphism(SNP)markers.These SNPs along with known bridge simple sequence repeat(SSR)markers allowed us to create the first high-density integrated consensus map for diploid roses.Individual maps were first created for populations J06-20-14-3דLittle Chief”(J14-3×LC),J06-20-14-3דVineyard Song”(J14-3×VS)and“Old Blush”דRed Fairy”(OB×RF)and these maps were linked with 824 SNPs and 13 SSR bridge markers.The anchor SSR markers were used to determine the numbering of the rose linkage groups.The diploid consensus map has seven linkage groups(LGs),a total length of 892.2 cM,and an average distance of 0.25 cM between 3527 markers.By combining three individual populations,the marker density and the reliability of the marker order in the consensus map was improved over a single population map.Extensive synteny between the strawberry and diploid rose genomes was observed.This consensus map will serve as the tool for the discovery of marker–trait associations in rose breeding using pedigree-based analysis.The high level of conservation observed between the strawberry and rose genomes will help further comparative studies within the Rosaceae family and may aid in the identification of candidate genes within QTL regions. | Muqing Yan David H.Byrne Patricia E.Klein Jizhou Yang Qianni Dong Natalie Anderson | 2018 | Horticulture Research2018，5，1： | 6 |
| 4 | Protective role of PI3-kinase/Akt/eNOS signaling in mechanical stress through inhibition of p38 mitogenactivated protein kinase in mouse lung显示文摘 | Xin-qi PENG Mahendra DAMARLA Jarrett SKIRBALL Stephanie NONAS Xiao-ying WANG Eugenia J HAN Emile J HASAN Xuan CAO Adel BOUEIZ Rachel DAMICO Rubin M TUDER Alfred M SClUTO Dana R ANDERSON Joe GNGARCIA David A KASS Paul M HASSOUN Jun-tian ZHANG | 2010 | Acta Pharmacologica Sinica2010，31，2： | 6 |
| 5 | 加拿大高校培养STEM教师的经验与启示——以英属哥伦比亚大学为例显示文摘采用深度访谈和内容分析等方法研究英属哥伦比亚大学STEM学者的教育理念以及该校在STEM教师的学科培养、教师准备和继续教育等方面的举措.发现该校有一些致力于培养创新型STEM教师的特色项目、课程或活动,构建了协同培养STEM教师的教育生态.启示:(1)开展整合性STEM教师教育,培养创新型STEM教育师资;(2)整合校内外STEM教育资源,构建协作型STEM教育生态;(3)打造在线STEM教育金课,提升职前职后STEM教师能力. | 袁智强 Marina Milner-Bolotin David Anderson | 2021 | 数学教育学报2021，30，3： | 5 |
| 6 | Efficacy of boceprevir, an NS3 protease inhibitor, in combination with peginterferon alfa-2b and ribavirin in treatment-naive patients with genotype 1 hepatitis C infection (SPRINT-1): an open-label, randomised, multicentre phase 2 trial显示文摘 | Paul Y Kwo Eric J Lawitz Jonathan McCone Eugene R Schiff John M Vierling David Pound Mitchell N Davis Joseph S Galati Stuart C Gordon Natarajan Ravendhran Lorenzo Rossaro Frank H Anderson Ira M Jacobson Raymond Rubin Kenneth Koury Lisa D Pedicone Clifford | 2010 | The Lancet2010，，9742： | 3 |
| 7 | Sentinel-lymph-node resection compared with conventional axillary-lymph-node dissection in clinically node-negative patients with breast cancer: overall survival findings from the NSABP B-32 randomised phase 3 trial显示文摘 | David N Krag Stewart J Anderson Thomas B Julian Ann M Brown Seth P Harlow Joseph P Costantino Takamaru Ashikaga Donald L Weaver Eleftherios P Mamounas Lynne M Jalovec Thomas G Frazier R Dirk Noyes André Robidoux Hugh MC Scarth Norman Wolmark | 2010 | Lancet Oncology2010，，10： | 3 |
