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| 1 | Reproducibility of thrombus volume quantification in multicenter computed tomography pulmonary angiography studies显示文摘AIM To evaluate reproducibility of pulmonary embolism(PE) clot volume quantification using computed tomography pulmonary angiogram(CTPA) in a multicenter setting.METHODS This study was performed using anonymized data in conformance with HIPAA and IRB Regulations(March 2015-November 2016). Anonymized CTPA data was acquired from 23 scanners from 18 imaging centers using each site's standard PE protocol. Two independent analysts measured PE volumes using a semi-automated region-growing algorithm on an FDA-approved image analysis platform. Total thrombus volume(TTV) was calculated per patient as the primary endpoint. Secondary endpoints were individual thrombus volume(ITV), Qanadli score and modified Qanadli score per patient. Inter-and intra-observer reproducibility were assessed using intra-class correlation coefficient(ICC) and BlandAltman analysis. RESULTS Analyst 1 found 72 emboli in the 23 patients with a mean number of emboli of 3.13 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.0041-47.34 cm3(mean +/-SD, 5.93 +/-10.15 cm3). On the second read, analyst 1 found the same number and distribution of emboli with a range of volumes for read 2 from 0.0041 – 45.52 cm3(mean +/-SD, 5.42 +/-9.53 cm3). Analyst 2 found 73 emboli in the 23 patients with a mean number of emboli of 3.17 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.00459-46.29 cm3(mean +/-SD, 5.91 +/-10.06 cm3). Inter-and intraobserver variability measurements indicated excellent reproducibility of the semi-automated method for quantifying PE volume burden. ICC for all endpoints was greater than 0.95 for inter-and intra-observer analysis. Bland-Altman analysis indicated no significant biases.CONCLUSION Semi-automated region growing algorithm for quantifying PE is reproducible using data from multiple scanners and is a suitable method for image analysis in multicenter clinical trials. | Audrey E Kaufman Alison N Pruzan Ching Hsu Sarayu Ramachandran Adam Jacobi Indravadan Patel Lee Schwocho Michele F Mercuri Zahi A Fayad Venkatesh Mani | 2018 | World Journal of Radiology2018，10，10： | 3 |
| 2 | Effect of varying computed tomography acquisition and reconstruction parameters on semi-automated clot volume quantification显示文摘AIM To examine effects of computed tomography(CT)image acquisition/reconstruction parameters on clot volume quantification in vitro for research method validation purposes.METHODS This study was performed in conformance with HIPAA and IRB Regulations(March 2015-November 2016).A ten blood clot phantom was designed and scanned on a dual-energy CT scanner(SOMATOM Force,Siemens Healthcare Gm BH,Erlangen,Germany)with varying pitch,iterative reconstruction,energy level and slicethickness.A range of clot and tube sizes were used in an attempt to replicate in vivo emboli found within central and segmental branches of the pulmonary arteries in patients with pulmonary emboli.Clot volume was the measured parameter and was analyzed by a single image analyst using a semi-automated region growing algorithm implemented in the FDA-approved Siemens syngo.via image analysis platform.Mixed model analysis was performed on the data.RESULTS On the acquisition side,the continuous factor of energy showed no statistically significant effect on absolute clot volume quantification(P=0.9898).On the other hand,when considering the fixed factor of pitch,there were statistically significant differences in clot volume quantification(P<0.0001).On the reconstruction side,with the continuous factor of reconstruction slice thickness no statistically significant effect on absolute clot volume quantification was demonstrated(P=0.4500).Also on the reconstruction side,with the fixed factor of using iterative reconstructions there was also no statistically significant effect on absolute clot volume quantification(P=0.3011).In addition,there was excellent R^2 correlation between the scale-measured mass of the clots both with respect to the CT measured volumes and with respect to volumes measure by the water displacement method.CONCLUSION Aside from varying pitch,changing CT acquisition parameters and using iterative reconstructions had no significant impact on clot volume quantification with a semi-automated region growing algorithm. | Audrey E Kaufman Alison N Pruzan Ching Hsu Sarayu Ramachandran Adam Jacobi Zahi A Fayad Venkatesh Mani | 2018 | World Journal of Radiology2018，10，3： | 3 |
