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| 1 | Factors Associated with Thrombolysis Outcome in Ischemic Stroke Patients with Atrial Fibrillation显示文摘The outcome of early intravenous thrombolysis for ischemic stroke in patients with atrial fibrillation(AF)is worse than that without thrombosis. How to increase the efficacy of intravenous thrombolysis for AF-related ischemic stroke remains largely unknown. In this study, we investigated factors that influence the effect of intravenous thrombolysis in these patients. Our results showed that thrombolysis was independently associated with a favorable outcome(P \ 0.001) and did not influence the mortality of AF-related ischemic stroke, although it increased the risk of hemorrhage within 24 h after treatment. Risk factors for a poor outcome at admission were:heart failure(P = 0.045); high systolic pressure(P = 0.039); high blood glucose(P = 0.030); and a high National Institutes of Health Stroke Scale(NIHSS) score(P \ 0.001). Moreover, high systolic pressure at admission(P = 0.007), high blood glucose(P = 0.027), and a high NIHSS score(P \ 0.001) were independent risk factors for mortality at 3 months. Besides thrombolysis, a high NIHSS score(P = 0.006) and warfarin taken within 48 h before stroke onset(P = 0.032) were also independent risk factors for symptomatic hemorrhage within 24 h after treatment. Ischemic stroke patients with AF benefited from intravenous thrombolysis with recombinant tissue plasminogen activator within 4.5 h after stroke. | Qiuyun Zhao Xiaobo Li Wanli Dong Min Ye Yongjun Cao Meijuan Zhang Qiantao Cheng Junshan Zhou Guofang Chen Ming Yu Shanshan Hong Xiue Wei Bei Wang Guiyun Cui Peng Zhang Hong Ding Rongzhen Xu Yan Chen Yun Xu | 2016 | Neuroscience Bulletin2016，32，2： | 13 |
| 2 | Blocking autocrine VEGF signaling by sunitinib, an anti-cancer drug, promotes embryonic stem cell selfrenewal and somatic cell reprogramming显示文摘 | Guofang Chen Xinxiu Xu Lihong Zhang Yanbin Fu Min Wang Haifeng Gu Xin Xie | 2014 | Cell Research2014，24，9： | 8 |
| 3 | Joint source-channel coded multidimensional modulation for variable-length codes显示文摘Resource-constrained networks such as deep space communications and mobile communications have the phenomena such us large-scale path loss,small-scale fading,and multipath effect,which are very hostile for information transmission.Combining Shannon’s source-channel coding theory with multidimensional modulation,an en/decoding method is proposed in this article called variable-length symbol-level joint sourcechannel and multidimensional modulation.Utilizing symbol-level source a priori information,an optimized symbol-level L-dimensional M-ary phase shift keying(LD-MPSK)constellation mapping function has been derived,which can increase free Euclidean distance between modulated symbols and enhance the decoding performance.It has been shown in the simulation results that the proposed scheme can achieve more than 2 dB signal-to-noise ratio gains compared with the conventional bit-level schemes under the condition of the same error rate. | CHENG Chen TU GuoFang ZHANG Can | 2014 | Science China(Information Sciences)2014，57，6： | 3 |
| 4 | Impact of COVID-2019 on stroke services in China: survey from the Chinese Stroke Association显示文摘Background The COVID-19 pandemic and physical distancing guidelines have compelled stroke practices worldwide to reshape their delivery of care significantly.We aimed to illustrate how the stroke services were interrupted during the pandemic in China.Methods A 61-item questionnaire designed on Wenjuanxing Form was completed by doctors or nurses who were involved in treating patients with stroke from 1 February to 31 March 2020.Results A total of 415 respondents completed the online survey after informed consent was obtained.Of the respondents,37.8%,35.2%and 27.0%were from mild,moderate and severe epidemic areas,respectively.Overall,the proportion of severe impact(reduction>50%)on the admission of transient ischaemic stroke,acute ischaemic stroke(AIS)and intracerebral haemorrhage(ICH)was 45.0%,32.0%and 27.5%,respectively.Those numbers were 