| 8 | Abdominal obesity adversely affects bone mass in children显示文摘AIM To determine the effect of childhood obesity and insulin resistance on bone health. METHODS We conducted a cross sectional study in pubertal adolescents and young adults 13-20 years old who were either overweight/obese or normal weight. Participants were Tanner 3 or above for pubertal stage, and had fasting blood work done to measure glucose, insulin, C-reactive protein and lipid levels. Homeostatic model of insulin resistance(HOMA-IR) was calculated using the formula(Fasting Blood Glucose *Insulin/405). Body composition and bone mineral density were measured using dual energy X-ray absorptiometry(DXA; Hologic QDR 4500, Waltham, MA, United Kingdom). RESULTS Percent trunk fat was associated inversely with whole body bone mineral content(BMC), whereas HOMA-IR was associated positively with whole body BMC.CONCLUSION Our results suggest that abdominal adiposity may have an adverse effect on whole body bone parameters and that this effect is not mediated by insulin resistance. | Sowmya Krishnan Michael P Anderson David A Fields Madhusmita Misra | 2018 | World Journal of Clinical Pediatrics2018，7，1： | 3 |
| 9 | Sofosbuvir with pegylated interferon alfa-2a and ribavirin for treatment-naive patients with hepatitis C genotype-1 infection (ATOMIC): an open-label, randomised, multicentre phase 2 trial显示文摘 | Kris V Kowdley Eric Lawitz Israel Crespo Tarek Hassanein Mitchell N Davis Michael DeMicco David E Bernstein Nezam Afdhal John M Vierling Stuart C Gordon Jane K Anderson Robert H Hyland Hadas Dvory-Sobol Di An Robert G Hindes Efsevia Albanis William T Symo | 2013 | The Lancet2013，，9883： | 3 |
| 10 | Impact of COVID-2019 on stroke services in China: survey from the Chinese Stroke Association显示文摘Background The COVID-19 pandemic and physical distancing guidelines have compelled stroke practices worldwide to reshape their delivery of care significantly.We aimed to illustrate how the stroke services were interrupted during the pandemic in China.Methods A 61-item questionnaire designed on Wenjuanxing Form was completed by doctors or nurses who were involved in treating patients with stroke from 1 February to 31 March 2020.Results A total of 415 respondents completed the online survey after informed consent was obtained.Of the respondents,37.8%,35.2%and 27.0%were from mild,moderate and severe epidemic areas,respectively.Overall,the proportion of severe impact(reduction>50%)on the admission of transient ischaemic stroke,acute ischaemic stroke(AIS)and intracerebral haemorrhage(ICH)was 45.0%,32.0%and 27.5%,respectively.Those numbers were 36.9%,27.9%and 22.3%;36.5%,22.1%and 22.6%;and 66.4%,47.5%and 41.1%in mild,moderate and severe epidemic areas,respectively(all p<0.0001).For AIS,thrombolysis was moderate(20%-50%reduction)or