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| 1 | Hepatitis C virus infection and type 1 and type 2 diabetes mellitus显示文摘Hepatitis C virus(HCV) infection and diabetes mellitus are two major public health problems that cause devastating health and financial burdens worldwide. Diabetes can be classified into two major types: type 1 diabetes mellitus(T1DM) and T2 DM. T2 DM is a common endocrine disorder that encompasses multifactorial mechanisms, and T1 DM is an immunologically mediated disease. Many epidemiological studies have shown an association between T2 DM and chronic hepatitis C(CHC) infection. The processes through which CHC is associated with T2 DM seem to involve direct viral effects, insulin resistance, proinflammatory cytokines, chemokines, and other immunemediated mechanisms. Few data have been reported on the association of CHC and T1 DM and reports on the potential association between T1 DM and acute HCV infection are even rarer. A small number of studies indicate that interferon-α therapy can stimulate pancreatic autoim-munity and in certain cases lead to the development of T1 DM. Diabetes and CHC have important interactions. Diabetic CHC patients have an increased risk of developing cirrhosis and hepatocellular carcinoma compared with nondiabetic CHC subjects. However, clinical trials on HCV-positive patients have reported improvements in glucose metabolism after antiviral treatment. Further studies are needed to improve prevention policies and to foster adequate and cost-effec-tive programmes for the surveillance and treatment of diabetic CHC patients. | Alessandro Antonelli Silvia Martina Ferrari Dilia Giuggioli Andrea Di Domenicantonio Ilaria Ruffilli Alda Corrado Silvia Fabiani Santino Marchi Clodoveo Ferri Ele Ferrannini Poupak Fallahi | 2014 | World Journal of Diabetes2014，5，5： | 7 |
| 2 | Duodenal duplication cyst causing severe pancreatitis:Imaging findings and pathological correlation显示文摘We here report a case of a 18-year-old man with a history of recurrent abdominal pain and a previous episode of severe acute pancreatitis. Abdominal ultrasonography, contrast enhanced multislice computer tomography, endoscopic retrograde cholangiopancreatography, endoscopic ultrasonography and magnetic resonance imaging demonstrated a cystic mass lesion. Only on delayed phase magnetic resonance images after GadoliniumBOPTA injection, it was possible to demonstrate the lesion's relationship with the biliary tree, differentiating the lesion from intraluminal duodenal diverticulum, and to achieve the diagnosis of duodenal duplication cyst, a recognized rare cause of acute pancreatitis. The diagnosis was confirmed by histology. | Alessandro Guarise Niccolo' Faccioli Mauro Ferrari Luigi Romano Alice Parisi Massimo Falconi | 2006 | World Journal of Gastroenterology2006，12，10： | 6 |
| 3 | Inflammatory bowel disease surgery in the biologic era显示文摘Anti-tumour necrosis factor(TNF)-α therapy has revolutionized inflammatory bowel disease(IBD) treatment. Infliximab and adalimumab either as monotherapy or in combination with an immunomodulator are able to induce clinical and biological remission in patients with moderate and severe Crohn's disease(CD) and ulcerative colitis(UC). These new therapies have led to a shift in the goals of IBD management from just controlling clinical symptoms to preventing disease progression. However, despite these advances in medical therapy, surgery is still required in 30%-40% of patients with CD and 20%-30% of patients with UC at some point during their lifetime. While biologics certainly play a major role in the medical treatment of IBD, there is concern about the effects of these anti-TNF-α agents on postoperative complications and morbidity. The purpose of this article is to review the role of surgery in the treatment of IBD in the age of biologics and the impact of these medications on per-operative outcomes. In this manuscript we review the relationship between biologic agents and surgery in the treatment of IBD. We also discuss in detail the periopetative risks and complications. | Linda Ferrari Mukta K Krane Alessandro Fichera | 2016 | World Journal of Gastrointestinal Surgery2016，8，5： | 4 |
