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| 1 | Duodenal duplication cyst causing severe pancreatitis:Imaging findings and pathological correlation显示文摘We here report a case of a 18-year-old man with a history of recurrent abdominal pain and a previous episode of severe acute pancreatitis. Abdominal ultrasonography, contrast enhanced multislice computer tomography, endoscopic retrograde cholangiopancreatography, endoscopic ultrasonography and magnetic resonance imaging demonstrated a cystic mass lesion. Only on delayed phase magnetic resonance images after GadoliniumBOPTA injection, it was possible to demonstrate the lesion's relationship with the biliary tree, differentiating the lesion from intraluminal duodenal diverticulum, and to achieve the diagnosis of duodenal duplication cyst, a recognized rare cause of acute pancreatitis. The diagnosis was confirmed by histology. | Alessandro Guarise Niccolo' Faccioli Mauro Ferrari Luigi Romano Alice Parisi Massimo Falconi | 2006 | World Journal of Gastroenterology2006，12，10： | 6 |
| 2 | High-resolution ex vivo analysis of the degradation and osseointegration of Mg-xGd implant screws in 3D显示文摘Biodegradable magnesium(Mg)alloys can revolutionize osteosynthesis,because they have mechanical properties similar to those of the bone,and degrade over time,avoiding the need of removal surgery.However,they are not yet routinely applied because their degradation behavior is not fully understood.In this study we have investigated and quantified the degradation and osseointegration behavior of two biodegradable Mg alloys based on gadolinium(Gd)at high resolution.Mg-5Gd and Mg-10Gd screws were inserted in rat tibia for 4,8 and 12 weeks.Afterward,the degradation rate and degradation homogeneity,as well as bone-to-implant interface,were studied with synchrotron radiation micro computed tomography and histology.Titanium(Ti)and polyether ether ketone(PEEK)were used as controls material to evaluate osseointegration.Our results showed that Mg-5Gd degraded faster and less homogeneously than Mg-10Gd.Both alloys gradually form a stable degradation layer at the interface and were surrounded by new bone tissue.The results were correlated to in vitro data obtained from the same material and shape.The average bone-to-implant contact of the Mg-xGd implants was comparable to that of Ti and higher than for PEEK.The results suggest that both Mg-xGd alloys are suitable as materials for bone implants. | Diana Krüger Silvia Galli Berit Zeller-Plumhoff D.C.Florian Wieland Niccolo Peruzzi Bjorn Wiese Philipp Heuser Julian Moosmann Ann Wennerberg Regine Willumeit-Romer | 2022 | Bioactive Materials2022，7，7： | 2 |
| 3 | Effect of the micro-environment on α-synuclein conversion and implication in seeded conversion assays显示文摘Background: α-Synuclein is a small soluble protein,whose physiological function in the healthy brain is poorly understood.Intracellular inclusions of α-synuclein,referred to as Lewy bodies(LBs),are pathological hallmarks ofαsynucleinopathies,such as Parkinson’s disease(PD)or dementia with Lewy bodies(DLB).Main body:Understanding of the molecular basis as well as the factors or conditions promoting α-synuclein misfolding and aggregation is an important step towards the comprehension of pathological mechanism ofαsynucleinopathies and for the development of efficient therapeutic strategies.Based on the conversion and aggregation mechanism of α-synuclein,novel diagnostic tests,such as protein misfolding seeded conversion assays,e.g.the real-time quaking-induced conversion(RT-QuIC),had been developed.In diagnostics, α-synuclein RT-QuIC exhibits a specificity between 82 and 100%while the sensitivity