severely impacted(>50%),as reported by 54.4%of the respondents,while thrombectomy was 39.3%.These were 44.4%,26.3%;44.2%,39.4%;and 78.2%,56.5%,in mild,moderate and severe epidemic areas,respectively(all p<0.0001).For patients with acute ICH,39.8%reported the impact was severe or moderate for those eligible for surgery who had surgery.Those numbers were 27.4%,39.0%and 58.1%in mild,moderate and severe epidemic areas,respectively.For staff resources,about 20%(overall)to 55%(severe epidemic)of the respondents reported moderate or severe impact on the on-duty doctors and nurses.Conclusion We found a significant reduction of admission for all types of patients with stroke during the pandemic.Patients were less likely to receive appropriate care,for example,thrombolysis/thrombectomy,after being admitted to the hospital.Stroke service in severe COVID-19 epidemic areas,for example,Wuhan,was much more severely impacted compared with other regions in China. | Xia Wang Menglu Ouyang Cheryl Carcel Chen Chen Lingli Sun Jie Yang Yao Zhang Guofang Chen Shoujiang You Yongjun Cao Lu Ma Xin Hu Yi Sui Craig Anderson Lili Song Yongjun Wang David Wang | 2020 | Stroke & Vascular Neurology2020，5，4： | 2 |
| 11 | 梅毒IgA快速检测试剂诊断早期现症梅毒的应用性评估显示文摘目的评估Burnet研究所自制的IgA快速检测试剂(POC)对早期梅毒的诊断性能。方法利用性病中心参比实验室库存的455份血清标本进行梅毒IgA-POC应用性评估,标本根据梅毒螺旋体血球凝集试验(TPHA)、快速血浆反应素环状卡片试验(RPR)及IgM酶联免疫吸附试验(IgM-ELISA)结果分为未感染组、既往感染组和早期现症组。对3组标本进行IgA—POC盲样检测,评估其对现症梅毒的诊断能力。结果IgA—POC对早期现症组的诊断灵敏度为92.6%(147/163),对既往感染组的排除诊断特异性为72.22%(104/144);对未感染的排除诊断特异性为97.97%(145/148),总特异性为85.27%,达到了WHO对梅毒快速诊断试剂的最低要求。IgA—POC对早期现症梅毒诊断灵敏度高于IgM—ELISA(59.51%)(Z=6.88,P〈0.05),但其对既往感染的排除诊断特异性低于lgM-ELISA(98.61%)(Z=6.18,P〈0.05),两种方法对未感染的排除诊断特异性差异无统计学意义(Z=1.16,P=0.25)。结论IgA—POC对早期现症梅毒的发现能力较IgM—ELISA强,可以应用于早期现症梅毒的筛查。 | 韩燕 魏万惠 尹跃平 David Anderson 王红春 Mary L Garcia Huy Van 朱小宇 陈凯 陈祥生 | 2018 | 中华皮肤科杂志2018，51，5： | 2 |
| 12 | 创伤后深静脉血栓的预防机械预防和药物预防的前瞻性、随机性比较显示文摘背景:骨创伤后的深静脉血栓是十分重要的问题,但相关研究甚少。本研究的目的是评估两种不同方法对预防钝性创伤后深静脉血栓和肺栓塞的有效性。
方法:共有224例住院患者参与此项预防创伤后静脉血栓形成的前瞻性随机性研究。200例患者最终完成研究,比较两种不同的预防方案。A组患者在钝性创伤后24-48h内使用依诺肝素(30mg,皮下,每天两次)。B组患者在人院后使用脉冲式足泵并延迟使用依诺肝素。所有患者在出院前均行静脉核磁共振和超声检查。
结果:A组共97例患者,B组共103例患者。22例患者(A组13人,B组9人)有深静脉血栓形成,其中A组2例还发生了肺栓塞。本组深静脉血栓的发生率为11%,A组13.4%,B组8.7%;A组和B组之间的差异无统计学意义。A组出现大的或闭塞性血栓共11例(发生率11.3%),B组仅3例(发生率2.9%)(p=0.025)。A组肺栓塞的发生率为2.1%,B组为0。A组有21例患者出现伤口并发症,B组为20例。住院期间发生深静脉血栓的患者人均用血7.4单位,无深静脉血栓的患者人均用血3.9单位(p〈0.05)。
结论:结果显示严重的肌肉骨骼创伤后,早期使用机械预防(足泵)并延迟使用依诺肝素对预防深静脉血栓是相当有效的。比较两组患者,B组患者大的或闭塞性血栓的发生率明显低于A组患者。
可信水平:治疗性研究,Ⅰ级。详细的可信水平描述参见作者须知。 | JAMES P. STANNARD ROBERT R. LOPEZ-BEN DAVID A. VOLGAS EDWARD R. ANDERSON MATT BUSBEE DONNA K. KARR GERALD R. McGWIN JR. JORGE E. ALONSO 罗从风(译) 费起礼(校) | 2006 | 骨科动态2006，2，3： | 2 |
| 13 | Sexually dimorphic expression of multiple doublesex -related genes in the embryonic mouse gonad显示文摘 | Shinseog Kim Jae R Kettlewell Robert C Anderson Vivian J Bardwell David Zarkower | 2002 | Gene Expression Patterns2002，，1： | 2 |
