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| 1 | Cryopreservation for delayed circulating tumor cell isolation is a valid strategy for prognostic association of circulating tumor cells in gastroesophageal cancer显示文摘AIM To demonstrate the feasibility of cryopreservation of peripheral blood mononuclear cells(PBMCs) for prognostic circulating tumor cell(CTC) detection in gastroesophageal cancer.METHODS Using 7.5 m L blood samples collected in EDTA tubes from patients with gastroesopheagal adenocarcinoma, CTCs were isolated by epithelial cell adhesion molecule based immunomagnetic capture using the Iso Flux platform. Paired specimens taken during the same blood draw(n = 15) were used to compare number of CTCs isolated from fresh and cryopreserved PBMCs. Blood samples were processed within 24 h to recover the PBMC fraction, with PBMCs used for fresh analysis immediately processed for CTC isolation. Cryopreservation of PBMCs lasted from 2 wk to 25.2 mo(median 14.6 mo). CTCs isolated from pre-treatment cryopreserved PBMCs(n = 43) were examined for associations with clinicopathological variables and survival outcomes.RESULTS While there was a significant trend to a decrease in CTC numbers associated with cryopreserved specimens(mean number of CTCs 34.4 vs 51.5, P = 0.04), this was predominately in samples with a total CTC count of > 50, with low CTC count samples less affected(P = 0.06). There was no significant association between the duration of cryopreservation and number of CTCs. In cryopreserved PBMCs from patient samples prior to treatment, a high CTC count(> 17) was associated with poorer overall survival(OS)(n = 43, HR = 4.4, 95%CI: 1.7-11.7, P = 0.0013). In multivariate analysis, after controlling for sex, age, stage, ECOG performance status, and primary tumor location, a high CTC count remained significantly associated with a poorer OS(HR = 3.7, 95%CI: 1.2-12.4, P = 0.03). CONCLUSION PBMC cryopreservation for delayed CTC isolation is a valid strategy to assist with sample collection, transporting and processing. | Daniel Brungs David Lynch Alison WS Luk Elahe Minaei Marie Ranson Morteza Aghmesheh Kara L Vine Martin Carolan Mouhannad Jaber Paul de Souza Therese M Becker | 2018 | World Journal of Gastroenterology2018，24，7： | 5 |
| 2 | Plants need their vitamins too 显示文摘 | Alison G Smith Martin T Croft | 2007 | Current Opinion in Plant Biology2007，10，： | 1 |
| 3 | Hepatotoxicity in an African antiretroviral therapy cohort: the effect of tuberculosis and hepatitis B显示文摘 | Christopher J Hoffmann Salome Charalambous Chloe L Thio Desmond J Martin Lindiwe Pemba Katherine L Fielding Gavin J Churchyard Richard E Chaisson Alison D Grant | 2007 | AIDS2007，，10： | 1 |
| 4 | Characterisation of salt films on dissolving metal surfaces in artificial corrosion pits via in situ synchrotron X-ray diffraction显示文摘 | Trevor Rayment Alison J. Davenport Andrew J. Dent Jean-Philippe Tinnes Richard J.K. Wiltshire Christopher Martin Graham Clark Paul Quinn J. Fred W. Mosselmans | 2008 | Electrochemistry Communications2008，，6： | 1 |
| 5 | Plants need their vitamins too 显示文摘 | Alison G Smith Martin T Croft | 2007 | Current Opinion in Plant Biology2007，10，： | 1 |
| 6 | The MacDQoL Individualized Measure of the Impact of Macular Degeneration on Quality of Life: Reliability and Responsiveness显示文摘 | Jan Mitchell James Wolffsohn Alison Woodcock Stephen J. Anderson Timothy Ffytche Martin Rubinstein Winfried Amoaku Clare Bradley | 2008 | American Journal of Ophthalmology2008，，3： | 1 |