36.9%,27.9%and 22.3%;36.5%,22.1%and 22.6%;and 66.4%,47.5%and 41.1%in mild,moderate and severe epidemic areas,respectively(all p<0.0001).For AIS,thrombolysis was moderate(20%-50%reduction)or severely impacted(>50%),as reported by 54.4%of the respondents,while thrombectomy was 39.3%.These were 44.4%,26.3%;44.2%,39.4%;and 78.2%,56.5%,in mild,moderate and severe epidemic areas,respectively(all p<0.0001).For patients with acute ICH,39.8%reported the impact was severe or moderate for those eligible for surgery who had surgery.Those numbers were 27.4%,39.0%and 58.1%in mild,moderate and severe epidemic areas,respectively.For staff resources,about 20%(overall)to 55%(severe epidemic)of the respondents reported moderate or severe impact on the on-duty doctors and nurses.Conclusion We found a significant reduction of admission for all types of patients with stroke during the pandemic.Patients were less likely to receive appropriate care,for example,thrombolysis/thrombectomy,after being admitted to the hospital.Stroke service in severe COVID-19 epidemic areas,for example,Wuhan,was much more severely impacted compared with other regions in China. | Xia Wang Menglu Ouyang Cheryl Carcel Chen Chen Lingli Sun Jie Yang Yao Zhang Guofang Chen Shoujiang You Yongjun Cao Lu Ma Xin Hu Yi Sui Craig Anderson Lili Song Yongjun Wang David Wang | 2020 | Stroke & Vascular Neurology2020，5，4： | 2 |
| 5 | Physicochemical properties and volatile components of pea flour fermented by Lactobacillus rhamnosus L08显示文摘Pea(Pisum sativum L.)is an important source of plant proteins.However,the use of pea flour as a food ingredient is greatly limited due to its strong beany flavor.In this work,we investigated the effects of Lactobacillus rhamnosus L08(L.rhamnosus L08)fermentation on the physicochemical characteristics,amino acids composition and volatile flavor compounds of pea flour.We found that L.rhamnosus L08 had the probiotic potential of utilizing pea flour as fermentation substrate.L.rhamnosus L08 fermentation significantly increased the content of most amino acids,and total amino acid content increased from 222.18 mg/g at 0 h to 262.35 mg/g at 6 h.A total of 44 volatile compounds were identified in pea flour.L.rhamnosus L08 fermentation increased the variety of acids and esters,while reduced the unpleasant flavor such as nonanal,decanal,octanal,1-hexanol and 2-ethyl-1-hexanol.The emulsifying stability and foam stability of pea flour were slightly enhanced during fermentation.Our results illustrate that lactic acid bacteria fermentation is a promising approach to eliminate undesirable aroma of pea flour.Moreover,this study provides theoretical support for the application of peas as high-quality protein source. | Mengqi Pei Zifu Zhao Song Chen E.I.Reshetnik S.L.Gribanova Chun Li Guofang Zhang Libo Liu Lin Zhao | 2022 | Food Bioscience2022，46，2： | 2 |
| 6 | Intravenous umbilical cord mesenchymal stem cell infusion for the treatment of combined malnutrition nonunion of the humerus and radial nerve injury显示文摘 | Guofang Xue Meilan He Jie Zhao Yan Chen Yun Tian Baozhen Zhao Bo Niu | 2011 | Regenerative medicine2011，6，6： | 1 |
| 7 | Optimal extent of fluorination enabling strong temperature-dependent aggregation, favorable blend morphology and high-efficiency polymer solar cells显示文摘Temperature-dependent aggregation is a key property for some donor polymers to realize favorable bulk-heterojunction(BHJ)morphologies and high-efficiency(>10%) polymer solar cells.Previous studies find that an important structural feature that enables such temperature-dependent aggregation property is the 2nd position branched alkyl chains sitting between two thiophene units.In this report,we demonstrate that an optimal extent of fluorination on the polymer backbone is a second essential structural feature that enables the strong temperature-dependent aggregation property.We compare the properties of three structurally similar polymers with 0,2 or 4 fluorine substitutions in each repeating unit through an in-depth morphological study.We show that the non-fluorinated polymer does not aggregate in solution(0.02 mg mL^(-1) in