| 14 | 对应用选择性环氧酶2抑制剂或传统非甾体类抗炎药物老年患者上消化道出血的观察研究显示文摘目的 对应用选择性环氧酶2(COX 2)抑制剂和非选择性的非甾体类抗炎药(NSAIDs)的老年患者上消化道出血的比率进行比较。 设计 观察性队列研究。 设置 利用来自加拿大安大略2000年4月17日~2001年3月31日的官方数据,以确认基于人群的、初次使用NSAID的队列患者。 对象 年龄≥66岁,开始服用非选择性NSAIDs(n=5391)、双氯芬酸(diclofenac)加米索前列醇(misoprostol)(n=5087)、罗非昔布(rofecoxib)(n=14 583)或塞来昔布(celecoxib)(n=18 908),以及随机选择的没有服用NSAIDs的对照组(n=100 000)。 衡量结局的主要指标 每个药物组因上消化道出血入院的比值比(经过调整潜在的混杂因子)。 结果 与对照组相比,多变量模型表明,在服用非选择性NSAIDs(调整比值比为4.0,95%,可信区间为2.3~6.9,)、双氯芬酸加米索前列醇(3.0,1.7~5.6)以及罗非昔布(1.9,1.3~2.8)时,上消化道出血的短期危险性是增加的,而塞来昔布并没有增加(1.0,0.7~1.6)。与塞来昔布相比,非选择性的NSAIDs(4.4,2.3~8.5)、双氯芬酸加 米索前列醇(3.2,1.6—6.5)以及罗非昔布(1.9,1.2~2.8)的上消化道出血危险性显著增加。与罗非昔布相比,非选择性NSAIDs的上消化道出血危险性显著增加(1.9,1.0~3.5)。 结论 选择性COX | Muhammad Mamdani Paula A Rochon David N Juurlink Alex Kopp Geoffrey M Anderson Gary Naglie Peter C Austin Andreas Laupacis 邓瑞雪 | 2003 | 英国医学杂志中文版2003，6，3： | 2 |
| 15 | Improved thermal conductivity for chemically functionalized exfoliated graphite/epoxy composites显示文摘 | Sabyasachi Ganguli Ajit K. Roy David P. Anderson | 2008 | Carbon2008，，5： | 2 |
| 16 | 2009 Canadian Cardiovascular Society/Canadian guidelines for the diagnosis and treatment of dyslipidemia and prevention of cardiovascular disease in the adult – 2009 recommendations显示文摘 | Jacques Genest Ruth McPherson Jiri Frohlich Todd Anderson Norm Campbell André Carpentier Patrick Couture Robert Dufour George Fodor Gordon A. Francis Steven Grover Milan Gupta Robert A. Hegele David C. Lau Lawrence Leiter Gary F. Lewis Eva Lonn G.B. John | 2009 | Canadian Journal of Cardiology2009，，10： | 2 |
| 17 | Technical outcomes of sentinel-lymph-node resection and conventional axillary-lymph-node dissection in patients with clinically node-negative breast cancer: results from the NSABP B-32 randomised phase III trial显示文摘 | David N Krag Stewart J Anderson Thomas B Julian Ann M Brown Seth P Harlow Takamaru Ashikaga Donald L Weaver Barbara J Miller Lynne M Jalovec Thomas G Frazier R Dirk Noyes André Robidoux Hugh MC Scarth Denise M Mammolito David R McCready Eleftherios P Mamo | 2007 | Lancet Oncology2007，，10： | 2 |
| 18 | Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery显示文摘 | Mary C Corretti Todd J Anderson Emelia J Benjamin David Celermajer Francois Charbonneau Mark A Creager John Deanfield Helmut Drexler Marie Gerhard-Herman David Herrington Patrick Vallance Joseph Vita Robert Vogel | 2002 | Journal of the American College of Cardiology2002，，： | 2 |
| 19 | Preservation of immune function in cervical cancer patients during chemoradiation using a novel integrative approach显示文摘 | Susan K. Lutgendorf Elizabeth Mullen-Houser Daniel Russell Koen DeGeest Geraldine Jacobson Laura Hart David Bender Barrie Anderson Thomas E. Buekers Michael J. Goodheart Michael H. Antoni Anil K. Sood David M. Lubaroff | 2010 | Brain Behavior and Immunity2010，，8： | 2 |
| 20 | The effect of age on prevalence of secondary forms of hypertension in 4429 consecutively referred patients显示文摘 | Gunnar H. Anderson Nancy Blakeman David H.P. Streeten | 1994 | Journal of Hypertension1994，，5： | 2 |
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