| 7 | Corneal epithelial defects following vitreoretinal surgery:incidence and outcomes from the DISCOVER study显示文摘AIM:To investigate the incidence,risk factors,clinical course,and outcomes of corneal epithelial defects(CED)following vitreoretinal surgery in a prospective study setting.METHODS:This was a post-hoc analysis of all participants in DISCOVER intraoperative optical coherence tomography study.Subjects with CED 1 d after surgery without intraoperative corneal debridement was defined as the postoperative CED group.Subjects who underwent intraoperative debridement were defined as intraoperative debridement group.Eyes were matched 2:1 with controls(eyes without postoperative CED)for comparative assessment.The primary outcomes were the incidence of CED on postoperative day one and the incidence of required intraoperative debridement.Secondary outcomes included time to defect closure,delayed healing(>2 wk),visual acuity(VA)and presence of scarring at one year and cornea consult.RESULTS:This study included 856 eyes that underwent vitreoretinal surgery.Intraoperative corneal debridement was performed to 61(7.1%)subjects and postoperative CED developed spontaneously in 94(11.0%)subjects.Significant factors associated with postoperative CED included prolonged surgical duration(P=0.003),diabetes mellitus(P=0.04),postoperative ocular hypotension(P<0.001).Prolonged surgical duration was associated with intraoperative debridement.Delayed defect closure time(>2 wk)was associated with corneal scar formation at the end of the 1 y in all epithelial defect subjects(P<0.001).The overall rate of corneal scarring for all eyes undergoing vitrectomy was 1.8%.CONCLUSION:Prolonged duration of surgery is the strongest factor associated with both intraoperative debridement and spontaneous postoperative CED.Delayed defect closure is associated with a greater risk of corneal scarring at one year.The overall rate of corneal scarring following vitrectomy is low at<2%. | Kubra Sarici Daniel Petkovsek Alison Martin Alex Yuan Jeffrey M.Goshe Sunil K.Srivastava Jamie L.Reese Justis P.Ehlers | 2022 | International Journal of Ophthalmology(English edition)2022，15，1： | 1 |
| 8 | Enhanced F cα RI ‐mediated neutrophil migration towards tumour colonies in the presence of endothelial cells显示文摘 | Marielle A. Otten Jantine E. Bakema Cornelis W. Tuk Martin J. Glennie Alison L. Tutt Robert H.J. Beelen Jan G. J. van de Winkel Marjolein van Egmond | 2012 | Eur J Immunol2012，，7： | 1 |
| 9 | Cloning and characterization of a gene involved in phytoene synthesis from tomato显示文摘 | John Ray Philippe Moureau Colin Bird Alison Bird Don Grierson Martin Maunders Mark Truesdale Peter Bramley Wolfgang Schuch | 1992 | Plant Molecular Biology1992，，： | 1 |
| 10 | Enhanced Detection of Thromboemboli With the Use of Targeted Microbubbles显示文摘 | Matthew J. Martin Emma M.L. Chung Alison H. Goodall Alberto Della Martina Kumar V. Ramnarine Lingke Fan Sarah V. Hainsworth A Ross Naylor David H. Evans | 2007 | Stroke2007，，10： | 1 |
| 11 | Nintedanib plus docetaxel as second-line therapy in patients with non-small-cell lung cancer: a network meta-analysis显示文摘 | Sanjay Popat Anders Mellemgaard Kyle Fahrbach Alison Martin Maria Rizzo Rolf Kaiser Ingolf Griebsch Martin Reck | 2015 | Future Oncol2015，，3： | 1 |
| 12 | Fracture strengths of potato tissue under compression and tension at two rates of loading显示文摘 | Martin G. Scanlon Alison E. Long | 1995 | Food Research International1995，，4： | 1 |
| 13 | Pants need their vitamins too显示文摘 | ALISON G S MARTIN T C MICHAEL M | 2007 | Current Opinion in Plant Biology2007，10，： | 1 |
| 14 | Exercise for osteoarthritis of the knee: a Cochrane systematic review显示文摘 | Fransen Marlene McConnell Sara Harmer Alison R Van der Esch Martin Simic Milena Bennell Kim L | 2015 | British Journal of Sports Medicine2015，，24： | 1 |