chlorobenzene) at room temperature,which results in poor polymer crystallinity and extremely large polymer domains.On the other hand,the polymer with four fluorine atoms in each repeating unit exhibits an excessively strong tendency to aggregate,which makes it difficult to process and causes a large domain.Only the polymer with two fluorine atoms in each repeating unit exhibits a suitable extent of temperature-dependent aggregation property.As a result,its blend film achieves a favorable morphology and high power conversion efficiency.This provides another key design rationale for developing donor polymers with suitable temperature-dependent aggregation properties and thus high performance. | Guofang Yang Zhengke Li Kui Jiang Jie Zhang Jianya Chen Guangye Zhang Fei Huang Wei Ma He Yan | 2017 | Science China Chemistry2017，60，4： | 1 |
| 8 | Melatonin in Chinese medicinal herbs显示文摘 | Huo Yushu Tan Dun-Xian | 2003 | Life Sciences2003，73，1： | 1 |
| 9 | Performance evaluation of the fixed relay in OFDMA systems显示文摘 | Gao Peng Wu Xiaoyan Meng Dexiang Chen Yanming Tu Guofang | 2010 | High Technology Letters2010，16，3： | 1 |
| 10 | 显示文摘 | Guofang Lin Qingwen Ma Jigang Chen Jianhua Shen Cuiqing Xiang Klaus Golka Dongsheng Zhang | 2001 | Archives of Toxicology2001，，9： | 1 |
| 11 | The Preparation of Marine Geochemical Certified Reference Materials-Polymetallic Nodule GSPN-1 and Marine Sediment GSMS-1 from the Pacific Ocean显示文摘 | Chen Guofang Wang Jiwu | 1998 | Geostandards Newsletter1998，22，1： | 1 |
| 12 | SOIL PILE INTERACTION UNDER STATIC, DYNAMIC AND CYCLIC LATERAL LOADS AND A PROPOSAL OF p-y CURVE FORMULA显示文摘In this paper, the studies on soil-pile interaction behaviors in saturated sands under static, dynamic and cyclic lateral loads by model testing are described. By comparing with the field test results for piles in soft sandy clay, a formula of p-y curves based on constitutive relationship of soils applicable for both sandy and soft clays is proposed. Good agreements arc obtained in comparison with the field test results performed by other investigators abroad. A p-y hysteresis curve formula based on the modified Masing’s doubling criterion is also proposed, and the results are in satisfactory agreement with field test results. | Gao, Ming Chen, Jinzhen Zhen, Guofang Fang, Huolang | 1989 | China Ocean Engineering1989，4，3： | 1 |
| 13 | Modeling fluid velocity response for wafer scanning in immersion lithography显示文摘 | Hui Chen Xin Fu Jun Zou Huayong Yang Xiaodong Ruan Guofang Gong | 2009 | Microelectronic Engineering2009，，5： | 1 |
| 14 | Studies of micelle and trace non-polar organic solvent on a new chemiluminescence system and its application to flow injection analysis显示文摘 | Zhang Guofang Chen Hongyuan | 2000 | Anal China Acta2000，409，： | 1 |
| 15 | Association of plasminogen activator inhibitor-1 4G/5G promoter polymorphism with recurrent cerebral infarction in China’s North Jiangsu Province显示文摘BACKGROUND: Many international studies have shown that plasminogen activator inhibitor-1 (PAI-1) 4G/5G promoter polymorphism does not increase the risk for cerebral infarction. OBJECTIVE: Using PCR methodology and agarose electrophoresis to detect PAI-1 4G/5G promoter polymorphism in patients with recurrent cerebral infarction in the North Jiangsu Province of China, and to compare results with healthy subjects and patients with first-occurrence cerebral infarction in the same region. DESIGN, TIME AND SETTING: Non-randomized, concurrent, control trial. A total of 122 cerebral infarction patients were admitted to Xuzhou Medical College Hospital's Department of Neurology and Xuzhou Central Hospital’s Department of Neurology between July 2003 and August 2006. PARTICIPANTS: The patients consisted of 63 males and 59 females, aged (62 ± 10) years. They were divided into first-occurrence (n = 58) and recurrence (n = 64) groups. In addition, 50 healthy subjects that underwent physical examination in the outpatient department, including 26 males and 24 females, aged (60 ±12) years, were selected as controls. METHODS AND MAIN OUTCOME MEASURES: PAI-1 4G/5G promoter polymorphism was