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| 1 | Prediction of delayed graft function using different scoring algorithms: A single-center experience显示文摘AIM To compare the performance of 3 published delayed graftfunction(DGF) calculators that compute the theoretical risk of DGF for each patient.METHODS This single-center,retrospective study included 247 consecutive kidney transplants from a deceased donor.These kidney transplantations were performed at our institution between January 2003 and December 2012.We compared the occurrence of observed DGF in our cohort with the predicted DGF according to three different published calculators. The accuracy of the calculators was evaluated by means of the c-index(receiver operating characteristic curve).RESULTS DGF occurred in 15.3% of the transplants under study.The c index of the Irish calculator provided an area under the curve(AUC) of 0.69 indicating an acceptable level of prediction,in contrast to the poor performance of the Jeldres nomogram(AUC = 0.54) and the Chapal nomogram(AUC = 0.51). With the Irish algorithm the predicted DGF risk and the observed DGF probabilities were close. The mean calculated DGF risk was significantly different between DGF-positive and DGF-negative subjects(P < 0.0001). However,at the level of the individual patient the calculated risk of DGF overlapped very widely with ranges from 10% to 51% for recipients with DGF and from 4% to 56% for those without DGF.The sensitivity,specificity and positive predictive value of a calculated DGF risk ≥ 30% with the Irish nomogram were 32%,91% and 38%. CONCLUSION Predictive models for DGF after kidney transplantation are performant in the population in which they were derived,but less so in external validations. | Magda Michalak Kristien Wouters Erik Fransen Rachel Hellemans Amaryllis H Van Craenenbroeck Marie M Couttenye Bart Bracke Dirk K Ysebaert Vera Hartman Kathleen De Greef Thiery Chapelle Geert Roeyen Gerda Van Beeumen Marie-Paule Emonds Daniel Abramowicz Jean-Louis Bosmans | 2017 | World Journal of Transplantation2017，7，5： | 3 |
| 2 | Clinical attitudes towards pain treatment post-orthopedic surgery: a multicenter study in Beijing显示文摘 | WANG Zhi-qiang ZHAN Si-yan Marlene Fransen LIN Jian-hao | 2012 | Chinese Medical Journal2012，，14： | 2 |
| 3 | Rupture of Infra-renal Aortic Aneurysm after Endovascular Repair: A Series from EUROSTAR Registry显示文摘 | G.A.J. Fransen S.R. Vallabhaneni C.J. van Marrewijk R.J.F. Laheij P.L. Harris J. Buth | 2003 | European Journal of Vascular & Endovascular Surgery2003，，5： | 2 |
| 4 | Learning curves in minimally invasive esophagectomy显示文摘Surgical innovation and pioneering are important for improving patient outcome, but can be associated with learning curves. Although learning curves in surgery are a recognized problem, the impact of surgical learning curves is increasing, due to increasing complexity of innovative surgical procedures, the rapid rate at which new interventions are implemented and a decrease in relative effectiveness of new interventions compared to old interventions. For minimally invasive esophagectomy(MIE), there is now robust evidence that implementation can lead to significant learning associated morbidity(morbidity during a learning curve, that could have been avoided if patients were operated by surgeons that have completed the learning curve). This article provides an overview of the evidence of the impact of learning curves after implementation of MIE. In addition, caveats for implementation and available evidence regarding factors that are important for safe implementation and safe pioneering of MIE are discussed. | Frans van Workum Laura Fransen Misha DP Luyer Camiel Rosman | 2018 | World Journal of Gastroenterology2018，24，44： | 2 |
| 5 | PRIMARY CELL CULTURE FOR EMBRYONIC CARDIAC MYOCYTES OF MEXICAN AXOLOTL AND DISTRIBUTION OF DESMIN AND VIMENTIN显示文摘INTRODUCTIONTheaxolotlprovidesavaluablemodelsystemforstudyingmuscledevelopmentandfunction.Electronmicroscopyrevealsthataxolot... | Zhu Yongze, Robert W Zajdel *, Margaret E Fransen *, Larry F Lemanski *(Department of Anatomy, Medical College of Yangzhou University, Yangzhou, 225001 Chian Department of Anatomy and Cell Biology, State University of New York, Health Science Cent | 1999 | 中国组织化学与细胞化学杂志1999，8，1： | 2 |
