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| 1 | Sudden cardiac death caused by myocarditis in persons aged 1-49 years:a nationwide study of 14 294 deaths in Denmark显示文摘Myocarditis is associated with an increased risk of sudden cardiac death (SCD) in the young.However,Information on nationwide burden of SCD caused by myocarditis (SCD-myocarditis) is sparse.For this study all deaths among persons in Denmark aged 1-35years in 2000-2009 and 36-49years in 2007-2009 (27.1 million person-years) were induded.Autopsy reports,death certificates,discharge summaries,and nationwide registries were used to identify all cases of SCD-myocarditis.In the 10-year study period,there were 14294 deaths,of which we identified 1 363 (10%) SCD.Among autopsied SCD (n=753,55%),cause of death was myocarditis in 42 (6%) cases corresponding to an SCD-myocarditis incidence of 0.16 (95%CI: 0.11-0.21) per 100000 person-years.Males had significantly higher incidence rates of SCD-myocarditis compared to females with an incidence rate ratio of 2.2 (95%CI:1.1-4.1).Myocarditis was not registered as cause of death In any of the non-autopsied SCD (n=610,45%).In conclusion,after nationwide unselected Inclusion of 14294 deaths,we found that 6% of all autopsied SCD was caused by myocarditis.No cases of SCD-myocarditis were reported in the non-autopsied SCD,which could reflect underdiagnosing of myocarditis in non-autopsied SCD.Furthermore,our data suggest a female protection towards SCDmyocarditis. | Thomas Hadberg Lynge Trine Skov Nielsen Bo Gregers Winkel Jacob Tfelt-Hansen Jytte Banner | 2019 | Forensic Sciences Research2019，4，3： | 3 |
| 2 | Pacemaker implantation in a patient with brugada and sick sinus syndrome显示文摘Brugada syndrome (BrS) is a rare and inherited primary arrhythmic syndrome characterized by ST-segment elevations in the right precordial leads (V1 -V3 ) with an increased risk of sudden cardiac death (SCD). Arrhythmias in BrS are often nocturne, and brady-arrhythmias are often seen in patients with loss-of-function mutations in SCN5A . In this case-report we present a 75-year old woman referred to our outpatient clinic for inherited cardiac diseases for a familial clinical work-up. Since childhood she had suffered from dizziness, absence seizures, and countless Syncope's. In 2004 sick sinus syndrome was suspected and she wastreated with implantation of a pacemaker (PM) at another institution. An inherited cardiac disease was one day suddenly suspected, as the patient had a 61-year old brother who was diagnosed with symptomatic BrS, and treated with an implantable cardioverter defibrillator (ICD) after aborted SCD. A mutation screening revealed a SCN5A [S231CfsX251 (c.692-693delCA )] loss-of-function mutation not previously reported, and as a part of the cascade screening in relatives she was therefore referred to our clinic. In the 7 year period after PM implantation she had experienced no cardiac symptoms, although her electrocardiogram changes now were consistent with a BrS type 1 pattern. A genetic test confirmed that she had the same mutation in SCN5A as her brother. In this case-report we present a loss-of function mutation in SCN5A not previously associated with BrS nor presented in healthy controls. Sinus node dysfunction has previously been documented in patients with symptomatic BrS, which suggests it is not a rare concomitant. The only accepted treatment of BrS is today implantation of an ICD. In the future studies should evaluate if PM in some cases of symptomatic BrS can be used instead of ICDs in patients with a loss-of-function SCN5A | Bjarke Risgaard Henning Bundgaard Reza Jabbari Stig HaunsФ Bo Gregers Winkel Jacob Tfelt-Hansen | 2013 | World Journal of Cardiology2013，5，3： | 1 |
| 3 | Evaluation and management of women witll endometriosis显示文摘 | Winkel CA | 2003 | Obstet Gynecol2003，102，2： | 1 |
| 4 | Dispersion Analysis of velocity and Aettenuation in Berea sandstone显示文摘 | | 1985 | Geophys Res1985，90，8： | 1 |
| 5 | Human antibodies as next generation therapeutics显示文摘 | van Dijk M A van de Winkel J G J | 2001 | Curr Opin Chem Biol2001，5，4： | 1 |
| 6 | Direct and vicarious victimization at school and at home as risk factors for suicidal cognition among Italian ado- lescents显示文摘 | Ba|dry A C Winkel F W | 2003 | Journal of Adolescence2003，26，6： | 1 |
| 7 | Theory of mind, humour processing and executive functioning in alcoholism 显示文摘 | Uekermann J Channon S Winkel K et aI | 2007 | Addiction2007，102，2： | 1 |
| 8 | Location,color,size,depth,and volume may predict endometriosis in lesions resected at surgery显示文摘 | Stratton P Winkel CA Sinaii N | 2002 | Fertil Steril2002，78，4： | 1 |
| 9 | Cloned human snRNP proteins B and B'differ only in their carboxy-terminal part 显示文摘 | Dam A Winkel I Zijistra-Baalbergen J | 1989 | EMBO J1989，8，12： | 1 |
| 10 | Randomizedclinical trial of telephone-administered cognitive-behav-ioral therapy to reduce post-traumatic stress disorder anddistress symptoms after hematopoietic stem-cell transplan-tation显示文摘 | DuHamel KN Mosher CE Winkel G | 2010 | J Clin Oncol2010，28，23： | 1 |
| 11 | A method for the monitoring of hormone levels in pregnancy显示文摘 | P Winkel P Gaede J Lyngbye | 1976 | J Clin Chem1976，22，： | 1 |
| 12 | The usefulness of ultrasound colour-doppler twinkling artefact for detec- ting urolithiasis compared with low dose nonenhanced computerized tomography 显示文摘 | Winkel R R Kalhauge A Fredfeldt K E | 2012 | Ultrasound Med Biol2012，38，7： | 1 |
| 13 | Metabolic and cardiovas?cular adverse effects associated with antipsychotic drugs显示文摘 | Hert M DetrauxJ van Winkel R | 2012 | Nat Rev Endocrinol2012，8，2： | 1 |
| 14 | Transitioning between work and family roles as a function of boundary flexibility and role salience显示文摘 | Doan E. Winkel Russell W. Clayton | 2009 | Journal of Vocational Behavior2009，，2： | 1 |
| 15 | Posterior reversible en- cephalopathy syndrome in childhood cancer显示文摘 | de Laat P Te Winkel ML Devos AS | 2011 | Ann Oncol2011，22，2： | 1 |
| 16 | Tu-mor infiltrating T lymphocytes in colorectal cancer:Tu- mor-selective activation and cytotoxic activity in situ显示文摘 | KOCH M BECKHVE P OP DEN WINKEL J | 2006 | Ann Surg2006，244，6： | 1 |
| 17 | The effect of raindrop impact and sheet erosion on infiltration rate and crust formation显示文摘 | Morin J Van Winkel J | 1996 | Soil Sci Soc Am J1996，60，： | 1 |
| 18 | Evaluation and management of woman with endometriosis显示文摘 | Winkel CA | 2003 | Obstet Gynecol2003，102，2： | 1 |
| 19 | The relationship be- tween anterior and apical compartment support 显示文摘 | Summers A Winkel LA Hussain HK | 2006 | Am J Obstet Gynecol2006，194，5： | 1 |
| 20 | Risk of cardiovascular disease in family members of young sudden cardiac death victims显示文摘 | Ranthe MF Winkel BG Andersen EW | 2013 | Eur Heart J2013，34，7： | 1 |
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