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| 1 | Mismatch repair, minichromosome maintenance complex component 2, cyclin A, and transforming growth factor β receptor type Ⅱ as prognostic factors for colorectal cancer: results of a 10-year prospective study using tissue microarray analysis显示文摘编码涉及 colorectal 癌症的很多条病原的小径的基因的表示能潜在地作为预示的标记扮演的背景。大未来的研究被要求建立他们的关联到我们调查了的疾病 prognosis.Methods 在 790 个病人的 19 个标记的关联用 immunohistochemistry 在 5 氟尿嘧啶的大 randomised 试用注册了并且在 situ 杂交发色。在全面 10 年的幸存和标记地位之间的关系是 assessed.Results Minichromosome 维护建筑群部件 2 (MCM2 ) 并且 cyclin A 显著地与全面幸存被联系。提高的 MCM2 表示与更好的预后被联系(HR=0.63, 95%CI:0.46-0.86 ).Cyclin A 表示在上面中部预言了改进耐心的预后(HR=0.71, 95%CI:0.53-0.95 ) 。为失配修理缺乏和转变生长因素受体类型(TGFBRII ) ,在那里的 overexpression 是有更差的预后的一个边线协会(HR=0.69, 95%C/ :0.46-1.04 和 HR=2.11, 95%CI:1.02-4.40,分别地) 。没有明显的协会被作出对有利的裁决这研究识别了的另外的 markers.Conclusion 房间增长和 cyclin A 表示在 colorectal 癌症的耐心的结果的同样预示的指示物。 | ZHAO Dong-bing Ian Chandler CHEN Zheng-ming PAN Hong-chao Sanjay Popat SHAO Yong-fu Richard S Houlston | 2011 | Chinese Medical Journal2011，，4： | 4 |
| 2 | Total knee arthroplasty in patients with Paget's disease of bone: A systematic review显示文摘AIM To determine the functional outcomes, complications and revision rates following total knee arthroplasty(TKA) in patients with Paget's disease of bone(PDB). METHODS A systematic review of the literature was performed. Four studies with a total of 54 TKAs were included for analysis. Functional outcomes, pain scores, complications and revision rates were assessed. The mean age was 72.0 years and the mean follow-up was 7.5 years.RESULTS All studies reported significant improvement in knee function and pain scores following TKA. There were 2 cases of aseptic loosening, with one patient requiring revision of the femoral component 10 years after the index procedure. Malalignment, bone loss, soft tissue contractures were the most commonly reported intraoperative challenges. There were five cases(9%) that were complicated by intra-operative patellar tendon avulsion.CONCLUSION The findings support the use of TKA in patients with PDB. The post-operative functional outcomes are largely similar to other patients, however there are specific perioperative challenges that have been highlighted, in particular the high risk for patellar tendon avulsion. | Ravi Popat Konstantinos Tsitskaris Steven Millington Sebastian Dawson-Bowling Sammy A Hanna | 2018 | World Journal of Orthopedics2018，9，10： | 2 |
| 3 | Taste masking of ciprofloxacin by ion-exchange resin and sustain release at gastric-intestinal through interpenetrating polymer network显示文摘The aim of the study was to taste mask ciprofloxacin(CP)by using ion-exchange resins(IERs)followed by sustain release of CP by forming interpenetrating polymer network(IPN).IERs based on the copolymerization of acrylic acid with different cross linking agents were synthesised.Drug-resin complexes(DRCs)with three different ratios of drug to IERs(1:1,1:2,1:4)were prepared&evaluated for taste masking by following in vivo and in vitro methods.Human volunteers graded ADC 1:4,acrylic acid-divinyl benzene(ADC-3)resin as tasteless.Characterization studies such as FTIR,SEM,DSC,P-XRD differentiated ADC 1:4,from physical mixture(PM 1:4)and confirmed the formation of complex.In vitro drug release of ADC 1:4 showed complete release of CP within 60 min at simulated gastric fluid(SGF)i.e.pH 1.2.IPN beads were prepared with ADC 1:4 by using sodium alginate(AL)and sodium alginate-chitosan(AL-CS)for sustain release of CP at SGF pH and followed by simulated intestinal fluid(SIF i.e.pH 7.4).FTIR spectra confirmed the formation of IPN beads.The release of CP was sustain at SGF pH(<20%)whereas in SIF media it was more(>75%).The kinetic model of IPN beads showed the release of CP was non-Fickian diffusion type. | A.Michael Rajesh Shreya A.Bhatt Harshad Brahmbhatt Pritpal Singh Anand Kiritkumar Mangaldas Popat | 2015 | Asian Journal of Pharmaceutical Sciences2015，10，4： | 2 |