varies between 70 and 100%among different laboratories.In addition,the α-synuclein RT-QuIC can be used to study the α-synuclein-seeding-characteristics of different α-synucleinopathies and to differentiate between DLB and PD.Conclusion:The variable diagnostic accuracy of current α-synuclein RT-QuIC occurs due to different protocols,cohorts and material etc..An impact of micro-environmental factors on the α-synuclein aggregation and conversion process and the occurrence and detection of differential misfolded α-synuclein types or strains might underpin the clinical heterogeneity of α-synucleinopathies. | Niccolo Candelise Matthias Schmitz Katrin Thüne Maria Cramm Alberto Rabano Saima Zafar Erik Stoops Hugo Vanderstichele Anna Villar-Pique Franc Llorens Inga Zerr | 2020 | Translational Neurodegeneration2020，9，1： | 1 |
| 4 | Designing the dynamic behavior of an engine suspension system through genetic algorithms显示文摘 | Baldanzini Niccolo | 2001 | Transactions of the ASME2001，123，3： | 1 |
| 5 | What makes turnips:anatomy,physiology and transcriptome during early stages of its hypocotyl-tuber development显示文摘Brassica species are characterized by their tremendous intraspecific diversity,exemplified by leafy vegetables,oilseeds,and crops with enlarged inflorescences or above ground storage organs.In contrast to potato tubers that are edible storage organs storing energy as starch and are the vegetative propagation modules,the storage organs of turnips,grown from true seed,are swollen hypocotyls with varying degrees of root and stem that mainly store glucose and fructose.To highlight their anatomical origin,we use the term“hypocotyl-tuber”for these turnip vegetative storage organs.We combined cytological,physiological,genetic and transcriptomic approaches,aiming to identify the initial stages,molecular pathways and regulatory genes for hypocotyl-tuber induction in turnips(B.rapa subsp.rapa).We first studied the development of the hypocotyl zone of turnip and Pak choi and found that 16 days after sowing(DAS)morphological changes occurred in the xylem which indicated the early tuberization stage.Tissue culture experiments showed a clear effect of auxin on hypocotyl-tuber growth.Differentially expressed genes between 1 and 6 weeks after sowing in turnip hypocotyls,located in genomic regions involved in tuber initiation and/or tuber growth defined by QTL and selective sweeps for tuber formation,were identified as candidate genes that were studied in more detail for their role in hypocotyl-tuber formation.This included a Bra-FLOR1 paralogue with increased expression 16 DAS,when the hypocotyl starts swelling,suggesting dual roles for duplicated flowering time genes in flowering and hypocotyltuber induction.Bra-CYP735A2 was identified for its possible role in tuber growth via trans-zeatin.Weigthed Coexpression Network Analysis(WGCNA)identified 59 modules of co-expressed genes.Bra-FLOR1 and Bra-CYP735A2 were grouped in a module that included several genes involved in carbohydrate transport and metabolism,cell-wall growth,auxin regulation and secondary metabolism that serve as starting points to illuminate the transcriptional regulation of hypocotyl-tuber formation and development. | Mengyang Liu Niccolo Bassetti Stefan Petrasch Ningwen Zhang Johan Bucher Shuxing Shen Jianjun Zhao Guusje Bonnema | 2019 | Horticulture Research2019，6，1： | 1 |