| 4 | Neutrophil gelatinase-associated lipocalin does not predict acute kidney injury in heart failure显示文摘BACKGROUND Acute cardiorenal syndrome type 1(CRS-1)is defined by a rapid cardiac dysfunction leading to acute kidney injury(AKI).Neutrophil gelatinaseassociated lipocalin(NGAL)is expressed on the surface of human neutrophils and epithelial cells,such as renal tubule cells,and its serum(sNGAL)and urinary have been used to predict AKI in different clinical settings.AIM To characterize CRS-1 in a cohort of patients with acute heart diseases,evaluating the potentiality of sNGAL as an early marker of CRS-1.METHODS We performed a retrospective cohort,multi-centre study.From January 2010 to December 2011,we recruited 202 adult patients admitted to the coronary intensive care unit(CICU)with a diagnosis of acute heart failure or acute coronary syndrome.We monitored the renal function to evaluate CRS-1 development and measured sNGAL levels within 24 h and after 72 h of CICU admission.RESULTS Overall,enrolled patients were hemodynamically stable with a mean arterial pressure of 92(82-107)mmHg,55/202(27.2%)of the patients developed CRS-1,but none of them required dialysis.Neither the NGAL delta value(AUC 0.40,95%CI:0.25-0.55)nor the NGAL peak(AUC 0.45,95%CI:0.36-0.54)or NGAL cutoff(≥140 ng/mL)values were statistically significant between the two groups(CRS-1 vs no-CRS1 patients).The area under the ROC curve for the prediction of CRS-1 was 0.40(95%CI:0.25-0.55)for the delta NGAL value and 0.45(95%CI:0.36-0.54)for the NGAL peak value.Finally,in multivariate analysis,the risk of developing CRS-1 was correlated with age>60 years,urea nitrogen at admission and 24 h-urine output(AUC 0.83,SE=60.5%SP=93%),while sNGAL was not significantly correlated.CONCLUSION In our population,sNGAL does not predict CRS-1,probably as a consequence of the mild renal injury and the low severity of heart disease.So,these data might suggest that patient selection should be taken into account when considering the utility of NGAL measurement as a biomarker of kidney damage. | Fiorenza Ferrari Elisa Scalzotto Pasquale Esposito Sara Samoni Flavio Mistrorigo Lilia Maria Rizo Topete Massimo De Cal Grazia Maria Virzì Valentina Corradi Rossella Torregrossa Roberto Valle Stefania Bianzina Nadia Aspromonte Matteo Floris Alessandro Fontanelli Alessandra Brendolan Claudio Ronco | 2020 | World Journal of Clinical Cases2020，8，9： | 3 |
| 5 | Genetic distinctions between autoimmune hepatitis in Italy and North America显示文摘AIM: Our goals were to analyze the known genetic predispositions for autoimmune hepatitis (AIH) in AIH Italian population and to compare them with North American counterparts.METHODS: Human leukocyte antigens (HLA) B8, C7, DR3,DR4, DR7, DR11, DR13, DQ2 and the B8-DR3-DQ2phenotype were determined by microlymphocytotoxicity and polymerase chain reaction in 74 Italian patients (57with type 1 and 17 with type 2 AIH) and 149 North American patients with type 1 AIH, and in adequate controls.RESULTS: B8-DR3-DQ2 occurred more frequently in Italian patients with type 1 AIH than in Italian controls (30% vs 7%, P<0.0001), but less frequently than in North American counterparts (30% vs48%, P = 0.02). DR4 occurred less frequently in Italian patients with type 1 AIH (23% vs43%,P= 0.01) and in controls (16% vs34%, P= 0.0003) than in North American counterparts. No differences were found in alleles' frequency between type 1 and type 2Italian AIH patients. DR11 had a frequency lower in type 1 Italian AIH patients than controls (17% vs35%, P= 0.01).CONCLUSION: HLA DR4 is not associated with AIH in Italy. The known HLA risk factors for ATH occur similarly in Italian patients with type 1 and type 2 AIH, and they are less frequent than in North American patients. B8-DR3-DQ2 is the predominant phenotype of type 1 AIH also in Italy, and HLA DR11 may be a regionally distinctive protective factor against type 1 AIH. | Paolo Muratori Albert J.Czaja Luigi Muratori Georgios Pappas Silvana Maccariello Fabio Cassani Alessandro Granito Rodolfo Ferrari Vilma Mantovani Marco Lenzi Francesco B.Bianchi | 2005 | World Journal of Gastroenterology2005，11，12： | 2 |
| 6 | 直肠癌新辅助放化疗和病理完全缓解显示文摘在过去几十年里,直肠癌的治疗已有了很大的进展,其中最为显著的要属20世纪90年代全直肠系膜切除术(TME)的问世和新辅助放化疗(CRT)的应用。临床Ⅰ级证据显示,新辅助放化疗(CRT)可使局部复发率降至6%以下,CRT也就此成为了目前直肠癌的标准治疗模式。CRT可使肿瘤降期,其中15%–27%的患者可以获得病理完全缓解(pCR),意味着CRT后在组织学标本中无任何肿瘤残留。CRT后获得pCR的患者预后良好,局部复发和远处转移风险下降,生存时间延长。因此,积极保留括约肌或保留器官的手术方式如局部切除术在直肠癌治疗中得以更多的应用,甚至非手术治疗也成为可能。尽管多学科综合治疗可使局部进展期直肠癌的局部复发率稳定在5%–6%,但其远处转移率却仍然高达25%以上,这也是患者的主要死因。因此,最近一些研究采用新辅助全量系统化疗以早期治疗远处微转移灶,从而提高肿瘤的系统控制率,仅对化疗无应答者或低位直肠癌(距肛缘不足5 cm)进行术前放疗。 | Linda Ferrari Alessandro Fichera | 2015 | Gastroenterology Report2015，3，4： | 2 |
| 7 | Stepwise combination algorithms of non-invasive markers to diagnose significant fibrosis in chronic hepatitis C显示文摘 | Giada Sebastiani Alessandro Vario Maria Guido Franco Noventa Mario Plebani Roberta Pistis Alessia Ferrari Alfredo Alberti | 2006 | Journal of Hepatology2006，，4： | 2 |