| 3 | Chemotherapy options in elderly and frail patients with metastatic colorectal cancer (MRC FOCUS2): an open-label, randomised factorial trial显示文摘 | Matthew T Seymour Lindsay C Thompson Harpreet S Wasan Gary Middleton Alison E Brewster Stephen F Shepherd M Sinead O’Mahony Timothy S Maughan Mahesh Parmar Ruth E Langley | 2011 | The Lancet2011，，9779： | 2 |
| 4 | Patient satisfaction and the impact of written material about postpartum contraceptive decisions显示文摘 | Lisa K Johnson Alison E | 2003 | American Journal of Obstetrics and Gynecology2003，188，5： | 1 |
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| 6 | Development of a quantitative polymerase chain reaction(q PCR)assay for the detection of dwarf gourami iridovirus(DGIV)and other megalocytiviruses and comparison with the Office International des Epizooties(OIE)reference PCR protocol显示文摘 | Anneke E R Joy A B Alison T | 2012 | Aquaculture2012，，： | 1 |
| 7 | Pluripotential liver stem cells: facultative stem cells located in the biliary tree显示文摘 | ALISON M R GOLDIN M H SARRAF C E | 1996 | Cell Prolif1996，29，7： | 1 |
| 8 | Imagining Stereotypes Away: The Moderation of Implicit Stereotypes Through Mental Imagery 显示文摘 | Irene V Blair Jennifer E Ma Alison P Lenton | 2001 | Journal of Personality and Social Psychology2001，，81： | 1 |
| 9 | Candidate gene association studies of the α4 ( CHRNA4 ) and b2 ( CHRNB2 ) neuronal nicotinic acetylcholine receptor subunit genes in Alzheimer's disease 显示文摘 | Lynnette J Luk W Alison E | 2004 | Neurosci Lett2004，358，： | 1 |
| 10 | Hepatotoxicity in an African antiretroviral therapy cohort: the effect of tuberculosis and hepatitis B显示文摘 | Christopher J Hoffmann Salome Charalambous Chloe L Thio Desmond J Martin Lindiwe Pemba Katherine L Fielding Gavin J Churchyard Richard E Chaisson Alison D Grant | 2007 | AIDS2007，，10： | 1 |
| 11 | Application strategies:An organizational perspective显示文摘 | Rynes Sara L and Barber Alison E | 1990 | The Academy of Management Review1990，15，2： | 1 |
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| 13 | Effects of heavy resistance exercise on skeletal muscle Il-6 and serum Il-10 expression显示文摘 | HARVEY ALISON E WATKINS AUSTEN MARK TAYLOR LEM W | 2004 | Med Sci Sports Exe2004，36，5： | 1 |
| 14 | The role of ion mobility spectrometry-mass spectrometry in the analysis of protein reference standards显示文摘 | Caroline P Gavin O Alison E A | 2013 | Analytical Chemistry2013，85，15： | 1 |
| 15 | Chemotherapy Significantly Increases the Risk of Radiation Pneumonitis in Radiation Therapy of Advanced Lung Cancer显示文摘 | Bhupesh P Alison E Rajeev M | | 0，，02： | 1 |
| 16 | Application Strategies: An organizational Perspective 显示文摘 | Rynes Sara L Barber Alison E | 1990 | The academy of Management Review1990，，2： | 1 |
| 17 | HIV transmission and high rates of late diagnoses among adults aged 50 years and over显示文摘 | Ruth DS Valerie CD Alison E | 2010 | AIDS2010，24，13： | 1 |
| 18 | A mathematical modelof a high sulphate waste water ananerobic treatment system显示文摘 | Anthony N Knobel Alison E Lewis | 2002 | Water Research2002，36，： | 1 |
| 19 | Rice yield and nitrogen utilization efficiency under alternative straw management practices显示文摘 | Alison J E Jeffrey A B William R H | 2000 | Agron J2000，92，6： | 1 |
| 20 | HIV transmission and high rates of late diagnoses among adults aged 50 years and over显示文摘 | Ruth D Smith Valerie C Delpech Alison E Brown Brian D Rice | 2010 | AIDS2010，，13： | 1 |
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