| 6 | Tissue microarray-chip featuring computerized immunophenotypical characterization more accurately subtypes ampullary adenocarcinoma than routine histology显示文摘BACKGROUND Ampullary adenocarcinomas(AACs)are heterogeneous tumors currently classified into three important sub-classes(SC):Intestinal(INT),Pancreato-Biliary(PB)and Mixed-Type(MT).The different subgroups have similar clinical presentation and are treated by pancreatoduodenectomy with curative intent.However,they respond differently to chemotherapy and have different prognostic outcomes.The SC are often difficult to identify with conventional histology alone.The clinical outcome of all three remains unclear,particularly for MT.AIM To identify two main subtypes of AACs,using an immunohistochemical(IHC)score based on CDX2,CK7 and CK20.METHODS Tissue samples from 21 patients who had undergone resection of AAC were classified by HE histology and IHC expression of CDX2,CK7 and CK 20.An IHC score was obtained for each marker by counting the number of positive cells(0=no stained cells;1<25%;2<50%and 3>50%)and their intensity(1=weak;2=moderate and 3=strong).A global score(GS)was then obtained by summation of the IHC scores of each marker.The MT tumors were grouped either with the INT or PB group based on the predominant immuno-molecular phenotype,obtaining only two AACs subtypes.The overall survival in INT and PB patients was obtained by Kaplan-Meier methods.RESULTS Histological parameters defined the AACs subtypes as follows:15%INT,45%PB and 40%MT.Using IHC expression and the GS,75%and 25%of MT samples were assigned to either the INT or the PB group.The mean value of the GS was 9.5(range 4-16).All INT samples had a GS above the average,distinct from the PB samples which had a GS score significantly below the average(P=0.0011).The INT samples were identified by high expression of CDX2 and CK20,whereas PB samples exhibited high expression of CK7 and no expression of CK20(P=0.0008).The INT group had a statistically significant higher overall survival than in the PB group(85.7 mo vs 20.3 mo,HR:8.39;95%CI:1.38 to 18.90;P=0.0152).CONCLUSION The combination of histopathological and molecular criteria enables the classification of AACs into two clinically relevant histo-molecular phenotypes,which appear to represent distinct disorders with potentially significant changes to the current therapeutic strategies. | Matteo Palmeri Niccola Funel Gregorio Di Franco Niccolo Furbetta Desiree Gianardi Simone Guadagni Matteo Bianchini Luca E Pollina Claudio Ricci Marco Del Chiaro Giulio Di Candio Luca Morelli | 2020 | World Journal of Gastroenterology2020，26，43： | 1 |
| 7 | Role of interleukin- 113 in postoperative cognitive dysfunction显示文摘 | Mario C Antonio RF Niccolo T | 2010 | Ann Neurol2010，68，3： | 1 |
| 8 | Stimulus Parameters for Goldmann Kinetic Perimetry in Nonorganic Visual Loss显示文摘 | Ebneter Andreas Pellanda Niccolo Kunz Andrea Mojon Stefania Mojon Daniel S | 2010 | Ophthalmologica2010，，3： | 1 |
| 9 | finplant placement in combina- tion with sinus nmmbrane elevation without biomaterials: a 1-year study on 15 patients显示文摘 | Piero B Mario V Niccolo N | 2012 | Clin hnplant Dent Relat Res2012，14，5： | 1 |
| 10 | Perioperative cognitive decline in the aging population显示文摘 | Niccolo Terrando Marek Brzezinski Vincent Degos | | 0，，09： | 1 |
| 11 | Microalgae for oil:strain selection,induction of lipid synthesis and outdoor mass cultivation in a low-cost photobioreactor显示文摘 | LILIANA R GRAZIELLA C Z NICCOLO B | | 0，，01： | 1 |
| 12 | Microalgae for oil:strain selection,Induction of lipid synthesis and outdoor mass cultivation in a low-cost photobioreactor 显示文摘 | Liliana R Graziella CZ Niccolo B Giulia P Natascia B Gimena B Mario RT | 2009 | Biotechnology2009，102，1： | 1 |
| 13 | Ligand-dependent cleavage of the P75 neurotrophin receptor Is necessary for NRIF nuclear translocation and apoptosis in sympathetic neurons 显示文摘 | Rajappa SK Niccolo Z Moses VC | 2006 | Neuron2006，50，： | 1 |