| 8 | Cytokines and HCV-Related Disorders显示文摘 | Poupak Fallahi Clodoveo Ferri Silvia Martina Ferrari Alda Corrado Domenico Sansonno Alessandro Antonelli Jürg Schifferli | 2012 | Clinical and Developmental Immunology2012，，： | 1 |
| 9 | Handling large datasets of hyperspectral images: Reducing data size without loss of useful information显示文摘 | Carlotta Ferrari Giorgia Foca Alessandro Ulrici | 2013 | Analytica Chimica Acta2013，，： | 1 |
| 10 | Differential Scanning Calorimetry as a Tool to Investigate the Transfer of Anticancer Drugs to Biomembrane Model显示文摘 | Maria Grazia Sarpietro Maria Lorena Accolla Christian Celia Alessandro Grattoni Francesco Castelli Massimo Fresta Mauro Ferrari Donatella Paolino | 2013 | Current Drug Targets2013，，9： | 1 |
| 11 | Role of molecular imaging in the management of patients affected by inflammatory bowel disease:State-of-the-art显示文摘AIM To present the current state-of-the art of molecular imaging in the management of patients affected by inflammatory bowel disease(IBD).METHODS A systematic review of the literature was performed in order to find important original articles on the role of molecular imaging in the management of patients affected by IBD. The search was updated until February 2016 and limited to articles in English.RESULTS Fifty-five original articles were included in this review, highlighting the role of single photon emission tomography and positron emission tomography. CONCLUSION To date, molecular imaging represents a useful tool to detect active disease in IBD. However, the available data need to be validated in prospective multicenter studies on larger patient samples. | Federico Caobelli Laura Evangelista Natale Quartuccio Demetrio Familiari Corinna Altini Angelo Castello Mariapaola Cucinotta Rossella Di Dato Cristina Ferrari Aurora Kokomani Iashar Laghai Riccardo Laudicella Silvia Migliari Federica Orsini Salvatore Antonio Pignata Cristina Popescu Erinda Puta Martina Ricci Silvia Seghezzi Alessandro Sindoni Martina Sollini Letterio Sturiale Anna Svyridenka Vittoria Vergura Pierpaolo Alongi | 2016 | World Journal of Radiology2016，8，10： | 1 |
| 12 | Hydraulic Circuit Design Rules to Remove the Dependence of the Injected Fuel Amount on Dwell Time in Multiiet CR Systems显示文摘 | Mirko Baratta Andrea Emilio Catania Alessandro Ferrari | 2008 | Journal of Fluids Engineering2008，130，12： | 1 |
| 13 | Localization of a Novel Locus for Autosomal Recessive Early-Onset Parkinsonism, PARK6, on Human Chromosome 1p35-p36显示文摘 | Enza Maria Valente Anna Rita Bentivoglio Peter H. Dixon Alessandro Ferraris Tamara Ialongo Marina Frontali Alberto Albanese Nicholas W. Wood | 2001 | The American Journal of Human Genetics2001，，4： | 1 |
| 14 | Immunopathogenesis of HCV-related endocrine manifestations in chronic hepatitis and mixed cryoglobulinemia显示文摘 | Alessandro Antonelli Clodoveo Ferri Silvia Martina Ferrari Michele Colaci Poupak Fallahi | 2008 | Autoimmunity Reviews2008，，1： | 1 |
| 15 | B-cells and mixed cryoglobulinemia显示文摘 | Clodoveo Ferri Alessandro Antonelli Maria Teresa Mascia Marco Sebastiani Poupak Fallahi Daniela Ferrari Marco Giunti Stefano A. Pileri Anna Linda Zignego | 2007 | Autoimmunity Reviews2007，，2： | 1 |
| 16 | Correspondence Regarding the Study by Chen-Lu Yang et al. Published in the Chinese Medical Journal, 129(18):2258-9显示文摘 | Alessandro Ferrari Jacinto Fabio Vicente Leite | 2016 | Chinese Medical Journal2016，，23： | 1 |
| 17 | Efficacy of different adhesive techniques on bonding to root cannal walls: an SEM invistigation显示文摘 | Marco Ferrari Alessandro Vichi Simone Grandini | 2001 | Dental Materials2001，，17： | 1 |
| 18 | Hydraulic circuit design rules to remove the dependence of the injected fuel amount on dwell time in muhijet CR systems显示文摘 | Mirko Baratta Andrea Emilio Catania Alessandro Ferrari | 2008 | ASME Journal of Fluids Engineering2008，130，12： | 1 |
| 19 | Start-up of a pilot-scale membrane bioreaetor to treat municipal wastewater 显示文摘 | Marco Ferraris Carolina Innella Alessandro Spagni | 2009 | Desalination2009，，237： | 1 |
| 20 | Comparing Attendance and Detection Rate of Colonoscopy With Sigmoidoscopy and FIT for Colorectal Cancer Screening显示文摘 | Nereo Segnan Carlo Senore Bruno Andreoni Alberto Azzoni Luigi Bisanti Alessandro Cardelli Guido Castiglione Cristiano Crosta Andrea Ederle Alberto Fantin Arnaldo Ferrari Mario Fracchia Franco Ferrero Stefano Gasperoni Serafino Recchia Mauro Risio Tiziana | 2007 | Gastroenterology2007，，7： | 1 |
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