| 6 | Artificial rearing influences the morphology,permeability and redox state of the gastrointestinal tract of low and normal birth weight piglets显示文摘Background: In this study the physiological implications of artificial rearing were investigated. Low(LBW) and normal birth weight(NBW) piglets were compared as they might react differently to stressors caused by artificial rearing. In total, 42 pairs of LBW and NBW piglets from 16 litters suckled the sow until d19 of age or were artificially reared starting at d3 until d19 of age. Blood and tissue samples that were collected after euthanasia at 0, 3, 5, 8 and 19 d of age. Histology, ELISA, and Ussing chamber analysis were used to study proximal and distal small intestine histomorphology, proliferation, apoptosis, tight junction protein expression, and permeability. Furthermore, small intestine,liver and systemic redox parameters(GSH, GSSG, GSH-Px and MDA) were investigated using HPLC.Results: LBW and NBW artificially reared piglets weighed respectively 40 and 33% more than LBW and NBW sowreared piglets at d19(P < 0.01). Transferring piglets to a nursery at d3 resulted in villus atrophy, increased intestinal FD-4 and HRP permeability and elevated GSSG/GSH ratio in the distal small intestine at d5(P < 0.05). GSH concentrations in the proximal small intestine remained stable, while they decreased in the liver(P < 0.05). From d5 until d19, villus width and crypt depth increased, whereas PCNA, caspase-3, occludin and claudin-3 protein expressions were reduced. GSH,GSSG and permeability recovered in artificially reared piglets(P < 0.05).Conclusion: The results suggest that artificial rearing altered the morphology, permeability and redox state without compromising piglet performance. The observed effects were not depending on birth weight. | Hans Vergauwen Jeroen Degroote Sara Prims Wei Wang Erik Fransen Stefaan De Smet Christophe Casteleyn Steven Van Cruchten Joris Michiels Chris Van Ginneken | 2017 | Journal of Animal Science and Biotechnology2017，8，3： | 2 |
| 7 | Peri-operative myocardial tissue injury and the release of inflammatory mediators in coronary artery bypass graft patients显示文摘 | Fransen EJ Maessen JG Hermens WT | 2000 | Cardiovasc Res2000，45，4： | 1 |
| 8 | Prevention of scar tissue formation inspinal surgery: State of the art and review of the lit-erature 显示文摘 | Fransen P | 2011 | J Neurosurg Sci2011，55，3： | 1 |
| 9 | Root morphological plasticity and nutrient acquisition of perennial grass species from habitats of different nutrient availability显示文摘 | FRANSEN B DE KROON H BERENDSE F | 1998 | Oecologia1998，115，： | 1 |
| 10 | Fungi as biological control agents of Bemisia tabaci显示文摘 | Lacey L A Fransen J J | | 0，，： | 1 |
| 11 | Hybrid retinal image registration显示文摘 | Chanwimaluang T Fan G L Fransen S R | 2006 | IEEE Transactions on Information Technology in Biomedicine2006，10，1： | 1 |
| 12 | Demonstration of ischemia-reperfusion injury separate frompostoperative infarction in coronary artery bypass graft patients显示文摘 | Fransen EJ Maessen JG Hermens WT | 1998 | Ann Thorac Surg1998，65，1： | 1 |
| 13 | RANTES production by T cells and CD8-mediated inhibition of human immunodeficiency virus gene expression before initiation of potent antiretroviral therapy predict sustained suppression of viral replication 显示文摘 | Fransen S Copeland KF Smieja M | 2000 | J Infect Dis2000，181，2： | 1 |
| 14 | Genetic and phylogenetic analysis of env subtype G and centre Africa显示文摘 | Tanssens W Hevndrick K Fransen K | 1994 | AIDS Res Hum Retroviruses1994，10，： | 1 |
| 15 | The role of dendritic cells in the pathogenesis of systemic lupus erythematosus 显示文摘 | Fransen J H van der Vlag J Ruben J | 2010 | Ar- thritis Res Ther2010，12，4： | 1 |
| 16 | A randomized trial of intraarterial treatment for acute ischemic stroke 显示文摘 | Berkhemer OA Fransen PS Beumer D et 81 | 2015 | N Engl J Med2015，372，1： | 1 |
| 17 | Mean values of Dedekind sums显示文摘 | Conrey J B Fransen E Klein R | 1982 | Journal of Number Theory1982，41，： | 1 |
| 18 | Root morphological and physiological plasticity of perennial grass species and the exploitation of spatial and temporal heterogeneous nutrient patches显示文摘 | Fransen B Blijjenberg J de Kroon H | 1999 | Plant and Soil1999，211，： | 1 |
| 19 | The embeddedness of responsible business practice: Exploring the interaction between national-institutional environments and corporate social responsibility 显示文摘 | Fransen L | 2013 | Journal of Business Ethic2013，115，2： | 1 |
| 20 | The Dis-ease Activity Score and the EULAR response cri-teria显示文摘 | Fransen J van Riel PL Fransen J | 2005 | Clin Exp Rheumatol2005，23，539： | 1 |
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