| 14 | Role of interleukin - 1β in postoperative cognitive dysfunction 显示文摘 | Mario C Antonio RF Niccolo T | 2010 | Ann Neurol2010，68，3： | 1 |
| 15 | Microalgae for oil:Strain selection, induction of lipid synthesis显示文摘 | LILIANA R GRAZIELLA C Z NICCOLO B | 2009 | Biotechnology and Bioengineering2009，102，1： | 1 |
| 16 | Physics and astrophysics of strong magnetic field systems with eXTP显示文摘In this paper we present the science potential of the enhanced X-ray Timing and Polarimetry(eXTP) mission for studies of strongly magnetized objects. We will focus on the physics and astrophysics of strongly magnetized objects, namely magnetars, accreting X-ray pulsars, and rotation powered pulsars. We also discuss the science potential of eXTP for QED studies. Developed by an international Consortium led by the Institute of High Energy Physics of the Chinese Academy of Sciences, the eXTP mission is expected to be launched in the mid 2020s. | Andrea Santangelo Silvia Zane Hua Feng RenXin Xu Victor Doroshenko Enrico Bozzo Ilaria Caiazzo Francesco Coti Zelati Paolo Esposito Denis González-Caniulef Jeremy Heyl Daniela Huppenkothen Gianluca Israel ZhaoSheng Li Lin Lin Roberto Mignani Nanda Rea Mauro Orlandini Roberto Taverna Hao Tong Roberto Turolla Cristina Baglio Federico Bernardini Niccolo'Bucciantini Marco Feroci Felix Fürst Ersin G??ü? Can Güngör Long Ji FangJun Lu Antonios Manousakis Sandro Mereghetti Romana Mikusincova Biswajit Paul Chanda Prescod-Weinstein George Younes Andrea Tiengo YuPeng Xu Anna Watts Shu Zhang Shuang-Nan Zhang | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 1 |
| 17 | Improved exercise tolerance and quality of life with cardiac rehabilitation of old patients after myocardial infarction 显示文摘 | Niccolo M Francesco F Stefano F | 2003 | Circulation2003，107，： | 1 |
| 18 | Localized Hypersensitivity and Late Coronary Thrombosis Secondary to a Sirolimus-Eluting Stent: Should We Be Cautious?显示文摘 | Renu Virmani Giulio Guagliumi Andrew Farb Giuseppe Musumeci Niccolo Grieco Teresio Motta Laurian Mihalcsik Maurizio Tespili Orazio Valsecchi Frank D. Kolodgie | 2004 | Circulation: Journal of the American Heart Association2004，，6： | 1 |
| 19 | Tumor necrosis factor-alpha triggers a cytokine cascade yielding postoperative cognitive decline显示文摘 | Niccolo Terrando Claudia Monaco Ma Da-qing | 2010 | Proc Natl Acad Sci USA2010，107，20： | 1 |
| 20 | Balloon aortic valvuloplasty as a bridge-to-decision in high risk patients with aortic stenosis: a new paradigm for the heart team decision making显示文摘BackgroundWhilst 有严重大动脉的狭窄的病人的多数能直接针对外科的大动脉的阀门代替(AVR ) 或 transcatheter 大动脉的阀门培植(TAVI ) ,在一些例子,另外的信息可以被需要完成诊断体育锻练。我们评估了汽球的角色大动脉的 valvuloplasty (BAV ) 作为在选择高风险的 patients.MethodsBetween 的 bridge-to-decision (BTD ) 2007 和 2012,在我们的机构的心队在 202 个病人要求了 BTD BAV。很低的左室的喷射部分,僧帽形的流回等级 ≥3,这些因素的脆弱,血液动力学的不稳定性,严肃的 comorbidity,或联合是为这策略的主要司机。我们评估了 BAV 怎么在整个耐心的组并且在为心脏的起作用的风险评估(EuroSCORE ) 的逻辑欧洲系统是的各特定的 subgroup.ResultsMean 影响了最后的治疗策略 23.5%±15.3% ,年龄 81 ±7 年。在里面医院死亡是 4.5% ,脑血管的事故 1% 并且全面脉管的复杂并发症 4%(0.5% 专业;3.5% 未成年者) 。熬过并且收到第二心队评估的有 BTD BAV 的 193 个病人, 72.6% 最后被认为为权威的治疗合格(25.4% 为 AVR;47.2% 为 TAVI ) :有左室的喷射部分恢复的 96.7% 病人;有僧帽形的流回减小的 70.5% 病人;在临床的血液动力学的不稳定性经历了 BAV 的 75.7% 病人;69.2% 脆弱的病人和不能是权威的 transcatheter 或外科的治疗的立即的候选人的介绍了大动脉的 valvuloplasty 能与严重大动脉的狭窄在高风险的病人被看作 bridge-to-decision 的严肃的 comorbidities.ConclusionsBalloon 的 68% 病人。 | Francesco Saia Carolina Moretti Gianni Dall'Ara Cristina Ciuca Nevio Taglieri Alessandra Berardini Pamela Gallo Marina Cannizzo Matteo Chiarabelli Niccolo Ramponi Linda Taffani Maria Letizia Bacchi-Reggiani Cinzia Marrozzini Claudio Rapezzi Antonio Marzocchi | 2016 | Journal of Geriatric Cardiology2016，13，6： | 0 |
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