detected and analyzed using PCR methodology and agarose electrophoresis. RESULTS: Significant differences were determined in terms of genotypic frequency and allele frequency of PAI-1 4G/5G promoter polymorphism, in patients with first-occurrence or recurrent cerebral infarction, when compared with healthy subjects (P < 0.05). There was, however, no significant difference between the first-occurrence and recurrence groups (P > 0.05). CONCLUSION: PAI-1 4G/5G promoter polymorphism is genetic risk factor for cerebral infarction in China. However, it may be associated with recurrence of cerebral infarction in patients from the North Jiangsu Province of China. | Deqin Geng Jijun Zhu Guofang Chen Xianbi Tang Qiaoyun Yang Jizhen Li Fumin Liu | 2008 | Neural Regeneration Research2008，3，7： | 1 |
| 16 | Vascular Endothelial Growth Factor‑Recruiting Nanofiber Bandages Promote Multifunctional Skin Regeneration via Improved Angiogenesis and Immunomodulation显示文摘Tissue injury leads to gradients of chemoattractants,which drive multiple processes for tissue repair,including the inflam-matory response as well as endogenous cell recruitment.However,a limited time window for the gradients of chemoattract-ants as well as their poor stability at the injury site may not translate into healthy tissue repair.Consequently,intelligent multifunctional scaffolds with the capability to stabilize injury-induced cytokines and chemokines hold great promise for tissue repair.Vascular endothelial growth factor(VEGF)plays a significant role in wound healing by promoting angiogen-esis.The overarching objective of this research was to develop intelligent multifunctional scaffolds with the capability to endogenously recruit VEGF and promote wound healing via angiogenic and immunomodulatory dual functions.Prominin-1-derived peptide(PR1P)was encapsulated into electrospun poly(L-lactide-coglycolide)/gelatin(P/G)-based bandages.The sustained release of PR1P recruited VEGF in situ,thereby stabilizing the protein concentration peak in vivo and affording a reparative microenvironment with an adequate angiogenic ability at the wound site.Meanwhile,PR1P-recruited VEGF-induced macrophage reprogramming towards M2-like phenotypes further conferred immunomodulatory functions to the bandages.These dual functions of proangiogenesis and immunomodulation formed a cascade amplification,which regulated matrix metalloproteinases(MMP-9)as well as inflammatory factors(nuclear factor(NF)-κb,tumor necrosis factor(TNF)-α)in the wound microenvironment via the VEGF/macrophages/microenvironment axis.Consequently,the bandages realized multifunctional regeneration in splinted excisional wounds in rats,with or without diabetes,affording a higher skin append-age neogenesis,sensory function,and collagen remodeling.Conclusively,our approach encompassing in situ recruitment of VEGF at the injury site with the capability to promote immunomodulation-mediated tissue repair affords a promising avenue for scarless wound regeneration,which may also have implications for other tissue engineering disciplines. | Yi Chen Zhengchao Yuan Weiyan Sun Muhammad Shafiq Jun Zhu Jiafei Chen Hai Tang Ling Hu Weikang Lin Yanxi Zeng Long Wang Lei Zhang Yunlang She Hui Zheng Guofang Zhao Dong Xie Xiumei Mo Chang Chen | 2023 | Advanced Fiber Materials2023，5，1： | 1 |
| 17 | Melatonin in Chinese medicinal herbs显示文摘 | CHEN GUOFANG HUO YUSHU TAN DUNXIAN | 2003 | Life Sciences2003，73，1： | 1 |
| 18 | Investigation on hydrophobic films from a hydrophobic powde 显示文摘 | Liqun Zhu Guofang Hao Yuan Chen | 2012 | Applied Surface Science2012，261，： | 1 |
| 19 | Regularity theorems and energy identities for Dirac-harmonic maps显示文摘 | Qun Chen Jürgen Jost Jiayu Li Guofang Wang | 2005 | Mathematische Zeitschrift2005，，1： | 1 |
| 20 | Metformin Inhibits Growth of Thyroid Carcinoma Cells, Suppresses Self-Renewal of Derived Cancer Stem Cells, and Potentiates the Effect of Chemotherapeutic Agents显示文摘 | Guofang Chen Shuhang Xu Kostja Renko Michael Derwahl | 2012 | The Journal of Clinical Endocrinology & Metabolism2012，，： | 1 |
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