| 15 | Effects of resistance training on cardiovascular health in non-obese active adolescents显示文摘AIM:To determine the benefits of a 10-wk resistance training programme on cardiovascular health in nonobese and active adolescents.METHODS:This is a pragmatic randomised controlled intervention.The study was carried out in a Hong Kong Government secondary school.Thirty-eight lean and active boys and girls were randomised to either the resistance training group or the control group.Students in the resistance training group received in-school 10-wk supervised resistance training twice per week,with each session lasting 70 min.Main outcome measures taken before and after training included brachial endothelial dependent flow-mediated dilation,body composition,fasting serum lipids,fasting glucose and insulin,high sensitive C-reactive protein,24-h ambulatory blood pressure and aerobic fitness.RESULTS:The only training related change was in endothelial dependent flow-mediated dilation which increased from 8.5%to 9.8%.A main effect of time and an interaction(P<0.005) indicated that this improvement was a result of the 10-wk resistance training.Main effects for time(P<0.05) in a number of anthropometric,metabolic and vascular variables were noted;however,there were no significant interactions indicating the change was more likely an outcome of normal growth and development as opposed to a training effect.CONCLUSION:Ten weeks of resistance training in school appears to have some vascular benefit in active,lean children. | Clare Chung-Wah Yu Alison Mary McManus Hung-Kwan So Ping Chook Chun-Ting Au Albert Martin Li Jack Tat-Chi Kam Raymond Chi-Hung So Christopher Wai-Kei Lam Iris Hiu-Shuen Chan Rita Yn-Tz Sung | 2016 | World Journal of Clinical Pediatrics2016，5，3： | 1 |
| 16 | Cloning and characterization of a gene involved in phytoene synthesis from tomato显示文摘 | John Ray Philippe Moureau Colin Bird Alison Bird Don Grierson Martin Maunders Mark Truesdale Peter Bramley Wolfgang Schuch | 1992 | Plant Molecular Biology1992，，3： | 1 |
| 17 | Fracture strengths of potato lissue under compression and tension at two rates of loading显示文摘 | Martin G Alison E | 1995 | Food Re- search International1995，28，4： | 1 |
| 18 | Conversations around Homework: Links to Parental Mental Health, Family Characteristics and Child Psychological Functioning显示文摘 | Lynne Murray Matt Woolgar Carla Martins Anna Christaki Alison Hipwell and Peter Cooper | 2006 | The British Psychological Society2006，，： | 1 |
| 19 | Fracture strengths of po- tato tissue under compression and tension at two rates of loading显示文摘 | Martin G Scanlon Alison E Long | 1995 | Food Research International1995，28，4： | 1 |
| 20 | Integrating species and successional classes for wood production in a mixed forest restoration system in a neotropical region显示文摘As forests in neotropical regions,particularly in developing countries,are devastated,interventions to restore biodiversity and its ecological functions are needed.Rural producers have thus been encouraged to grow trees for wood production as an economic activity.The objective of this study was to quantify the increment of wood density of four forest species from different successional classes of a mixed system of restoration in a neotropical forest in Brazil.Tree discs were sampled at breast height and analyzed radially by X-ray densitometry to obtain apparent density and basic density.Three trees each of a species from the pioneer,early and late secondary successional stages and of the dominant species in the climax community.The radial profiles indicated increasing density from the pith to bark of trunks,except for some variations due to wood defects and growth.Average density was 0.576 g cm^(-3),0.655 g cm^(-3),0.706 g cm^(-3)and 0.775 g cm^(-3),respectively,for Peltophorum dubium,Schinus terebinthifolius,Cariniana estrellensis and Hymenaea courbaril.Radial profiles indicated higher amplitudes in the apparent densities for slow-growing species.X-ray densitometry generated parameters such as minimum,average and maximum densities,and radial density variations.These parameters are important for understanding the ecological functional role of successional classes of the Atlantic Forest from the Neotropical region. | Ananias Francisco Dias Junior Ana Lucia Martins Sodero Pincelli Ana Paula Camara da Silva Alison Moreira da Silva Natalia Dias de Souza Mario Tommasiello Filho Jose Otavio Brito | 2021 | Journal of Forestry Research2021，32，6： | 1 |
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