| 4 | Extraskeletal myxoid chon-drosarcoma:a retrospective review from2referral centers emphasi-zing long-term outcomes with surgery and chemotherapy显示文摘 | Drilon AD Popat S Bhuchar G | 2008 | Cancer2008，113，12： | 1 |
| 5 | Chondroitinase ABC promotes axon regeneration and functional recovery following spinal cord injury显示文摘 | Bradbury EJ Moon LD Popat RJ | 2002 | Nature2002，416，： | 1 |
| 6 | Influence of engineered titaniananotubular surfaces on bone cells显示文摘 | Popat KC Leoni L Grimes CA | | 0，，21： | 1 |
| 7 | Small - cell lung cancer (SCLC) : ESMO Clinical Practice Guidelines for diagnosis, treatment and follow- up 显示文摘 | Frtlh M De Ruysscher D Popat S | 2013 | Ann Oncol2013，24，6： | 1 |
| 8 | Influence of ertgineered titania nanotubular surfaces on bone cells 显示文摘 | Popat KC Leoni L Grimes CA | 2007 | Biomaterials2007，28，21： | 1 |
| 9 | Chondroitinase ABC promotes functional recovery after spinal cord injury 显示文摘 | Bradbury E J Moon L D F Popat R J | 2002 | Nature2002，416，： | 1 |
| 10 | Decreased Sta-phylococcus epidermis adhesion and increased osteoblastfunctionality on antibiotic-loaded titania nanotubes显示文摘 | Popat KC Eltgroth M Latempa TJ | 2007 | Bio-materials2007，28，32： | 1 |
| 11 | Use of bortezomib as induction therapy prior to stem cell transplantation in frontline treatment of multiple myeloma:impact on stem cell harvesting and engraftment显示文摘 | Oakervee H Popat R Cavenagh JD | | 0，，： | 1 |
| 12 | Decreased Staphylococcus epidermis adhesion and increased osteoblast functionality on antibiotic-loaded titania nanotubes显示文摘 | Popat KC Eltgroth M Latempa TJ | | 0，，32： | 1 |
| 13 | Difficuh Airway Society Guidelines for the management of tracheal extubation 显示文摘 | Popat M Mitchell V Dravid R | 2012 | Anaes- thesia2012，67，3： | 1 |
| 14 | Platinum-based chemotherapy in triple-negative breast cancer显示文摘 | Sirohi B Arnedos M Popat S | 2008 | Ann Oncol2008，19，11： | 1 |
| 15 | Systematic review of microsatel-lite instability and colorectal cancer prognosis显示文摘 | Popat S Hubner R Houlston RS | 2005 | J Clin Oncol2005，23，3： | 1 |
| 16 | PAD combination therapy(ps-341/bortezomib, doxorubicin and dexamethasone)for previously untreated patients with multiple myeloma显示文摘 | OAKERVEE HE POPAT R CURRY N | 2005 | Br J Haematol2005，129，6： | 1 |
| 17 | Treatment of nasopharyngeal carcinoma with Epstein-Barr virus-specific T lymphocytes显示文摘 | Straathof KC Bollard CM Popat U | 2005 | Blood2005，105，5： | 1 |
| 18 | Quality of life changes in patients with neurogenic versus idiopathic detrusor overactivity after intradetrusor injections of botulinum neurotoxin type A and correlations with lower urinary tract symptoms and urodynamic changes显示文摘 | Kalsi V Apostolidis A Popat R | | 0，，03： | 1 |
| 19 | Chondroitinase ABC promotes fundtional recovery after spinal cord injury显示文摘 | Bradbury EJ Moon LDH Popat RJ | 2004 | Nature2004，416，： | 1 |
| 20 | Chondrotiti-nase ABC promotes functional recovery after spinal cord injury显示文摘 | MOON L D POPAT R J | 2002 | Nature2002，416，6881： | 1 |
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